{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:17:48Z","timestamp":1771622268731,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.biomaterials.2009.06.048","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T05:09:14Z","timestamp":1247893754000},"page":"5885-5891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The use of an endothelium-targeted cationic copolymer to enhance the barrier function of lung capillary endothelial monolayers"],"prefix":"10.1016","volume":"30","author":[{"given":"Kristina M.","family":"Giantsos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavla","family":"Kopeckova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randal O.","family":"Dull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biomaterials.2009.06.048_bib1","doi-asserted-by":"crossref","first-page":"H285","DOI":"10.1152\/ajpheart.2000.278.1.H285","article-title":"Capillary endothelial surface layer selectively reduces plasma solute distribution volume","volume":"278","author":"Vink","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.biomaterials.2009.06.048_bib2","doi-asserted-by":"crossref","first-page":"H2016","DOI":"10.1152\/ajpheart.1991.261.6.H2016","article-title":"EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries","volume":"261","author":"Pohl","year":"1991","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.06.048_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbrc.2007.01.137","article-title":"The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress","volume":"355","author":"Pahakis","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.biomaterials.2009.06.048_bib4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000104871","article-title":"The endothelial glycocalyx prefers albumin for evoking shear stress-induced nitric oxide-mediated coronary dilation","volume":"44","author":"Jacob","year":"2007","journal-title":"J Vasc Res"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib5","doi-asserted-by":"crossref","first-page":"L1452","DOI":"10.1152\/ajplung.00376.2006","article-title":"Heparan sulfates mediate pressure-induced increase in lung endothelial hydraulic conductivity via nitric oxide\/reactive oxygen species","volume":"292","author":"Dull","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"10.1016\/j.biomaterials.2009.06.048_bib6","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/physrev.1995.75.3.519","article-title":"Flow mediated endothelial mechanotransduction","volume":"75","author":"Davies","year":"1995","journal-title":"Physiol Rev"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0006-3495(01)76006-7","article-title":"Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells","volume":"80","author":"Helmke","year":"2001","journal-title":"Biophys J"},{"issue":"10","key":"10.1016\/j.biomaterials.2009.06.048_bib8","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1161\/01.RES.0000101744.47866.D5","article-title":"Heparan sulfate proteoglycan is a mechanosensor on endothelial cells","volume":"93","author":"Florian","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib9","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1161\/01.RES.85.8.682","article-title":"Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling","volume":"85","author":"Wei","year":"1999","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.biomaterials.2009.06.048_bib10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/10611860600834219","article-title":"Water-soluble HPMA copolymer-prostaglandin E1 conjugates containing a cathepsin K sensitive spacer","volume":"14","author":"Pan","year":"2006","journal-title":"J Drug Target"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib11","series-title":"Quantitative analytical chemistry","author":"Fritz","year":"1987"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.06.048_bib12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0003-2697(71)90031-5","article-title":"Condensation of ninhydrin with aldehydes and primary amines to yield highly fluorescent ternary products: II. Application to the detection and assay of peptides, amino acids, amines, and amino sugars","volume":"42","author":"Samejima","year":"1971","journal-title":"Anal Biochem"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mvr.2006.01.003","article-title":"Digital Imaging system and virtual instrument platform for measuring hydraulic conductivity of vascular endothelial monolayers","volume":"71","author":"Hubert","year":"2006","journal-title":"Microvasc Res"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib14","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/bc060068p","article-title":"Methacrylamide polymers with hydrolysis-sensitive cationic side groups as degradable gene carriers","volume":"17","author":"Luten","year":"2006","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1021\/bc980148w","article-title":"Structure\u2013activity relationships of water-soluble cationic methacrylate\/methacrylamide polymers for nonviral gene delivery","volume":"10","author":"Pvd","year":"1999","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2009.06.048_bib16","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/bc050017c","article-title":"Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers","volume":"16","author":"Eldred","year":"2005","journal-title":"Bioconjug Chem"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2009.06.048_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0168-3659(02)00045-7","article-title":"Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations","volume":"81","author":"Reschel","year":"2002","journal-title":"J Control Release"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209006449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209006449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:12:31Z","timestamp":1758899551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961209006449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":17,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0142961209006449"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.06.048","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The use of an endothelium-targeted cationic copolymer to enhance the barrier function of lung capillary endothelial monolayers","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}