{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:40:21Z","timestamp":1793313621768,"version":"4.5.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biofilm"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bioflm.2024.100246","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T03:18:38Z","timestamp":1734664718000},"page":"100246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Cystic fibrosis and the clinical biofilm revolution A survey of the Danish CF Center's contribution"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-725X","authenticated-orcid":false,"given":"Niels","family":"H\u00f8iby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioflm.2024.100246_bib1","first-page":"735","article-title":"Das Coeliakiesyndrom bei angeborener zystischer Pankreasfibromatose und Bronchiektasien","volume":"86","author":"Fanconi","year":"1936","journal-title":"Wien Med Wschr"},{"key":"10.1016\/j.bioflm.2024.100246_bib2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1001\/archpedi.1938.01980140114013","article-title":"Cystic fibrosis of pancreas and its relation to celiac disease: clinical and pathological study","volume":"56","author":"Andersen","year":"1938","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.bioflm.2024.100246_bib3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0022-3476(38)80155-4","article-title":"Inspissation of secretion, dilatation of the ducts and acini, atrophy and fibrosis of the pancreas in infants. A clinical note","volume":"13","author":"Blackfan","year":"1938","journal-title":"J Pediatr"},{"key":"10.1016\/j.bioflm.2024.100246_bib4","first-page":"1574","article-title":"Om den s\u00e5kaldte congenite cystiske pancreasfibrose. Meddelelse af 5 tilf\u00e6lde","volume":"39","author":"Flensborg","year":"1948","journal-title":"Nord Med"},{"key":"10.1016\/j.bioflm.2024.100246_bib5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/apm.12915","article-title":"Cystic fibrosis \u2013 an example of personalized and precision medicine","volume":"127","author":"Skov","year":"2019","journal-title":"APMIS"},{"key":"10.1016\/j.bioflm.2024.100246_bib6","first-page":"269","article-title":"Cystisk fibrose","volume":"50","author":"Flensborg","year":"1972","journal-title":"Mdskr Prakt L\u00e6geg"},{"key":"10.1016\/j.bioflm.2024.100246_bib7","first-page":"1","article-title":"Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey based on 18 publications 1973-1977","volume":"262","author":"H\u00f8iby","year":"1977","journal-title":"Acta Pathol Microbiol Scand Suppl C"},{"key":"10.1016\/j.bioflm.2024.100246_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1651-2227.1989.tb11099.x","article-title":"Estimated risk of cross-infection with Pseudomonas aeruginosa in Danish Cystic Fibrosis patients","volume":"78","author":"H\u00f8iby","year":"1989","journal-title":"Acta P\u00e6diat Scand"},{"key":"10.1016\/j.bioflm.2024.100246_bib9","first-page":"298","article-title":"Identification and quantitation of precipitins against Pseudomonas aeruginosa in patients with Cystic Fibrosis by means of crossed immunoelectrophoresis with intermediate gel","volume":"81","author":"H\u00f8iby","year":"1973","journal-title":"Acta Pathol Microbiol Scand Suppl B"},{"key":"10.1016\/j.bioflm.2024.100246_bib10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1099\/13500872-145-6-1349","article-title":"Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung","volume":"145","author":"Mathee","year":"1999","journal-title":"Microbiology"},{"key":"10.1016\/j.bioflm.2024.100246_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/2049-632X.12165","article-title":"A personal history of research on microbial biofilms and biofilm infections","volume":"70","author":"H\u00f8iby","year":"2014","journal-title":"Pathogens and Disease"},{"key":"10.1016\/j.bioflm.2024.100246_bib12","first-page":"541","article-title":"Epidemiological investigations of the respiratory tract bacteriology in patients with Cystic Fibrosis","volume":"82","author":"H\u00f8iby","year":"1974","journal-title":"Acta Pathol Microbiol Scand Suppl B"},{"issue":"Suppl. 2","key":"10.1016\/j.bioflm.2024.100246_bib13","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S1569-1993(11)60011-8","article-title":"Chronic Pseudomonas aeruginosa infection definition: EuroCareCF working group report","volume":"10","author":"Pressler","year":"2011","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1128\/iai.39.1.198-201.1983","article-title":"Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection","volume":"39","author":"Blackwood","year":"1983","journal-title":"Infect immune"},{"key":"10.1016\/j.bioflm.2024.100246_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0882-4010(89)90102-2","article-title":"Different sensitivity of Pseudomonas aeruginosa exotoxin A and diphtheria toxin to enzymes from polymorphonuclear leukocytes","volume":"6","author":"D\u00f6ring","year":"1989","journal-title":"Microb