{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:50:04Z","timestamp":1789609804435,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["30973652"],"award-info":[{"award-number":["30973652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for New Century Excellent Talents in University and National Nature Science Foundation of China","award":["81071333"],"award-info":[{"award-number":["81071333"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.biomaterials.2012.06.050","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T04:45:14Z","timestamp":1341981914000},"page":"6898-6907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["A brain-vectored angiopep-2 based polymeric micelles for the treatment of intracranial fungal infection"],"prefix":"10.1016","volume":"33","author":[{"given":"Kun","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinning","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CMR.8.4.515","article-title":"Cryptococcosis in the era of AIDs-100 years after the discovery of Cryptococcus neoformans","volume":"8","author":"Mitchell","year":"1995","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.06.050_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1007031514495","article-title":"Cryptococcal meningitis in the immunocompromised host: intracranial hypertension and other complications","volume":"146","author":"Stevens","year":"1999","journal-title":"Mycopathologia"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.06.050_bib3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/AAC.01263-09","article-title":"Effects of immunomodulatory and organism-associated molecules on the permeability of an in\u00a0vitro blood-brain barrier model to amphotericin B and fluconazole","volume":"54","author":"Pyrgos","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.biomaterials.2012.06.050_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ijid.2007.01.013","article-title":"Central nervous system aspergillosis in children: a systematic review of reported cases","volume":"11","author":"Dotis","year":"2007","journal-title":"Int J Infect Dis"},{"issue":"5","key":"10.1016\/j.biomaterials.2012.06.050_bib5","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: a review of 929 reported cases","volume":"41","author":"Roden","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/313757","article-title":"Practice guidelines for the management of cryptococcal disease","volume":"30","author":"Saag","year":"2000","journal-title":"Infect Dis Soc of America Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.06.050_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1086\/315643","article-title":"Comparative efficacy and distribution of lipid formulations of amphotericin B in experimental Candida albicans infection of the central nervous system","volume":"182","author":"Groll","year":"2000","journal-title":"J\u00a0Infect Dis"},{"issue":"8","key":"10.1016\/j.biomaterials.2012.06.050_bib8","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1128\/AAC.46.8.2420-2426.2002","article-title":"Efficacy of intravenous liposomal amphotericin B (AmBisome) against coccidioidal meningitis in rabbits","volume":"46","author":"Clemons","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.06.050_bib9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/clinids\/12.2.308","article-title":"Amphotericin B: 30 years of clinical experience","volume":"12","author":"Gallis","year":"1990","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.biomaterials.2012.06.050_bib10","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1093\/clinids\/22.Supplement_2.S133","article-title":"Lipid formulations of amphotericin B: recent progress and future directions","volume":"2","author":"Hiemenz","year":"1996","journal-title":"Clin Infect Dis Suppl"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.06.050_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jac\/dkm264","article-title":"Efficacy of amphotericin B lipid complex in a rabbit model of coccidioidal meningitis","volume":"60","author":"Capilla","year":"2007","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.06.050_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1086\/653606","article-title":"Comparison of 2 doses of liposomal amphotericin B and conventional amphotericin B deoxycholate for treatment of AIDS-associated acute cryptococcal meningitis: a randomized, double-blind clinical trial of efficacy and safety","volume":"51","author":"Hamill","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.06.050_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1086\/588792","article-title":"High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial","volume":"47","author":"Bicanic","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.06.050_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2010.06.018","article-title":"Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain","volume":"147","author":"Shao","year":"2010","journal-title":"J\u00a0Control Release"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib15","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/j.1471-4159.2008.05492.x","article-title":"Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2","volume":"106","author":"Demeule","year":"2008","journal-title":"J\u00a0Neurochem"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.06.050_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/bjp.2008.260","article-title":"Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2","volume":"155","author":"R\u00e9gina","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"36","key":"10.1016\/j.biomaterials.2012.06.050_bib17","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1016\/j.biomaterials.2009.08.049","article-title":"Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimers","volume":"30","author":"Ke","year":"2009","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.biomaterials.2012.06.050_bib18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jemt.10090","article-title":"Functional expression and localization of P-glycoprotein at the blood brain barrier","volume":"57","author":"Bendayan","year":"2002","journal-title":"Microsc Res Tech"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.06.050_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1007093521681","article-title":"Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain","volume":"20","author":"Golden","year":"2000","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.06.050_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tips.2005.11.009","article-title":"Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs","volume":"27","author":"Breedveld","year":"2006","journal-title":"Trends