{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:18:59Z","timestamp":1790374739231,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"30","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.biomaterials.2006.05.054","type":"journal-article","created":{"date-parts":[[2006,7,24]],"date-time":"2006-07-24T09:09:36Z","timestamp":1153732176000},"page":"5212-5219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["The correlation of RANK, RANKL and TNF\u03b1 expression with bone loss volume and polyethylene wear debris around hip implants"],"prefix":"10.1016","volume":"27","author":[{"given":"Christopher A.","family":"Holding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Findlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumen","family":"Stamenkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Neale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.S.K.","family":"Dharmapatni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Callary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush R.","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald J.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Howie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2006.05.054_bib1","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.5694\/j.1326-5377.2004.tb05911.x","article-title":"The Australian Orthopaedic Association National Joint Replacement Registry","volume":"180","author":"Graves","year":"2004","journal-title":"Med J Aust"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib2","first-page":"46","article-title":"The problem is osteolysis","author":"Harris","year":"1995","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00003086-199006000-00021","article-title":"Resurfacing hip arthroplasty. Classification of loosening and the role of prosthesis wear particles","author":"Howie","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib4","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1302\/0301-620X.72B6.2246301","article-title":"Aggressive granulomatous lesions in cementless total hip arthroplasty","volume":"72","author":"Santavirta","year":"1990","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/rheumatology\/33.4.309","article-title":"Interleukin-1 production by activated macrophages surrounding loosened orthopaedic implants: a potential role in osteolysis","volume":"33","author":"al Saffar","year":"1994","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1023\/A:1008967200706","article-title":"Comparison of the response of three human monocytic cell lines to challenge with polyethylene particles of known size and dose","volume":"12","author":"Matthews","year":"2001","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s002239900473","article-title":"Human osteoclast formation from blood monocytes, peritoneal macrophages, and bone marrow cells","volume":"62","author":"Quinn","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib8","doi-asserted-by":"crossref","first-page":"B902","DOI":"10.1302\/0301-620X.83B6.0830902","article-title":"The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis","volume":"83","author":"Haynes","year":"2001","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/ar384","article-title":"Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear","volume":"4","author":"Looney","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2106\/00004623-200306000-00018","article-title":"Relationship between polyethylene wear and osteolysis in hips with a second-generation porous-coated cementless cup after seven years of follow-up","volume":"85-A","author":"Orishimo","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2106\/00004623-198870020-00015","article-title":"A rat model of resorption of bone at the cement\u2013bone interface in the presence of polyethylene wear particles","volume":"70-A","author":"Howie","year":"1988","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib12","first-page":"46","article-title":"Osteolysis model with continuous infusion of polyethylene particles","author":"Kim","year":"1998","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1302\/0301-620X.82B4.0820595","article-title":"The effects of the concentration of high-density polyethylene particles on the bone\u2013implant interface","volume":"82","author":"Brooks","year":"2000","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/03009740410005944","article-title":"A novel murine model of orthopaedic wear-debris associated osteolysis","volume":"33","author":"Ren","year":"2004","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jor.1100150108","article-title":"Effects of polyethylene on macrophages","volume":"15","author":"Horowitz","year":"1997","journal-title":"J Orthop Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib16","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0883-5403(99)90035-9","article-title":"Cytokine response of human macrophage-like cells after contact with polyethylene and pure titanium particles","volume":"14","author":"Rader","year":"1999","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/00016470410001222","article-title":"Effects of polyethylene and TiAlV wear particles on expression of RANK, RANKL and OPG mRNA","volume":"75","author":"Baumann","year":"2004","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib18","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1016\/j.biomaterials.2004.06.034","article-title":"Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterials","volume":"26","author":"Garrigues","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1359\/jbmr.2000.15.1.2","article-title":"The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption","volume":"15","author":"Hofbauer","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib20","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00011-004-1303-z","article-title":"Bone lysis and inflammation","volume":"53","author":"Haynes","year":"2004","journal-title":"Inflamm Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0142-9612(03)00556-8","article-title":"Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFkappaB, RANK ligand and osteoprotegerin","volume":"25","author":"Crotti","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2106\/00004623-199306000-00007","article-title":"Production of cytokines around loosened cemented acetabular components","volume":"75-A","author":"Jiranek","year":"1993","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib23","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/endo.143.3.8701","article-title":"TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL","volume":"143","author":"Fuller","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.blo.0000069001.16315.f4","article-title":"Measurement of bone defects adjacent to acetabular components of hip replacement","author":"Stamenkov","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00004728-200001000-00029","article-title":"CT of metal implants: reduction of artifacts using an extended CT scale technique","volume":"24","author":"Link","year":"2000","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib26","first-page":"1615","article-title":"Cathepsin K in aseptic hip prosthesis loosening: expression in osteoclasts without polyethylene wear particles","volume":"28","author":"Hansen","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S8756-3282(99)00176-3","article-title":"Bidirectional signaling between stromal and hemopoietic cells regulates interleukin-1 expression during human osteoclast formation","volume":"25","author":"Haynes","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib28","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1016\/j.biomaterials.2004.01.003","article-title":"Regulation of osteoclast activity in peri-implant tissues","volume":"25","author":"Haynes","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","article-title":"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic function","volume":"390","author":"Anderson","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor \u03b1 stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0736-0266(02)00106-7","article-title":"Two distinct cellular mechanisms of osteoclast formation and bone resorption in periprosthetic osteolysis","volume":"21","author":"Sabokbar","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib32","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI11176","article-title":"TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand","volume":"106","author":"Lam","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib33","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00420.2004","article-title":"RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro","volume":"289","author":"Frick","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/oxfordjournals.jbchem.a003071","article-title":"IL-1alpha stimulation of osteoclast survival through the PI 3-kinase\/Akt and ERK pathways","volume":"131","author":"Lee","year":"2002","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib35","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1002\/art.21236","article-title":"Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2","volume":"52","author":"Zhang","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.biomaterials.2006.05.054_bib36","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0736-0266(03)00093-7","article-title":"Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs","volume":"21","author":"Schwarz","year":"2003","journal-title":"placebo. J Orthop Res"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961206005047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961206005047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:52:26Z","timestamp":1758898346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961206005047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":36,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0142961206005047"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2006.05.054","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The correlation of RANK, RANKL and TNF\u03b1 expression with bone loss volume and polyethylene wear debris around hip implants","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2006.05.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}