{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:29:43Z","timestamp":1791872983785,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.biomaterials.2004.02.014","type":"journal-article","created":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T05:36:05Z","timestamp":1079501765000},"page":"5037-5044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model"],"prefix":"10.1016","volume":"25","author":[{"given":"D.","family":"Stubbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Deakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chapman-Sheath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Debes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Gillies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.R.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2004.02.014_BIB1","first-page":"611","article-title":"Bone regeneration in a coralline hydroxyapatite implant","volume":"29","author":"Holmes","year":"1978","journal-title":"Surg Forum"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/00006534-197905000-00004","article-title":"Bone regeneration within a coralline hydroxyapatite implant","volume":"63","author":"Holmes","year":"1979","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB3","doi-asserted-by":"crossref","unstructured":"Holmes R, Mooney V, Bucholz R, Tencer A. A coralline hydroxyapatite bone graft substitute. Preliminary report. Clin Orthop 1984;188:252\u201362.","DOI":"10.1097\/00003086-198409000-00036"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2106\/00004623-198668060-00013","article-title":"Porous hydroxyapatite as a bone-graft substitute in metaphyseal defects. A histometric study","volume":"68","author":"Holmes","year":"1986","journal-title":"J Bone Jt Surg Am"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB5","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00004424-198611000-00004","article-title":"Coralline hydroxyapatite bone-graft substitutes in a canine metaphyseal defect model. Radiographic\u2013histometric correlation","volume":"21","author":"Sartoris","year":"1986","journal-title":"Invest Radiol"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0030-5898(20)30395-3","article-title":"Hydroxyapatite and tricalcium phosphate bone graft substitutes","volume":"18","author":"Bucholz","year":"1987","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jbm.820240602","article-title":"Investigation of a hydroxyapatite and calcium sulfate composite supplemented with an osteoinductive factor","volume":"24","author":"Damien","year":"1990","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB8","first-page":"472","article-title":"The possible use of coralline hydroxyapatite as a bone implant","volume":"30","author":"Light","year":"1991","journal-title":"J Foot Surg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jab.770060202","article-title":"Histological and electron microscopic analysis of tissue response to synthetic composite bone graft in the canine","volume":"6","author":"St John","year":"1995","journal-title":"J Appl Biomater"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00181863","article-title":"Hydroxyapatite-glass composite as a bone substitute in large metaphyseal cavities in rabbits","volume":"19","author":"Suominen","year":"1995","journal-title":"Int Orthop"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1067-2516(96)80058-5","article-title":"Coralline hydroxyapatite bone graft substitutes","volume":"35","author":"Elsinger","year":"1996","journal-title":"J Foot Ankle Surg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB12","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0090-3019(98)00049-4","article-title":"Comparison of hydroxyapatite granules to autogenous bone graft in fusion cages in a goat model","volume":"49","author":"Mooney","year":"1998","journal-title":"Surg Neurol"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1440-1622.2001.02128.x","article-title":"Synthetic bone graft substitutes","volume":"71","author":"Moore","year":"2001","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1148\/radiology.159.1.3513246","article-title":"Coralline hydroxyapatite bone graft substitutes","volume":"159","author":"Sartoris","year":"1986","journal-title":"Radiology"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1749-6632.1988.tb38509.x","article-title":"Mechanical and bone ingrowth properties of a polymer-coated, porous, synthetic, coralline hydroxyapatite bone-graft material","volume":"523","author":"Tencer","year":"1988","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/jbm.820260705","article-title":"Bone formation process in porous calcium carbonate and hydroxyapatite","volume":"26","author":"Ohgushi","year":"1992","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB17","first-page":"360","article-title":"[Coral substituted for bone grafting in posterior vertebral arthrodesis in children. Initial results]","volume":"75","author":"Pouliquen","year":"1989","journal-title":"Rev Chir Orthop Reparatrice Appar Mot"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00297191","article-title":"Formation of a calcium phosphate-rich layer on absorbable calcium carbonate bone graft substitutes","volume":"55","author":"Damien","year":"1994","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00001665-199409000-00003","article-title":"Use of coral granules in the craniofacial skeleton","volume":"5","author":"Marchac","year":"1994","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/088532829500900306","article-title":"Effect of demineralized bone matrix on bone growth within a porous HA material","volume":"9","author":"Damien","year":"1995","journal-title":"J Biomater Appl"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s001040050125","article-title":"[Biocoral\u2014an alternative bone substitute]","volume":"67","author":"Soost","year":"1996","journal-title":"Chirurg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00223-001-1087-x","article-title":"Hydroxyapatite\/calcium