{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:29:11Z","timestamp":1791246551528,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011045","name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012948","name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur, de la Recherche et de l'Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004584","name":"Conseil R\u00e9gional de Bretagne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004584","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biofilm"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bioflm.2023.100113","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T22:21:58Z","timestamp":1679610118000},"page":"100113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Impact of mucus and biofilm on antimicrobial photodynamic therapy: Evaluation using Ruthenium(II) complexes"],"prefix":"10.1016","volume":"5","author":[{"given":"Rapha\u00eblle","family":"Youf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lemercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Montier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5922-5683","authenticated-orcid":false,"given":"Tony","family":"Le Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioflm.2023.100113_bib1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S1473-3099(18)30310-4","volume":"18","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bioflm.2023.100113_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3934\/microbiol.2018.2.274","article-title":"Extracellular polymeric substances, a key element in understanding biofilm phenotype","volume":"4","author":"Di Martino","year":"2018","journal-title":"AIMS Microbiol"},{"key":"10.1016\/j.bioflm.2023.100113_bib3","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1128\/JB.00858-07","article-title":"The EPS matrix: the \u201chouse of biofilm cells","volume":"189","author":"Flemming","year":"2007","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bioflm.2023.100113_bib4","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1002\/ppul.24530","article-title":"Mucins and cystic fibrosis","volume":"54","author":"Morrison","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2023.100113_bib5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00007.2018","article-title":"Structure, gating, and regulation of the CFTR anion channel","volume":"99","author":"Csan\u00e1dy","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bioflm.2023.100113_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00018-016-2393-9","article-title":"Cystic fibrosis: a clinical view","volume":"74","author":"Castellani","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.bioflm.2023.100113_bib7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0140-6736(03)12567-6","article-title":"Cystic fibrosis","volume":"361","author":"Ratjen","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bioflm.2023.100113_bib8","article-title":"The cystic fibrosis lung microenvironment alters antibiotic activity: causes and effects","volume":"30","author":"Bossche","year":"2021","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.bioflm.2023.100113_bib9","unstructured":"Lin, Q. Cystic fibrosis acidic microenvironment determines antibiotic susceptibility and biofilm formation of Pseudomonas aeruginosa. 29."},{"key":"10.1016\/j.bioflm.2023.100113_bib10","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.3390\/ijms22063128","article-title":"Pseudomonas aeruginosa: an audacious pathogen with an adaptable arsenal of virulence factors","volume":"22","author":"Jurado-Mart\u00edn","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bioflm.2023.100113_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/17476348.2016.1177460","article-title":"Pseudomonas aeruginosa infection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches","volume":"10","author":"Lund-Palau","year":"2016","journal-title":"Expet Rev Respir Med"},{"key":"10.1016\/j.bioflm.2023.100113_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/mdr.2019.0425","article-title":"Antibiotic tolerance in biofilm and stationary-phase planktonic cells of Staphylococcus aureus","volume":"27","author":"Kamble","year":"2021","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.bioflm.2023.100113_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature02122","article-title":"A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance","volume":"426","author":"Mah","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bioflm.2023.100113_bib14","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1093\/jac\/dky241","article-title":"Human airway mucus alters susceptibility of Pseudomonas aeruginosa biofilms to tobramycin, but not colistin","volume":"73","author":"M\u00fcller","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bioflm.2023.100113_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jcf.2005.05.010","article-title":"Anti-inflammatory therapy in cystic fibrosis","volume":"4","author":"Dinwiddie","year":"2005","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2023.100113_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tim.2008.12.003","article-title":"Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways","volume":"17","author":"Hassett","year":"2009","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.bioflm.2023.100113_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2014.01.007","article-title":"Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier","volume":"178","author":"Suk","year":"2014","journal-title":"J Contr Release"},{"key":"10.1016\/j.bioflm.2023.100113_bib18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.semdp.2019.04.006","article-title":"Emerging respiratory infections: the infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella","volume":"36","author":"Bradley","year":"2019","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/j.bioflm.2023.100113_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202100189","article-title":"Photodynamic inactivation of Streptococcus pneumoniae with external illumination at 808 Nm through the ex vivo porcine thoracic cage","volume":"15","author":"D\u00edaz Tovar","year":"2022","journal-title":"J Biophot"},{"key":"10.1016\/j.bioflm.2023.100113_bib20","doi-asserted-by":"crossref","first-page":"E320","DOI":"10.3390\/antibiotics9060320","article-title":"Antimicrobial photodynamic therapy in the control of COVID-19","volume":"9","author":"Almeida","year":"2020","journal-title":"Antibiotics (Berlin)"},{"key":"10.1016\/j.bioflm.2023.100113_bib23","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/pharmaceutics13121995","article-title":"Antimicrobial photodynamic therapy: latest developments with a focus on combinatory strategies","volume":"13","author":"Youf","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioflm.2023.100113_bib24","doi-asserted-by":"crossref","unstructured":"Alves, E.; Faustino, M.A.; Neves, M.G.; Cunha, A.; Tome, J.; Almeida, A. An insight on bacterial cellular targets of photodynamic inactivation. Future Med Chem 6, 