{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:23:53Z","timestamp":1791131033940,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.biomaterials.2006.04.043","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T22:55:54Z","timestamp":1149634554000},"page":"4698-4705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":212,"title":["In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model"],"prefix":"10.1016","volume":"27","author":[{"given":"Yoon","family":"Yeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Highley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Bellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Kohane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2006.04.043_bib1","series-title":"Peritoneal surgery","first-page":"441","article-title":"Developing pharmacologic agents for adhesion prevention","author":"Rodgers","year":"2000"},{"issue":"1","key":"10.1016\/j.biomaterials.2006.04.043_bib2","first-page":"42","article-title":"Physical barriers in adhesion prevention","volume":"41","author":"Saravelos","year":"1996","journal-title":"J Reprod Med"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2508.2001.00422.x","article-title":"Adhesion prevention: state of art","volume":"10","author":"Al-Musawi","year":"2001","journal-title":"Gynaecol Endosc"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1006\/jsre.1995.1218","article-title":"Prevention of tissue injury and postsurgical adhesions by precoating tissues with hyaluronic acid solutions","volume":"59","author":"Burns","year":"1995","journal-title":"J Surg Res"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/jsre.2001.6288","article-title":"Polyanionic polysaccharides reduce intro-abdominal adhesion and abscess formation in a rat peritonitis model","volume":"101","author":"Reijnen","year":"2001","journal-title":"J Surg Res"},{"issue":"3","key":"10.1016\/j.biomaterials.2006.04.043_bib6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0015-0282(97)80085-4","article-title":"Reproduction of adhesion formation with hyaluronic acid after peritoneal surgery in rabbits","volume":"67","author":"Rodgers","year":"1997","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.biomaterials.2006.04.043_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0015-0282(98)00496-8","article-title":"A novel hyaluronan-based gel in laparoscopic adhesion prevention: preclinical evaluation in an animal model","volume":"69","author":"Laco","year":"1998","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.biomaterials.2006.04.043_bib8","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0015-0282(16)58642-7","article-title":"A hyaluronate based gel for the prevention of postsurgical adhesions: evaluation in two animal species","volume":"56","author":"Burns","year":"1996","journal-title":"Fertil Steril"},{"issue":"3","key":"10.1016\/j.biomaterials.2006.04.043_bib9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0015-0282(97)00573-6","article-title":"Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate\/carboxymethylcellulose gel","volume":"69","author":"Leach","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib10","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.fertnstert.2004.09.038","article-title":"Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions","volume":"83","author":"Li","year":"2005","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.biomaterials.2006.04.043_bib11","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.0886-0440.2003.00303.x","article-title":"Next-generation hydrogel films as tissue sealants and adhesion barriers","volume":"18","author":"Bennett","year":"2003","journal-title":"J Card Surg"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib12","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jbm.820280710","article-title":"Optimization of photopolymerized bioerodible hydrogel properties for adhesion prevention","volume":"28","author":"Sawhney","year":"1994","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib13","doi-asserted-by":"crossref","unstructured":"Pressato D, Bigon E, Dona M, Pavesio A, Renier D, Bonafini L, et al. Hyaluronan derivatives in postsurgical adhesion prevention. In: Kennedy JF, Phillips GO, Williams PA, editors. Hyaluronan: Proceedings of an International Meeting, September 2000, North East Wales Institute, UK. Cambridge, England: Woodhead Publishing, 2002. p. 491\u2013499.","DOI":"10.1533\/9781845693121.491"},{"issue":"2","key":"10.1016\/j.biomaterials.2006.04.043_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00000658-200202000-00006","article-title":"Fewer intraperitoneal adhesions with use of hyaluronic acid-carboxymethylcellulose membrane: a randomized clinical trial","volume":"235","author":"Vrijland","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/gyn.1991.7.97","article-title":"The use of hyaluronic-acid polymers to reduce postoperative adhesions","volume":"7","author":"Grainger","year":"1991","journal-title":"J Gynecol Surg"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/030006059902700503","article-title":"The effect of