{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:15:45Z","timestamp":1792804545882,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.biomaterials.2011.05.072","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T17:58:15Z","timestamp":1308938295000},"page":"6754-6763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Hydrogel-based biomimetic environment for in\u00a0vitro modulation of branching morphogenesis"],"prefix":"10.1016","volume":"32","author":[{"given":"Hiroyuki","family":"Miyajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyun","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuen Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Egusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Imazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2011.05.072_bib1","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.biocel.2009.04.015","article-title":"Multi-scale mechanics from molecules to morphogenesis","volume":"41","author":"Davidson","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib2","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1126\/science.1079478","article-title":"Shaping the vertebrate body plan by polarized embryonic cell movements","volume":"298","author":"Keller","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib3","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1016\/j.cub.2005.03.016","article-title":"Conserved patterns of cell movements during vertebrate gastrulation","volume":"15","author":"Solnica-Krezel","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrm2592","article-title":"Mechanotransduction in development: a growing role for contractility","volume":"10","author":"Wozniak","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jbiomech.2009.09.010","article-title":"Emergent morphogenesis: elastic mechanics of a self-deforming tissue","volume":"43","author":"Davidson","year":"2010","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1115\/1.1324665","article-title":"How is a tissue built?","volume":"122","author":"Cowin","year":"2000","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib7","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1083\/jcb.121.6.1343","article-title":"Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans","volume":"121","author":"Hird","year":"1993","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/ten.2006.0058","article-title":"Mechanical strain regulates endothelial cell patterning in\u00a0vitro","volume":"13","author":"Matsumoto","year":"2007","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib9","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.284.5420.1635","article-title":"Genetic control of branching morphogenesis","volume":"284","author":"Metzger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.semcdb.2007.01.006","article-title":"Salivary gland development","volume":"18","author":"Tucker","year":"2007","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0012-1606(86)90122-3","article-title":"Collagenase inhibitor stimulates cleft formation during early morphogenesis of mouse salivary gland","volume":"113","author":"Nakanishi","year":"1986","journal-title":"Dev Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib12","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.biomaterials.2008.02.014","article-title":"The enhancement of submandibular gland branch formation on chitosan membranes","volume":"29","author":"Yang","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1083\/jcb.129.2.521","article-title":"Antibodies against domain E3 of laminin-1 and integrin alpha 6 subunit perturb branching epithelial morphogenesis of submandibular gland, but by different modes","volume":"129","author":"Kadoya","year":"1995","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nature01712","article-title":"Fibronectin requirement in branching morphogenesis","volume":"423","author":"Sakai","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.01690","article-title":"FGFR2b signaling regulates ex\u00a0vivo submandibular gland epithelial cell proliferation and branching morphogenesis","volume":"132","author":"Steinberg","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/(SICI)1097-0177(199906)215:2<148::AID-DVDY7>3.0.CO;2-V","article-title":"EGF-dependent lobule formation and FGF7-dependent stalk elongation in branching morphogenesis of mouse salivary epithelium in\u00a0vitro","volume":"215","author":"Morita","year":"1999","journal-title":"Dev Dyn"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib17","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1016\/j.biomaterials.2007.07.001","article-title":"Physical properties of alginate hydrogels and their effects on in\u00a0vitro follicle development","volume":"28","author":"West","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nmat1392","article-title":"Non-viral gene delivery regulated by stiffness of cell adhesion substrates","volume":"4","author":"Kong","year":"2005","journal-title":"Nat Mater"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib20","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1073\/pnas.0405873102","article-title":"FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness","volume":"102","author":"Kong","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0012-1606(02)00047-7","article-title":"Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis","volume":"255","author":"Larsen","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib22","doi-asserted-by":"crossref","first-page":"e1000809","DOI":"10.1371\/journal.pgen.1000809","article-title":"Kidney development in the absence of Gdnf and Spry1 requires Fgf10","volume":"6","author":"Michos","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0070-2153(07)81008-8","article-title":"Branched organs: mechanics of morphogenesis by multiple mechanisms","volume":"81","author":"Lubkin","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.13182\/NSE96-A24205","article-title":"Moving-particle semi-implicit method for fragmentation of incompressible fluid","volume":"123","author":"Koshizuka","year":"1996","journal-title":"Nucl Sci Eng"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib25","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/nme.2222","article-title":"A\u00a0hamiltonian particle method for non-linear