{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:38:41Z","timestamp":1789778321580,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.biomaterials.2005.01.051","type":"journal-article","created":{"date-parts":[[2005,3,12]],"date-time":"2005-03-12T11:55:56Z","timestamp":1110628556000},"page":"5414-5426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":363,"title":["Size-controlled hydroxyapatite nanoparticles as self-organized organic\u2013inorganic composite materials"],"prefix":"10.1016","volume":"26","author":[{"given":"Viorel Marin","family":"Rusu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuen-How","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Tiersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fratzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2005.01.051_bib1","first-page":"31","article-title":"Characterizing natural fibre composites with hierarchical structure","volume":"210","author":"Fratzl","year":"2002","journal-title":"Fibre Diffraction Rev"},{"issue":"11","key":"10.1016\/j.biomaterials.2005.01.051_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/1521-4095(20020605)14:11<775::AID-ADMA775>3.0.CO;2-0","article-title":"Bio-inspired materials chemistry","volume":"14","author":"Dujardin","year":"2002","journal-title":"Adv Mater"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0928-4931(98)00044-7","article-title":"Biomimetic materials: recent developments in organic\u2013inorganic hybrids","volume":"6","author":"Ahmad","year":"1998","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1381-5148(98)00054-6","article-title":"Biomedical applications of functional polymers","volume":"39","author":"Grodzinski","year":"1999","journal-title":"React Function Polym"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib5","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0142-9612(00)00102-2","article-title":"Biomaterial developments for bone tissue engineering","volume":"21","author":"Burg","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib6","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","article-title":"Scaffolds in tissue engineering bone and cartilage","volume":"21","author":"Hutmacher","year":"2000","journal-title":"Biomaterials"},{"issue":"18","key":"10.1016\/j.biomaterials.2005.01.051_bib7","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1016\/S0142-9612(02)00133-3","article-title":"XPS study for the microstructure development of hydroxyapatite-collagen nanocomposites cross-linked using glutaraldehyde","volume":"23","author":"Chang","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib8","first-page":"673","article-title":"Preparation and mechanical properties of chitosan\/hydroxyapatite nanocomposites","volume":"192\u2013195","author":"Yamaguchi","year":"2001","journal-title":"Key Eng Mater"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/1097-4636(200104)55:1<20::AID-JBM30>3.0.CO;2-F","article-title":"Preparation and microstructure analysis of chitosan\/hydroxyapatite nanocomposites","volume":"55","author":"Yamaguchi","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib10","first-page":"31","article-title":"In vitro biomineralization of chitosan","volume":"192\u2013195","author":"Beppu","year":"2001","journal-title":"Key Eng Mater"},{"issue":"10","key":"10.1016\/j.biomaterials.2005.01.051_bib11","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/(SICI)1521-3765(19981002)4:10<1898::AID-CHEM1898>3.0.CO;2-U","article-title":"Biomimetic crystallisation of apatite in a porous polymer matrix","volume":"4","author":"Schwarz","year":"1998","journal-title":"Chem Eur J"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib12","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/(SICI)1099-0518(199708)35:11<2295::AID-POLA21>3.0.CO;2-8","article-title":"Biodegradable and biocompatible inorganic\u2013organic hybrid materials I. Synthesis and characterization","volume":"35","author":"Tian","year":"1997","journal-title":"J Polym Sci Part A: Polym Chem"},{"issue":"5","key":"10.1016\/j.biomaterials.2005.01.051_bib13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0142-9612(03)00582-9","article-title":"Preparation and characterization of biodegradable chitosan\/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture","volume":"25","author":"Hu","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib14","unstructured":"Ng C-H, Rusu VM, Peter MG. Formation of chitosan hydroxyapatite composites in the presence of different organic acids. Adv Chitin Sci; 7, in press."},{"issue":"17","key":"10.1016\/j.biomaterials.2005.01.051_bib15","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/S0142-9612(03)00115-7","article-title":"Preparation of hydroxyapatite-gelatin nanocomposites","volume":"24","author":"Chang","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0008-6215(91)84142-2","article-title":"Determination of the degree of N-Acetyl groups in partially N-Deacetylated chitins (Chitosans) by high-field N.M.R. spectroscopy","volume":"211","author":"V\u00e5rum","year":"1991","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib17","unstructured":"Lee VF, PhD thesis in university microfilms; 1974, 74\/29446."