{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:54:32Z","timestamp":1776452072706,"version":"3.51.2"},"reference-count":92,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biologicals"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.biologicals.2009.10.007","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T06:06:06Z","timestamp":1263535566000},"page":"72-77","source":"Crossref","is-referenced-by-count":62,"title":["Optimal use of blood in trauma patients"],"prefix":"10.1016","volume":"38","author":[{"given":"John B.","family":"Holcomb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip C.","family":"Spinella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biologicals.2009.10.007_bib2","series-title":"Deaths: final data for 2004","author":"CDC","year":"2007"},{"issue":"9524","key":"10.1016\/j.biologicals.2009.10.007_bib3","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(06)68770-9","article-title":"Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data","volume":"367","author":"Lopez","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.biologicals.2009.10.007_bib4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00005373-199511000-00022","article-title":"Analysis of preventable trauma deaths and inappropriate trauma care in a rural state","volume":"39","author":"Esposito","year":"1995","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/01.TA.0000058124.78958.6B","article-title":"Effect of a voluntary trauma system on preventable death and inappropriate care in a rural state","volume":"54","author":"Esposito","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/01.ta.0000251558.38388.47","article-title":"Preventable deaths from hemorrhage at a level I Canadian trauma center","volume":"62","author":"Tien","year":"2007","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jamcollsurg.2003.09.003","article-title":"Trauma fatalities: time and location of hospital deaths","volume":"198","author":"Demetriades","year":"2004","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib8","first-page":"950","article-title":"Epidemiology of immediate and early trauma deaths at an urban Level I trauma center","volume":"64","author":"Peng","year":"1998","journal-title":"Am Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00005373-199502000-00006","article-title":"Epidemiology of trauma deaths: a reassessment","volume":"38","author":"Sauaia","year":"1995","journal-title":"J Trauma"},{"issue":"6","key":"10.1016\/j.biologicals.2009.10.007_bib10","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/TA.0b013e31815078ae","article-title":"Preventable or potentially preventable mortality at a mature trauma center","volume":"63","author":"Teixeira","year":"2007","journal-title":"J Trauma"},{"issue":"5","key":"10.1016\/j.biologicals.2009.10.007_bib11","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S1072-7515(98)00082-9","article-title":"Lethal injuries and time to death in a level I trauma center","volume":"186","author":"Acosta","year":"1998","journal-title":"J Am Coll Surg"},{"issue":"3","key":"10.1016\/j.biologicals.2009.10.007_bib12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/01.sla.0000234655.83517.56","article-title":"Patterns of errors contributing to trauma mortality: lessons learned from 2,594 deaths","volume":"244","author":"Gruen","year":"2006","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.biologicals.2009.10.007_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jamcollsurg.2005.05.003","article-title":"Trauma deaths in a mature urban trauma system: is \u201ctrimodal\u201d distribution a valid concept?","volume":"201","author":"Demetriades","year":"2005","journal-title":"J Am Coll Surg"},{"issue":"10","key":"10.1016\/j.biologicals.2009.10.007_bib14","first-page":"950","article-title":"Epidemiology of immediate and early trauma deaths at an urban Level I trauma center","volume":"64","author":"Peng","year":"1998","journal-title":"Am Surg"},{"issue":"4","key":"10.1016\/j.biologicals.2009.10.007_bib15","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1097\/TA.0b013e31816a2417","article-title":"StO2 Study Group. Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome","volume":"64","author":"Moore","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1182\/asheducation-2007.1.187","article-title":"Blood and coagulation support in trauma care","author":"Hess","year":"2007","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"6","key":"10.1016\/j.biologicals.2009.10.007_bib17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1537-2995.2004.03409.x","article-title":"Blood transfusion rates in the care of acute trauma","volume":"44","author":"Como","year":"2004","journal-title":"Transfusion"},{"issue":"11","key":"10.1016\/j.biologicals.2009.10.007_bib18","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1111\/j.1537-2995.2007.01429.x","article-title":"Warm storage of whole blood for 72hours","volume":"47","author":"Hughes","year":"2007","journal-title":"Transfusion"},{"key":"10.1016\/j.biologicals.2009.10.007_bib19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/TA.0b013e3181877a9c","article-title":"The coagulopathy of trauma: a review of mechanisms","volume":"65","author":"Hess","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib20","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/TA.0b013e318169cd3c","article-title":"Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis","volume":"64","author":"Brohi","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/TA.0b013e318185fa9f","article-title":"Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice","volume":"65","author":"Hoyt","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy","volume":"54","author":"Brohi","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.TA.0000075338.21177.EF","article-title":"Early coagulopathy predicts mortality in trauma","volume":"55","author":"MacLeod","year":"2003","journal-title":"J Trauma"},{"issue":"3","key":"10.1016\/j.biologicals.2009.10.007_bib24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/SLA.0b013e318185a9ad","article-title":"Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients","volume":"248","author":"Holcomb","year":"2008","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.biologicals.2009.10.007_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.amjsurg.2008.12.014","article-title":"A high ratio