cross-linked hyaluronate hydrogel on the reduction of post-surgical adhesion reformation in rabbits","volume":"27","author":"Osada","year":"1999","journal-title":"J Int Med Res"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/(SICI)1097-4636(199911)47:2<152::AID-JBM5>3.0.CO;2-I","article-title":"New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels","volume":"47","author":"Bulpitt","year":"1999","journal-title":"J Biomed Mater Res"},{"issue":"19","key":"10.1016\/j.biomaterials.2006.04.043_bib18","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1016\/j.biomaterials.2003.12.012","article-title":"Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid","volume":"25","author":"Jia","year":"2004","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biomaterials.2006.04.043_bib19","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jbm.1261","article-title":"Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium","volume":"59","author":"Kohane","year":"2002","journal-title":"J Biomed Mater Res"},{"issue":"2","key":"10.1016\/j.biomaterials.2006.04.043_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jbm.a.30654","article-title":"Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum","volume":"77A","author":"Kohane","year":"2006","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib21","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1016\/S0032-3861(98)00550-3","article-title":"Synthesis of cross-linked poly(aldehyde guluronate) hydrogels","volume":"40","author":"Bouhadir","year":"1999","journal-title":"Polymer"},{"issue":"3","key":"10.1016\/j.biomaterials.2006.04.043_bib22","first-page":"172","article-title":"Inhibition of postsurgical adhesions in a standardized rabbit model: intraperitoneal treatment with tissue plasminogen activator","volume":"36","author":"Orita","year":"1991","journal-title":"Int J Fertil"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0003-2697(62)90095-7","article-title":"A modified uronic acid carbazole reaction","volume":"4","author":"Bitter","year":"1962","journal-title":"Anal Biochem"},{"issue":"9","key":"10.1016\/j.biomaterials.2006.04.043_bib24","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1021\/ma035970w","article-title":"Synthesis and characterization of in situ cross-linkable hyaluronic acid-based hydrogels with potential application for vocal fold regeneration","volume":"37","author":"Jia","year":"2004","journal-title":"Macromolecules"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib25","doi-asserted-by":"crossref","unstructured":"Yeo Y, Burdick JA, Highley CB, Marini R, Langer R, Kohane DS. Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res 2006:in press.","DOI":"10.1002\/jbm.a.30740"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib26","series-title":"Peritoneal surgery","first-page":"3","article-title":"Peritoneum, peritoneal healing, and adhesion formation","author":"diZerega","year":"2000"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0022-3476(00)90051-9","article-title":"A new disorder of hyaluronan metabolism associated with generalized folding and thickening of the skin","volume":"136","author":"Ramsden","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib28","first-page":"6410","article-title":"Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors","volume":"62","author":"Hiltunen","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1365-2168.2001.01647.x","article-title":"Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1","volume":"88","author":"Falk","year":"2001","journal-title":"Br J Surg"},{"issue":"12","key":"10.1016\/j.biomaterials.2006.04.043_bib30","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/humrep\/deg481","article-title":"Reactive oxygen species and adhesion formation: clinical implications in adhesion prevention","volume":"18","author":"Binda","year":"2003","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.biomaterials.2006.04.043_bib31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1055\/s-0037-1614993","article-title":"Modulation of pro- and antifibrinolytic properties of human peritoneal mesothelial cells by transforming growth factor beta1 (TGF-beta1), tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta)","volume":"79","author":"Tietze","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.biomaterials.2006.04.043_bib32","series-title":"Peritoneal surgery","first-page":"499","article-title":"Polymer solutions and films as tissue-protective and barrier adjuvants","author":"Peck","year":"2000"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961206004376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961206004376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:52:32Z","timestamp":1758898352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961206004376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":32,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0142961206004376"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2006.04.043","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2006.04.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}