{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:54:00Z","timestamp":1792508040059,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology, Government of West Bengal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.biomaterials.2009.07.008","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T05:01:38Z","timestamp":1248411698000},"page":"5737-5750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":289,"title":["Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy"],"prefix":"10.1016","volume":"30","author":[{"given":"Sarbari","family":"Acharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahima","family":"Dilnawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeeb K.","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.biomaterials.2009.07.008_bib1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.biomaterials.2006.11.013","article-title":"Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs","volume":"28","author":"Liu","year":"2007","journal-title":"Biomaterials"},{"issue":"1\u20133","key":"10.1016\/j.biomaterials.2009.07.008_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2005.09.039","article-title":"Folate-conjugated methoxy poly(ethylene glycol)\/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery","volume":"109","author":"Park","year":"2005","journal-title":"J Control Release"},{"issue":"24","key":"10.1016\/j.biomaterials.2009.07.008_bib3","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S1359-6446(03)02903-9","article-title":"Nanotech approaches to drug delivery and imaging","volume":"8","author":"Sahoo","year":"2003","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.biomaterials.2009.07.008_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nano.2006.11.008","article-title":"The present and future of nanotechnology in human health care","volume":"3","author":"Sahoo","year":"2007","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"2\u20133","key":"10.1016\/j.biomaterials.2009.07.008_bib5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jconrel.2005.08.013","article-title":"Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin","volume":"108","author":"Mo","year":"2005","journal-title":"J Control Release"},{"issue":"3","key":"10.1016\/j.biomaterials.2009.07.008_bib6","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1158\/1078-0432.CCR-03-0043","article-title":"Determinants of rapamycin sensitivity in breast cancer cells","volume":"10","author":"Noh","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"23","key":"10.1016\/j.biomaterials.2009.07.008_bib7","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1200\/JCO.2005.66.130","article-title":"Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer","volume":"23","author":"Chan","year":"2005","journal-title":"J Clin Oncol"},{"issue":"20","key":"10.1016\/j.biomaterials.2009.07.008_bib8","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1093\/jnci\/93.20.1519","article-title":"Rapamycin may prevent post-transplant lymphoma","volume":"93","author":"Garber","year":"2001","journal-title":"J Natl Cancer Inst"},{"issue":"56","key":"10.1016\/j.biomaterials.2009.07.008_bib9","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1204091","article-title":"The rapamycin-sensitive signal transduction pathway as a target for cancer therapy","volume":"19","author":"Hidalgo","year":"2000","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.biomaterials.2009.07.008_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00007890-199508000-00010","article-title":"Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells","volume":"60","author":"Muthukkumar","year":"1995","journal-title":"Transplantation"},{"issue":"17","key":"10.1016\/j.biomaterials.2009.07.008_bib11","first-page":"3895","article-title":"Rapamycin inhibits constitutive p70S6K phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells","volume":"56","author":"Seufferlein","year":"1996","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.biomaterials.2009.07.008_bib12","first-page":"886","article-title":"Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells","volume":"59","author":"Hosoi","year":"1999","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.biomaterials.2009.07.008_bib13","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S1097-2765(03)00180-1","article-title":"Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53\/p21(Cip1)","volume":"11","author":"Huang","year":"2003","journal-title":"Mol Cell"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2009.07.008_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-5173(00)00617-7","article-title":"Solubilization of rapamycin","volume":"213","author":"Simamora","year":"2001","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1016\/j.biomaterials.2009.07.008_bib15","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/jbm.a.31557","article-title":"Delivery of rapamycin-loaded nanoparticle down regulates ICAM-1 expression and maintains an immunosuppressive profile in human CD34+ progenitor-derived dendritic cells","volume":"85","author":"Das","year":"2008","journal-title":"J Biomed Mater Res A"},{"issue":"4","key":"10.1016\/j.biomaterials.2009.07.008_bib16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/jbm.a.31373","article-title":"Delivery of rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells","volume":"84","author":"Haddadi","year":"2007","journal-title":"J Biomed Mater Res Part A"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2009.07.008_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijpharm.2007.07.045","article-title":"Preparation of rapamycin-loaded chitosan\/PLA nanoparticles for immunosuppression in corneal transplantation","volume":"349","author":"Yuan","year":"2008","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/10717540802481307","article-title":"New approach for local delivery of rapamycin by bioadhesive PLGA-carbopol nanoparticles","volume":"16","author":"Zou","year":"2009","journal-title":"Drug