{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:35:57Z","timestamp":1791149757595,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.biomaterials.2003.08.047","type":"journal-article","created":{"date-parts":[[2003,10,16]],"date-time":"2003-10-16T11:11:48Z","timestamp":1066302708000},"page":"1239-1247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate\/calcium carbonate"],"prefix":"10.1016","volume":"25","author":[{"given":"Carsten","family":"Schiller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wehm\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Eufinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Epple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Weihe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2003.08.047_BIB1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1010-5182(05)80007-1","article-title":"Reconstruction of craniofacial bone defects with individual alloplastic implants based on CAD\/CAM-manipulated CT-data","volume":"23","author":"Eufinger","year":"1995","journal-title":"J Cranio Maxillofac Surg"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0901-5027(00)80059-4","article-title":"Synthesis of CAD\/CAM, robotics and biomaterial implant fabrication","volume":"29","author":"Weihe","year":"2000","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s100060100317","article-title":"Die Versorgung kraniofazialer Knochendefekte mit individuell vorgefertigten Titanimplantaten. Nachuntersuchung und Auswertung von 76 Patienten mit 78 Titanimplantaten der Jahre 1994\u20131998","volume":"5","author":"Kamyszek","year":"2001","journal-title":"Mund Kiefer Gesichtschirurgie"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.matsci.28.1.271","article-title":"The material bone","volume":"28","author":"Weiner","year":"1998","journal-title":"Annu Rev Mater Sci"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/(SICI)1097-4636(199905)45:2<100::AID-JBM4>3.0.CO;2-0","article-title":"Graded structure of bioactive titanium prepared by chemical treatment","volume":"45","author":"Kim","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB6","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0142-9612(98)00244-0","article-title":"Synthesis of functionally graded CO3 apatite as surface biodegradable crystals","volume":"20","author":"Okazaki","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4028\/www.scientific.net\/MSF.308-311.325","article-title":"Functionally graded bioceramics","volume":"308\u2013311","author":"Pompe","year":"1999","journal-title":"Mater Sci Forum"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/1097-4636(200011)52:2<333::AID-JBM12>3.0.CO;2-T","article-title":"Preparation of graded porous titanium coatings on titanium implant materials by plasma spraying","volume":"52","author":"Yang","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB9","first-page":"97","article-title":"Functionally graded materials of biodegradable polyesters and bone-like calcium phosphates for bone replacement","volume":"114","author":"Schiller","year":"2001","journal-title":"Ceram Trans"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB10","first-page":"73","article-title":"Gradient tissue reaction induced by functionally graded implant","volume":"114","author":"Watari","year":"2001","journal-title":"Ceram Trans"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB11","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1016\/S0142-9612(02)00200-4","article-title":"Easy assessment of the biocompatibility of Ni\u2013Ti alloys by in-vitro cell culture experiments on a functionally graded Ni\u2013NiTi\u2013Ti material","volume":"23","author":"Bogdanski","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jbm.10220","article-title":"Synthesis of functionally graded MgCO3 apatite accelerating osteoblast adhesion","volume":"62","author":"Yamasaki","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB13","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/S0142-9612(01)00390-8","article-title":"Continuous synthesis of amorphous carbonated apatites","volume":"23","author":"Tadic","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB14","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/S0142-9612(02)00634-8","article-title":"Carbonated apatites can be used as pH-stabilizing filler for biodegradable polyesters","volume":"24","author":"Schiller","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB15","first-page":"2593","volume":"17","author":"Schindler","year":"1979","journal-title":"J Polym Sci"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/actp.1990.010410604","article-title":"Biologisch abbaubare Polymere. 1. Mitt","volume":"41","author":"Rafler","year":"1990","journal-title":"Acta Polym"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0079-6107(96)00011-9","article-title":"X-ray computed microtomography (CT) using synchrotron radiation (SR)","volume":"65","author":"Bonse","year":"1996","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1117\/12.363719","article-title":"New developments in attenuation and phase-contrast microtomography using synchrotron radiation with low and high photon energies","volume":"3772","author":"Beckmann","year":"1999","journal-title":"Proc SPIE"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/31798","article-title":"A marriage of bone and nacre","volume":"392","author":"Westbrook","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB20","first-page":"47","article-title":"Das Begasungsverfahren zur Beladung resorbierbarer Polymere mit thermolabilen Substanzen","volume":"20","author":"Tschakaloff","year":"1996","journal-title":"Dtsch Z Mund Kiefer GesichtsChir"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0168-3659(99)00138-8","article-title":"Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery","volume":"64","author":"Sheridan","year":"2000","journal-title":"J Control Rel"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB22","doi-asserted-by":"crossref","unstructured":"Howdle SM, Watson MS, Whitaker MJ, Popov VK, Davies MC, Mandel FS, Wang JD, Shakesheff KM. Supercritical fluid mixing: preparation of thermally sensitive polymer composites containing bioactive materials. Chem Commun 2001;109\u201310.","DOI":"10.1039\/b008188o"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB23","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/adma.200290003","article-title":"Incorporation of proteins into polymer materials by a novel supercritical fluid processing method","volume":"14","author":"Watson","year":"2002","journal-title":"Adv Mater"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1023\/A:1011256107282","article-title":"Porous HA ceramic for bone replacement","volume":"12","author":"Flautre","year":"2001","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB25","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0142-9612(00)00030-2","article-title":"Osteoconduction at porous hydroxyapatite with various pore configurations","volume":"21","author":"Chang","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB26","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1016\/S0142-9612(00)00129-0","article-title":"Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation","volume":"21","author":"B\u00f6stman","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF00154549","article-title":"The influence of basic filler materials on the degradation of amorphous d- and l-lactide copolymer","volume":"7","author":"van der Meer","year":"1996","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1097-4636(199722)38:2<105::AID-JBM4>3.0.CO;2-U","article-title":"Technique to control pH in vicinity of biodegrading PLA\u2013PGA implants","volume":"38","author":"Agrawal","year":"1997","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB29","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jbm.10024","article-title":"In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes","volume":"58","author":"Ignatius","year":"2001","journal-title":"J Biomed Mater Res Appl Biomater"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/1097-4636(200102)54:2<162::AID-JBM2>3.0.CO;2-3","article-title":"Biologically and chemically optimized composites of carbonated apatite and polyglycolide as bone substitution materials","volume":"54","author":"Linhart","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1515\/bmte.1996.41.10.278","article-title":"Ein neues Osteoblasten-Zellkultursystem zur normgerechten Pr\u00fcfung von Biomaterialien","volume":"41","author":"Hendrich","year":"1996","journal-title":"Biomed Tech"},{"key":"10.1016\/j.biomaterials.2003.08.047_BIB32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0141-3910(99)00111-1","article-title":"Properties and morphology of poly(l-lactide), 4. Effects of structural parameters on long-term hydrolysis of poly(l-lactide) in phosphate-buffered solution","volume":"67","author":"Tsuji","year":"2000","journal-title":"Polym Degr Stabil"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961203006744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961203006744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:37:27Z","timestamp":1758897447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961203006744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":32,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0142961203006744"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2003.08.047","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate\/calcium carbonate","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2003.08.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}