{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:21:46Z","timestamp":1792668106621,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["2009AA043703"],"award-info":[{"award-number":["2009AA043703"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["2012AA040406"],"award-info":[{"award-number":["2012AA040406"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012595","name":"Scientific Research Foundation of the Graduate School of Southeast University","doi-asserted-by":"publisher","award":["YBJJ1020"],"award-info":[{"award-number":["YBJJ1020"]}],"id":[{"id":"10.13039\/501100012595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B07013"],"award-info":[{"award-number":["B07013"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2011609045"],"award-info":[{"award-number":["2011609045"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20110031120004"],"award-info":[{"award-number":["20110031120004"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK081346"],"award-info":[{"award-number":["DK081346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL081202"],"award-info":[{"award-number":["HL081202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61273341"],"award-info":[{"award-number":["61273341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91023045"],"award-info":[{"award-number":["91023045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.biomaterials.2012.08.067","type":"journal-article","created":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T16:15:56Z","timestamp":1348416956000},"page":"9019-9026","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells"],"prefix":"10.1016","volume":"33","author":[{"given":"Ting-Hsuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Garfinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Tintut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda L.","family":"Demer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ming","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2012.08.067_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-chembioeng-061010-114257","article-title":"Tissue engineering and regenerative medicine: history, progress, and challenges","volume":"2","author":"Berthiaume","year":"2011","journal-title":"Annu Rev Chem Biomol Eng"},{"issue":"9176","key":"10.1016\/j.biomaterials.2012.08.067_bib2","doi-asserted-by":"crossref","first-page":"SI32","DOI":"10.1016\/S0140-6736(99)90247-7","article-title":"Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation","volume":"354","author":"Vacanti","year":"1999","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.08.067_bib3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1161\/01.RES.24.3.339","article-title":"Fiber orientation in the canine left ventricle during diastole and systole","volume":"24","author":"Streeter","year":"1969","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.08.067_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1034\/j.1600-0676.2000.020001003.x","article-title":"Morphological mechanisms for regulating blood flow through hepatic sinusoids","volume":"20","author":"McCuskey","year":"2000","journal-title":"Liver"},{"key":"10.1016\/j.biomaterials.2012.08.067_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ncomms1165","article-title":"An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells","volume":"2","author":"Tsutsui","year":"2011","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.08.067_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.clpt.6100301","article-title":"Stem cells: a revolution in therapeutics \u2013 recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies","volume":"82","author":"Mimeault","year":"2007","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.biomaterials.2012.08.067_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1163\/156856201744489","article-title":"Scaffold design and fabrication technologies for engineering tissues \u2013 state of the art and future perspectives","volume":"12","author":"Hutmacher","year":"2001","journal-title":"J\u00a0Biomater Sci Polym Ed"},{"issue":"11","key":"10.1016\/j.biomaterials.2012.08.067_bib8","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.addr.2004.05.001","article-title":"Three-dimensional tissue fabrication","volume":"56","author":"Tsang","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"issue":"13","key":"10.1016\/j.biomaterials.2012.08.067_bib9","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/S0142-9612(03)00110-8","article-title":"Cell sheet engineering for myocardial tissue reconstruction","volume":"24","author":"Shimizu","year":"2003","journal-title":"Biomaterials"},{"issue":"34","key":"10.1016\/j.biomaterials.2012.08.067_bib10","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1016\/j.biomaterials.2007.07.052","article-title":"Reconstruction of functional tissues with cell sheet engineering","volume":"28","author":"Yang","year":"2007","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.08.067_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0167-7799(03)00033-7","article-title":"Organ printing: computer-aided jet-based 3D tissue engineering","volume":"21","author":"Mironov","year":"2003","journal-title":"Trends Biotechnol"},{"issue":"3","key":"10.1016\/j.biomaterials.2012.08.067_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/(SICI)1097-0290(20000205)67:3<312::AID-BIT7>3.0.CO;2-F","article-title":"Laser-guided direct writing of living cells","volume":"67","author":"Odde","year":"2000","journal-title":"Biotechnol Bioeng"},{"issue":"6","key":"10.1016\/j.biomaterials.2012.08.067_bib13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1039\/b602036d","article-title":"Rapid heterogeneous liver-cell on-chip patterning via the enhanced field-induced