{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:18:42Z","timestamp":1770513522670,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry of Health and Welfare Affairs, Republic of Korea","award":["HI12C0005"],"award-info":[{"award-number":["HI12C0005"]}]},{"name":"Korea Healthcare Technology R&D Project, Ministry of Health and Welfare Affairs, Republic of Korea","award":["A091120"],"award-info":[{"award-number":["A091120"]}]},{"name":"Ministry of Science, ICT & Future Planning","award":["2011-0019730"],"award-info":[{"award-number":["2011-0019730"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.biomaterials.2014.03.083","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T04:31:04Z","timestamp":1398141064000},"page":"5711-5720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix"],"prefix":"10.1016","volume":"35","author":[{"given":"Byung Hyune","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung-Hwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Sook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Ram","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Ra","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Wook","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-1367","authenticated-orcid":false,"given":"Byoung-Hyun","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.biomaterials.2014.03.083_bib1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/BOR.0b013e3283103d12","article-title":"Angiogenesis in osteoarthritis","volume":"20","author":"Ashraf","year":"2008","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0002-9440(10)63889-8","article-title":"Short-term exposure of cartilage to blood results in chondrocyte apoptosis","volume":"162","author":"Hooiveld","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biomaterials.2014.03.083_bib3","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1017\/erm.2012.3","article-title":"Antiangiogenic and anticancer molecules in cartilage","volume":"14","author":"Patra","year":"2012","journal-title":"Expert Rev Mol Med"},{"issue":"51","key":"10.1016\/j.biomaterials.2014.03.083_bib4","doi-asserted-by":"crossref","first-page":"32419","DOI":"10.1074\/jbc.272.51.32419","article-title":"Identification of chondromodulin I as a novel endothelial cell growth inhibitor","volume":"272","author":"Hiraki","year":"1997","journal-title":"J\u00a0Biol Chem"},{"issue":"Suppl.\u00a0A","key":"10.1016\/j.biomaterials.2014.03.083_bib5","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1053\/joca.2001.0450","article-title":"Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation","volume":"9","author":"Shukunami","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.biomaterials.2014.03.083_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0092-8674(00)81848-6","article-title":"Endostatin: an endogenous inhibitor of angiogenesis and tumor growth","volume":"88","author":"O'Reilly","year":"1997","journal-title":"Cell"},{"issue":"16","key":"10.1016\/j.biomaterials.2014.03.083_bib7","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1093\/emboj\/18.16.4414","article-title":"Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding","volume":"18","author":"Yamaguchi","year":"1999","journal-title":"EMBO J"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1432-1033.1994.tb19070.x","article-title":"Cartilage oligomeric matrix protein and thrombospondin 1. Purification from articular cartilage, electron microscopic structure, and chondrocyte binding","volume":"223","author":"DiCesare","year":"1994","journal-title":"Eur J Biochem"},{"issue":"1","key":"10.1016\/j.biomaterials.2014.03.083_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/71517","article-title":"Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1","volume":"6","author":"Jim\u00e9nez","year":"2000","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.biomaterials.2014.03.083_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/mvre.2001.2311","article-title":"Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1","volume":"62","author":"Davies Cde","year":"2001","journal-title":"Microvasc Res"},{"issue":"27","key":"10.1016\/j.biomaterials.2014.03.083_bib11","doi-asserted-by":"crossref","first-page":"20806","DOI":"10.1074\/jbc.M110.118521","article-title":"Type IIB procollagen NH(2)-propeptide induces death of tumor cells via interaction with integrins alpha(V)beta(3) and alpha(V)beta(5)","volume":"285","author":"Wang","year":"2010","journal-title":"J\u00a0Biol Chem"},{"issue":"11","key":"10.1016\/j.biomaterials.2014.03.083_bib12","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1177\/002215549704501104","article-title":"Type IIA procollagen amino propeptide is localized in human embryonic