{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:49:56Z","timestamp":1792784996440,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Taiwan National Science Council I-RiCE Program","award":["NSC101-2911-I-009-101"],"award-info":[{"award-number":["NSC101-2911-I-009-101"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["VGH102E1-007"],"award-info":[{"award-number":["VGH102E1-007"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["VGH102C-001"],"award-info":[{"award-number":["VGH102C-001"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC102-2120-M-010-002"],"award-info":[{"award-number":["NSC102-2120-M-010-002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC100-2314-B-010-030-MY3"],"award-info":[{"award-number":["NSC100-2314-B-010-030-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC102-2321-B-010-008"],"award-info":[{"award-number":["NSC102-2321-B-010-008"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Economic Affairs, Taiwan","award":["102-EC-17-A-17-S1-203"],"award-info":[{"award-number":["102-EC-17-A-17-S1-203"]}],"id":[{"id":"https:\/\/ror.org\/042ge0913","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Education"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.biomaterials.2014.01.024","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T03:30:18Z","timestamp":1390534218000},"page":"3607-3617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering"],"prefix":"10.1016","volume":"35","author":[{"given":"Wei-Cheng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Hua","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2014.01.024_bib1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1053\/j.gastro.2008.02.092","article-title":"Live donors in liver transplantation","volume":"134","author":"Brown","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/ajpgi.00138.2009","article-title":"Progress and future challenges in stem cell-derived liver technologies","volume":"297","author":"Dalgetty","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib3","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/hep.20469","article-title":"In\u00a0vitro hepatic differentiation of human mesenchymal stem cells","volume":"40","author":"Lee","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.scr.2008.07.005","article-title":"The therapeutic potential of bone marrow-derived mesenchymal stem cells on hepatic cirrhosis","volume":"2","author":"Dai","year":"2009","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib5","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1053\/j.gastro.2008.03.015","article-title":"Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells","volume":"134","author":"Kuo","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/biot.201000230","article-title":"Tissue engineering for clinical applications","volume":"5","author":"Bhatia","year":"2010","journal-title":"Biotechnol J"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00586-008-0745-3","article-title":"Scaffolding in tissue engineering: general approaches and tissue-specific considerations","volume":"17","author":"Chan","year":"2008","journal-title":"Eur Spine J"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1089\/ten.1999.5.407","article-title":"Polymer substrate topography actively regulates the multicellular organization and liver-specific functions of cultured hepatocytes","volume":"5","author":"Ranucci","year":"1999","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00000658-199807000-00002","article-title":"Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels","volume":"228","author":"Kim","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.biomaterials.2006.08.043","article-title":"Assessment of hepatocellular function within PEG hydrogels","volume":"28","author":"Underhill","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib11","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1089\/ten.2005.11.626","article-title":"Hepatic organoid formation in collagen sponge of cells isolated from human liver tissues","volume":"11","author":"Sugimoto","year":"2005","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3727\/000000003108746966","article-title":"De novo liver tissue formation in rats using a novel collagen-polypropylene scaffold","volume":"12","author":"Takimoto","year":"2003","journal-title":"Cell Transplant"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/ten.2006.12.33","article-title":"Alginate\/galactosylated chitosan\/heparin scaffold as a new synthetic extracellular matrix for hepatocytes","volume":"12","author":"Seo","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ten.a.2007.0131","article-title":"Mature human hepatocytes from ex\u00a0vivo differentiation of alginate-encapsulated hepatoblasts","volume":"14","author":"Cheng","year":"2008","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-bioeng-071910-124743","article-title":"Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds","volume":"13","author":"Badylak","year":"2011","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.molmed.2011.03.005","article-title":"Organ engineering based on decellularized matrix scaffolds","volume":"17","author":"Song","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm1684","article-title":"Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart","volume":"14","author":"Ott","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm.2193","article-title":"Regeneration and orthotopic transplantation of a bioartificial lung","volume":"16","author":"Ott","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib19","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nm.3154","article-title":"Regeneration and experimental orthotopic transplantation of a bioengineered kidney","volume":"19","author":"Song","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/hep.24067","article-title":"The use of whole organ decellularization for the generation of a vascularized liver organoid","volume":"53","author":"Baptista","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib21","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","article-title":"An overview of tissue and whole organ decellularization processes","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib22","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00383-009-2389-8","article-title":"Development of hepatic tissue engineering","volume":"25","author":"Fiegel","year":"2009","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib23","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm.2170","article-title":"Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix","volume":"16","author":"Uygun","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib24","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1016\/j.biomaterials.2006.02.014","article-title":"Decellularization of tissues and organs","volume":"27","author":"Gilbert","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib25","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1089\/ten.tec.2012.0334","article-title":"Determining the optimal decellularization and sterilization protocol for preparing a tissue scaffold of a human-sized liver tissue","volume":"19","author":"Kajbafzadeh","year":"2013","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib26","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1016\/j.biomaterials.2011.06.005","article-title":"Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix","volume":"32","author":"Lang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(12)60633-3","article-title":"Transplantation of an allogeneic vein bioengineered with autologous stem cells: a proof-of-concept study","volume":"380","author":"Olausson","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/ten.tec.2010.0698","article-title":"A\u00a0whole-organ regenerative medicine approach for liver replacement","volume":"17","author":"Soto-Gutierrez","year":"2011","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/hep.24012","article-title":"Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds","volume":"53","author":"Wang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib30","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2012.05.015","article-title":"Mesenchymal stromal cells: new directions","volume":"10","author":"Keating","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib31","doi-asserted-by":"crossref","first-page":"8995","DOI":"10.1016\/j.biomaterials.2012.08.058","article-title":"The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice","volume":"33","author":"Ji","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0167-4889(02)00323-3","article-title":"Cytokine regulation of liver development","volume":"1592","author":"Kinoshita","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0925-4773(02)00328-3","article-title":"Mechanisms controlling early development of the liver","volume":"120","author":"Duncan","year":"2003","journal-title":"Mech Dev"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2005.10.049","article-title":"Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem\/progenitor cells","volume":"130","author":"Oertel","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib35","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/hep.22047","article-title":"Identification of adult hepatic progenitor cells capable of repopulating injured rat liver","volume":"47","author":"Yovchev","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.biomaterials.2014.01.024_bib36","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1634\/stemcells.2007-0631","article-title":"Embryonic porcine liver as a source for transplantation: advantage of intact liver implants over isolated hepatoblasts in overcoming homeostatic inhibition by the quiescent host liver","volume":"26","author":"Katchman","year":"2008","journal-title":"Stem Cells"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014296121400026X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014296121400026X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:59:43Z","timestamp":1758902383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014296121400026X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S014296121400026X"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2014.01.024","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2014.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}