{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:22:57Z","timestamp":1791044577740,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["10904119"],"award-info":[{"award-number":["10904119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30971500"],"award-info":[{"award-number":["30971500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["20090451076"],"award-info":[{"award-number":["20090451076"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2010CB529800"],"award-info":[{"award-number":["2010CB529800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2010CB530100"],"award-info":[{"award-number":["2010CB530100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018621","name":"Program for Changjiang Scholars and Innovative Research Team in University","doi-asserted-by":"publisher","award":["IRT0745"],"award-info":[{"award-number":["IRT0745"]}],"id":[{"id":"10.13039\/501100018621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.biomaterials.2010.07.099","type":"journal-article","created":{"date-parts":[[2010,8,22]],"date-time":"2010-08-22T04:28:53Z","timestamp":1282451333000},"page":"8724-8731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Neurotoxin-conjugated upconversion nanoprobes for direct visualization of\u00a0tumors under near-infrared irradiation"],"prefix":"10.1016","volume":"31","author":[{"given":"Xue-Feng","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu-Quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biomaterials.2010.07.099_bib1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/nbt994","article-title":"In vivo cancer targeting and imaging with semiconductor quantum dots","volume":"22","author":"Gao","year":"2004","journal-title":"Nat Biotechnol"},{"issue":"22","key":"10.1016\/j.biomaterials.2010.07.099_bib2","doi-asserted-by":"crossref","first-page":"9266","DOI":"10.1073\/pnas.0702427104","article-title":"Nanoprobes with near-infrared persistent luminescence for in vivo imaging","volume":"104","author":"le Masne de Chermont","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.biomaterials.2010.07.099_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/85734","article-title":"Up-converting phosphor reporters for nucleic acid microarrays","volume":"19","author":"van de Rijek","year":"2001","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.biomaterials.2010.07.099_bib4","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1039\/b809132n","article-title":"Recent advances in the chemistry of lanthanide-doped up-conversion nanocrystals","volume":"38","author":"Wang","year":"2009","journal-title":"Chem Soc Rev"},{"issue":"1","key":"10.1016\/j.biomaterials.2010.07.099_bib5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0013-9351(87)80066-X","article-title":"Cytotoxicity of the rare-earth-metals cerium, lanthanum, and neodymium in vitro-comparisons with cadmium in a pulmonary macrophage primary culture system","volume":"43","author":"Palmer","year":"1987","journal-title":"Environ Res"},{"issue":"23\u201324","key":"10.1016\/j.biomaterials.2010.07.099_bib6","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/adma.200400772","article-title":"Highly efficient multicolor up-conversion emission in transparent colloids of lanthanide-doped NaYF4 nanocrystals","volume":"16","author":"Heer","year":"2004","journal-title":"Adv Mater"},{"issue":"17","key":"10.1016\/j.biomaterials.2010.07.099_bib7","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/adma.200402046","article-title":"Synthesis and upconversion luminescence of hexagonal-phase NaYF4:Yb, Er3+ phosphors of controlled size and morphology","volume":"17","author":"Zeng","year":"2005","journal-title":"Adv Mater"},{"issue":"19","key":"10.1016\/j.biomaterials.2010.07.099_bib8","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.1021\/ja060212h","article-title":"High-quality sodium rare-earth fluoride nanocrystals: controlled synthesis and optical properties","volume":"128","author":"Mai","year":"2006","journal-title":"J Am Chem Soc"},{"issue":"18","key":"10.1016\/j.biomaterials.2010.07.099_bib9","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1002\/adfm.200600053","article-title":"Synthesis of hexagonal-phase NaYF4:Yb, Er and NaYF4:Yb, Tm nanocrystals with efficient up-conversion fluorescence","volume":"16","author":"Yi","year":"2006","journal-title":"Adv Funct Mater"},{"issue":"3","key":"10.1016\/j.biomaterials.2010.07.099_bib10","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1021\/nl070235+","article-title":"Synthesis of colloidal upconverting NaYF4: Er3+\/Yb3+ and Tm3+\/Yb3+ monodisperse nanocrystals","volume":"7","author":"Boyer","year":"2007","journal-title":"Nano Lett"},{"issue":"11","key":"10.1016\/j.biomaterials.2010.07.099_bib11","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1021\/nn9012093","article-title":"Monodisperse upconverting nanocrystals by microwave-assisted synthesis","volume":"3","author":"Wang","year":"2009","journal-title":"Acs