{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:45:51Z","timestamp":1791150351734,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.biomaterials.2007.12.023","type":"journal-article","created":{"date-parts":[[2008,1,16]],"date-time":"2008-01-16T11:54:25Z","timestamp":1200484465000},"page":"1686-1692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Osteotropic \u03b2-cyclodextrin for local bone regeneration"],"prefix":"10.1016","volume":"29","author":[{"given":"Xin-Ming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Wiswall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Rutledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed P.","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2007.12.023_bib1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.brs.0000259227.51180.ca","article-title":"Bone morphogenetic proteins and bone defects: a systematic review","volume":"32","author":"Mussano","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cden.2005.11.003","article-title":"Craniofacial bone tissue engineering","volume":"50","author":"Wan","year":"2006","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib3","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1097\/00005131-200511101-00006","article-title":"Bone morphogenic protein science and studies","volume":"19","author":"Lane","year":"2005","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/8756-3282(93)90241-2","article-title":"Local stimulation of new bone formation by prostaglandin E1: quantitative histomorphometry and comparison of delivery by minipumps and controlled-release pellets","volume":"14","author":"Miller","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0169-6009(91)90109-D","article-title":"Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats","volume":"15","author":"Jee","year":"1991","journal-title":"Bone Miner"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib6","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","article-title":"Stimulation of bone formation in vitro and in rodents by statins","volume":"286","author":"Mundy","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib7","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bone.2004.01.002","article-title":"Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats","volume":"34","author":"Tanaka","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1359\/jbmr.051110","article-title":"A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats","volume":"21","author":"Ke","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/jrf.0.0370179","article-title":"Secretory function of the prostate, seminal vesicle and other male accessory organs of reproduction","volume":"37","author":"Mann","year":"1974","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1615\/CritRevEukaryotGeneExpr.v13.i24.170","article-title":"Prostaglandin E \u2013 a powerful anabolic agent for generalized or site-specific bone formation","volume":"13","author":"Vrotsos","year":"2003","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","article-title":"Cyclodextrin-based pharmaceutics: past, present and future","volume":"3","author":"Davis","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jconrel.2007.06.021","article-title":"Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity","volume":"122","author":"Liu","year":"2007","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib13","first-page":"117","volume":"vol. 4","author":"Higuchi","year":"1965"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib14","first-page":"1861","article-title":"Local simvastatin effects on mandibular bone growth and inflammation","volume":"76","author":"Stein","year":"2005","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/8756-3282(95)00445-9","article-title":"Bisphosphonates: a review of their pharmacokinetic properties","volume":"18","author":"Lin","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib16","first-page":"18","article-title":"Pharmacokinetics of alendronate: an overview","volume":"101","author":"Lin","year":"1999","journal-title":"Int J Clin Pract Suppl"},{"issue":"Suppl. 1","key":"10.1016\/j.biomaterials.2007.12.023_bib17","first-page":"61","article-title":"Bisphosphonates: structure\u2013activity relations from\u00a0a clinical perspective","volume":"57","author":"Papapoulos","year":"1997","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib18","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1248\/cpb.40.747","article-title":"Improvement of stability and dissolution of prostaglandin E1 by maltosyl-beta-cyclodextrin in lyophilized formulation","volume":"40","author":"Yamamoto","year":"1992","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib19","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1248\/cpb.32.4237","article-title":"Improving the aqueous stability of prostaglandin E2 and prostaglandin A2 by inclusion complexation with methylated-beta-cyclodextrins","volume":"32","author":"Hirayama","year":"1984","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2004.11.021","article-title":"Preparation of prostaglandin E1\u2013hydroxypropyl-beta-cyclodextrin complex and its nasal delivery in rats","volume":"290","author":"Gu","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(98)00052-0","article-title":"Mechanisms of drug release from cyclodextrin complexes","volume":"36","author":"Stella","year":"1999","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib22","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.biomaterials.2007.04.024","article-title":"Anabolic effects of bisphosphonates on peri-implant bone stock","volume":"28","author":"von Knoch","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib23","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1359\/jbmr.070701","article-title":"Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells","volume":"22","author":"Duque","year":"2007","journal-title":"J Bone Miner Res."},{"key":"10.1016\/j.biomaterials.2007.12.023_bib24","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/art.20383","article-title":"Bisphosphonates: environmental protection for the joint?","volume":"50","author":"Goldring","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib25","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1021\/jm011107f","article-title":"Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure\u2013activity relationships","volume":"45","author":"Adam","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib26","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00000542-200510000-00007","article-title":"First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide","volume":"103","author":"Gijsenbergh","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.biomaterials.2007.12.023_bib27","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1592\/phco.27.8.1181","article-title":"Sugammadex: a novel agent for the reversal of neuromuscular blockade","volume":"27","author":"Nicholson","year":"2007","journal-title":"Pharmacotherapy"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961207010496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961207010496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:00:19Z","timestamp":1758898819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961207010496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0142961207010496"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2007.12.023","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteotropic \u03b2-cyclodextrin for local bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2007.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}