{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:39:17Z","timestamp":1778963957842,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006561","name":"Oxford Cancer Imaging Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.biomaterials.2012.10.054","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T05:15:39Z","timestamp":1353302139000},"page":"1146-1154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Nanographene oxide-based radioimmunoconstructs for in\u00a0vivo targeting and SPECT imaging of HER2-positive tumors"],"prefix":"10.1016","volume":"34","author":[{"given":"Bart","family":"Cornelissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Able","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Kersemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Waghorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre","family":"Myhra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Jurkshat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Crossley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Vallis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2012.10.054_bib1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1102896","article-title":"Electric field effect in atomically thin carbon films","volume":"306","author":"Novoselov","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/smll.200901680","article-title":"Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs","volume":"6","author":"Zhang","year":"2009","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib3","doi-asserted-by":"crossref","first-page":"1230001","DOI":"10.1142\/S179398441100030X","article-title":"Recent advances in graphene-based nanomaterials for biomedical applications","volume":"2","author":"Bao","year":"2012","journal-title":"Nano Life"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib4","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1016\/j.biomaterials.2011.07.071","article-title":"Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/smll.201001522","article-title":"Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide","volume":"7","author":"Zhang","year":"2011","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12274-008-8021-8","article-title":"Nano-graphene oxide for cellular imaging and drug delivery","volume":"1","author":"Sun","year":"2008","journal-title":"Nano Res"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib7","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/smll.201100191","article-title":"Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery","volume":"7","author":"Bao","year":"2011","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib8","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s11426-010-4114-9","article-title":"Poly(ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy","volume":"53","author":"Dong","year":"2010","journal-title":"Sci China"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib9","doi-asserted-by":"crossref","first-page":"9274","DOI":"10.1021\/ja103169v","article-title":"Aptamer\/graphene oxide nanocomplex for in situ molecular probing in living cells","volume":"132","author":"Wang","year":"2010","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib10","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1021\/am2009647","article-title":"Composites of aminodextran-coated fe(3)o(4) nanoparticles and graphene oxide for cellular magnetic resonance imaging","volume":"3","author":"Chen","year":"2011","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib11","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1021\/nl100996u","article-title":"Graphene in mice: ultrahigh in\u00a0vivo tumor uptake and efficient photothermal therapy","volume":"10","author":"Yang","year":"2010","journal-title":"Nano Lett"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib12","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1021\/ja2010175","article-title":"Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy","volume":"133","author":"Robinson","year":"2011","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib13","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1021\/nn204625e","article-title":"In\u00a0vivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographene","volume":"6","author":"Hong","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib14","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1016\/j.biomaterials.2012.02.031","article-title":"In\u00a0vivo targeting and positron emission tomography imaging of tumor vasculature with Ga-66-labeled nano-graphene","volume":"33","author":"Hong","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib15","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1021\/nn1024303","article-title":"In\u00a0vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice","volume":"5","author":"Yang","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib16","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1021\/bc200397j","article-title":"Graphene oxide-polyethylenimine nanoconstruct as a gene delivery vector and bioimaging tool","volume":"22","author":"Kim","year":"2011","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib17","doi-asserted-by":"crossref","first-page":"127rv2","DOI":"10.1126\/scitranslmed.3001539","article-title":"Improving treatment of HER2-positive cancers: opportunities and challenges","volume":"4","author":"Stern","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/CCO.0b013e32833f8c3a","article-title":"Molecular imaging of HER2-positive breast cancer: a step toward an individualized \u2018image and treat\u2019 strategy","volume":"22","author":"Capala","year":"2010","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1158\/1078-0432.CCR-05-1109","article-title":"Strategies for delaying or treating in\u00a0vivo acquired resistance to trastuzumab in human breast cancer xenografts","volume":"12","author":"du Manoir","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib20","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/ja01539a017","article-title":"Preparation of graphitic oxide","volume":"80","author":"Hummers","year":"1958","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib21","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1002\/anie.201007520","article-title":"The real graphene oxide revealed: stripping the oxidative debris from the graphene-like sheets","volume":"50","author":"Rourke","year":"2011","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib22","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1021\/nn2033055","article-title":"Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung","volume":"5","author":"Wang","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0006-291X(80)80132-X","article-title":"Studies on the catabolism and distribution of fibrinogen in rats. Application of the iodogen labelling technique","volume":"97","author":"Nieuwenhuizen","year":"1980","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nprot.2006.49","article-title":"Conjugation of chelating agents to proteins and radiolabeling with trivalent metallic isotopes","volume":"1","author":"Cooper","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib25","first-page":"20.9.1","article-title":"ErbB2 transgenic mice: a tool for investigation of the immune prevention and treatment of mammary carcinomas","volume":"82","author":"Quaglino","year":"2008","journal-title":"Curr Prot Immunol"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib26","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided\u00a03D active contour segmentation of anatomical structures: significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib27","doi-asserted-by":"crossref","first-page":"17667","DOI":"10.1021\/ja1078943","article-title":"Graphene oxide nanocolloids","volume":"132","author":"Luo","year":"2010","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib28","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1039\/b920539j","article-title":"The chemistry of graphene","volume":"20","author":"Loh","year":"2010","journal-title":"J\u00a0Mater Chem"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1039\/B917103G","article-title":"The chemistry of graphene oxide","volume":"39","author":"Dreyer","year":"2010","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib30","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/adma.201104964","article-title":"Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles","volume":"24","author":"Yang","year":"2012","journal-title":"Adv Mater"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib31","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1039\/c2nr31040f","article-title":"Graphene: a versatile nanoplatform for biomedical applications","volume":"4","author":"Zhang","year":"2012","journal-title":"Nanoscale"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib32","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.carbon.2010.11.005","article-title":"Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration","volume":"49","author":"Zhang","year":"2011","journal-title":"Carbon"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00259-008-0923-x","article-title":"Associations between the uptake of 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human tumour xenografts","volume":"36","author":"McLarty","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib34","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2967\/jnumed.107.042234","article-title":"Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer","volume":"48","author":"Sampath","year":"2007","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib35","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.2174\/138161208785777432","article-title":"Cell penetrating peptides for in\u00a0vivo molecular imaging applications","volume":"14","author":"Kersemans","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib36","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1021\/bm800246x","article-title":"Facile, efficient approach to accomplish tunable chemistries and variable biodistributions for shell cross-linked nanoparticles","volume":"9","author":"Sun","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2012.10.054_bib37","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1016\/j.carbon.2011.05.056","article-title":"In\u00a0vitro and in\u00a0vivo behaviors of dextran functionalized graphene","volume":"49","author":"Zhang","year":"2011","journal-title":"Carbon"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961212012057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961212012057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:48:43Z","timestamp":1758901723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961212012057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0142961212012057"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2012.10.054","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanographene oxide-based radioimmunoconstructs for in\u00a0vivo targeting and SPECT imaging of HER2-positive tumors","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2012.10.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}