elastodynamics","volume":"74","author":"Suzuki","year":"2008","journal-title":"Int J Numer Methods Eng"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature09642","article-title":"Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding","volume":"469","author":"Stewart","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib27","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1091\/mbc.5.9.967","article-title":"Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth","volume":"5","author":"Hansen","year":"1994","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0167-7799(90)90139-O","article-title":"Alginate as immobilization matrix for cells","volume":"8","author":"Smidsr\u00f8d","year":"1990","journal-title":"TIBTECH"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/096368979300200603","article-title":"Correction of bilirubin conjugation in the Gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartificial liver","volume":"2","author":"Fremond","year":"1993","journal-title":"Cell Transplant"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S","article-title":"Injection molding of chondrocyte\/alginate constructs in the shape of facial implants","volume":"55","author":"Chang","year":"2001","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0142-9612(98)00107-0","article-title":"Alginate hydrogels as synthetic extracellular matrix materials","volume":"20","author":"Rowley","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib32","first-page":"641","article-title":"Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension","volume":"152","author":"Atala","year":"1994","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib33","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/0142-9612(93)90203-E","article-title":"Cell biology of hydrogels","volume":"14","author":"Smetana","year":"1993","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0091-679X(07)83022-6","article-title":"Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation","volume":"83","author":"Engler","year":"2007","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0021-9290(75)90075-5","article-title":"The elastic and ultimate properties of compact bone tissue","volume":"8","author":"Reilly","year":"1975","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/dbio.1999.9249","article-title":"Measurements of mechanical properties of the blastula wall reveal which hypothesized mechanisms of primary invagination are physically plausible in the sea urchin Strongylocentrotus purpuratus","volume":"209","author":"Davidson","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1165\/ajrcmb.19.1.3158","article-title":"A\u00a0correlation between epithelial proliferation rates, basement membrane component localization patterns, and morphogenetic potential in the embryonic mouse lung","volume":"19","author":"Mollard","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1097-0177(199810)213:2<228::AID-AJA8>3.0.CO;2-I","article-title":"Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in\u00a0vitro","volume":"213","author":"Nogawa","year":"1998","journal-title":"Dev Dyn"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1432-0436.2006.00088.x","article-title":"Salivary gland branching morphogenesis","volume":"74","author":"Patel","year":"2006","journal-title":"Differentiation"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib40","doi-asserted-by":"crossref","first-page":"ra55","DOI":"10.1126\/scisignal.2000304","article-title":"Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis","volume":"2","author":"Makarenkova","year":"2009","journal-title":"Sci Signal"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment","volume":"6","author":"McBeath","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib42","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1242\/dev.024166","article-title":"Mechanical control of tissue and organ development","volume":"137","author":"Mammoto","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib43","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/cm.20382","article-title":"The hard life of soft cells","volume":"66","author":"Jammy","year":"2009","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib44","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1073\/pnas.0530201100","article-title":"Mechanosensation through integrins: cells act locally but think globally","volume":"100","author":"Ingber","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib45","first-page":"1","article-title":"Modeling the wetting effects in droplet impingement using particle method","volume":"18","author":"Xie","year":"2007","journal-title":"Comput Model Eng Sci"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/jcs.071001","article-title":"Mechanisms of mechanical signaling in development and disease","volume":"124","author":"Janmey","year":"2011","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib47","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib48","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1242\/dev.036269","article-title":"Beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity","volume":"136","author":"Zhang","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib49","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ydbio.2009.09.037","article-title":"Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesis","volume":"336","author":"Daley","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.biomaterials.2011.05.072_bib50","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver regeneration","volume":"213","author":"Michalopoulos","year":"2007","journal-title":"J\u00a0Cell Physiol"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961211006430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961211006430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:29:42Z","timestamp":1758900582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961211006430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":50,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0142961211006430"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2011.05.072","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogel-based biomimetic environment for in\u00a0vitro modulation of branching morphogenesis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2011.05.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}