{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T18:40:37Z","timestamp":1778006437211,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC98-3112-B-038-002"],"award-info":[{"award-number":["NSC98-3112-B-038-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC99-3112-B-038-001"],"award-info":[{"award-number":["NSC99-3112-B-038-001"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 100-2314-B-038-013"],"award-info":[{"award-number":["NSC 100-2314-B-038-013"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 100-2120-M-038-002"],"award-info":[{"award-number":["NSC 100-2120-M-038-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.biomaterials.2013.12.005","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T08:31:34Z","timestamp":1389169894000},"page":"2680-2691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["The effect of type II collagen on MSC osteogenic differentiation and\u00a0bone defect repair"],"prefix":"10.1016","volume":"35","author":[{"given":"Li-Hsuan","family":"Chiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Fu T.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwu-Fen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Chean","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Lang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hui","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2013.12.005_bib1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1101\/gad.990702","article-title":"FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease","volume":"16","author":"Ornitz","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bbrc.2013.09.114","article-title":"Mesenchymal stem cells from osteoporotic patients feature impaired signal transduction but sustained osteoinduction in response to BMP-2 stimulation","volume":"440","author":"Prall","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/aja.1002000409","article-title":"Retarded chondrogenesis in transgenic mice with a type II collagen defect results in fracture healing abnormalities","volume":"200","author":"Hiltunen","year":"1994","journal-title":"Dev Dyn"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib5","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1073\/pnas.88.17.7640","article-title":"Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia","volume":"88","author":"Vandenberg","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib6","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1101\/gad.9.22.2821","article-title":"Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone","volume":"9","author":"Li","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/ten.tec.2008.0297","article-title":"Chondrogenic priming of human bone marrow stromal cells: a better route to bone repair?","volume":"15","author":"Farrell","year":"2009","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib8","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1016\/j.actbio.2010.01.037","article-title":"Chondrogenic pre-induction of human mesenchymal stem cells on beta-TCP: enhanced bone quality by endochondral heterotopic bone formation","volume":"6","author":"Janicki","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib9","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1359\/jbmr.090510","article-title":"MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny","volume":"24","author":"Szabova","year":"2009","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib10","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/jcp.22976","article-title":"Diverse effects of type II collagen on osteogenic and adipogenic differentiation of mesenchymal stem cells","volume":"227","author":"Chiu","year":"2012","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/scd.2009.0208","article-title":"TGF-beta enhances the integrin alpha2beta1-mediated attachment of mesenchymal stem cells to type I collagen","volume":"19","author":"Warstat","year":"2010","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/oxfordjournals.jbchem.a002824","article-title":"Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen","volume":"129","author":"Mizuno","year":"2001","journal-title":"J\u00a0Biochem"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/15419060500242836","article-title":"ERK signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells on collagen I and vitronectin","volume":"11","author":"Salasznyk","year":"2004","journal-title":"Cell Commun Adhes"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib14","doi-asserted-by":"crossref","first-page":"055005","DOI":"10.1088\/1748-6041\/4\/5\/055005","article-title":"A\u00a0bone-like nano-hydroxyapatite\/collagen loaded injectable scaffold","volume":"4","author":"Huang","year":"2009","journal-title":"Biomed Mater"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jor.21032","article-title":"Repair of\u00a0large osteochondral defects in rabbits using porous hydroxyapatite\/collagen (HAp\/Col) and fibroblast growth factor-2 (FGF-2)","volume":"28","author":"Maehara","year":"2010","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib16","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1089\/ten.tec.2009.0212","article-title":"Quality of regenerated bone enhanced by implantation of octacalcium phosphate-collagen composite","volume":"16","author":"Masuda","year":"2010","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib17","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1432-0436.2001.670405.x","article-title":"Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2","volume":"67","author":"Carlberg","year":"2001","journal-title":"Differentiation"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1432-0436.1999.6420067.x","article-title":"Chondrogenic differentiation of murine C3H10T1\/2 multipotential mesenchymal cells: I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures","volume":"64","author":"Denker","year":"1999","journal-title":"Differentiation"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.biomaterials.2010.09.046","article-title":"The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells","volume":"32","author":"Ao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib20","first-page":"1","article-title":"Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat","volume":"68","author":"Sarikcioglu","year":"2009","journal-title":"Folia Morphol (Warsz)"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib21","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1074\/jbc.270.16.9420","article-title":"Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP)","volume":"270","author":"Stanford","year":"1995","journal-title":"J\u00a0Biol Chem"},{"issue":"Pt 4","key":"10.1016\/j.biomaterials.2013.12.005_bib22","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1242\/jcs.107.4.993","article-title":"Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge","volume":"107","author":"Tuckwell","year":"1994","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib23","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1177\/00220345010800061201","article-title":"Osteoblast integrin adhesion and signaling regulate mineralization","volume":"80","author":"Schneider","year":"2001","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1432-1033.1991.tb15852.x","article-title":"Isolation of human type X collagen and immunolocalization in fetal human cartilage","volume":"196","author":"Kirsch","year":"1991","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib25","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1302\/0301-620X.59B4.72756","article-title":"The role of three genetically distinct collagen types in endochondral ossification and calcification of cartilage","volume":"59-B","author":"von der Mark","year":"1977","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib26","doi-asserted-by":"crossref","first-page":"29309","DOI":"10.1074\/jbc.272.46.29309","article-title":"Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells","volume":"272","author":"Takeuchi","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib27","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1128\/MCB.16.10.5623","article-title":"Evidence for in\u00a0vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases","volume":"16","author":"Schlaepfer","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/363045a0","article-title":"Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation","volume":"363","author":"Egan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1359\/jbmr.081107","article-title":"JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation","volume":"24","author":"Matsuguchi","year":"2009","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jbm.a.31082","article-title":"Pre-culture period of mesenchymal stem cells in osteogenic media influences their in\u00a0vivo bone forming potential","volume":"82","author":"Castano-Izquierdo","year":"2007","journal-title":"J\u00a0Biomed Mater Res A"},{"key":"10.1016\/j.biomaterials.2013.12.005_bib31","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","author":"Einhorn","year":"1998","journal-title":"Clin Orthop Relat Res"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961213014749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961213014749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:59:37Z","timestamp":1758902377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961213014749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0142961213014749"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2013.12.005","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of type II collagen on MSC osteogenic differentiation and\u00a0bone defect repair","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2013.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}