Pathog"},{"key":"10.1016\/j.bioflm.2024.100246_bib16","first-page":"307","article-title":"Detection of proteases of Pseudomonas aeruginosa in immune complexes isolated from sputum of Cystic Fibrosis patients","volume":"92","author":"D\u00f6ring","year":"1984","journal-title":"Acta Pathol Microbiol Scand Suppl C"},{"key":"10.1016\/j.bioflm.2024.100246_bib17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1699-0463.1992.tb00858.x","article-title":"Lipopolysaccharide is present in immune-complexes isolated from sputum in patients with Cystic Fibrosis and chronic Pseudomonas aeruginosa lung infection","volume":"100","author":"Kronborg","year":"1992","journal-title":"APMIS"},{"key":"10.1016\/j.bioflm.2024.100246_bib18","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1128\/iai.56.9.2270-2278.1988","article-title":"Longitudinal study of antibody response to lipopolysaccharides during chronic Pseudomonas aeruginosa lung infection in Cystic Fibrosis","volume":"56","author":"Fomsgaard","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.bioflm.2024.100246_bib19","first-page":"229","article-title":"IgA og IgG antibodies against surface antigens of Pseudomonas aeruginosa in sputum and serum from patients with Cystic Fibrosis","volume":"87","author":"Schi\u00f8tz","year":"1979","journal-title":"Acta Pathol Microbiol Scand Suppl C"},{"key":"10.1016\/j.bioflm.2024.100246_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/jcm.28.4.747-755.1990","article-title":"Immunoglobulin A and immunoglobulin G antibody responses to alginates from Pseudomonas aeruginosa in cystic fibrosis","volume":"28","author":"Pedersen","year":"1990","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bioflm.2024.100246_bib21","first-page":"65","article-title":"Pseudomonas aeruginosa infection in Cystic Fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis","volume":"58","author":"H\u00f8iby","year":"1977","journal-title":"Scand J Respir Dis"},{"key":"10.1016\/j.bioflm.2024.100246_bib22","first-page":"459","article-title":"Pseudomonas aeruginosa infection in Cystic Fibrosis. Humoral and cellular immune responses against Pseudomonas aeruginosa","volume":"83","author":"H\u00f8iby","year":"1975","journal-title":"Acta Pathol Microbiol Scand Suppl C"},{"key":"10.1016\/j.bioflm.2024.100246_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1034\/j.1600-0463.2000.d01-64.x","article-title":"The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of a Th2 type","volume":"108","author":"Moser","year":"2000","journal-title":"APMIS"},{"key":"10.1016\/j.bioflm.2024.100246_bib24","first-page":"275","article-title":"Immunoglobulins and albumin in sputum from patients with Cystic Fibrosis. A study of protein stability and presence of proteases","volume":"88","author":"Schi\u00f8tz","year":"1980","journal-title":"Acta Pathol Microbiol Scand Suppl C"},{"key":"10.1016\/j.bioflm.2024.100246_bib25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1136\/thx.50.8.880","article-title":"DNA conce ntration and length in sputum of patients with cystic fibrosis during inhalation with recombinant human DNase","volume":"50","author":"Brandt","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.bioflm.2024.100246_bib26","first-page":"37","article-title":"Immune complexes in the sputum of Cystic Fibrosis patients with chronic Pseudomonas aeruginosa lung infection","volume":"86","author":"Schi\u00f8tz","year":"1978","journal-title":"Acta Pathol Microbiol Scand Suppl C"},{"key":"10.1016\/j.bioflm.2024.100246_bib27","first-page":"597","article-title":"Elastase from polymorphonuclear leukocytes - a regulatory enzyme in immune complex disease","volume":"64","author":"D\u00f6ring","year":"1986","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.bioflm.2024.100246_bib28","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1651-2227.1988.tb10766.x","article-title":"Excretion of urinary collagen metabolites correlates to severity of pulmonary disease in cystic fibrosis","volume":"77","author":"Ammitzb\u00f8ll","year":"1988","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.bioflm.2024.100246_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/thx.2009.114512","article-title":"Polymorphonuclear leukocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis","volume":"65","author":"Kolpen","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.bioflm.2024.100246_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2014.00554","article-title":"Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum","volume":"5","author":"Line","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bioflm.2024.100246_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jcf.2017.08.012","article-title":"Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis","volume":"17","author":"Mauch","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ppul.21011","article-title":"Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients","volume":"44","author":"Bjarnsholt","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib33","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1651-2227.1983.tb09789.x","article-title":"Frequent