{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:42:30Z","timestamp":1791304950466,"version":"4.3.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.biomaterials.2009.09.017","type":"journal-article","created":{"date-parts":[[2009,9,26]],"date-time":"2009-09-26T04:39:20Z","timestamp":1253939960000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Over-expression of receptor activator of nuclear factor-\u03baB ligand (RANKL), inflammatory cytokines, and chemokines in periprosthetic osteolysis of loosened total hip arthroplasty"],"prefix":"10.1016","volume":"31","author":[{"given":"Chen-Ti","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor-Luen","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiou-Shia","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Mou","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.biomaterials.2009.09.017_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jbmr.5650080907","article-title":"Bone resorption activity of particulate-stimulated macrophages","volume":"8","author":"Glant","year":"1993","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2009.09.017_bib2","first-page":"171","article-title":"Periprosthetic osteolysis in total hip arthroplasty: the role of particulate wear debris","volume":"45","author":"Maloney","year":"1996","journal-title":"Instr Course Lect"},{"issue":"6","key":"10.1016\/j.biomaterials.2009.09.017_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/(SICI)1097-4636(1999)48:6<899::AID-JBM20>3.0.CO;2-E","article-title":"The characterization of macrophages and osteoclasts in tissues harvested from revised total hip prostheses","volume":"48","author":"Chun","year":"1999","journal-title":"J Biomed Mater Res"},{"issue":"2","key":"10.1016\/j.biomaterials.2009.09.017_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.biomaterials.2009.09.017_bib5","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.biomaterials.2009.09.017_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.biomaterials.2009.09.017_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/000164701753532835","article-title":"Correlation of synovial fluid cytokine levels with histological and clinical parameters of primary and revision total hip and total knee replacements","volume":"72","author":"Clarke","year":"2001","journal-title":"Acta Orthop Scand"},{"issue":"3","key":"10.1016\/j.biomaterials.2009.09.017_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1097-4636(19970605)35:3<399::AID-JBM14>3.0.CO;2-A","article-title":"Macrophage activation and migration in interface tissue around loosening total hip arthroplasty components","volume":"35","author":"Ishiguro","year":"1997","journal-title":"J Biomed Mater Res"},{"issue":"5\u20136","key":"10.1016\/j.biomaterials.2009.09.017_bib9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s004020050475","article-title":"Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement","volume":"120","author":"Lassus","year":"2000","journal-title":"Arch Orthop Trauma Surg"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.09.017_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1302\/0301-620X.81B1.0810155","article-title":"Induction of macrophage C\u2013C chemokine expression by titanium alloy and bone cement particles","volume":"81","author":"Nakashima","year":"1999","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.09.017_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1302\/0301-620X.81B1.0810163","article-title":"Cytokine levels in synovial fluid from hips with well-functioning or loose prostheses","volume":"81","author":"Nivbrant","year":"1999","journal-title":"J Bone Joint Surg Br"},{"issue":"5","key":"10.1016\/j.biomaterials.2009.09.017_bib12","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0002-9440(10)63560-2","article-title":"Receptor activator of nuclear factor kappaB ligand (RANKL)\/osteoprotegerin (OPG) ratio is increased in severe osteolysis","volume":"163","author":"Grimaud","year":"2003","journal-title":"Am J Pathol"},{"issue":"8","key":"10.1016\/j.biomaterials.2009.09.017_bib13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1302\/0301-620X.85B8.13311","article-title":"Imbalance of RANKL\/RANK\/OPG system in interface tissue in loosening of total hip replacement","volume":"85","author":"Mandelin","year":"2003","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.09.017_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.09.017_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jbm.a.30609","article-title":"Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris","volume":"77","author":"Fritz","year":"2006","journal-title":"J Biomed Mater Res A"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.09.017_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S8756-3282(03)00086-3","article-title":"Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease","volume":"33","author":"Bendre","year":"2003","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.biomaterials.2009.09.017_bib17","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/art.10227","article-title":"Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles","volume":"46","author":"Carmody","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.biomaterials.2009.09.017_bib18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/sj.gt.3302192","article-title":"Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis","volume":"11","author":"Yang","year":"2004","journal-title":"Gene Ther"},{"issue":"1","key":"10.1016\/j.biomaterials.2009.09.017_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcp.10188","article-title":"Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release","volume":"194","author":"Lisignoli","year":"2003","journal-title":"J Cell Physiol"},{"issue":"7","key":"10.1016\/j.biomaterials.2009.09.017_bib20","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1182\/blood-2004-07-2534","article-title":"Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migration","volume":"105","author":"Kwak","year":"2005","journal-title":"Blood"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209009478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961209009478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:11:52Z","timestamp":1758899512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961209009478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0142961209009478"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.09.017","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Over-expression of receptor activator of nuclear factor-\u03baB ligand (RANKL), inflammatory cytokines, and chemokines in periprosthetic osteolysis of loosened total hip arthroplasty","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2009.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}