{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:58:24Z","timestamp":1792709904941,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2011CB606203"],"award-info":[{"award-number":["2011CB606203"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2009CB930000"],"award-info":[{"award-number":["2009CB930000"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21034002"],"award-info":[{"award-number":["21034002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91127028"],"award-info":[{"award-number":["91127028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51273046"],"award-info":[{"award-number":["51273046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.biomaterials.2013.01.021","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T04:18:21Z","timestamp":1359173901000},"page":"2865-2874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":187,"title":["Effect of RGD nanospacing on differentiation of stem cells"],"prefix":"10.1016","volume":"34","author":[{"given":"Xuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2013.01.021_bib1","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1126\/science.276.5317.1425","article-title":"Geometric control of cell life and death","volume":"276","author":"Chen","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib3","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1002\/anie.200805179","article-title":"Engineering substrate topography at the micro- and nanoscale to control cell function","volume":"48","author":"Bettinger","year":"2009","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biomaterials.2009.09.047","article-title":"Myoblast morphology and organization on biochemically micro-patterned hydrogel coatings under cyclic mechanical strain","volume":"31","author":"Ahmed","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/0957-4484\/22\/21\/212001","article-title":"Nanoscale tissue engineering: spatial control over cell\u2013materials interactions","volume":"22","author":"Wheeldon","year":"2011","journal-title":"Nanotechnology"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib6","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.biomaterials.2011.12.012","article-title":"Switchable adhesive substrates: revealing geometry dependence in collective cell behavior","volume":"33","author":"Rolli","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","author":"Geiger","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib8","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1242\/jcs.03098","article-title":"Integrin ligands at a glance","volume":"119","author":"Humphries","year":"2006","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib9","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1016\/S0142-9612(03)00343-0","article-title":"RGD modified polymers: biomaterials for stimulated cell adhesion and beyond","volume":"24","author":"Hersel","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/jbm.a.30027","article-title":"Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides","volume":"69A","author":"Shin","year":"2004","journal-title":"J\u00a0Biomed Mater Res Part A"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib11","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1016\/j.biomaterials.2010.02.064","article-title":"Design and synthesis of a potent peptide containing both specific and non-specific cell-adhesion motifs","volume":"31","author":"Lai","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib12","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1016\/j.biomaterials.2010.07.014","article-title":"Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion","volume":"31","author":"Zhang","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/term.338","article-title":"Enhanced osteoblastic differentiation of mesenchymal stem cells seeded in RGD-functionalized PLLA scaffolds and cultured in a flow perfusion bioreactor","volume":"5","author":"Alvarez-Barreto","year":"2011","journal-title":"J\u00a0Tissue Eng Regenerative Med"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/jbm.b.32728","article-title":"Encapsulation of cell-adhesive RGD peptides into a polymeric physical hydrogel to prevent postoperative tissue adhesion","volume":"100B","author":"Zhang","year":"2012","journal-title":"J\u00a0Biomed Mater Res Part B-Appl Biomater"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cphc.200301014","article-title":"Activation of integrin function by nanopatterned adhesive interfaces","volume":"5","author":"Arnold","year":"2004","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib16","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/smll.200600596","article-title":"Influence of different ECM mimetic peptide sequences embedded in a nonfouling environment on the specific adhesion of human-skin keratinocytes and fibroblasts on deformable substrates","volume":"3","author":"Salber","year":"2007","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib17","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1016\/j.biomaterials.2009.12.006","article-title":"The regulation of stem cell differentiation by cell\u2013cell contact on micropatterned material surfaces","volume":"31","author":"Tang","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib18","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1016\/j.biomaterials.2011.01.078","article-title":"Critical areas of cell adhesion on micropatterned surfaces","volume":"32","author":"Yan","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.biomaterials.2011.10.003","article-title":"Cell adhesion, spreading, and proliferation on surface functionalized with RGD nanopillar arrays","volume":"33","author":"Kafi","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1126\/science.1069040","article-title":"Crystal structure of the extracellular segment of integrin \u03b1V\u03b23 in complex with an Arg-Gly-Asp ligand","volume":"296","author":"Xiong","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib21","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1021\/nl803548b","article-title":"Impact of order and disorder in RGD nanopatterns