{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:41:16Z","timestamp":1792708876029,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Foundation for Support to Research of Southern Rio Grande State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.biochi.2026.10.021","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:19:10Z","timestamp":1792563550000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Divergent Effects of Trichomonas vaginalis on Cervical Cancer Cells HPV-positive and HPV-negative: Interplay with Purinergic Signaling"],"prefix":"10.1016","author":[{"given":"Giulia Bongiorni","family":"Galego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4694-2749","authenticated-orcid":false,"given":"Lynza Freitas","family":"Holanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Biz","family":"Willig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Trindade dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magno Sinval Pereira","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-586X","authenticated-orcid":false,"given":"L\u00facia Maria","family":"Kliemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6480","authenticated-orcid":false,"given":"Diogo Andr\u00e9","family":"Pilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-5105","authenticated-orcid":false,"given":"Tiana","family":"Tasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biochi.2026.10.021_bib1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.biochi.2026.10.021_bib2","article-title":"Global burden of trichomoniasis: current status, trends, and projections (1990\u20132021)","volume":"13","author":"Wei","year":"2025","journal-title":"Front Public Health"},{"issue":"5","key":"10.1016\/j.biochi.2026.10.021_bib3","doi-asserted-by":"crossref","first-page":"800","DOI":"10.4269\/ajtmh.13-0723","article-title":"Neglected parasitic infections in the United States: trichomoniasis","volume":"90","author":"Secor","year":"2014","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.biochi.2026.10.021_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/sextrans-2018-053635","article-title":"Aptima Trichomonas vaginalis assay elucidates significant underdiagnosis of trichomoniasis among women in Brazil according to an observational study","volume":"95","author":"Bruni","year":"2019","journal-title":"Sex Transm Infect"},{"issue":"2","key":"10.1016\/j.biochi.2026.10.021_bib5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/pathogens13020126","article-title":"The past, present, and future in the diagnosis of a neglected sexually transmitted infection: trichomoniasis","volume":"13","author":"Ib\u00e1\u00f1ez-Escribano","year":"2024","journal-title":"Pathogens"},{"issue":"4","key":"10.1016\/j.biochi.2026.10.021_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.biochi.2026.10.021_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/venereology3010004","article-title":"From wet mount to nucleic acid amplification techniques: current diagnostic methods and future perspectives based on patenting of new assays, stains, and diagnostic images for Trichomonas vaginalis detection","volume":"3","author":"Cardoso","year":"2024","journal-title":"Venereology"},{"issue":"4","key":"10.1016\/j.biochi.2026.10.021_bib8","doi-asserted-by":"crossref","first-page":"e00912","DOI":"10.1128\/spectrum.00912-22","article-title":"In vitro effect of 5-nitroimidazole drugs against Trichomonas vaginalis clinical isolates","volume":"10","author":"Mtshali","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"Suppl 2","key":"10.1016\/j.biochi.2026.10.021_bib9","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1093\/cid\/ciac030","article-title":"Diagnosis and management of Trichomonas vaginalis: summary of evidence reviewed for the 2021 CDC STI treatment guidelines","volume":"74","author":"Kissinger","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.biochi.2026.10.021_bib10","unstructured":"World Health Organization. Cervical cancer. 2024. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cervical-cancer. Accessed 19 November 2025."},{"key":"10.1016\/j.biochi.2026.10.021_bib11","unstructured":"Pan American Health Organization. Cervical cancer \u2013 Towards the elimination of cervical cancer in the Americas. Available from: https:\/\/www.paho.org\/en\/topics\/cervical-cancer. Accessed 20 November 2025."},{"key":"10.1016\/j.biochi.2026.10.021_bib12","unstructured":"Minist\u00e9rio da Sa\u00fade. Taxa de HPV na genital atinge 54,4% das mulheres e 41,6% dos homens no Brasil, diz estudo [Internet]. 2023 Dec 15. Available from: https:\/\/www.gov.br\/saude\/pt-br\/assuntos\/noticias\/2023\/dezembro\/taxa-de-hpv-na-genital-atinge-54-4-das-mulheres-e-41-6-dos-homens-no-brasil-diz-estudo. Accessed 19 November 2025."},{"issue":"10","key":"10.1016\/j.biochi.2026.10.021_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1055\/a-1545-4279","article-title":"2020 WHO classification of female genital tumors","volume":"81","author":"H\u00f6hn","year":"2021","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.biochi.2026.10.021_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13027-023-00490-2","article-title":"The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis","volume":"18","author":"Zhang","year":"2023","journal-title":"Infect Agent Cancer"},{"issue":"3","key":"10.1016\/j.biochi.2026.10.021_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008126","article-title":"IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages","volume":"14","author":"Han","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"10.1016\/j.biochi.2026.10.021_bib16","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/pros.23826","article-title":"Inflammatory mediators of prostate epithelial cells stimulated with Trichomonas vaginalis promote