tissues","volume":"45","author":"Oganesian","year":"1997","journal-title":"J\u00a0Histochem Cytochem"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/03008207.2011.629310","article-title":"Articular cartilage glycosaminoglycans inhibit the adhesion of endothelial cells","volume":"53","author":"Bara","year":"2012","journal-title":"Connect Tissue Res"},{"issue":"5","key":"10.1016\/j.biomaterials.2014.03.083_bib14","doi-asserted-by":"crossref","first-page":"R202","DOI":"10.1186\/ar4040","article-title":"Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties","volume":"14","author":"Calamia","year":"2012","journal-title":"Arthr Res Ther"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0008-6363(00)00233-9","article-title":"In\u00a0vitro tubulogenesis of endothelial cells by relaxation of the coupling extracellular matrix-cytoskeleton","volume":"49","author":"Deroanne","year":"2001","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.biomaterials.2014.03.083_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.yexcr.2004.03.035","article-title":"The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in\u00a0vitro","volume":"297","author":"Sieminski","year":"2004","journal-title":"Exp Cell Res"},{"issue":"6","key":"10.1016\/j.biomaterials.2014.03.083_bib17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.87.6.434","article-title":"Endothelial cell apoptosis in angiogenesis and vessel regression","volume":"87","author":"Dimmeler","year":"2000","journal-title":"Circ Res"},{"issue":"6626","key":"10.1016\/j.biomaterials.2014.03.083_bib18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.biomaterials.2014.03.083_bib19","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.yexcr.2006.04.003","article-title":"The inhibitory effects of endostatin on endothelial cells are modulated by extracellular matrix","volume":"312","author":"Delaney","year":"2006","journal-title":"Exp Cell Res"},{"issue":"11","key":"10.1016\/j.biomaterials.2014.03.083_bib20","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1158\/0008-5472.CAN-07-6390","article-title":"Beta 1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts","volume":"68","author":"Park","year":"2008","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1525-1594.2007.00363.x","article-title":"In\u00a0vivo cartilage tissue engineering using a cell-derived extracellular matrix scaffold","volume":"31","author":"Jin","year":"2007","journal-title":"Artif Organs"},{"issue":"4","key":"10.1016\/j.biomaterials.2014.03.083_bib22","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/jbm.a.32419","article-title":"Cartilage engineering using cell-derived extracellular matrix scaffold in\u00a0vitro","volume":"92","author":"Jin","year":"2010","journal-title":"J\u00a0Biomed Mater Res A"},{"issue":"20","key":"10.1016\/j.biomaterials.2014.03.083_bib23","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1016\/j.biomaterials.2010.03.053","article-title":"The chondrogenic differentiation of mesenchymal stem cells on an extracellular matrix scaffold derived from porcine chondrocytes","volume":"31","author":"Choi","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2014.03.083_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13770-012-0043-3","article-title":"Cartilage tissue engineering using chondrocyte derived extracellular matrix scaffold suppressed vessel invasion during chondrogenesis of mesenchymal stem cells in\u00a0vivo","volume":"9","author":"Choi","year":"2012","journal-title":"Tissue Eng Regen Med"},{"issue":"23\u201324","key":"10.1016\/j.biomaterials.2014.03.083_bib25","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1089\/ten.tea.2010.0605","article-title":"The maturity of tissue-engineered cartilage in\u00a0vitro affects the reparability for osteochondral defect","volume":"17","author":"Jin","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2014.03.083_bib26","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1002\/adfm.201102695","article-title":"Using cartilage extracellular matrix (CECM) membrane to enhance the reparability of the bone marrow stimulation technique for articular cartilage effect in canine model","volume":"22","author":"Li","year":"2012","journal-title":"Adv Funct Mater"},{"issue":"6","key":"10.1016\/j.biomaterials.2014.03.083_bib27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00003226-199811000-00008","article-title":"Angiogenesis in corneal disease: histologic evaluation of 254 human corneal buttons with