carbonate (HA\/CC) vs. plaster of Paris","volume":"71","author":"Jamali","year":"2002","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB23","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1600-051X.1998.tb02410.x","article-title":"A 5-year follow-up of 16 patients treated with coralline calcium carbonate (BIOCORAL) bone replacement grafts in infrabony defects","volume":"25","author":"Yukna","year":"1998","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0736-0266(03)00012-3","article-title":"A resorbable porous ceramic composite bone graft substitute in a rabbit metaphyseal defect model","volume":"21","author":"Walsh","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB25","unstructured":"Cuestas Carnero RA. Plaster of Paris and anorganic bone in the filling of surgical cavities. Trans Int Conf Oral Surg 1970;524\u20135."},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB26","first-page":"895","article-title":"Calcium sulfate","volume":"17","author":"Anson","year":"1996","journal-title":"Compend Contin Educ Dent"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB27","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0030-5898(05)70114-0","article-title":"Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone","volume":"30","author":"Tay","year":"1999","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00007632-200001010-00004","article-title":"Plaster of Paris as an osteoconductive material for interbody vertebral fusion in mature sheep","volume":"25","author":"Hadjipavlou","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00001665-200011040-00009","article-title":"Calcium sulfate bone void filler","volume":"11","author":"Pietrzak","year":"2000","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB30","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1007\/s005860100275","article-title":"Plaster of Paris as bone substitute in spinal surgery","volume":"10","author":"Hadjipavlou","year":"2001","journal-title":"Eur Spine J"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00003086-200101000-00008","article-title":"The use of a surgical grade calcium sulfate as a bone graft substitute","volume":"382","author":"Kelly","year":"2001","journal-title":"Clin Orthop"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB32","first-page":"1","article-title":"Bone substitutes in 2003","volume":"69","author":"Delloye","year":"2003","journal-title":"Acta Orthop Belg"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB33","doi-asserted-by":"crossref","unstructured":"Borrelli Jr J, Prickett WD, Ricci WM. Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin Orthop 2003;411:245\u201354.","DOI":"10.1097\/01.blo.0000069893.31220.6f"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB34","doi-asserted-by":"crossref","first-page":"s577","DOI":"10.3928\/0147-7447-20030502-10","article-title":"Resorption evaluation of a large bolus of calcium sulfate in a canine medullary defect","volume":"26","author":"Turner","year":"2003","journal-title":"Orthopedics"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB35","doi-asserted-by":"crossref","first-page":"s571","DOI":"10.3928\/0147-7447-20030502-09","article-title":"Osseous healing using injectable calcium sulfate-based putty for the delivery of demineralized bone matrix and cancellous bone chips","volume":"26","author":"Turner","year":"2003","journal-title":"Orthopedics"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB36","doi-asserted-by":"crossref","first-page":"s581","DOI":"10.3928\/0147-7447-20030502-11","article-title":"Healing of large defects treated with calcium sulfate pellets containing demineralized bone matrix particles","volume":"26","author":"Urban","year":"2003","journal-title":"Orthopedics"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00003086-200301000-00033","article-title":"Response of a calcium sulfate bone graft substitute in a confined cancellous defect","volume":"406","author":"Walsh","year":"2003","journal-title":"Clin Orthop"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB38","first-page":"1","article-title":"Using calcium sulfate as a graft enhancer and membrane barrier","volume":"14","author":"Sottosanti","year":"2003","journal-title":"Dent Implantol Update"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB39","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/01.blo.0000063788.32430.8f","article-title":"Calcium sulfate used as bone graft substitute in acetabular fracture fixation","volume":"410","author":"Moed","year":"2003","journal-title":"Clin Orthop"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB40","first-page":"35","article-title":"Adverse reactions to OsteoSet bone graft substitute, the incidence in a consecutive series","volume":"22","author":"Lee","year":"2002","journal-title":"Iowa Orthop J"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jab.770020307","article-title":"Bone graft and bone graft substitutes","volume":"2","author":"Damien","year":"1991","journal-title":"J Appl Biomater"},{"key":"10.1016\/j.biomaterials.2004.02.014_BIB42","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0278-2391(88)90109-7","article-title":"Hydroxylapatite as a bone graft substitute in orthognathic surgery","volume":"46","author":"Holmes","year":"1988","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961204001528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961204001528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:39:01Z","timestamp":1758897541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961204001528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":42,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0142961204001528"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2004.02.014","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2004.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}