Deliv"},{"issue":"2","key":"10.1016\/j.biomaterials.2009.07.008_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/10611860701794353","article-title":"Polymeric nanoparticles for cancer therapy","volume":"16","author":"Parveen","year":"2008","journal-title":"J Drug Target"},{"issue":"2","key":"10.1016\/j.biomaterials.2009.07.008_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ijc.20405","article-title":"Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer","volume":"112","author":"Sahoo","year":"2004","journal-title":"Int J Cancer"},{"issue":"8","key":"10.1016\/j.biomaterials.2009.07.008_bib21","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.addr.2007.06.003","article-title":"Biodegradable nanoparticles for cytosolic delivery of therapeutics","volume":"59","author":"Vasir","year":"2007","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11095-007-9400-7","article-title":"Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles","volume":"25","author":"Scott","year":"2008","journal-title":"Pharm Res"},{"issue":"16","key":"10.1016\/j.biomaterials.2009.07.008_bib23","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1073\/pnas.0601755103","article-title":"Targeted nanoparticle\u2013aptamer bioconjugates for cancer chemotherapy in vivo","volume":"103","author":"Farokhzad","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib24","first-page":"19","article-title":"Immunohistochemical expression of EGF-R in malignant surface epithelial ovarian neoplasms (SEON)","volume":"15","author":"Janinis","year":"1994","journal-title":"Eur J Gynaecol Oncol"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10555-005-5047-1","article-title":"Biological significance of c-erbB family oncogenes in head and neck cancer","volume":"24","author":"Rogers","year":"2005","journal-title":"Cancer Metastasis Rev"},{"issue":"4","key":"10.1016\/j.biomaterials.2009.07.008_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/106689690501300403","article-title":"Remarkably high frequency of EGFR expression in breast carcinomas with squamous differentiation","volume":"13","author":"Bossuyt","year":"2005","journal-title":"Int J Surg Pathol"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.1003","article-title":"EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival","volume":"196","author":"Suo","year":"2002","journal-title":"J Pathol"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2009.07.008_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2007.03.012","article-title":"Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody","volume":"120","author":"Kocbek","year":"2007","journal-title":"J Control Release"},{"issue":"9","key":"10.1016\/j.biomaterials.2009.07.008_bib29","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.biomaterials.2008.12.010","article-title":"Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His","volume":"30","author":"Feng","year":"2009","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biomaterials.2009.07.008_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jconrel.2007.06.019","article-title":"Development of bionanocapsules targeting brain tumors","volume":"122","author":"Tsutsui","year":"2007","journal-title":"J Control Release"},{"issue":"5","key":"10.1016\/j.biomaterials.2009.07.008_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/mp050032z","article-title":"Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention","volume":"2","author":"Sahoo","year":"2005","journal-title":"Mol Pharmacol"},{"issue":"11","key":"10.1016\/j.biomaterials.2009.07.008_bib32","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1023\/A:1012126301290","article-title":"The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent","volume":"14","author":"Desai","year":"1997","journal-title":"Pharm Res"},{"issue":"2","key":"10.1016\/j.biomaterials.2009.07.008_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1023\/A:1022219003551","article-title":"Dynamics of endocytosis and exocytosis of poly(d,l-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells","volume":"20","author":"Panyam","year":"2003","journal-title":"Pharm Res"},{"issue":"3","key":"10.1016\/j.biomaterials.2009.07.008_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1021\/mp049970+","article-title":"Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells","volume":"1","author":"Prabha","year":"2004","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.biomaterials.2009.07.008_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jconrel.2006.05.021","article-title":"Release of anti-restenosis drugs from poly(ethylene oxide)\u2013poly(dl-lactic-co-glycolic acid) nanoparticles","volume":"114","author":"Zweers","year":"2006","journal-title":"J\u00a0Control Release"},{"issue":"8","key":"10.1016\/j.biomaterials.2009.07.008_bib36","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s12272-001-1267-5","article-title":"The intracellular uptake ability of chitosan-coated poly(d,l-lactideco-glycolide) nanoparticles","volume":"31","author":"Kim","year":"2008","journal-title":"Arch Pharm Res"},{"issue":"29","key":"10.1016\/j.biomaterials.2009.07.008_bib37","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1016\/j.biomaterials.2008.07.004","article-title":"Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging","volume":"29","author":"Jain","year":"2008","journal-title":"Biomaterials"},{"issue":"13","key":"10.1016\/j.biomaterials.2009.07.008_bib38","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1158\/0008-5472.CAN-05-3018","article-title":"Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma","volume":"66","author":"Vega","year":"2006","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/02652040400026285","article-title":"Praziquantel-loaded PLGA nanoparticles: preparation and characterization","volume":"22","author":"Mainardes","year":"2005","journal-title":"J Microencapsul"},{"issue":"18","key":"10.1016\/j.biomaterials.2009.07.008_bib40","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1016\/j.biomaterials.2003.11.001","article-title":"In vitro degradation of insulin-loaded