{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:12:56Z","timestamp":1769595176839,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.biomaterials.2005.07.014","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T07:32:49Z","timestamp":1124436769000},"page":"430-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"title":["Poly (d,l-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord"],"prefix":"10.1016","volume":"27","author":[{"given":"Andres","family":"Hurtado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence D.F.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Maquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bas","family":"Blits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"J\u00e9r\u00f4me","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Oudega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2005.07.014_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/exnr.1996.0065","article-title":"Methylprednisilone administration improves axonal regeneration into SC grafts in transected adult rat thoracic spinal cord","volume":"138","author":"Chen","year":"1996","journal-title":"Exp Neurol"},{"issue":"15","key":"10.1016\/j.biomaterials.2005.07.014_bib2","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1523\/JNEUROSCI.22-15-06670.2002","article-title":"Schwann cell but not olfactory ensheathing glia transplants improve hindlimb performance in the moderately contused adult rat thoracic spinal cord","volume":"22","author":"Takami","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/exnr.1995.1056","article-title":"A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord","volume":"134","author":"Xu","year":"1995","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1018557923309","article-title":"Bridging Schwann cell transplants promote axonal regeneration from both the proximal and distal stumps of transacted adult rat spinal cord","volume":"26","author":"Xu","year":"1997","journal-title":"J Neurocytol"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1098-1136(199703)19:3<247::AID-GLIA7>3.0.CO;2-W","article-title":"A combination of insulin-like growth factor and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord","volume":"19","author":"Oudega","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/(SICI)1097-4636(19981215)42:4<642::AID-JBM22>3.0.CO;2-K","article-title":"Poly(alpha-hydroxyacids) for application in the spinal cord: resorbability and biocompatibility with adult Schwann cells and spinal cord","volume":"42","author":"Gautier","year":"1998","journal-title":"J Biomed Mater Res"},{"issue":"10","key":"10.1016\/j.biomaterials.2005.07.014_bib7","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0142-9612(00)00346-X","article-title":"Axonal regeneration into Schwann cell grafts within resorbable poly(alpha-hydroxyacid) guidance channels in the adult rat spinal cord","volume":"22","author":"Oudega","year":"2001","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.biomaterials.2005.07.014_bib8","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0142-9612(03)00503-9","article-title":"Freeze-dried poly(d,l-lactic acid) macroporous guidance scaffolds impregnated with brain-derived neurotrophic factor in the transected adult rat thoracic spinal cord","volume":"25","author":"Patist","year":"2004","journal-title":"Biomaterials"},{"issue":"24","key":"10.1016\/j.biomaterials.2005.07.014_bib9","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1002\/j.1460-2075.1994.tb06935.x","article-title":"The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin","volume":"13","author":"Urfer","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1046\/j.1460-9568.1998.00071.x","article-title":"Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord","volume":"10","author":"Menei","year":"1998","journal-title":"Eur J Neurosci"},{"issue":"8","key":"10.1016\/j.biomaterials.2005.07.014_bib11","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1523\/JNEUROSCI.11-08-02433.1991","article-title":"Isolation and functional characterization of Schwann cells derived from adult peripheral nerve","volume":"11","author":"Morrissey","year":"1991","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.biomaterials.2005.07.014_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/exnr.2000.7413","article-title":"Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function","volume":"164","author":"Blits","year":"2000","journal-title":"Exp Neurol"},{"issue":"6","key":"10.1016\/j.biomaterials.2005.07.014_bib13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1089\/neu.1998.15.387","article-title":"Adenoviral vector-mediated gene delivery to injured rat peripheral nerve","volume":"15","author":"Dijkhuizen","year":"1998","journal-title":"J Neurotrauma"},{"issue":"6","key":"10.1016\/j.biomaterials.2005.07.014_bib14","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0142-9612(02)00423-4","article-title":"Image analysis of the axonal ingrowth into poly(d,l-lactide) porous scaffolds in relation to the 3-D porous structure","volume":"24","author":"Blacher","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib15","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0142-9612(00)00357-4","article-title":"Poly(d,l-lactide) foams modified by poly(ethylene oxide)-block-poly(d,l-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration","volume":"22","author":"Maquet","year":"2001","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biomaterials.2005.07.014_bib16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1357-2725(96)00146-X","article-title":"The apoptotic cysteine protease CPP32","volume":"29","author":"Kumar","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/exnr.1996.0098","article-title":"Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection","volume":"139","author":"Basso","year":"1996","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib19","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2004.21.1415","article-title":"Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord","author":"Meijs","year":"2004","journal-title":"J Neurotrauma"},{"issue":"1","key":"10.1016\/j.biomaterials.2005.07.014_bib20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0306-4522(02)00970-3","article-title":"Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hindlimb function","volume":"118","author":"Blits","year":"2003","journal-title":"Neurosci"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0079-6123(02)37006-7","article-title":"Cell death in models of spinal cord injury","volume":"137","author":"Beattie","year":"2002","journal-title":"Prog Brain Res"},{"issue":"1","key":"10.1016\/j.biomaterials.2005.07.014_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3171\/jns.1991.75.1.0015","article-title":"Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms","volume":"75","author":"Tator","year":"1991","journal-title":"J Neurosurg"},{"issue":"2","key":"10.1016\/j.biomaterials.2005.07.014_bib23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1006\/exnr.1999.7173","article-title":"Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury","volume":"159","author":"Brewer","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.biomaterials.2005.07.014_bib24","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1006\/exnr.1997.6693","article-title":"The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord","volume":"148","author":"Guest","year":"1997","journal-title":"Exp Neurol"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961205006095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961205006095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:48:09Z","timestamp":1758898089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961205006095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0142961205006095"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2005.07.014","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly (d,l-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2005.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}