{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:19:16Z","timestamp":1788808756783,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.biomaterials.2010.06.027","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T08:00:10Z","timestamp":1279699210000},"page":"7519-7525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues"],"prefix":"10.1016","volume":"31","author":[{"given":"Ilaria","family":"Roato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Caldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"D\u2019Amelio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Godio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Patan\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Astore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Grappiolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Boggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Scagnelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Molfetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Ferracini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2010.06.027_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","article-title":"Osteoarthritis: new insights. Part 1: the disease and its risk factors","volume":"133","author":"Felson","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/17453670710014482","article-title":"Prosthesis survival after total hip arthroplasty\u2013does surgical approach matter? analysis of 19,304 Charnley and 6,002 exeter primary total hip arthroplasties reported to the Norwegian Arthroplasty Register","volume":"78","author":"Arthursson","year":"2007","journal-title":"Acta Orthop"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib3","first-page":"341","article-title":"Revision total knee arthroplasty: planning, management, and controversies","volume":"57","author":"Fehring","year":"2008","journal-title":"Instr Course Lect"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib4","first-page":"171","article-title":"Periprosthetic osteolysis in total hip arthroplasty: the role of particulate wear debris","volume":"45","author":"Maloney","year":"1996","journal-title":"Instr Course Lect"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib5","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","article-title":"Wear particles, periprosthetic osteolysis and the immune system","volume":"28","author":"Goodman","year":"2007","journal-title":"Biomaterials"},{"issue":"Suppl. 1","key":"10.1016\/j.biomaterials.2010.06.027_bib6","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1096\/fj.04-1823fje","article-title":"Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement","volume":"19","author":"Roato","year":"2005","journal-title":"Faseb J"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jbm.a.10200","article-title":"The role of the TH1 and TH2 immune responses in loosening and osteolysis of cemented total hip replacements","volume":"64","author":"Arora","year":"2003","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib9","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1016\/S0142-9612(02)00059-5","article-title":"A study of tissue interface membranes from revision accord knee arthroplasty: the role of T lymphocytes","volume":"23","author":"Baldwin","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/1097-4636(20010605)55:3<433::AID-JBM1033>3.0.CO;2-N","article-title":"Chronic antigen-specific immune-system activation may potentially be involved in the loosening of cemented acetabular components","volume":"55","author":"Farber","year":"2001","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/00016470152846556","article-title":"No lymphokines in T-cells around loosened hip prostheses","volume":"72","author":"Li","year":"2001","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib12","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0142-9612(00)00099-5","article-title":"Expression of the CD69 activation antigen on lymphocytes of patients with hip prosthesis","volume":"21","author":"Granchi","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.orthres.2004.09.001","article-title":"Lymphocyte responses in patients with total hip arthroplasty","volume":"23","author":"Hallab","year":"2005","journal-title":"J Orthop Res"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib14","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.4049\/jimmunol.0803897","article-title":"Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells","volume":"182","author":"Kiesel","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib15","article-title":"A dedicated image analysis software tool for the evaluation of the resorption activity of cultured osteoclasts","volume":"52","author":"Brianza","year":"2008","journal-title":"JIST"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib16","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood-2004-02-0474","article-title":"T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG\/TRAIL interaction","volume":"104","author":"Colucci","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bone.2008.02.017","article-title":"Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis","volume":"43","author":"D\u2019Amelio","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib18","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1371\/journal.pone.0000124","article-title":"IL-7 up-regulates TNF-alpha-dependent osteoclastogenesis in patients affected by solid tumor","volume":"1","author":"Roato","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.blo.0000238813.95035.1b","article-title":"The cellular and molecular biology of periprosthetic osteolysis","volume":"454","author":"Purdue","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1302\/0301-620X.76B3.8175831","article-title":"Titanium: epitome of biocompatibility or cause for concern","volume":"76","author":"Williams","year":"1994","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7150\/ijbs.5.182","article-title":"Association between apoptotis and CD4(+)\/CD8(+) T-lymphocyte ratio in aseptic loosening after total hip replacement","volume":"5","author":"Landgraeber","year":"2009","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib22","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"Gravallese","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib23","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1902\/jop.2005.76.11-S.2033","article-title":"Immune response: the key to bone resorption in periodontal disease","volume":"76","author":"Taubman","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib24","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1023\/A:1021137921463","article-title":"Expression profile of T cell associated molecules in the interfacial tissue of aseptically loosened prosthetic joints","volume":"13","author":"Hercus","year":"2002","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib25","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/ar2681","article-title":"RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro","volume":"11","author":"Sutherland","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.biomaterials.2010.06.027_bib26","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1002\/art.21236","article-title":"Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2","volume":"52","author":"Zhang","year":"2005","journal-title":"Arthritis Rheum"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961210007908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961210007908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:21:27Z","timestamp":1758900087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961210007908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":26,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0142961210007908"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2010.06.027","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2010.06.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}