dielectrophoresis trap","volume":"6","author":"Ho","year":"2006","journal-title":"Lab Chip"},{"issue":"2\u20133","key":"10.1016\/j.biomaterials.2012.08.067_bib14","first-page":"101","article-title":"Effects of morphological patterning on endothelial cell migration","volume":"38","author":"Li","year":"2001","journal-title":"Biorheology"},{"issue":"24","key":"10.1016\/j.biomaterials.2012.08.067_bib15","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1242\/jcs.088898","article-title":"Cellular self-organization by autocatalytic alignment feedback","volume":"124","author":"Junkin","year":"2011","journal-title":"J\u00a0Cell Sci"},{"issue":"25","key":"10.1016\/j.biomaterials.2012.08.067_bib16","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1073\/pnas.0308436101","article-title":"Pattern formation by vascular mesenchymal cells","volume":"101","author":"Garfinkel","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.08.067_bib17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/CIRCRESAHA.111.255927","article-title":"Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics","volume":"110","author":"Chen","year":"2012","journal-title":"Circ Res"},{"issue":"12","key":"10.1016\/j.biomaterials.2012.08.067_bib18","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1039\/b810329a","article-title":"Photolithographic patterning of organosilane monolayer for generating large area two-dimensional B lymphocyte arrays","volume":"8","author":"Li","year":"2008","journal-title":"Lab Chip"},{"issue":"11","key":"10.1016\/j.biomaterials.2012.08.067_bib19","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/hq1001.097104","article-title":"Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells","volume":"21","author":"Hsiai","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.08.067_bib20","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1172\/JCI116391","article-title":"Bone morphogenetic protein expression in human atherosclerotic lesions","volume":"91","author":"Bostr\u00f6m","year":"1993","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.biomaterials.2012.08.067_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1098\/rsfs.2012.0001","article-title":"Patterns of periodic holes created by increased cell motility","volume":"2","author":"Chen","year":"2012","journal-title":"Interface Focus"},{"issue":"26","key":"10.1016\/j.biomaterials.2012.08.067_bib22","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1073\/pnas.1118073109","article-title":"Independent regulation of tumor cell migration by matrix stiffness and confinement","volume":"109","author":"Pathak","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3\/4","key":"10.1016\/j.biomaterials.2012.08.067_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/107632704323061834","article-title":"Traveling wave model to interpret a wound-healing cell migration assay for human peritoneal mesothelial cells","volume":"10","author":"Maini","year":"2004","journal-title":"Tissue Eng"},{"issue":"10","key":"10.1016\/j.biomaterials.2012.08.067_bib24","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1073\/pnas.96.10.5549","article-title":"Stripe formation in juvenile Pomacanthus explained by a generalized Turing mechanism with chemotaxis","volume":"96","author":"Painter","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"641","key":"10.1016\/j.biomaterials.2012.08.067_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1098\/rstb.1952.0012","article-title":"The chemical basis of morphogenesis","volume":"237","author":"Turing","year":"1952","journal-title":"Phil Trans R Soc Lond B"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.08.067_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0022-5193(71)90051-8","article-title":"Traveling bands of chemotactic bacteria: a theoretical analysis","volume":"30","author":"Keller","year":"1971","journal-title":"J\u00a0Theor Biol"},{"issue":"7","key":"10.1016\/j.biomaterials.2012.08.067_bib27","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/aic.690380712","article-title":"Measurement of individual cell migration parameters for human tissue cells","volume":"38","author":"DiMilla","year":"1992","journal-title":"AIChE J"},{"issue":"29","key":"10.1016\/j.biomaterials.2012.08.067_bib28","doi-asserted-by":"crossref","first-page":"11930","DOI":"10.1073\/pnas.1103345108","article-title":"E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components","volume":"108","author":"Kim","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.biomaterials.2012.08.067_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000025634","article-title":"BMP-2 gene expression and effects on human vascular smooth muscle cells","volume":"36","author":"Willette","year":"1999","journal-title":"J\u00a0Vasc Res"},{"issue":"5651","key":"10.1016\/j.biomaterials.2012.08.067_bib30","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"issue":"33","key":"10.1016\/j.biomaterials.2012.08.067_bib31","doi-asserted-by":"crossref","first-page":"11594","DOI":"10.1073\/pnas.0502575102","article-title":"Emergent patterns of growth controlled by multicellular form and mechanics","volume":"102","author":"Nelson","year":"2005","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961212009702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961212009702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:59:21Z","timestamp":1777485561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961212009702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":31,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0142961212009702"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2012.08.067","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2012.08.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}