{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:41:51Z","timestamp":1791304911307,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Stanford Medical Scholars Program"},{"DOI":"10.13039\/100001279","name":"Orthopaedic Research and Education Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.biomaterials.2011.04.046","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T20:54:30Z","timestamp":1306097670000},"page":"5535-5542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles"],"prefix":"10.1016","volume":"32","author":[{"given":"Jeremy I.","family":"Pearl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afraaz R.","family":"Irani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart B.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2011.04.046_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003086-200112000-00007","article-title":"Wear and periprosthetic osteolysis: the problem","author":"Harris","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0021-9975(98)80075-3","article-title":"Characterization of wear debris associated with aseptic loosening of a canine hip prosthesis","volume":"119","author":"Day","year":"1998","journal-title":"J\u00a0Comp Pathol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib3","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.biomaterials.2004.04.035","article-title":"The role of macrophages in osteolysis of total joint replacement","volume":"26","author":"Ingham","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00003086-200112000-00008","article-title":"Osteolysis: basic science","author":"Jacobs","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A\u00a0human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib6","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nature02761","article-title":"Inferences, questions and possibilities in Toll-like receptor signalling","volume":"430","author":"Beutler","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20050978","article-title":"Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis","volume":"202","author":"Kim","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib11","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.4049\/jimmunol.169.10.5874","article-title":"Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)\/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages","volume":"169","author":"Schilling","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib12","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","article-title":"Tumor necrosis factor-alpha mediates orthopedic implant osteolysis","volume":"154","author":"Merkel","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S8756-3282(98)00068-4","article-title":"Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography","volume":"23","author":"Muller","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib15","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1359\/jbmr.2001.16.11.2082","article-title":"Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation","volume":"16","author":"Bi","year":"2001","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/(SICI)1097-4636(20000315)49:4<469::AID-JBM5>3.0.CO;2-A","article-title":"Macrophage cytokine response to particles and lipopolysaccharide in\u00a0vitro","volume":"49","author":"Daniels","year":"2000","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib17","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI32205","article-title":"Microbial translocation augments the function of adoptively transferred self\/tumor-specific CD8+ T cells via TLR4 signaling","volume":"117","author":"Paulos","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib18","doi-asserted-by":"crossref","first-page":"15809","DOI":"10.1074\/jbc.C400613200","article-title":"Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B","volume":"280","author":"Loiarro","year":"2005","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib20","first-page":"3","article-title":"Genomic structure, induction, and production of TNF-alpha","volume":"56","author":"Spriggs","year":"1992","journal-title":"Immunol Ser"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1189\/jlb.1103536","article-title":"Post-transcriptional regulation of proinflammatory proteins","volume":"76","author":"Anderson","year":"2004","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib22","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1093\/emboj\/19.15.4154","article-title":"TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha","volume":"19","author":"Piecyk","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib23","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.4049\/jimmunol.164.8.4301","article-title":"IL-1 receptor-associated kinase modulates host responsiveness to endotoxin","volume":"164","author":"Swantek","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.20042372","article-title":"Interleukin-1 receptor-associated kinase-1\u00a0p.ays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction","volume":"201","author":"Uematsu","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib25","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1126\/science.1112304","article-title":"Achieving stability of lipopolysaccharide-induced NF-kappaB activation","volume":"309","author":"Covert","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib26","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1101\/gad.12.18.2821","article-title":"Tumor necrosis factor receptor-associated factors (TRAFs)\u2013a family of adapter proteins that regulates life and death","volume":"12","author":"Arch","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","article-title":"TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling","volume":"13","author":"Lomaga","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib28","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.4049\/jimmunol.0802907","article-title":"TLR activation induces TNF-alpha production from adult neural stem\/progenitor cells","volume":"182","author":"Covacu","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib29","doi-asserted-by":"crossref","first-page":"20431","DOI":"10.1074\/jbc.M110333200","article-title":"TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells","volume":"277","author":"Abreu","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib30","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/diabetes.50.12.2792","article-title":"Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB","volume":"50","author":"Bierhaus","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib31","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.2337\/diacare.21.8.1310","article-title":"Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes","volume":"21","author":"Hofmann","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib32","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1161\/01.CIR.96.7.2262","article-title":"Advanced glycation end product (AGE)-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE","volume":"96","author":"Bierhaus","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib33","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.20040689","article-title":"MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha","volume":"200","author":"Sato","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.biomaterials.2011.04.046_bib34","doi-asserted-by":"crossref","first-page":"16732","DOI":"10.1074\/jbc.M212473200","article-title":"CpG oligodeoxynucleotides modulate the osteoclastogenic activity of osteoblasts via Toll-like receptor 9","volume":"278","author":"Zou","year":"2003","journal-title":"J\u00a0Biol Chem"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961211004534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961211004534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:30:10Z","timestamp":1758900610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961211004534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":34,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0142961211004534"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2011.04.046","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2011.04.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}