{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:45:58Z","timestamp":1786985158997,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.biomaterials.2007.10.045","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:28:59Z","timestamp":1196159339000},"page":"917-924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of covalent cross-links between the membrane components of microcapsules on the dissemination of encapsulated malignant cells"],"prefix":"10.1016","volume":"29","author":[{"given":"Julie","family":"Dusseault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Perreault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Hall\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.biomaterials.2007.10.045_bib1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nbt1004","article-title":"Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages","volume":"22","author":"Seaberg","year":"2004","journal-title":"Nat Biotechnol"},{"issue":"25","key":"10.1016\/j.biomaterials.2007.10.045_bib2","doi-asserted-by":"crossref","first-page":"16105","DOI":"10.1073\/pnas.252618999","article-title":"Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells","volume":"99","author":"Hori","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.biomaterials.2007.10.045_bib3","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","article-title":"Insulin production by human embryonic stem cells","volume":"50","author":"Assady","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0070-2153(03)58004-8","article-title":"Stem cells: a promising source of pancreatic islets for transplantation in type 1 diabetes","volume":"58","author":"Street","year":"2003","journal-title":"Curr Top Dev Biol"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s001090050338","article-title":"In vivo delivery of recombinant human growth hormone from genetically engineered human fibroblasts implanted within Baxter immunoisolation devices","volume":"77","author":"Josephs","year":"1999","journal-title":"J Mol Med"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s001090050340","article-title":"Correction of diabetic nod mice with insulinomas implanted within Baxter immunoisolation devices","volume":"77","author":"Loudovaris","year":"1999","journal-title":"J Mol Med"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/diab.42.6.901","article-title":"Murine insulinoma cell with normal glucose-regulated insulin secretion","volume":"42","author":"Efrat","year":"1993","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10731190009119782","article-title":"Gene therapy for hemophilia","volume":"28","author":"Hortelano","year":"2000","journal-title":"Artif Cells Blood Substit Immobil Biotechnol"},{"issue":"10","key":"10.1016\/j.biomaterials.2007.10.045_bib9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1089\/hum.2004.15.945","article-title":"Combined immunotherapy and antiangiogenic therapy of cancer with microencapsulated cells","volume":"15","author":"Cirone","year":"2004","journal-title":"Hum Gene Ther"},{"issue":"2","key":"10.1016\/j.biomaterials.2007.10.045_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ymthe.2005.04.002","article-title":"Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules","volume":"12","author":"Orive","year":"2005","journal-title":"Mol Ther"},{"issue":"7","key":"10.1016\/j.biomaterials.2007.10.045_bib11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/1043034041361172","article-title":"Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions","volume":"15","author":"Schwenter","year":"2004","journal-title":"Hum Gene Ther"},{"issue":"16","key":"10.1016\/j.biomaterials.2007.10.045_bib12","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1089\/hum.1998.9.16-2341","article-title":"Ex vivo fibroblast transduction in rabbits results in long-term (>600 days) factor IX expression in a small percentage of animals","volume":"9","author":"Chen","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1999.tb08500.x","article-title":"Encapsulation for somatic gene therapy","volume":"875","author":"Chang","year":"1999","journal-title":"Ann NY Acad Sci"},{"issue":"6","key":"10.1016\/j.biomaterials.2007.10.045_bib14","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/S0002-9440(10)62488-1","article-title":"Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells","volume":"166","author":"Fujikawa","year":"2005","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.biomaterials.2007.10.045_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00125-004-1349-z","article-title":"Insulin expressing cells from differentiated embryonic stem cells are not beta cells","volume":"47","author":"Sipione","year":"2004","journal-title":"Diabetologia"},{"issue":"6859","key":"10.1016\/j.biomaterials.2007.10.045_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/35102154","article-title":"The end of the beginning for pluripotent stem cells","volume":"414","author":"Donovan","year":"2001","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.biomaterials.2007.10.045_bib17","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.gt.3302015","article-title":"Gene- and cell-based therapeutics for type I diabetes mellitus","volume":"10","author":"Bottino","year":"2003","journal-title":"Gene Ther"},{"issue":"4472","key":"10.1016\/j.biomaterials.2007.10.045_bib18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1126\/science.6776628","article-title":"Microencapsulated islets as bioartificial endocrine pancreas","volume":"210","author":"Lim","year":"1980","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jss.2004.02.018","article-title":"Causes of limited survival of microencapsulated pancreatic islet grafts","volume":"121","author":"de Groot","year":"2004","journal-title":"J Surg Res"},{"issue":"10","key":"10.1016\/j.biomaterials.2007.10.045_bib20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0142-9612(96)84680-1","article-title":"Alginate polycation microcapsules. I. Interaction between alginate and polycation","volume":"17","author":"Thu","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib21","unstructured":"Leblond FA, Hall\u00e9 JP. Semi-permeable multi-layered microcapsule with covalently linked layers and method for producing the same. US Patent # 7,128,931. 