Nano"},{"issue":"46","key":"10.1016\/j.biomaterials.2010.07.099_bib12","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1002\/anie.200602975","article-title":"Monodisperse silica-coated polyvinylpyrrolidone\/NaYF4 nanocrystals with multicolor upconversion fluorescence emission","volume":"45","author":"Li","year":"2006","journal-title":"Angew Chem Int Ed"},{"issue":"23","key":"10.1016\/j.biomaterials.2010.07.099_bib13","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.1088\/0957-4484\/17\/23\/013","article-title":"Synthesis of polyethylenimine\/NaYF4 nanoparticles with up-conversion fluorescence","volume":"17","author":"Wang","year":"2006","journal-title":"Nanotechnology"},{"issue":"17","key":"10.1016\/j.biomaterials.2010.07.099_bib14","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1021\/ja800868a","article-title":"Upconversion multicolor fine-tuning: visible to near-Infrared emission from lanthanide-doped NaYF4 nanoparticles","volume":"130","author":"Wang","year":"2008","journal-title":"J Am Chem Soc"},{"issue":"10","key":"10.1016\/j.biomaterials.2010.07.099_bib15","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1021\/ja076151k","article-title":"Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanophosphors as biological labels","volume":"130","author":"Chen","year":"2008","journal-title":"J Am Chem Soc"},{"issue":"2","key":"10.1016\/j.biomaterials.2010.07.099_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/nl0519175","article-title":"In vivo and scanning electron microscopy imaging of upconverting nanophosphors in caenorhabditis elegans","volume":"6","author":"Lim","year":"2006","journal-title":"Nano Lett"},{"issue":"30","key":"10.1016\/j.biomaterials.2010.07.099_bib17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.biomaterials.2007.10.051","article-title":"Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals","volume":"29","author":"Chatterjeea","year":"2008","journal-title":"Biomaterials"},{"issue":"30","key":"10.1016\/j.biomaterials.2010.07.099_bib18","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1016\/j.biomaterials.2008.07.012","article-title":"Biocompatibility of silica coated NaYF4 up-conversion fluorescent nanocrystals","volume":"29","author":"Jalil","year":"2008","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.biomaterials.2010.07.099_bib19","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1021\/nl802223f","article-title":"High contrast in vitro and in vivo photoluminescence bioimaging using near infrared to near infrared up-conversion in Tm3+ and Yb3+ doped fluoride nanophosphors","volume":"8","author":"Nyk","year":"2008","journal-title":"Nano Lett"},{"issue":"29","key":"10.1016\/j.biomaterials.2010.07.099_bib20","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/j.biomaterials.2009.06.015","article-title":"Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors","volume":"30","author":"Xiong","year":"2009","journal-title":"Biomaterials"},{"issue":"21","key":"10.1016\/j.biomaterials.2010.07.099_bib21","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.1021\/ac901960d","article-title":"High contrast upconversion luminescence targeted imaging in vivo using peptide-labeled nanophosphors","volume":"81","author":"Xiong","year":"2009","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.biomaterials.2010.07.099_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12274-010-1008-2","article-title":"Dopant-controlled synthesis of water-soluble hexagonal NaYF4 nanorods with efficient up-conversion fluorescence for multicolor bioimaging","volume":"3","author":"Yu","year":"2010","journal-title":"Nano Res"},{"issue":"12","key":"10.1016\/j.biomaterials.2010.07.099_bib23","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1021\/nl8032284","article-title":"High affinity scFv-hapten pair as a tool for quantum dot labeling and tracking of single proteins in live cells","volume":"8","author":"Iyer","year":"2008","journal-title":"Nano Lett"},{"issue":"7","key":"10.1016\/j.biomaterials.2010.07.099_bib24","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1021\/nl900789e","article-title":"Neurotoxin quantum dot conjugates detect endogenous targets expressed in live cancer cells","volume":"9","author":"Orndorff","year":"2009","journal-title":"Nano Lett"},{"issue":"3","key":"10.1016\/j.biomaterials.2010.07.099_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/bip.10257","article-title":"Therapeutic cancer targeting peptides","volume":"66","author":"Aina","year":"2002","journal-title":"Biopolymers"},{"issue":"2","key":"10.1016\/j.biomaterials.2010.07.099_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/1389450024605427","article-title":"Molecular design of bioconjugated cell adhesion peptide with a water-soluble polymeric modifier for enhancement of antimetastatic effect","volume":"3","author":"Yamamoto","year":"2002","journal-title":"Curr Drug Targets"},{"issue":"6","key":"10.1016\/j.biomaterials.2010.07.099_bib27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/nl0502569","article-title":"Optical