{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:21:32Z","timestamp":1790680892046,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.biomaterials.2006.09.028","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T07:37:56Z","timestamp":1160552276000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":158,"title":["A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier"],"prefix":"10.1016","volume":"28","author":[{"given":"Rohidas","family":"Arote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Kyung","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu-Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Hyun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Woon","family":"Nah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Haing","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Su","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2006.09.028_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/38410","article-title":"Gene therapy\u2014promises, problems and prospects","volume":"389","author":"Verma","year":"1997","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biomaterials.2006.09.028_bib2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/mthe.2000.0142","article-title":"Development of biomaterials for gene therapy","volume":"2","author":"Han","year":"2000","journal-title":"Mol Ther"},{"issue":"5","key":"10.1016\/j.biomaterials.2006.09.028_bib3","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1021\/bc034014g","article-title":"A degradable polyethyleneimine derivative with low toxicity for highly efficient gene delivery","volume":"14","author":"Forrest","year":"2003","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-3659(99)00090-5","article-title":"Poly(ethylenimine) and its role in gene delivery","volume":"60","author":"Godbey","year":"1999","journal-title":"J Control Release"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib5","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/(SICI)1097-4636(19990605)45:3<268::AID-JBM15>3.0.CO;2-Q","article-title":"Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle","volume":"45","author":"Godbey","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1023\/A:1014861900478","article-title":"A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity","volume":"16","author":"Fischer","year":"1999","journal-title":"Pharm Res"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib8","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1021\/ja0015388","article-title":"Degradable poly (\u03b2-amino esters): synthesis, characterization and self assembly with plasmid DNA","volume":"122","author":"Lynn","year":"2000","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib9","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1002\/anie.200351244","article-title":"Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery","volume":"42","author":"Anderson","year":"2003","journal-title":"Angew Chem-Int Ed"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib10","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1039\/b309487a","article-title":"Novel poly(amino ester) obtained from Michael addition polymerization of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers","author":"Liu","year":"2003","journal-title":"Chem Commun"},{"issue":"3","key":"10.1016\/j.biomaterials.2006.09.028_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ymthe.2004.11.015","article-title":"Structure\/property studies of polymeric gene delivery using a library of poly (\u03b2-amino esters)","volume":"11","author":"Anderson","year":"2005","journal-title":"Mol Ther"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib12","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1021\/bc025541n","article-title":"Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier","volume":"13","author":"Lim","year":"2002","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib13","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/bc0255135","article-title":"Poly(ethylenimine-co-l-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery","volume":"13","author":"Peterson","year":"2002","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib14","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/bc0100455","article-title":"Efficient gene transfer using reversibly cross-linked low molecular weight polyethyleneimine","volume":"12","author":"Gosselin","year":"2001","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1021\/bc0501597","article-title":"PEI-g-Chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo","volume":"17","author":"Wong","year":"2006","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jconrel.2005.04.008","article-title":"Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers","volume":"105","author":"Park","year":"2005","journal-title":"J Control Release"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib17","series-title":"Biodegradable polymers as drug delivery systems","first-page":"71","author":"Pitt","year":"1990"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib18","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0142-9612(02)00370-8","article-title":"A novel degradable polycaprolactone networks for tissue engineering","volume":"24","author":"Kweon","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1021\/bc025504w","article-title":"Design and formulation of polyplexes based on pluronic\u2013polyethyleneimine conjugates for gene transfer","volume":"13","author":"Gebhart","year":"2002","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0169-409X(01)00202-2","article-title":"Design and gene delivery activity of modified polyethylenimines","volume":"53","author":"Kircheis","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biomaterials.2006.09.028_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-3659(03)00076-2","article-title":"Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine","volume":"89","author":"Kunath","year":"2003","journal-title":"J Control Release"},{"issue":"22","key":"10.1016\/j.biomaterials.2006.09.028_bib22","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1073\/pnas.93.22.12349","article-title":"Evidence for the role of proteoglycans in cation- mediated gene transfer","volume":"93","author":"Mislick","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.biomaterials.2006.09.028_bib23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2144\/01301st03","article-title":"Preparation of a low molecular weight polyethylenimine for efficient cell transfection","volume":"30","author":"Bieber","year":"2001","journal-title":"Biotechniques"},{"issue":"104","key":"10.1016\/j.biomaterials.2006.09.028_bib24","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/215934a0","article-title":"A membrane effect of basic polymers dependent on molecular size","volume":"215","author":"Ryser","year":"1967","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biomaterials.2006.09.028_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jps.10286","article-title":"Barriers to nonviral gene delivery","volume":"92","author":"Wiethoff","year":"2003","journal-title":"J Pharm Sci"},{"issue":"2","key":"10.1016\/j.biomaterials.2006.09.028_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1525-0016(03)00177-1","article-title":"Biodistribution and pharmacokinetics of aerosol and intravenously administered DNA-polyethyleneimine complexes: optimization of pulmonary delivery and retention","volume":"8","author":"Koshkina","year":"2003","journal-title":"Mol Ther"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961206008258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961206008258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:55:14Z","timestamp":1758898514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961206008258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0142961206008258"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2006.09.028","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2006.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}