2006."},{"issue":"13","key":"10.1016\/j.biomaterials.2007.10.045_bib22","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.biomaterials.2004.05.013","article-title":"Microencapsulation of living cells in semi-permeable membranes with covalently cross-linked layers","volume":"26","author":"Dusseault","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00007890-198510000-00018","article-title":"An improved method for isolation of mouse pancreatic islets","volume":"40","author":"Gotoh","year":"1985","journal-title":"Transplantation"},{"issue":"7","key":"10.1016\/j.biomaterials.2007.10.045_bib24","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1210\/en.2002-0185","article-title":"IGF-II allows prolonged blood glucose normalization with a reduced islet cell mass transplantation","volume":"144","author":"Robitaille","year":"2003","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2337\/diab.40.1.37","article-title":"Effect of alginate\u2013polylysine\u2013alginate microencapsulation on in vitro insulin release from rat pancreatic islets","volume":"40","author":"Fritschy","year":"1991","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.biomaterials.2007.10.045_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/096368979400300503","article-title":"Studies on small (<300\u03bcm) microcapsules: II\u2014parameters governing the production of alginate beads by high voltage electrostatic pulses","volume":"3","author":"Hall\u00e9","year":"1994","journal-title":"Cell Transplant"},{"issue":"13","key":"10.1016\/j.biomaterials.2007.10.045_bib27","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.biomaterials.2004.05.013","article-title":"Microencapsulation of living cells in semi-permeable covalently cross-linked membranes","volume":"26","author":"Dusseault","year":"2005","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biomaterials.2007.10.045_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1525-1594.2002.06853.x","article-title":"MTS colorimetric assay in combination with a live\u2013dead assay for testing encapsulated L929 fibroblasts in alginate poly-l-lysine microcapsules in vitro","volume":"26","author":"Bunger","year":"2002","journal-title":"Artif Organs"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1126\/science.146.3643.524","article-title":"Semipermeable microcapsules","volume":"146","author":"Chang","year":"1964","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2337\/diacare.29.01.06.dc05-1270","article-title":"Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases","volume":"29","author":"Calafiore","year":"2006","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0169-409X(01)00240-X","article-title":"Novel crosslinking methods to design hydrogels","volume":"54","author":"Hennink","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"10.1016\/j.biomaterials.2007.10.045_bib32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00986726","article-title":"A practical approach to crosslinking","volume":"17","author":"Mattson","year":"1993","journal-title":"Mol Biol Rep"},{"issue":"3","key":"10.1016\/j.biomaterials.2007.10.045_bib33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00534-005-0983-2","article-title":"Regenerative medicine of the pancreatic beta cells","volume":"12","author":"Yamada","year":"2005","journal-title":"J Hepatobiliary Pancreat Surg"},{"issue":"3","key":"10.1016\/j.biomaterials.2007.10.045_bib34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2165\/00024677-200302030-00004","article-title":"Pancreatic islet cell transplantation: progress in the clinical setting","volume":"2","author":"Ridgway","year":"2003","journal-title":"Treat Endocrinol"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.biomaterials.2007.10.045_bib36","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nbt841","article-title":"Bone marrow-derived stem cells initiate pancreatic regeneration","volume":"21","author":"Hess","year":"2003","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.biomaterials.2007.10.045_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00441-002-0614-z","article-title":"Identification and characterization of small cells in the adult pancreas: potential progenitor cells?","volume":"310","author":"Petropavlovskaia","year":"2002","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.biomaterials.2007.10.045_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3727\/000000005783992151","article-title":"Expression of progenitor cell markers during expansion of sorted human pancreatic beta cells","volume":"12","author":"Bouckenooghe","year":"2005","journal-title":"Gene Expr"},{"key":"10.1016\/j.biomaterials.2007.10.045_bib39","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1210\/endo.137.9.8756573","article-title":"Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor","volume":"137","author":"Mashima","year":"1996","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.biomaterials.2007.10.045_bib40","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1677\/joe.0.1720653","article-title":"Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo","volume":"172","author":"Shaw","year":"2002","journal-title":"J Endocrinol"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961207008551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961207008551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:00:39Z","timestamp":1758898839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961207008551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0142961207008551"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2007.10.045","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of covalent cross-links between the membrane components of microcapsules on the dissemination of encapsulated malignant cells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2007.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}