141\u2013164.","DOI":"10.4155\/fmc.13.211"},{"key":"10.1016\/j.bioflm.2023.100113_bib25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20150942","article-title":"New photosensitizers for photodynamic therapy","volume":"473","author":"Abrahamse","year":"2016","journal-title":"Biochem J"},{"key":"10.1016\/j.bioflm.2023.100113_bib26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3390\/biomedicines9060584","article-title":"Natural photosensitizers in antimicrobial photodynamic therapy","volume":"9","author":"Polat","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bioflm.2023.100113_bib27","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3390\/pharmaceutics13060874","article-title":"Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review","volume":"13","author":"Munteanu","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioflm.2023.100113_bib28","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1039\/C5TB02726H","article-title":"Ruthenium(II) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy","volume":"4","author":"Kne\u017eevi\u0107","year":"2016","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.bioflm.2023.100113_bib29","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1039\/C4CS00343H","article-title":"Ruthenium complexes as antimicrobial agents","volume":"44","author":"Li","year":"2015","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.bioflm.2023.100113_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2008\/276109","article-title":"Photodynamic therapy and the development of metal-based photosensitisers","volume":"2008","author":"Josefsen","year":"2008","journal-title":"Met Base Drugs"},{"key":"10.1016\/j.bioflm.2023.100113_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/antibiotics9020090","article-title":"Metal complexes, an untapped source of antibiotic potential?","volume":"9","author":"Frei","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.bioflm.2023.100113_bib32","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/cmdc.201800392","article-title":"Ruthenium(II) polypyridyl complexes as photosensitizers for antibacterial photodynamic therapy: a structure-activity study on clinical bacterial strains","volume":"13","author":"Le Gall","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bioflm.2023.100113_bib33","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.3390\/pharmaceutics14081664","article-title":"Ruthenium(II) polypyridyl complexes for antimicrobial photodynamic therapy: prospects for application in cystic fibrosis lung airways","volume":"14","author":"Youf","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bioflm.2023.100113_bib34","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1099\/jmm.0.45969-0","article-title":"Microcolony Formation: a novel biofilm model of Pseudomonas aeruginosa for the cystic fibrosis lung","volume":"54","author":"Sriramulu","year":"2005","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.bioflm.2023.100113_bib35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2123564119","article-title":"Lung surfactant negatively affects the photodynamic inactivation of bacteria-in vitro and molecular dynamic simulation analyses","volume":"119","author":"Kassab","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bioflm.2023.100113_bib36","doi-asserted-by":"crossref","first-page":"e02204","DOI":"10.1128\/AAC.02204-19","article-title":"Activity of antibiotics against Pseudomonas aeruginosa in an in vitro model of biofilms in the context of cystic fibrosis: influence of the culture medium","volume":"64","author":"Diaz Iglesias","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bioflm.2023.100113_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jconrel.2006.11.010","article-title":"Delivery of photosensitisers and light through mucus: investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic fibrosis pulmonary infection","volume":"117","author":"Donnelly","year":"2007","journal-title":"J Contr Release"},{"key":"10.1016\/j.bioflm.2023.100113_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111787","article-title":"The detection sensitivity of commonly used singlet oxygen probes in aqueous environments","volume":"204","author":"Entradas","year":"2020","journal-title":"J Photochem Photobiol B Biol"},{"key":"10.1016\/j.bioflm.2023.100113_bib39","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1021\/acs.chemrev.0c00781","article-title":"Singlet oxygen quantum yields in environmental waters","volume":"121","author":"Ossola","year":"2021","journal-title":"Chem Rev"},{"key":"10.1016\/j.bioflm.2023.100113_bib40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000500357","article-title":"The extracellular matrix: reloaded revolutions","volume":"11","author":"Egesten","year":"2019","journal-title":"J Innate Immun"},{"key":"10.1016\/j.bioflm.2023.100113_bib41","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","article-title":"Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action","volume":"9","author":"Roy","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.bioflm.2023.100113_bib42","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3389\/fphar.2020.01096","article-title":"Novel anti-inflammatory approaches for cystic fibrosis lung disease: identification of molecular targets and design of innovative therapies","volume":"11","author":"Mitri","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bioflm.2023.100113_bib43","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1128\/AAC.04937-14","article-title":"Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia","volume":"59","author":"Banaschewski","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bioflm.2023.100113_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2018.05.018","article-title":"Mucus-penetrating nanoparticles: promising drug delivery systems for the photodynamic therapy of intestinal cancer","volume":"129","author":"Anderski","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.bioflm.2023.100113_bib45","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1038\/s41467-020-16993-0","article-title":"Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy","volume":"11","author":"Karges","year":"2020","journal-title":"Nat Commun"}],"container-title":["Biofilm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590207523000102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590207523000102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:03:12Z","timestamp":1762920192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590207523000102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":43,"alternative-id":["S2590207523000102"],"URL":"https:\/\/doi.org\/10.1016\/j.bioflm.2023.100113","relation":{},"ISSN":["2590-2075"],"issn-type":[{"value":"2590-2075","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of mucus and biofilm on antimicrobial photodynamic therapy: Evaluation using Ruthenium(II) complexes","name":"articletitle","label":"Article Title"},{"value":"Biofilm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioflm.2023.100113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100113"}}