poly(n-butylcyanoacrylate) nanoparticles","volume":"25","author":"Sullivan","year":"2004","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.colsurfb.2007.04.015","article-title":"Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin","volume":"59","author":"Pan","year":"2007","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/02652040500286227","article-title":"Effect of drug physicochemical properties on in vitro characteristics of amphiphilic cyclodextrin nanospheres and nanocapsules","volume":"23","author":"Memisoglu-Bilensoy","year":"2006","journal-title":"J Microencapsul"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jconrel.2007.01.008","article-title":"Development and evaluation of novel biodegradable microspheres based on poly(d,l-lactide-co-glycolide) and poly(epsilon-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: in vitro and in vivo studies","volume":"119","author":"Mundargi","year":"2007","journal-title":"J Control Release"},{"issue":"11","key":"10.1016\/j.biomaterials.2009.07.008_bib44","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s10856-007-3075-9","article-title":"Preparation and characterization of rapamycin-loaded PLGA coating stent","volume":"18","author":"Pan","year":"2007","journal-title":"J Mater Sci Mater Med"},{"issue":"27","key":"10.1016\/j.biomaterials.2009.07.008_bib45","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1016\/j.biomaterials.2007.05.006","article-title":"Development of gelatin nanoparticles with biotinylated EGF conjugation for lung cancer targeting","volume":"28","author":"Tseng","year":"2007","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2009.07.008_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-5173(01)00923-1","article-title":"Characterization of nanoparticle uptake by endothelial cells","volume":"233","author":"Davda","year":"2002","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/mp034002c","article-title":"Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles","volume":"1","author":"Panyam","year":"2004","journal-title":"Mol Pharmacol"},{"issue":"9","key":"10.1016\/j.biomaterials.2009.07.008_bib48","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/ijc.21532","article-title":"In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer","volume":"118","author":"Ito","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biomaterials.2009.07.008_bib49","doi-asserted-by":"crossref","first-page":"045102","DOI":"10.1088\/0957-4484\/19\/04\/045102","article-title":"Folate-conjugated polymer micelles for active targeting to cancer cells: preparation, in vitro evaluation of targeting ability and cytotoxicity","volume":"19","author":"You","year":"2008","journal-title":"Nanotechnology"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.07.008_bib50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1586\/17434440.1.1.115","article-title":"Nanoparticles of biodegradable polymers for new-concept chemotherapy","volume":"1","author":"Feng","year":"2004","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.biomaterials.2009.07.008_bib51","first-page":"559","article-title":"Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: role in PLGA nanoparticle endocytosis","volume":"9","author":"Qaddoumi","year":"2003","journal-title":"Mol Vis"},{"issue":"5","key":"10.1016\/j.biomaterials.2009.07.008_bib52","doi-asserted-by":"crossref","first-page":"C1339","DOI":"10.1152\/ajpcell.00099.2003","article-title":"Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress","volume":"285","author":"Muro","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"issue":"10","key":"10.1016\/j.biomaterials.2009.07.008_bib53","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1096\/fj.02-0088com","article-title":"Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery","volume":"16","author":"Panyam","year":"2002","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.biomaterials.2009.07.008_bib54","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.2353\/ajpath.2006.051078","article-title":"Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma","volume":"169","author":"Peponi","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biomaterials.2009.07.008_bib55","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCINTERVENTIONS.108.830018","article-title":"Inhibition of apoptosis through localized delivery of rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured","volume":"1","author":"Reddy","year":"2008","journal-title":"Circ Cardiovasc Intervent"},{"issue":"20","key":"10.1016\/j.biomaterials.2009.07.008_bib56","first-page":"5645","article-title":"Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors","volume":"62","author":"Kenerson","year":"2002","journal-title":"Cancer Res"},{"issue":"33","key":"10.1016\/j.biomaterials.2009.07.008_bib57","doi-asserted-by":"crossref","first-page":"17785","DOI":"10.1016\/S0021-9258(19)77904-6","article-title":"Insulin stimulates the translation of ribosomal proteins and the transcription of rDNA in mouse myoblasts","volume":"263","author":"Hammond","year":"1988","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.biomaterials.2009.07.008_bib58","doi-asserted-by":"crossref","first-page":"9666","DOI":"10.1073\/pnas.171301998","article-title":"p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD","volume":"98","author":"Harada","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.biomaterials.2009.07.008_bib59","first-page":"3373","article-title":"p53\/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin","volume":"61","author":"Huang","year":"2001","journal-title":"Cancer Res"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209006929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209006929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:14:46Z","timestamp":1758899686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961209006929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":59,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0142961209006929"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.07.008","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}