{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:54:30Z","timestamp":1777528470772,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.biomaterials.2009.04.045","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T12:59:07Z","timestamp":1243601947000},"page":"4416-4426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Spleen-specific suppression of TNF-\u03b1 by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models"],"prefix":"10.1016","volume":"30","author":[{"given":"Lei","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhua","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2009.04.045_bib1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrd1175","article-title":"Anti-TNF-alpha therapies: the next generation","volume":"5","author":"Palladino","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib3","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM200011303432202","article-title":"Infliximab and methotrexate in the treatment of rheumatoid arthritis","volume":"343","author":"Lipsky","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nri802","article-title":"Development of anti-TNF therapy for rheumatoid arthritis","volume":"2","author":"Feldmann","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/0929867054864859","article-title":"Antisense oligonucleotides: the state of the art","volume":"12","author":"Aboul-Fadl","year":"2005","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2174\/1566524043360375","article-title":"Antisense strategies","volume":"4","author":"Crooke","year":"2004","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/154545704322988058","article-title":"Use of antisense oligonucleotides in functional genomics and target validation","volume":"14","author":"Ravichandran","year":"2004","journal-title":"Oligonucleotides"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.mn.7800121","article-title":"Use of antisense oligonucleotides: advantages, controls and cardiovascular tissue","volume":"9","author":"Golden","year":"2002","journal-title":"Microcirculation"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2174\/138920107782109985","article-title":"Antisense technology: a selective tool for gene expression regulation and gene targeting","volume":"8","author":"Sahu","year":"2007","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1440-1681.2006.04403.x","article-title":"Antisense oligonucleotides: from design to therapeutic application","volume":"33","author":"Chan","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/jbm.a.31328","article-title":"Galactosylated low molecular weight chitosan as a carrier delivering oligonucleotides to Kupffer cells instead of hepatocytes in vivo","volume":"84A","author":"Dong","year":"2007","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/MNM.0b013e328013eae3","article-title":"Evaluation of hepatic function with Tc-99m-galactosylated serum albumin scintigraphy in patients with malaria: comparison with Tc-99m-colloid scintigraphy and liver ultrasonography","volume":"28","author":"Lee","year":"2007","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bcp.2004.11.011","article-title":"Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides","volume":"69","author":"Ponnappa","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0300-483X(03)00043-X","article-title":"Species differences in the structure and function of the immune system","volume":"188","author":"Haley","year":"2003","journal-title":"Toxicologist"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib16","first-page":"11","article-title":"Felty syndrome complicating juvenile rheumatoid arthritis","volume":"205","author":"Bloom","year":"1998","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib17","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.271.5253.1289","article-title":"Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers","volume":"271","author":"Matsumoto","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib18","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.4049\/jimmunol.163.12.6575","article-title":"TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes","volume":"63","author":"Kuprash","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1263\/jbb.103.22","article-title":"Synthesis of an agarose\u2013gelatin conjugate for use as a tissue engineering scaffold","volume":"103","author":"Sakai","year":"2007","journal-title":"J Biosci Bioeng"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.113.3.485","article-title":"Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes \u2013 comparison of the experimental process with human disease","volume":"113","author":"Pearson","year":"1961","journal-title":"J Exp Med"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib21","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1084\/jem.162.3.962","article-title":"Synergy between adjuvant arthritis and collagen-induced arthritis in rats","volume":"162","author":"Taurog","year":"1985","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1084\/jem.20040566","article-title":"15-epi-lipoxin A(4)-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation","volume":"200","author":"Paul-Clark","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib23","doi-asserted-by":"crossref","first-page":"25125","DOI":"10.1074\/jbc.273.39.25125","article-title":"Tetranucleotide GGGA motif in primary RNA transcripts. Novel target site for antisense design","volume":"273","author":"Tu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1084\/jem.189.2.403","article-title":"Lymphotoxin and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen","volume":"189","author":"Ngo","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cgh.2007.02.016","article-title":"Serious adverse events with infliximab: analysis of spontaneously reported adverse events","volume":"5","author":"Hansen","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib26","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/bies.950171111","article-title":"The macrophage","volume":"17","author":"Gordon","year":"1995","journal-title":"Bioessays"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib27","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.biomaterials.2008.12.072","article-title":"The control of anchorage-dependent cell behavior within a hydrogel\/microcarrier system in an osteogenic model","volume":"30","author":"Wang","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib28","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/btpr.52","article-title":"Enhancing cell affinity of non-adhesive hydrogel substrate: the role of silica hybridization","volume":"24","author":"Wang","year":"2008","journal-title":"Biotechnol Prog"},{"key":"10.1016\/j.biomaterials.2009.04.045_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1081\/IPH-100103856","article-title":"Splenectomy and sepsis: the role of the spleen in the immune-mediated bacterial clearance","volume":"23","author":"Altamura","year":"2001","journal-title":"Immunopharmacol Immunotoxicol"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209004694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209004694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:10:41Z","timestamp":1758899441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961209004694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":29,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0142961209004694"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.04.045","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spleen-specific suppression of TNF-\u03b1 by cationic hydrogel-delivered antisense nucleotides for the prevention of arthritis in animal models","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.04.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}