antibiotic therapy improves survival of Cystic Fibrosis patients with chronic Pseudomonas aeruginosa infection","volume":"72","author":"Szaff","year":"1983","journal-title":"Acta P\u00e6diat Scand"},{"key":"10.1016\/j.bioflm.2024.100246_bib34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1651-2227.1987.tb17271.x","article-title":"Management of Pseudomonas aeruginosa lung infection in Danish Cystic Fibrosis patients","volume":"76","author":"Pedersen","year":"1987","journal-title":"Acta P\u00e6diat Scand"},{"key":"10.1016\/j.bioflm.2024.100246_bib35","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1164\/ajrccm.156.4.9612044","article-title":"Controlled trial of inhaled budesonide in patients with cystic fibrosis and chronic bronchopulmonary Pseudomonas aeruginosa infection","volume":"156","author":"Bisgaard","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.bioflm.2024.100246_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0195-6701(83)90062-2","article-title":"Epidemiology of Pseudomonas aeruginosa infection and the role of contamination of the environment in a Cystic Fibrosis clinic","volume":"4","author":"Zimakoff","year":"1983","journal-title":"J Hosp Infect"},{"key":"10.1016\/j.bioflm.2024.100246_bib37","series-title":"A consensus report","first-page":"1","article-title":"Epidemiology of pulmonary infection by Pseudomonas in patients with cystic fibrosis","author":"D\u00f6ring","year":"1993"},{"key":"10.1016\/j.bioflm.2024.100246_bib38","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1067\/mic.2000.106337","article-title":"Infection control in cystic fibrosis: practical recommendations for the hospital, clinic and social settings","volume":"28","author":"Saiman","year":"2000","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.bioflm.2024.100246_bib39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1651-2227.1982.tb09643.x","article-title":"Antimicrobial chemotherapy in cystic fibrosis patients","volume":"301","author":"H\u00f8iby","year":"1982","journal-title":"Acta P\u00e6diat Scand"},{"key":"10.1016\/j.bioflm.2024.100246_bib40","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/jac\/19.6.831","article-title":"Colistin inhalation therapy in Cystic Fibrosis patients with chronic Pseudomonas aeruginosa lung infection. A prospective double-blind placebo-controlled trial","volume":"19","author":"Jensen","year":"1987","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jcf.2008.02.003","article-title":"Spread of colistin-resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients","volume":"7","author":"Johansen","year":"2008","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib42","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/jac\/17.4.505","article-title":"An epidemic spread of multiresistant Pseudomonas aeruginosa in a Cystic Fibrosis centre","volume":"17","author":"Pedersen","year":"1986","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jac\/48.3.391","article-title":"Characterization of paired mucoid\/non-mucoid Pseudomonas aeruginosa isolates fom Danish cystic fibrosis patients: antibiotic resistance, beta-lactamase activity and riboprinting","volume":"48","author":"Ciofu","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-pharmtox-010814-124712","article-title":"Unraveling the physiological complexities of antibiotic lethality","volume":"55","author":"Dwyer","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.bioflm.2024.100246_bib45","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1128\/AAC.00493-13","article-title":"Sub-lethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa","volume":"57","author":"J\u00f8rgensen","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib46","doi-asserted-by":"crossref","first-page":"163e00766","DOI":"10.1128\/AAC.00766-19","article-title":"Lack of KatA catalase in P. aeruginosa accelerates evolution of antibiotic resistance in ciprofloxacin-treated biofilms","volume":"63","author":"Ahmed","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib47","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0140-6736(85)92222-6","article-title":"Nebulised colomycin for early pseudomonas colonization in cystic fibrosis. Letter to the editor","volume":"i","author":"Littlewood","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.bioflm.2024.100246_bib48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/jac\/20.4.585","article-title":"Comparison of the efficacy and safety of ciprofloxacin and ofloxacin in the treatment of chronic Pseudomonas aeruginosa infection in Cystic Fibrosis patients","volume":"20","author":"Jensen","year":"1987","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib49","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0140-6736(91)91446-2","article-title":"Prevention