neovascularization","volume":"17","author":"Cursiefen","year":"1997","journal-title":"Cornea"},{"issue":"10","key":"10.1016\/j.biomaterials.2014.03.083_bib28","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/01.brs.0000162624.95262.73","article-title":"Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in\u00a0vitro","volume":"30","author":"Johnson","year":"2005","journal-title":"Spine"},{"issue":"1","key":"10.1016\/j.biomaterials.2014.03.083_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0026-2862(77)90141-8","article-title":"Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis","volume":"14","author":"Ausprunk","year":"1977","journal-title":"Microvasc Res"},{"issue":"9","key":"10.1016\/j.biomaterials.2014.03.083_bib30","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1002\/art.30335","article-title":"Chondromodulin I stabilizes the chondrocyte phenotype and inhibits endochondral ossification of cartilage repair tissue","volume":"63","author":"Klinger","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.biomaterials.2014.03.083_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/08820530902800017","article-title":"Review of the ocular angiogenesis animal models","volume":"24","author":"Montezuma","year":"2009","journal-title":"Semin Ophthalmol"},{"issue":"6","key":"10.1016\/j.biomaterials.2014.03.083_bib32","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/0002-9394(68)90821-0","article-title":"Prevention of corneal vascularization","volume":"66","author":"Ey","year":"1968","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"10.1016\/j.biomaterials.2014.03.083_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/ICO.0000000000000007","article-title":"Comparative study of ranibizumab and bevacizumab on corneal neovascularization in rabbits","volume":"33","author":"Kim","year":"2014","journal-title":"Cornea"},{"issue":"10","key":"10.1016\/j.biomaterials.2014.03.083_bib34","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00417-007-0542-4","article-title":"Inhibition of corneal angiogenesis by ascorbic acid in the rat model","volume":"245","author":"Peyman","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib35","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1001\/archopht.1940.00860130586006","article-title":"Plastic repair of conjunctival defects with fetal membrane","volume":"23","author":"De Rotth","year":"1940","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"10.1016\/j.biomaterials.2014.03.083_bib36","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ajo.2007.08.003","article-title":"Evaluation of visual acuity and color vision in normal human eyes with a suture-less temporary amniotic membrane patch","volume":"144","author":"Ijiri","year":"2007","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"10.1016\/j.biomaterials.2014.03.083_bib37","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.ophtha.2008.04.039","article-title":"Ex\u00a0vivo expansion and transplantation of limbal epithelial stem cells","volume":"115","author":"Shortt","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.biomaterials.2014.03.083_bib38","doi-asserted-by":"crossref","unstructured":"Feng Y, Borrelli M, Reichl S, Schrader S, Geerling G. Review of alternative carrier materials for ocular surface reconstruction. Curr Eye Res [Epub ahead of Print. Jan 9, 2014]. http:\/\/dx.doi.org\/10.3109\/02713683.2013.853803.","DOI":"10.3109\/02713683.2013.853803"},{"issue":"5","key":"10.1016\/j.biomaterials.2014.03.083_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.matbio.2004.06.003","article-title":"Endostatin\/collagen XVIII-an inhibitor of angiogenesis-is expressed in cartilage and fibrocartilage","volume":"23","author":"Pufe","year":"2004","journal-title":"Matrix Biol"},{"issue":"5","key":"10.1016\/j.biomaterials.2014.03.083_bib40","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00223-009-9287-x","article-title":"Endostatin affects osteoblast behavior in\u00a0vitro, but collagen XVIII\/endostatin is not essential for skeletal development in\u00a0vivo","volume":"85","author":"Sipola","year":"2009","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.03.083_bib41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1014027218980","article-title":"Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes","volume":"4","author":"Erg\u00fcn","year":"2001","journal-title":"Angiogenesis"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961214003585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961214003585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:59:57Z","timestamp":1758902397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961214003585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":41,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0142961214003585"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2014.03.083","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2014.03.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}