{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:27:34Z","timestamp":1791300454785,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.biomaterials.2003.09.097","type":"journal-article","created":{"date-parts":[[2003,11,21]],"date-time":"2003-11-21T07:58:31Z","timestamp":1069401511000},"page":"3081-3086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier"],"prefix":"10.1016","volume":"25","author":[{"given":"Cedric","family":"Chauvierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Marden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Vauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Labarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Couvreur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Leclerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2003.09.097_BIB1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.2042-7158.1979.tb13510.x","article-title":"Poly(cyanoacrylate) nanoparticles as potential lysosomotropic carriers","volume":"31","author":"Couvreur","year":"1979","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0378-5173(83)90166-7","article-title":"Pharmacokinetics and distribution of a biodegradable drug-carrier","volume":"15","author":"Grislain","year":"1983","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-3659(99)00063-2","article-title":"Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting","volume":"60","author":"Peracchia","year":"1999","journal-title":"J Control Rel"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB4","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1002\/1520-6017(200011)89:11<1452::AID-JPS8>3.0.CO;2-P","article-title":"Design of folic acid-conjugated nanoparticles for drug targeting","volume":"89","author":"Stella","year":"2000","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0005-2736(94)90296-8","article-title":"Entrapment of Hb into liposomes by the dehydration\u2013rehydration method","volume":"1196","author":"Brandl","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0169-409X(99)00051-4","article-title":"Two future generations of blood substitutes based on polyhemoglobin-SOD-catalase and nanoencapsulation","volume":"40","author":"Chang","year":"2000","journal-title":"Adv Drug Delivery Rev"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0169-409X(99)00045-9","article-title":"Blood substitutes","volume":"40","author":"Winslow","year":"2000","journal-title":"Adv Drug Delivery Rev"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB8","series-title":"Polymeric biomaterials","first-page":"1","article-title":"Polysaccharides as biomaterials","author":"Dumitriu","year":"2001"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB9","unstructured":"Chauvierre C, Couvreur P, Labarre D, Vauthier C. Block-structure copolymer consisting of a saccharide segment bound to at least a biodegradable hydrophobic segment, and corresponding particles. World Patent No. 0239979, 2002."},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00877245","article-title":"Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles","volume":"10","author":"Kattan","year":"1992","journal-title":"Invest New Drug"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0003-2697(73)90256-X","article-title":"A convenient chromatographic method for the preparation of human hemoglobin","volume":"54","author":"Williams","year":"1973","journal-title":"Anal Biochem"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB12","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0021-9258(18)76122-X","article-title":"Spectrophotometric studies. I. Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood","volume":"98","author":"Drabkin","year":"1932","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0038-1642398","article-title":"Binding of heparin fractions to von Willebrand factor","volume":"71","author":"Baruch","year":"1994","journal-title":"Thromb Haemostasis"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB14","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1021\/bi00405a041","article-title":"T-state hemoglobin with four ligands bound","volume":"27","author":"Marden","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0301-4622(02)00090-X","article-title":"Myoglobin as a model system for designing heme protein based blood substitutes","volume":"98","author":"Dou","year":"2002","journal-title":"Biophys Chem"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB16","series-title":"Polymeric biomaterials","first-page":"753","article-title":"Polymeric micro- and nanoparticles as drug carriers","author":"Barratt","year":"2001"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB17","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1023\/A:1011930127562","article-title":"Long-circulating nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate)","volume":"15","author":"Passirani","year":"1998","journal-title":"Pharm Res"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0169-409X(99)00047-2","article-title":"Purification and chemical modifications of hemoglobin in developing hemoglobin based oxygen carriers","volume":"40","author":"Haney","year":"2000","journal-title":"Adv Drug Delivery Rev"},{"key":"10.1016\/j.biomaterials.2003.09.097_BIB19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-5173(02)00235-1","article-title":"Development of hemoglobin aquasomes from spherical hydroxyapatite cores precipitated in the presence of half-generation poly(amidoamine) dendrimer","volume":"241","author":"Khopade","year":"2002","journal-title":"Int J Pharm"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961203008585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961203008585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:38:25Z","timestamp":1758897505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961203008585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":19,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0142961203008585"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2003.09.097","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2003.09.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}