of chronic colonization with Pseudomonas aeruginosa in patients with Cystic Fibrosis by early treatment with Ciprofloxacin and inhalation with Colistin","volume":"338","author":"Valerius","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.bioflm.2024.100246_bib50","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1034\/j.1399-3003.2000.16d30.x","article-title":"Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus","volume":"16","author":"D\u00f6ring","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.bioflm.2024.100246_bib51","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jcf.2008.06.009","article-title":"Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience","volume":"7","author":"Hansen","year":"2008","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib52","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/(SICI)1099-0496(199603)21:3<153::AID-PPUL1>3.0.CO;2-R","article-title":"Improved survival in the Danish center-treated cystic fibrosis centre: results of aggressive treatment","volume":"21","author":"Frederiksen","year":"1996","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1099-0496(199603)21:3<151::AID-PPUL1950210303>3.0.CO;2-W","article-title":"Denmark to the rescue","volume":"21","author":"Stern","year":"1996","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/1099-0496(199603)21:3<149::AID-PPUL1950210302>3.0.CO;2-C","article-title":"Survival estimates in cystic fibrosis: snapshots of a moving target","volume":"21","author":"Corey","year":"1996","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib55","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/(SICI)1099-0496(199705)23:5<330::AID-PPUL4>3.0.CO;2-O","article-title":"Antibiotic treatment at time of initial colonization with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration in pulmonary function in patients with cystic fibrosis","volume":"23","author":"Frederiksen Koch","year":"1997","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/(SICI)1099-0496(199909)28:3<159::AID-PPUL1>3.0.CO;2-1","article-title":"Changing epidemiology of Pseudomonas aeruginosa infection in Danish cystic fibrosis patients (1974-1995)","volume":"28","author":"Frederiksen","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib57","first-page":"323","article-title":"The preservation of Function: treatment of new acquisition of a pathogen","volume":"28","author":"Rabin","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib58","first-page":"325","article-title":"Something is (not) rotten in Denmark (Hamlet (not) W. Shakespeare)","volume":"28","author":"Schidlow","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib59","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ppul.10457","article-title":"Antibody response to Pseudomonas aeruginosa in cystic fibrosis patients - a marker of therapeutic success? A 30-year cohort study of survival in Danish CF patients after onset of chronic P. aeruginosa lung infection","volume":"37","author":"Johansen","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.bioflm.2024.100246_bib60","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jcf.2016.08.005","article-title":"Phenotypic shift of the P. aeruginosa populations form cystic fibrosis lungs after 2-week antipseudomonal treatment","volume":"16","author":"Fernandez-Barat","year":"2017","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib61","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/thx.52.4.318","article-title":"Epidemiology of chronic Pseudomonas aeruginosa infections in the airways of lung transplant recipients with cystic fibrosis","volume":"52","author":"Walter","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.bioflm.2024.100246_bib62","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jcf.2020.01.012","article-title":"Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation","volume":"19","author":"Schwensen","year":"2020","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ismej.2011.83","article-title":"Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection","volume":"6","author":"Hansen","year":"2012","journal-title":"ISME J"},{"key":"10.1016\/j.bioflm.2024.100246_bib64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/thx.47.2.109","article-title":"Seasonal onset of initial colonization and chronic Pseudomonas aeruginosa infection in Danish Cystic Fibrosis patients","volume":"47","author":"Johansen","year":"1992","journal-title":"Thorax"},{"key":"10.1016\/j.bioflm.2024.100246_bib65","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jcf.2012.04.011","article-title":"Colonization and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response","volume":"11","author":"Johansen","year":"2012","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib66","first-page":"222","article-title":"Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients \u2013 can chronic lung infection be