of plasma and platelets to packed red blood cells in the first 6hours of massive transfusion improves outcomes in a large multicenter study","volume":"197","author":"Zink","year":"2009","journal-title":"Am J Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib26","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/TA.0b013e318160ba2f","article-title":"Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries","volume":"64","author":"Spinella","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib27","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1537-2995.2008.01743.x","article-title":"Giving plasma at a 1:1 ratio with red cells in resuscitation: who might benefit?","volume":"48","author":"Hess","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.biologicals.2009.10.007_bib28","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1046\/j.1537-2995.2003.00576.x","article-title":"Blood use in war and disaster: lessons from the past century","volume":"43","author":"Hess","year":"2003","journal-title":"Transfusion"},{"key":"10.1016\/j.biologicals.2009.10.007_bib29","series-title":"Blood","author":"Starr","year":"2002"},{"issue":"1","key":"10.1016\/j.biologicals.2009.10.007_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1423-0410.2006.00778.x","article-title":"An update on solutions for red cell storage","volume":"91","author":"Hess","year":"2006","journal-title":"Vox Sang"},{"issue":"2","key":"10.1016\/j.biologicals.2009.10.007_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1423-0410.2008.01117.x","article-title":"Current issues relating to the transfusion of stored red blood cells","volume":"96","author":"Zimrin","year":"2009","journal-title":"Vox Sang"},{"key":"10.1016\/j.biologicals.2009.10.007_bib32","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1537-2995.2004.03409.x","article-title":"Blood transfusion rates in the care of acute trauma","volume":"44","author":"Como","year":"2004","journal-title":"Transfusion"},{"key":"10.1016\/j.biologicals.2009.10.007_bib33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.amjsurg.2005.03.034","article-title":"Are we giving enough coagulation factors during major trauma resuscitation?","volume":"190","author":"Ho","year":"2005","journal-title":"Am J Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000542-199603000-00032","article-title":"A report by the American Society of Anesthesiologists Task Force on Blood Component Therapy","volume":"84","author":"Practice Guidelines for blood component therapy","year":"1996","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.biologicals.2009.10.007_bib35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00005373-200009000-00021","article-title":"United States Army Rangers in Somalia: an analysis of combat casualties on an urban battlefield","volume":"49","author":"Mabry","year":"2000","journal-title":"J Trauma"},{"issue":"1","key":"10.1016\/j.biologicals.2009.10.007_bib36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.ta.0000222671.84335.64","article-title":"Fresh whole blood transfusion: a controversial military practice","volume":"61","author":"Kauvar","year":"2006","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib37","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1097\/01.ta.0000219013.64168.b2","article-title":"The use of fresh whole blood in massive transfusion","volume":"60","author":"Repine","year":"2006","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib38","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1097\/01.CCM.0000285996.65226.A9","article-title":"The risks associated with fresh whole blood and RBC transfusions in a combat support hospital","volume":"35","author":"Spinella","year":"2007","journal-title":"Crit Care Med"},{"issue":"4 Suppl","key":"10.1016\/j.biologicals.2009.10.007_bib39","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1097\/TA.0b013e31819d85fb","article-title":"Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries","volume":"66","author":"Spinella","year":"2009","journal-title":"J Trauma"},{"issue":"7 Suppl","key":"10.1016\/j.biologicals.2009.10.007_bib40","doi-asserted-by":"crossref","first-page":"S340","DOI":"10.1097\/CCM.0b013e31817e2ef9","article-title":"Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applications","volume":"36","author":"Spinella","year":"2008","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.biologicals.2009.10.007_bib41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00268-007-9201-5","article-title":"31st CSH Research Working Group. Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital","volume":"32","author":"Spinella","year":"2008","journal-title":"World J Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib42","first-page":"618","article-title":"The preventive treatment of wound shock","volume":"70","author":"Cannon","year":"1918","journal-title":"JAMA"},{"key":"10.1016\/j.biologicals.2009.10.007_bib43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00000658-194506000-00001","article-title":"Preparation of battle casualties for surgery","volume":"121","author":"Beecher","year":"1945","journal-title":"Ann Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib44","first-page":"S46","article-title":"Fluid resuscitation in modern combat casualty care: lessons learned from Somalia","volume":"54","author":"Holcomb","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib45","series-title":"Yearbook of intensive care and emergency medicine","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/3-540-33396-7_25","article-title":"Hemostatic resuscitation","author":"McMullin","year":"2006"},{"key":"10.1016\/j.biologicals.2009.10.007_bib46","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1537-2995.2006.00816.x","article-title":"Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma","volume":"46","author":"Hess","year":"2006","journal-title":"Transfusion"},{"key":"10.1016\/j.biologicals.2009.10.007_bib47","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/TA.0b013e3180324124","article-title":"Damage control resuscitation: directly addressing the early coagulopathy of trauma","volume":"62","author":"Holcomb","year":"2007","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/TA.0b013e3181271ba3","article-title":"The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital","volume":"63","author":"Borgman","year":"2007","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib49","doi-asserted-by":"crossref","first-page":"S267","DOI":"10.1097\/CCM.0b013e31817da7dc","article-title":"Damage