{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:46:28Z","timestamp":1790379988167,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.biomaterials.2014.07.033","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T13:31:14Z","timestamp":1407677474000},"page":"9208-9223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"title":["The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells"],"prefix":"10.1016","volume":"35","author":[{"given":"Hong-juan","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2014.07.033_bib1","first-page":"69","article-title":"Global caner statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrd2137","article-title":"Tumour-initiating cells: challenges and opportunities for anticancer drug discovery","volume":"8","author":"Zhou","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000318862","article-title":"Predictive value of cancer stem-like cells and cancer-associated genetic markers for peritoneal recurrence of colorectal cancer in patients after curative surgery","volume":"78","author":"Nakamura","year":"2010","journal-title":"Oncology"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib5","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.3892\/ol.2013.1272","article-title":"CD44+ gastric cancer cells with stemness properties are chemoradioresistant and highly invasive","volume":"5","author":"Sun","year":"2013","journal-title":"Oncol Lett"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib6","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/stem.30","article-title":"Identification of gastric cancer stem cells using the cell surface marker CD44","volume":"27","author":"Takaishi","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib7","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00432-011-1038-5","article-title":"Identification of CD44+CD24+ gastric cancer stem cells","volume":"137","author":"Zhang","year":"2011","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/cr.2011.109","article-title":"Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients","volume":"22","author":"Chen","year":"2012","journal-title":"Cell Res"},{"issue":"41","key":"10.1016\/j.biomaterials.2014.07.033_bib9","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.3748\/wjg.14.6376","article-title":"Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance","volume":"14","author":"Ghaffarzadehgan","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1096-9098(199905)71:1<22::AID-JSO5>3.0.CO;2-I","article-title":"Prognostic significance of CD44 and nm23 expression in patients with stage II and stage IIIA gastric carcinoma","volume":"71","author":"Yoo","year":"1999","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3748\/wjg.v12.i1.36","article-title":"CD44v6 in peripheral blood and bone marrow of patients with gastric cancer as micro-metastasis","volume":"12","author":"Wang","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"4","key":"10.1016\/j.biomaterials.2014.07.033_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/mp800024g","article-title":"Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor","volume":"5","author":"Platt","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00280-010-1462-2","article-title":"Hyaluronic acid-paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts","volume":"68","author":"Stefano","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib14","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/bc300632w","article-title":"Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors","volume":"24","author":"Wei","year":"2013","journal-title":"Bioconjug Chem"},{"issue":"1","key":"10.1016\/j.biomaterials.2014.07.033_bib15","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/mp900242f","article-title":"CD44-targeted microparticles for delivery of cisplatin to peritoneal metastases","volume":"7","author":"Li","year":"2010","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib16","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.biomaterials.2013.09.089","article-title":"Biodegradable self-assembled nanoparticles of poly (D,L-lactide-coglycolide)\/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer","volume":"35","author":"Huang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib17","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1016\/j.biomaterials.2014.01.011","article-title":"Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib18","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1021\/mp2000428","article-title":"Characterization of CD44-mediated cancer cell uptake and intracellular distribution of hyaluronan-grafted liposomes","volume":"8","author":"Qhattal","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2011.09.006","article-title":"Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery","volume":"421","author":"Liu","year":"2011","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib20","doi-asserted-by":"crossref","first-page":"7941","DOI":"10.1016\/j.biomaterials.2011.06.077","article-title":"Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging","volume":"32","author":"Lim","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib21","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.biomaterials.2009.12.043","article-title":"The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(\u03b3-benzyl L-glutamate)-b-hyaluronan polymersomes","volume":"31","author":"Upadhyay","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib22","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ijc.11615","article-title":"Loading mitomycin C inside long circulation hyaluronan targeting nano-liposomes increases its antitumor activity in three mice tumor models","volume":"108","author":"Peer","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jconrel.2011.06.031","article-title":"Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response","volume":"156","author":"Mizrahy","year":"2011","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","article-title":"Identification of selective inhibitors of cancer stem cells by high-throughput screening","volume":"138","author":"Gupta","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.bbrc.2010.03.138","article-title":"Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells","volume":"394","author":"Fuchs","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.biomaterials.2014.07.033_bib26","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ygyno.2013.03.005","article-title":"The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells","volume":"129","author":"Kusunoki","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/157340611794859307","article-title":"Effects of salinomycin on cancer stem cell in human lung adenocarcinoma","volume":"7","author":"Wang","year":"2011","journal-title":"Med Chem"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib28","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1245\/s10434-011-1561-2","article-title":"Salinomycin selectively targets \u2018CD133+\u2019 cell subpopulations and decreases malignant traits in colorectal cancer lines","volume":"18","author":"Dong","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2008.03.022","article-title":"A\u00a0potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes","volume":"129","author":"Liu","year":"2008","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib30","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1039\/c2cc17995d","article-title":"Targeting carbon nanotubes against cancer","volume":"48","author":"Fabbro","year":"2012","journal-title":"Chem Commun"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib31","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.280.5367.1253","article-title":"Fullerene pipes","volume":"280","author":"Liu","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib32","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1021\/nn9006362","article-title":"Cell behaviors on polysaccharide-wrapped single-wall carbon nanotubes: a quantitative study of the surface properties of biomimetic nanofibrous scaffolds","volume":"3","author":"Zhang","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib33","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/nl060177c","article-title":"Oops they did it again! Carbon nanotubes hoax scientists in viability assays","volume":"6","author":"W\u00f6rle-Knirsch","year":"2006","journal-title":"Nano Lett"},{"issue":"19","key":"10.1016\/j.biomaterials.2014.07.033_bib34","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1158\/0008-5472.CAN-09-2994","article-title":"Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission","volume":"69","author":"Hirsch","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1248\/bpb.32.825","article-title":"Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells","volume":"32","author":"Takehara","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib36","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.biomaterials.2011.01.038","article-title":"The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery","volume":"32","author":"Yao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxlet.2006.11.001","article-title":"Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants","volume":"168","author":"Pulskamp","year":"2007","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00396-009-2126-9","article-title":"An investigation on dispersion of carbon nanotubes in chitosan aqueous solutions","volume":"288","author":"Shieh","year":"2010","journal-title":"Colloid Polym Sci"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib39","doi-asserted-by":"crossref","first-page":"15636","DOI":"10.1039\/c003767b","article-title":"Novel biocompatible chitosan decorated single-walled carbon nanotubes (SWNTs) for biomedical applications: theoretical and experimental investigations","volume":"12","author":"Piovesan","year":"2010","journal-title":"Phys Chem Chem Phys"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib40","first-page":"78","article-title":"Non-covalent modification of multi-walled carbon nanotubes with a low molecular weight chitosan and their stability in the aqueous solutions","volume":"37","author":"Sun","year":"2009","journal-title":"New Chem Mater"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib41","doi-asserted-by":"crossref","first-page":"536","DOI":"10.18433\/J3JC7C","article-title":"Chitosan mediated targeted drug delivery system: a review","volume":"13","author":"Patel","year":"2010","journal-title":"J\u00a0Pharm Pharm Sci"},{"key":"10.1016\/j.biomaterials.2014.07.033_bib42","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1016\/j.biomaterials.2009.07.025","article-title":"Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes","volume":"30","author":"Zhang","year":"2009","journal-title":"Biomaterials"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961214008424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961214008424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:02:04Z","timestamp":1758902524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961214008424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":42,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0142961214008424"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2014.07.033","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2014.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}