postponed?","volume":"51","author":"Aasn\u00e6s","year":"2013","journal-title":"Rhinology"},{"key":"10.1016\/j.bioflm.2024.100246_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jcf.2012.07.001","article-title":"Secretory IgA as a diagnostic tool for early Pseudomonas aeruginosa colonization","volume":"12","author":"Aasn\u00e6s","year":"2013","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib68","first-page":"1","article-title":"Secretory IgA response against Pseudomonas aeruginosa in the upper airways and the link with chronic lung infection in cystic fibrosis","volume":"75","author":"Mauch","year":"2017","journal-title":"Pathogens Dis"},{"issue":"e52","key":"10.1016\/j.bioflm.2024.100246_bib69","first-page":"1","article-title":"Can secretory Immunoglobulin A in saliva predict a change in lung function status in patients with cystic fibrosis? A prospective pilot study","volume":"12","author":"Alanin","year":"2018","journal-title":"Health Sci Rep"},{"key":"10.1016\/j.bioflm.2024.100246_bib70","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4193\/Rhin17.243","article-title":"The accessibility of topical treatment in the paranasal sinuses on operated cystic fibrosis patients assessed by scintigraphy","volume":"56","author":"Aasn\u00e6s","year":"2018","journal-title":"Rhinology"},{"key":"10.1016\/j.bioflm.2024.100246_bib71","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/00016489.2020.1841909","article-title":"Autologous fibrin sealant co-delivered with antibiotics is a robust method for topical antibiotic treatment after sinus surgery","volume":"141","author":"Aasn\u00e6s","year":"2021","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bioflm.2024.100246_bib72","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jcf.2019.01.005","article-title":"Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients","volume":"18","author":"M\u00f8ller","year":"2019","journal-title":"J Cyst Fibros"},{"key":"10.1016\/j.bioflm.2024.100246_bib73","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3390\/microorganisms12112115","article-title":"Pseudomonas aeruginosa in the frontline of the greatest challenge of biofilm infection \u2013 tolerance to antibiotics","volume":"12","author":"H\u00f8iby","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.bioflm.2024.100246_bib74","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1128\/AAC.01721-15","article-title":"OligoG CF-5\/20 disruption of mucoid Pseudomonas aeruginosa biofilm in a murine lung infection model","volume":"60","author":"Wang","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bioflm.2024.100246_bib75","first-page":"1","article-title":"Aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combinations","volume":"77","author":"Henriksen","year":"2019","journal-title":"Pathogens and Diseases"},{"key":"10.1016\/j.bioflm.2024.100246_bib76","article-title":"The TransformCF study group","author":"Bryrup","year":"2024","journal-title":"APMIS"},{"key":"10.1016\/j.bioflm.2024.100246_bib77","first-page":"1","article-title":"The future of cystic fibrosis: a global perspective","author":"Ratjen","year":"2014","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.bioflm.2024.100246_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cmi.2014.10.024","article-title":"ESCMID\u2217 guideline for the diagnosis and treatment of biofilm infections 2014","volume":"21","author":"H\u00f8iby","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.bioflm.2024.100246_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioflm.2023.100135","article-title":"To update or not to update the ESCMID guidelines for the diagnosis and treatment of biofilm infection \u2013 that is the question! The opinion of the ESGB board","volume":"6","author":"H\u00f8iby","year":"2023","journal-title":"Biofilm"},{"key":"10.1016\/j.bioflm.2024.100246_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41579-022-00682-4","article-title":"Tolerance and resistance of biofilm infections","author":"Ciofu","year":"2022","journal-title":"Nat Rev Microbiol"}],"container-title":["Biofilm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590207524000716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590207524000716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T07:59:07Z","timestamp":1754639947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590207524000716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":80,"alternative-id":["S2590207524000716"],"URL":"https:\/\/doi.org\/10.1016\/j.bioflm.2024.100246","relation":{},"ISSN":["2590-2075"],"issn-type":[{"value":"2590-2075","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cystic fibrosis and the clinical biofilm revolution A survey of the Danish CF Center's contribution","name":"articletitle","label":"Article Title"},{"value":"Biofilm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioflm.2024.100246","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100246"}}