proliferative and invasive properties of prostate cancer cells","volume":"79","author":"Han","year":"2019","journal-title":"Prostate"},{"key":"10.1016\/j.biochi.2026.10.021_bib17","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/pim.12357","article-title":"Signalling pathways associated with IL-6 production and epithelial-mesenchymal transition induction in prostate epithelial cells stimulated with Trichomonas vaginalis","volume":"38","author":"Han","year":"2016","journal-title":"Parasite Immunol"},{"issue":"3","key":"10.1016\/j.biochi.2026.10.021_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1568026620999200904122212","article-title":"The role of purinergic signaling in Trichomonas vaginalis infection","volume":"21","author":"Ferla","year":"2021","journal-title":"Curr Top Med Chem"},{"issue":"PtB","key":"10.1016\/j.biochi.2026.10.021_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.biochi.2025.08.015","article-title":"Adenosine deprivation modulates purine metabolism and enhances Trichomonas vaginalis cytotoxicity","volume":"239","author":"Menezes","year":"2025","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.biochi.2026.10.021_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0166-6851(02)00330-4","article-title":"Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis","volume":"127","author":"Munagala","year":"2003","journal-title":"Mol Biochem Parasitol"},{"issue":"4","key":"10.1016\/j.biochi.2026.10.021_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s11302-017-9584-1","article-title":"Adenosine reduces reactive oxygen species and interleukin-8 production by Trichomonas vaginalis-stimulated neutrophils","volume":"13","author":"Frasson","year":"2017","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.biochi.2026.10.021_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.633603","article-title":"CD39 and CD73 as promising therapeutic targets: what could be the limitations?","volume":"12","author":"Battastini","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.biochi.2026.10.021_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11302-020-09755-6","article-title":"Ectonucleoside triphosphate diphosphohydrolases and ecto-5'-nucleotidase in purinergic signaling: how the field developed and where we are now","volume":"17","author":"Zimmermann","year":"2021","journal-title":"Purinergic Signal"},{"issue":"1","key":"10.1016\/j.biochi.2026.10.021_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11302-020-09693-3","article-title":"Purinergic signaling and tumor microenvironment in cervical cancer","volume":"16","author":"Pfaffenzeller","year":"2020","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.biochi.2026.10.021_bib25","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1017\/erm.2024.30","article-title":"Adenosinergic signalling in cervical cancer microenvironment","volume":"27","author":"Iser","year":"2025","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.biochi.2026.10.021_bib26","doi-asserted-by":"crossref","first-page":"62914","DOI":"10.18632\/oncotarget.17516","article-title":"MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2026.10.021_bib27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/ph16040586","article-title":"Betulinic acid-Brosimine B hybrid compound has a synergistic effect with imatinib in chronic myeloid leukemia cell line, modulating apoptosis and autophagy","volume":"16","author":"Willig","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.biochi.2026.10.021_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6209849","article-title":"Ki-67 expression by immunohistochemistry and quantitative real-time PCR as predictor of clinical response to neoadjuvant chemotherapy in locally advanced breast cancer","volume":"2017","author":"Prihantono","year":"2017","journal-title":"J Oncol"},{"issue":"8","key":"10.1016\/j.biochi.2026.10.021_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.pt.2018.05.006","article-title":"Trichomonas vaginalis: pathogenesis, symbiont interactions, and host cell immune responses","volume":"34","author":"Mercer","year":"2018","journal-title":"Trends Parasitol"},{"issue":"5","key":"10.1016\/j.biochi.2026.10.021_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.15698\/mic2023.05.796","article-title":"Infinity war: Trichomonas vaginalis and interactions with host immune response","volume":"10","author":"Bongiorni","year":"2023","journal-title":"Microb Cell"},{"issue":"1\u20132","key":"10.1016\/j.biochi.2026.10.021_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jri.2009.08.007","article-title":"Impact of T. vaginalis infection on innate immune responses and reproductive outcome","volume":"83","author":"Fichorova","year":"2009","journal-title":"J Reprod Immunol"},{"issue":"4","key":"10.1016\/j.biochi.2026.10.021_bib32","first-page":"910","article-title":"2D and 3D cell cultures \u2013 a comparison of different types of cancer cell cultures","volume":"14","author":"K apa\u0142czy\u0144ska","year":"2018","journal-title":"Arch Med Sci"},{"issue":"6","key":"10.1016\/j.biochi.2026.10.021_bib33","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/mmi.14840","article-title":"Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter","volume":"116","author":"Natto","year":"2021","journal-title":"Mol Microbiol"},{"issue":"2","key":"10.1016\/j.biochi.2026.10.021_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.micinf.2016.11.001","article-title":"Adenosine, but not guanosine, protects vaginal epithelial cells from Trichomonas vaginalis cytotoxicity","volume":"19","author":"Menezes","year":"2017","journal-title":"Microbes Infect"},{"issue":"19","key":"10.1016\/j.biochi.2026.10.021_bib35","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1091\/mbc.e14-01-0042","article-title":"Adenosine