{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:16Z","timestamp":1792785016374,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH ARRA","award":["RC4HL106625"],"award-info":[{"award-number":["RC4HL106625"]}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["R21HL094611"],"award-info":[{"award-number":["R21HL094611"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["HL076122"],"award-info":[{"award-number":["HL076122"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"crossref","award":["ES007122"],"award-info":[{"award-number":["ES007122"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH NCRR","award":["P20 RR-155557"],"award-info":[{"award-number":["P20 RR-155557"]}]},{"name":"NIH","award":["P30 CA22435"],"award-info":[{"award-number":["P30 CA22435"]}]},{"name":"INBRE Program of the National Institute of General Medical Sciences (NIGMS)","award":["8P20GM103449"],"award-info":[{"award-number":["8P20GM103449"]}],"id":[{"id":"https:\/\/ror.org\/04q48ey07","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources (NCRR)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.biomaterials.2013.01.028","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T17:18:27Z","timestamp":1359998307000},"page":"3256-3269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs"],"prefix":"10.1016","volume":"34","author":[{"given":"Dino","family":"Sokocevic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Bonenfant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy E.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary D.","family":"Borg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa J.","family":"Lathrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Wai","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"DeSarno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taka","family":"Ashikaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Loi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2013.01.028_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1513\/pats.200807-072GO","article-title":"General overview of lung transplantation and review of organ allocation","volume":"6","author":"Orens","year":"2009","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/mt.2010.177","article-title":"Breathing new life into lung transplantation therapy","volume":"18","author":"Panoskaltsis-Mortari","year":"2010","journal-title":"Mol Ther"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib3","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1089\/ten.tea.2009.0659","article-title":"Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded","volume":"16","author":"Price","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib4","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1089\/ten.tea.2009.0730","article-title":"Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation","volume":"16","author":"Cortiella","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1126\/science.1189345","article-title":"Tissue-engineered lungs for in\u00a0vivo implantation","volume":"329","author":"Petersen","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib6","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm.2193","article-title":"Regeneration and orthotopic transplantation of a bioartificial lung","volume":"16","author":"Ott","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib7","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.athoracsur.2011.05.018","article-title":"Enhanced in\u00a0vivo function of bioartificial lungs in rats","volume":"92","author":"Song","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.tea.2011.0301","article-title":"Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrow-derived mesenchymal stromal cells","volume":"18","author":"Daly","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1089\/ten.tec.2011.0567","article-title":"Comparative assessment of detergent-based protocols for mouse lung de-cellularization and re-cellularization","volume":"18","author":"Wallis","year":"2012","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1089\/ten.tec.2011.0584","article-title":"A\u00a0rapid lung de-cellularization protocol supports embryonic stem cell differentiation in\u00a0vitro and following implantation","volume":"18","author":"Jensen","year":"2012","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib11","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1089\/ten.tea.2011.0594","article-title":"A\u00a0nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in\u00a0vitro recellularization with mesenchymal stem cells","volume":"18","author":"Bonvillain","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000324896","article-title":"Matrix composition and mechanics of decellularized lung scaffolds","volume":"195","author":"Petersen","year":"2012","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0140-6736(12)60073-7","article-title":"Engineered whole organs and complex tissues","volume":"379","author":"Badylak","year":"2012","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.biomaterials.2013.01.028_bib14","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1089\/scd.2011.0105","article-title":"Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung","volume":"20","author":"Hoffman","year":"2011","journal-title":"Stem Cells Dev"},{"issue":"14","key":"10.1016\/j.biomaterials.2013.01.028_bib15","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1073\/pnas.1432929100","article-title":"Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects","volume":"100","author":"Ortiz","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib16","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1634\/stemcells.20-6-530","article-title":"Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality","volume":"20","author":"Sekiya","year":"2002","journal-title":"Stem Cells"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0300-483X(97)00108-X","article-title":"Mouse lung epithelial cell lines \u2013 tools for the study of differentiation and the neoplastic phenotype","volume":"123","author":"Malkinson","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib18","series-title":"Biostatistical analysis","author":"Zar","year":"1974"},{"issue":"9","key":"10.1016\/j.biomaterials.2013.01.028_bib19","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/rccm.201204-0754OC","article-title":"Acellular normal and fibrotic human lung matrices as a culture system for in\u00a0vitro investigation","volume":"186","author":"Booth","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.biomaterials.2013.01.028_bib20","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.biomaterials.2012.09.050","article-title":"Proteomic analysis of a decellularized human vocal fold mucosa scaffold using 2D electrophoresis and high-resolution mass spectrometry","volume":"34","author":"Welham","year":"2013","journal-title":"Biomaterials"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961213000446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961213000446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:46:21Z","timestamp":1758901581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961213000446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":20,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0142961213000446"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2013.01.028","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2013.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}