Pharmacol Sci"},{"issue":"7","key":"10.1016\/j.biomaterials.2012.06.050_bib21","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1081\/DDC-120039793","article-title":"Potential mechanisms by which Peceol increases the gastrointestinal absorption of amphotericin B.","volume":"30","author":"Risovic","year":"2004","journal-title":"Drug Dev Ind Pharm"},{"issue":"6","key":"10.1016\/j.biomaterials.2012.06.050_bib22","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.addr.2007.08.042","article-title":"Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections","volume":"60","author":"Sachs-Barrable","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/bdd.604","article-title":"Mechanism of decrease of oral bioavailability of cyclosporin A during immunotherapy upon coadministration of amphotericin B","volume":"29","author":"Ishizaki","year":"2008","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.biomaterials.2012.06.050_bib24","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<3989::AID-IMMU3989>3.0.CO;2-X","article-title":"Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria","volume":"28","author":"Lou","year":"1998","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib25","first-page":"435","article-title":"Establishment of an in\u00a0vitro model of brain-blood barrier","volume":"36","author":"Xie","year":"2004","journal-title":"Beijing Da Xue Xue Bao"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.06.050_bib26","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s11064-011-0652-6","article-title":"Cryptotanshinione inhibits \u03b2-amyloid aggregation and protects damage from \u03b2-amyloid in SH-SY5Y Cells","volume":"37","author":"Mei","year":"2012","journal-title":"Neurochem Res"},{"issue":"7","key":"10.1016\/j.biomaterials.2012.06.050_bib27","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.biomaterials.2009.11.026","article-title":"A\u00a0specific tumor-targeting magnetofluorescent nanoprobe for dual-modality molecular imaging","volume":"31","author":"Ke","year":"2010","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib28","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.biomaterials.2006.09.035","article-title":"Shell-crosslinked Pluronic L121 micelles as a drug delivery vehicle","volume":"28","author":"Yang","year":"2007","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib29","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1086\/341567","article-title":"Development of a murine model of cerebral aspergillosis","volume":"186","author":"Chiller","year":"2002","journal-title":"J\u00a0Infect Dis"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.06.050_bib30","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/AAC.47.2.813-815.2003","article-title":"Efficacy of amphotericin B or itraconazole in a murine model of central nervous system Aspergillus infection","volume":"47","author":"Chiller","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.06.050_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1086\/367961","article-title":"A\u00a0murine model of coccidioidal meningitis","volume":"187","author":"Kamberi","year":"2003","journal-title":"J\u00a0Infect Dis"},{"issue":"8","key":"10.1016\/j.biomaterials.2012.06.050_bib32","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1021\/nn200739q","article-title":"A\u00a0folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model","volume":"5","author":"Wang","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2012.06.050_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"issue":"11","key":"10.1016\/j.biomaterials.2012.06.050_bib34","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s12272-001-2131-0","article-title":"Cytotoxicity of amphotericin B-incorporated polymeric micelles composed of poly(DL-lactide-co-glycolide)\/dextran graft copolymer","volume":"31","author":"Bang","year":"2008","journal-title":"Arch Pharm Res"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.06.050_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1128\/AAC.48.3.985-991.2004","article-title":"Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis","volume":"48","author":"Larsen","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.biomaterials.2012.06.050_bib36","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1128\/AAC.49.12.4867-4875.2005","article-title":"Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis","volume":"49","author":"Clemons","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.06.050_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/A:1016243313027","article-title":"Comparative tissue distribution and elimination of amphotericin B colloidal dispersion (Amphocil) and Fungizone after repeated dosing in rats","volume":"12","author":"Wang","year":"1995","journal-title":"Pharm Res"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.06.050_bib38","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/AAC.42.4.899","article-title":"Comparison of fungizone, Amphotec, AmBisome, and Abelcet for treatment of systemic murine cryptococcosis","volume":"42","author":"Clemons","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"issue":"73","key":"10.1016\/j.biomaterials.2012.06.050_bib39","article-title":"Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment","volume":"3","author":"Chow","year":"2011","journal-title":"Sci Transi Med"},{"issue":"7","key":"10.1016\/j.biomaterials.2012.06.050_bib40","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1007\/s11095-006-0282-x","article-title":"A\u00a0new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells","volume":"23","author":"Wong","year":"2006","journal-title":"Pharm Res"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961212007004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961212007004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:42:00Z","timestamp":1758901320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961212007004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":40,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0142961212007004"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2012.06.050","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A brain-vectored angiopep-2 based polymeric micelles for the treatment of intracranial fungal infection","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2012.06.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}