uptake is the major effector of extracellular ATP toxicity in human cervical cancer cells","volume":"25","author":"Mello","year":"2014","journal-title":"Mol Biol Cell"},{"issue":"1","key":"10.1016\/j.biochi.2026.10.021_bib36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000369674","article-title":"Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma","volume":"35","author":"Nakajima","year":"2015","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"10.1016\/j.biochi.2026.10.021_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11302-011-9254-7","article-title":"Involvement of purinergic signaling on nitric oxide production by neutrophils stimulated with Trichomonas vaginalis","volume":"8","author":"Frasson","year":"2012","journal-title":"Purinergic Signal"},{"issue":"5","key":"10.1016\/j.biochi.2026.10.021_bib38","article-title":"Purine and purinergic receptors in health and disease","volume":"4","author":"Ai","year":"2023","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.biochi.2026.10.021_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12885-017-3128-5","article-title":"CD73 promotes proliferation and migration of human cervical cancer cells independent of its enzyme activity","volume":"17","author":"Gao","year":"2017","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.biochi.2026.10.021_bib40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1139\/bcb-2013-0051","article-title":"Ectonucleotidase expression profile and activity in human cervical cancer cell lines","volume":"92","author":"Beckenkamp","year":"2014","journal-title":"Biochem Cell Biol"},{"issue":"1","key":"10.1016\/j.biochi.2026.10.021_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0304-3835(96)04362-5","article-title":"High-risk HPV-positive human cancer cell lines show different sensitivity to cisplatin-induced apoptosis correlated with the p21Waf1\/Cip1 level","volume":"108","author":"Funaoka","year":"1996","journal-title":"Cancer Lett"},{"key":"10.1016\/j.biochi.2026.10.021_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3904870","article-title":"Trichomonas vaginalis induces SiHa cell apoptosis by NF-\u03baB inactivation via reactive oxygen species","volume":"2017","author":"Quan","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.biochi.2026.10.021_bib43","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s13071-021-05098-2","article-title":"Trichomonas vaginalis induces apoptosis via ROS and ER stress response through ER-mitochondria crosstalk in SiHa cells","volume":"14","author":"Gao","year":"2021","journal-title":"Parasit Vectors"},{"issue":"15","key":"10.1016\/j.biochi.2026.10.021_bib44","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.micinf.2012.09.004","article-title":"The effects of environmental factors on the virulence of Trichomonas vaginalis","volume":"14","author":"Figueroa-Angulo","year":"2012","journal-title":"Microbes Infect"},{"issue":"9","key":"10.1016\/j.biochi.2026.10.021_bib45","doi-asserted-by":"crossref","first-page":"404","DOI":"10.15698\/mic2016.09.526","article-title":"Trichomoniasis \u2013 are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide?","volume":"3","author":"Menezes","year":"2016","journal-title":"Microb Cell"},{"key":"10.1016\/j.biochi.2026.10.021_bib46","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3389\/fimmu.2019.01676","article-title":"E6\/E7 and E6* from HPV16 and HPV18 upregulate IL-6 expression independently of p53 in keratinocytes","volume":"10","author":"Artaza-Irigaray","year":"2019","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.biochi.2026.10.021_bib47","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1128\/IAI.00631-06","article-title":"Trichomonas vaginalislipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells","volume":"74","author":"Fichorova","year":"2006","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.biochi.2026.10.021_bib48","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1038\/s41418-021-00823-x","article-title":"Ki-67 gene expression","volume":"28","author":"Uxa","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.biochi.2026.10.021_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155977","article-title":"Inhibition of adenosine deaminase activity reverses resistance to the cytotoxic effect of high adenosine levels in cervical cancer cells","volume":"158","author":"Monroy-Mora","year":"2022","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.biochi.2026.10.021_bib50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00280-007-0593-6","article-title":"The depletion of cellular ATP by AG2034 mediates cell death or cytostasis in a hypoxanthine-dependent manner in human prostate cancer cells","volume":"62","author":"Obajimi","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biochi.2026.10.021_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1710880","article-title":"Gut microbiota-derived metabolites in immunomodulation and gastrointestinal cancer immunotherapy","volume":"16","author":"Luo","year":"2025","journal-title":"Front Immunol"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426002671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426002671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:32:17Z","timestamp":1792708337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908426002671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":51,"alternative-id":["S0300908426002671"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2026.10.021","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Divergent Effects of Trichomonas vaginalis on Cervical Cancer Cells HPV-positive and HPV-negative: Interplay with Purinergic Signaling","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2026.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}