},{"issue":"11","key":"10.1016\/j.biomaterials.2005.01.051_bib18","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/1521-4079(200211)37:11<1234::AID-CRAT1234>3.0.CO;2-X","article-title":"Determination of the bone mineral crystallite size and lattice strain from diffraction line broadening","volume":"37","author":"Danilchenko","year":"2002","journal-title":"Cryst Res Technol"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib19","series-title":"X-ray diffraction procedures for polycrystallite and amorphous materials","author":"Klug","year":"1974"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib20","volume":"vol. 29","author":"Barrett","year":"1986"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib21","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/S0955-2219(00)00154-0","article-title":"Densification behavior and mechanisms of synthetic hydroxyapatites","volume":"20","author":"Landi","year":"2000","journal-title":"J Eur Ceram Soc"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/1521-4117(200012)17:5\/6<236::AID-PPSC236>3.0.CO;2-0","article-title":"Particles size distribution measurements of polymeric dispersions: a comparative study","volume":"17","author":"Elizalde","year":"2000","journal-title":"Part Part Syst Charact"},{"issue":"19","key":"10.1016\/j.biomaterials.2005.01.051_bib23","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0142-9612(97)00069-0","article-title":"Nano-apatite\/polymer composites: mechanical and physicochemical characteristics","volume":"18","author":"Liu","year":"1997","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib24","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.1063187","article-title":"Self-assembly and mineralization of peptide-amphiphile nanofibers","volume":"294","author":"Hartgerink","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib25","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jbm.10280","article-title":"Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods","volume":"62","author":"Koutsopoulos","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1008937507714","article-title":"Calcium phosphate bone cements for clinical applications","volume":"10","author":"Fernandez","year":"1999","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib27","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/S0955-2219(02)00413-2","article-title":"Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles","volume":"23","author":"Pang","year":"2003","journal-title":"J Eur Ceram Soc"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/jab.770020106","article-title":"Determination of the ratio of Hap\/TCP mixtures by X-ray-diffraction","volume":"2","author":"Toth","year":"1991","journal-title":"J Appl Biomater"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib29","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1","article-title":"Biological and medical significance of calcium phosphates","volume":"41","author":"Dorozhkin","year":"2002","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.14356\/kona.2003017","article-title":"Characterization of a nanosized iron powder by comparative methods","volume":"21","author":"Kescskes","year":"2003","journal-title":"Kona"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib31","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/S0955-2219(02)00413-2","article-title":"Influence of temperature, ripening time and calcinations on the morphology and crystallinity of hydroxyapatite nanoparticles","volume":"23","author":"Pang","year":"2003","journal-title":"J Eur Ceram Soc"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib32","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s002239900244","article-title":"X-ray pole figure analysis of apatite crystals and collagen molecules in bone","volume":"60","author":"Sasaki","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jemt.1060110103","article-title":"Image analysis of electron micrographs relating to mineralization in calcifying cartilage: theoretical considerations","volume":"11","author":"Hunziker","year":"1989","journal-title":"J Electron Microsc"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib34","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S1047-8477(02)00635-4","article-title":"Characteristic of mineral particles in the human\/bone cartilage","volume":"141","author":"Zizak","year":"2003","journal-title":"J Struct Biol"},{"key":"10.1016\/j.biomaterials.2005.01.051_bib35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0141-8130(98)00036-1","article-title":"Effect of temperature on the intrinsic viscosity and conformation of chitosan in dilute HCl solution","volume":"23","author":"Chen","year":"1998","journal-title":"Int J Biol Macromol"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961205000864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961205000864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:45:55Z","timestamp":1758897955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961205000864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":35,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0142961205000864"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2005.01.051","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Size-controlled hydroxyapatite nanoparticles as self-organized organic\u2013inorganic composite materials","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2005.01.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}