on cell adhesion","volume":"9","author":"Huang","year":"2009","journal-title":"Nano Lett"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/nl104378f","article-title":"Nanolithographic control of the spatial organization of cellular adhesion receptors at the single-molecule level","volume":"11","author":"Schvartzman","year":"2011","journal-title":"Nano Lett"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib23","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/nl104079r","article-title":"Impact of local versus global ligand density on cellular adhesion","volume":"11","author":"Deeg","year":"2011","journal-title":"Nano Lett"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib24","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nmat2269","article-title":"Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells","volume":"7","author":"Benoit","year":"2008","journal-title":"Nat Mater"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nmeth.1487","article-title":"Mechanical regulation of cell function with geometrically modulated elastomeric substrates","volume":"7","author":"Fu","year":"2010","journal-title":"Nat Methods"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib26","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1016\/j.biomaterials.2010.05.002","article-title":"Osteogenic differentiation of human mesenchymal stem cells using RGD-modified BMP-2 coated microspheres","volume":"31","author":"Park","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/mabi.201000479","article-title":"The effect of conjugating RGD into 3D alginate hydrogels on adipogenic differentiation of human adipose-derived stromal cells","volume":"11","author":"Kang","year":"2011","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib28","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1016\/j.biomaterials.2011.02.029","article-title":"Advantages of RGD peptides for directing cell association with biomaterials","volume":"32","author":"Bellis","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib29","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.biomaterials.2011.11.023","article-title":"Control of cell nucleus shapes via micropillar patterns","volume":"33","author":"Pan","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.biomaterials.2011.09.071","article-title":"A\u00a0graphene-based platform for induced pluripotent stem cells culture and differentiation","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment","volume":"6","author":"McBeath","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib32","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1016\/j.biomaterials.2011.07.035","article-title":"Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion","volume":"32","author":"Peng","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib33","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1529\/biophysj.106.089730","article-title":"Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands","volume":"92","author":"Cavalcanti-Adam","year":"2007","journal-title":"Biophys J"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib34","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1021\/nl801483w","article-title":"Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing","volume":"8","author":"Arnold","year":"2008","journal-title":"Nano Lett"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1359-0286(99)00018-2","article-title":"Surfaces that resist bioadhesion","volume":"4","author":"Kingshott","year":"1999","journal-title":"Curr Opin Solid State Mater Sci"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jbm.a.32485","article-title":"Patterning N-type and S-type neuroblastoma cells with Pluronic F108 and ECM proteins","volume":"93A","author":"Corey","year":"2009","journal-title":"J\u00a0Biomed Mater Res Part A"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib37","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1021\/nl070098g","article-title":"Mimicking cellular environments by nanostructured soft interfaces","volume":"7","author":"Graeter","year":"2007","journal-title":"Nano Lett"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/la990070n","article-title":"Ordered deposition of inorganic clusters from micellar block copolymer films","volume":"16","author":"Spatz","year":"2000","journal-title":"Langmuir"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib39","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/bm800477s","article-title":"Technique of surface modification of a cell-adhesion-resistant hydrogel by a cell-adhesion-available inorganic microarray","volume":"9","author":"Sun","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib40","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1039\/b927168f","article-title":"Nanostructured interfaces with RGD arrays to control cell\u2013matrix interaction","volume":"6","author":"Huang","year":"2010","journal-title":"Soft Matter"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib41","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1016\/j.biomaterials.2012.05.010","article-title":"The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces","volume":"33","author":"Peng","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.01.021_bib42","doi-asserted-by":"crossref","first-page":"15472","DOI":"10.1021\/la103065x","article-title":"Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation","volume":"26","author":"Aydin","year":"2010","journal-title":"Langmuir"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961213000379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961213000379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:59:12Z","timestamp":1777485552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961213000379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0142961213000379"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2013.01.021","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of RGD nanospacing on differentiation of stem cells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2013.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}