{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:48:35Z","timestamp":1771487315433,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.biomaterials.2004.01.017","type":"journal-article","created":{"date-parts":[[2004,2,21]],"date-time":"2004-02-21T05:23:03Z","timestamp":1077340983000},"page":"5583-5591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Histomorphometric, ultrastructural and microhardness evaluation of the osseointegration of a nanostructured titanium oxide coating by metal-organic chemical vapour deposition: an in vivo study"],"prefix":"10.1016","volume":"25","author":[{"given":"Gianluca","family":"Giavaresi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Ambrosio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni A.","family":"Battiston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Casellato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalba","family":"Gerbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Finia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2 Nicoli","family":"Aldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Rimondini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Giardino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2004.01.017_BIB1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0901-5027(96)80015-4","article-title":"Factors in implant integration failure after bone grafting. An osteometric and endocrinologic matched analysis","volume":"25","author":"Blomqvist","year":"1996","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s007840050054","article-title":"Failure of oral implants","volume":"2","author":"Duyck","year":"1998","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB3","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jbm.820250708","article-title":"Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs","volume":"25","author":"Buser","year":"1991","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB4","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jbm.820291009","article-title":"Anchorage of TiO2 blasted, HA-coated, and machined implants","volume":"29","author":"Gotfredsen","year":"1995","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB5","doi-asserted-by":"crossref","first-page":"605.616","DOI":"10.1016\/0142-9612(96)88711-4","article-title":"Bone response to surface-modified titanium implants","volume":"17","author":"Larsson","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB6","first-page":"247","article-title":"Biomaterial and implant surfaces","volume":"3","author":"Kasemo","year":"1988","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0169-4332(90)90100-E","article-title":"Surface spectroscopic characterization of titanium implant materials","volume":"44","author":"Lausmaa","year":"1990","journal-title":"Appl Surf Sci"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0368-2048(95)02530-8","article-title":"Surface spectroscopic characterization of titanium implant materials","volume":"81","author":"Lausmaa","year":"1996","journal-title":"J Electron Spectrosc Relat Phenom"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB9","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1039\/b002968h","article-title":"Al2O3 thin films from aluminium dimethylisopropoxide by metal-organic chemical vapour deposition","volume":"10","author":"Barreca","year":"2000","journal-title":"J Mater Chem"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0040-6090(94)90849-4","article-title":"Influence of substrate on structural-properties of TiO2 thin-films obtained via MOCVD","volume":"239","author":"Battiston","year":"1994","journal-title":"Thin Solid Films"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0169-4332(00)00844-8","article-title":"Surface studies of in vitro biocompatibility of titanium oxide coatings","volume":"172","author":"Casaletto","year":"2001","journal-title":"Appl Surf Sci"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/(SICI)1521-3862(199908)5:4<159::AID-CVDE159>3.0.CO;2-E","article-title":"MOCVD growth and characterization of ZrO2 thin films obtained from unusualorgano-zirconium precursors","volume":"5","author":"Codato","year":"1999","journal-title":"Chem Vapor Depos"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00004770-200302000-00011","article-title":"Fabrication of hard coatings on NiTi instruments","volume":"29","author":"Tripi","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0142-9612(96)00130-5","article-title":"Surface characterization of C\/Ti6Al4V coating treated with ion beam","volume":"18","author":"Demri","year":"1997","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/10454411910020010601","article-title":"Osseointegration and matrix production at the implant surface","volume":"2","author":"Stanford","year":"1991","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB16","series-title":"Handbook of biomaterial properties","first-page":"340","article-title":"Oxide cermics: inert ceramic materials in midicine and dentistry","author":"Li","year":"1998"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB17","first-page":"S583","article-title":"Strategies to affect bone remodeling","volume":"8","author":"Le Geros","year":"1993","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.0909-8836..t01-6-.x","article-title":"Biological factors contributing to failures of osseointegrated oral implants. (II) Etiopathogenesis","volume":"106","author":"Esposito","year":"1998","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB19","unstructured":"Battiston G, Gerbasi R, Rimondini L, Ambrosio L, Rondelli G. Procedimento di trattamento della superficie di un impianto dentale, in particolare in titanio e impianto ottenuto con il procedimento, Italian Patent No. VE2001A000051, 30\/11\/2001."},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB20","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0736-0266(01)00158-9","article-title":"The effect of pulsed electromagnetic fields on the osseointegration of hydroxypatite implants in cancellous bone","volume":"20","author":"Fini","year":"2002","journal-title":"J Orthop Res"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-7799(00)01536-5","article-title":"Nanotechniques and approaches in biotechnology","volume":"19","author":"Curtis","year":"2001","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0142-9612(02)00427-1","article-title":"Fibroblast reaction to island topography","volume":"24","author":"Dalby","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB23","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1016\/S0142-9612(03)00208-4","article-title":"Nanoscale features influence epithelial cell morphology and cytokine production","volume":"24","author":"Andersson","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB24","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/mawe.200290001","article-title":"In vitro corrosion characterization and cell proliferation on surface-modified Ti","volume":"33","author":"Rimondini","year":"2002","journal-title":"Materialwiss"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB25","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1177\/039139880302600811","article-title":"In vitro biocompatibility of titanium oxide for prosthetic devices nanostructured by low pressure metal-organic chemical vapour deposition","volume":"26","author":"Giavaresi","year":"2003","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB26","series-title":"Mechanical testing of bone and the bone\u2013implant interface","first-page":"247","article-title":"Microhardness testing of bone","author":"Huja","year":"2000"},{"key":"10.1016\/j.biomaterials.2004.01.017_BIB27","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/039139880302600611","article-title":"In vitro behaviour of osteoblasts cultured on orthopaedic biomaterials with different surface roughness, uncoated and fluorohydroxyapatite-coated, relative to the in vivo osteointegration rate","volume":"26","author":"Fini","year":"2003","journal-title":"Int J Artif Organs"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961204000559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961204000559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:39:31Z","timestamp":1758897571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961204000559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":27,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0142961204000559"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2004.01.017","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histomorphometric, ultrastructural and microhardness evaluation of the osseointegration of a nanostructured titanium oxide coating by metal-organic chemical vapour deposition: an in vivo study","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2004.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}