control resuscitation: a sensible approach to the exsanguinating surgical patient","volume":"36","author":"Beekley","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.biologicals.2009.10.007_bib50","first-page":"S110","article-title":"Blood pressure at which rebleeding occurs after resuscitation in swine with aortic injury","volume":"54","author":"Sondeen","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib51","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1056\/NEJM199410273311701","article-title":"Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries","volume":"331","author":"Bickell","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biologicals.2009.10.007_bib52","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1423-0410.2008.01074.x","article-title":"Red blood cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiply injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie","volume":"95","author":"Maegele","year":"2008","journal-title":"Vox Sang"},{"key":"10.1016\/j.biologicals.2009.10.007_bib53","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/TA.0b013e3181826ddf","article-title":"Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival","volume":"65","author":"Gunter","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib54","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/TA.0b013e31817e5166","article-title":"Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60years?","volume":"65","author":"Duchesne","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib55","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/TA.0b013e3181878028","article-title":"An FFP: PRBC transfusion ratio >\/=1:1.5 is associated with a lower risk of mortality after massive transfusion","volume":"65","author":"Sperry","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib56","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1097\/01.ta.0000199549.80731.e6","article-title":"Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol","volume":"60","author":"Malone","year":"2006","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib57","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1097\/TA.0b013e318160a57b","article-title":"The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital","volume":"64","author":"Stinger","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/TA.0b013e31819313bb","article-title":"Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications","volume":"66","author":"Cotton","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib59","first-page":"1616","article-title":"Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level I trauma center","volume":"66","author":"Dente","year":"2009","journal-title":"J\u00a0Trauma"},{"issue":"2","key":"10.1016\/j.biologicals.2009.10.007_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/TA.0b013e3181ad5957","article-title":"Inflammation and Host Response to Injury Investigators. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome","volume":"67","author":"Watson","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib61","first-page":"1177","article-title":"Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization","volume":"64","author":"Cotton","year":"2008","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib62","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/00005373-199705000-00016","article-title":"Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited","volume":"42","author":"Cosgriff","year":"1997","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib63","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archsurg.134.9.964","article-title":"Improved survival following massive transfusion in patients who have undergone trauma","volume":"134","author":"Cinat","year":"1999","journal-title":"Arch Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib64","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/01.ta.0000250497.08101.8b","article-title":"Fresh frozen plasma should be given earlier to patients requiring massive transfusion","volume":"62","author":"Gonzalez","year":"2007","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/TA.0b013e31817e5c77","article-title":"Impact of plasma transfusion in massively transfused trauma patients","volume":"66","author":"Teixeira","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib66","first-page":"836","article-title":"Serial changes in primary hemostasis after massive transfusion","volume":"98","author":"Harrigan","year":"1985","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.biologicals.2009.10.007_bib67","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00000658-197907000-00020","article-title":"Hemostasis in massively transfused trauma patients","volume":"190","author":"Counts","year":"1979","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.biologicals.2009.10.007_bib68","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00003246-197603000-00002","article-title":"Fluid resuscitation following injury: rationale for the use of balanced salt solutions","volume":"4","author":"Carrico","year":"1976","journal-title":"Crit Care Med"},{"key":"10.1016\/j.biologicals.2009.10.007_bib69","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1537-2995.2007.01160.x","article-title":"Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice","volume":"47","author":"Johansson","year":"2007","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.biologicals.2009.10.007_bib70","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jtcvs.2008.08.044","article-title":"Reconstituted fresh whole blood improves clinical outcomes compared with stored component blood therapy for neonates undergoing cardiopulmonary bypass for cardiac surgery: a randomized controlled trial","volume":"136","author":"Gruenwald","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"6","key":"10.1016\/j.biologicals.2009.10.007_bib71","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/AOG.0b013e3181a4b390","article-title":"Whole blood in the management of hypovolemia due to obstetric hemorrhage","volume":"113","author":"Alexander","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.biologicals.2009.10.007_bib72","first-page":"506","volume":"47","author":"Moore","year":"1968","journal-title":"Moderation. Anesth