and MRI multifunctional nanoprobe for targeting gliomas","volume":"5","author":"Veiseh","year":"2005","journal-title":"Nano Lett"},{"issue":"2","key":"10.1016\/j.biomaterials.2010.07.099_bib28","doi-asserted-by":"crossref","first-page":"C361","DOI":"10.1152\/ajpcell.1993.264.2.C361","article-title":"Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion","volume":"264","author":"DeBin","year":"1993","journal-title":"Am J\u00a0Physiol"},{"issue":"6","key":"10.1016\/j.biomaterials.2010.07.099_bib29","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.M205662200","article-title":"Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2","volume":"278","author":"Deshane","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.biomaterials.2010.07.099_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1017\/S1740925X06000044","article-title":"A role for ion channels in glioma cell invasion","volume":"2","author":"McFerrin","year":"2006","journal-title":"Neuron Glia Biol"},{"issue":"3","key":"10.1016\/j.biomaterials.2010.07.099_bib31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/glia.440150306","article-title":"Tumor antigens in astrocytic gliomas","volume":"15","author":"Kurpad","year":"1995","journal-title":"Glia"},{"issue":"14","key":"10.1016\/j.biomaterials.2010.07.099_bib32","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1158\/0008-5472.CAN-06-3948","article-title":"Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci","volume":"67","author":"Veiseh","year":"2007","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.biomaterials.2010.07.099_bib33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.canlet.2009.10.011","article-title":"BmKCT toxin inhibits glioma proliferation and tumor metastasis","volume":"291","author":"Fan","year":"2010","journal-title":"Cancer Lett"},{"issue":"2","key":"10.1016\/j.biomaterials.2010.07.099_bib34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/smll.200800646","article-title":"Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles","volume":"5","author":"Veiseh","year":"2009","journal-title":"Small"},{"issue":"27","key":"10.1016\/j.biomaterials.2010.07.099_bib35","doi-asserted-by":"crossref","first-page":"19058","DOI":"10.1074\/jbc.M802054200","article-title":"Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease","volume":"283","author":"Han","year":"2008","journal-title":"J Biol Chem"},{"issue":"11\u201312","key":"10.1016\/j.biomaterials.2010.07.099_bib36","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0956-5663(00)00115-9","article-title":"Evaluation of antibody immobilization methods for piezoelectric biosensor application","volume":"15","author":"Babacan","year":"2000","journal-title":"Biosens Bioelectron"},{"issue":"33","key":"10.1016\/j.biomaterials.2010.07.099_bib37","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1039\/b606572b","article-title":"A systematic examination of surface coatings on the optical and chemical properties of semiconductor quantum dots","volume":"8","author":"Smith","year":"2006","journal-title":"Phys Chem Chem Phys"},{"issue":"4","key":"10.1016\/j.biomaterials.2010.07.099_bib38","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biomaterials.2009.09.090","article-title":"Folate receptor targeted, rare-earth oxide nanocrystals for bi-modal fluorescence and magnetic imaging of cancer cells","volume":"31","author":"Setua","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2010.07.099_bib39","series-title":"Bioconjugate techniques","author":"Hermanson","year":"2008"},{"issue":"31","key":"10.1016\/j.biomaterials.2010.07.099_bib40","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1016\/j.biomaterials.2008.07.025","article-title":"The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis","volume":"29","author":"Chen","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2010.07.099_bib41","series-title":"American National Standard for safe use of lasers, ANSI Z136. 1-2000","year":"2000"},{"issue":"11","key":"10.1016\/j.biomaterials.2010.07.099_bib42","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nnano.2009.326","article-title":"Bioimaging: second window for in vivo imaging","volume":"4","author":"Smith","year":"2009","journal-title":"Nat Nano"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961210009713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961210009713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:22:32Z","timestamp":1758900152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961210009713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":42,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0142961210009713"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2010.07.099","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurotoxin-conjugated upconversion nanoprobes for direct visualization of\u00a0tumors under near-infrared irradiation","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2010.07.099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}