Analg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib73","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.shk.0000209564.84822.f2","article-title":"The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies","volume":"26","author":"Cotton","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.biologicals.2009.10.007_bib74","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1097\/01.TA.0000070166.29649.F3","article-title":"Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure","volume":"54","author":"Balogh","year":"2003","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib75","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/01.sla.0000094387.50865.23","article-title":"Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial","volume":"238","author":"Brandstrup","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib76","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1056\/NEJMoa062200","article-title":"Comparison of two fluid-management strategies in acute lung injury","volume":"354","author":"Wiedemann","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biologicals.2009.10.007_bib77","article-title":"The protective effects of day 0 fresh frozen plasma (FFP) on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between day 0 and day 5","author":"Pati","year":"2009","journal-title":"Accepted J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00000658-198601000-00008","article-title":"Prophylactic platelet administration during massive transfusion. A prospective, randomized, double-blind clinical study","volume":"203","author":"Reed","year":"1986","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.biologicals.2009.10.007_bib79","first-page":"481","article-title":"Blood component supplementation during massive transfusion of AS-1 red cells in trauma patients","volume":"34","author":"Faringer","year":"1993","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib80","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/TA.0b013e318196c3ac","article-title":"The relationship of blood product ratio to mortality: survival benefit or survival bias?","volume":"66","author":"Snyder","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib81","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/TA.0b013e31817de3e1","article-title":"Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma: packed red blood cells the answer?","volume":"65","author":"Kashuk","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib82","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/SLA.0b013e31818990ed","article-title":"Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients","volume":"248","author":"Scalea","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib83","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.1097\/01.CCM.0000214288.88308.26","article-title":"Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm?","volume":"34","author":"Gajic","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.biologicals.2009.10.007_bib84","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1182\/blood-2004-07-2929","article-title":"Transfusion-related acute lung injury","volume":"105","author":"Silliman","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biologicals.2009.10.007_bib85","first-page":"S46","article-title":"Risks of fresh frozen plasma and platelets","volume":"60","author":"MacLennan","year":"2006","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib86","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ccc.2003.12.002","article-title":"Efficacy of red blood cell transfusion in the critically ill","volume":"20","author":"Napolitano","year":"2004","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.biologicals.2009.10.007_bib87","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1365-3148.2007.00729.x","article-title":"Coagulation parameters of thawed fresh-frozen plasma during storage at different temperatures","volume":"17","author":"Lamboo","year":"2007","journal-title":"Transfus Med"},{"key":"10.1016\/j.biologicals.2009.10.007_bib88","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/TA.0b013e31817c9687","article-title":"Age of transfused blood: an independent predictor of mortality despite universal leukoreduction","volume":"65","author":"Weinberg","year":"2008","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib89","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0002-9610(99)00239-1","article-title":"Age of transfused blood is an independent risk factor for postinjury multiple organ failure","volume":"178","author":"Zallen","year":"1999","journal-title":"Am J Surg"},{"key":"10.1016\/j.biologicals.2009.10.007_bib90","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/01.ta.0000220386.84012.bf","article-title":"Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma","volume":"60","author":"Yucel","year":"2006","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib91","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/TA.0b013e3181961c35","article-title":"Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)?","volume":"66","author":"Nunez","year":"2009","journal-title":"J Trauma"},{"key":"10.1016\/j.biologicals.2009.10.007_bib92","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jamcollsurg.2007.05.007","article-title":"Early predictors of massive transfusion in combat casualties","volume":"205","author":"Schreiber","year":"2007","journal-title":"J Am Coll Surg"},{"issue":"2 Suppl","key":"10.1016\/j.biologicals.2009.10.007_bib93","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1097\/TA.0b013e318160a566","article-title":"A predictive model for massive transfusion in combat casualty patients","volume":"64","author":"McLaughlin","year":"2008","journal-title":"J Trauma"}],"container-title":["Biologicals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1045105609001572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1045105609001572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T10:13:39Z","timestamp":1634724819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1045105609001572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":92,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S1045105609001572"],"URL":"https:\/\/doi.org\/10.1016\/j.biologicals.2009.10.007","relation":{},"ISSN":["1045-1056"],"issn-type":[{"value":"1045-1056","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}