{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:58:25Z","timestamp":1792123105611,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"the Dutch Ministry of Economic Affairs"},{"name":"the Dutch Arthritis Foundation","award":["LLP-22"],"award-info":[{"award-number":["LLP-22"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.biomaterials.2015.02.109","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T11:13:23Z","timestamp":1426677203000},"page":"426-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses"],"prefix":"10.1016","volume":"53","author":[{"given":"Audrey","family":"Petit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everaldo M.","family":"Redout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris H.","family":"van de Lest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janny C.","family":"de Grauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Meyboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"van Midwoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Vermonden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim E.","family":"Hennink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ren\u00e9 van Weeren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2015.02.109_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1023\/A:1020006909285","article-title":"Determinants of locomotor disability in people aged 55 years and over: the Rotterdam study","volume":"17","author":"Odding","year":"2001","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib2","first-page":"S10","article-title":"Epidemiology of osteoarthritis and associated comorbidities","volume":"4","author":"Suri","year":"2012","journal-title":"PMR"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib3","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cveq.2010.07.007","article-title":"Pain in osteoarthritis","volume":"26","author":"van Weeren","year":"2010","journal-title":"Vet Clin North Am Equine Pract"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3810\/psm.2011.09.1922","article-title":"The NSAID dilemma: managing osteoarthritis in high-risk patients","volume":"39","author":"Roth","year":"2011","journal-title":"Phys Sportsmed"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.joca.2005.02.004","article-title":"Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: a human in\u00a0vitro study","volume":"13","author":"Mastbergen","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/FPC.0b013e32834f94cb","article-title":"Celecoxib pathways: pharmacokinetics and pharmacodynamics","volume":"22","author":"Gong","year":"2012","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1517\/14740338.4.6.1005","article-title":"Celecoxib and cardiovascular risks","volume":"4","author":"Brophy","year":"2005","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tvjl.2010.09.019","article-title":"Intra-articular drug delivery: the challenge to extend drug residence time within the joint","volume":"190","author":"Edwards","year":"2011","journal-title":"Vet J"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib9","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.3390\/ijms11104106","article-title":"Efficacy of intra-articular injection of celecoxib in a rabbit model of osteoarthritis","volume":"11","author":"Jiang","year":"2010","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejpb.2009.06.009","article-title":"Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance","volume":"73","author":"Butoescu","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib11","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.addr.2006.01.018","article-title":"Intra-articular drug delivery in osteoarthritis","volume":"58","author":"Gerwin","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib13","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/j.pmrj.2012.02.010","article-title":"Injectable medications for osteoarthritis","volume":"4","author":"Hameed","year":"2012","journal-title":"PM R"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1053\/berh.2001.0177","article-title":"Injections in the treatment of osteoarthritis","volume":"15","author":"Xavier","year":"2001","journal-title":"Best Pract Res Cl Rh"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.addr.2012.07.007","article-title":"Remote and local control of stimuli responsive materials for therapeutic applications","volume":"65","author":"Chan","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib16","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.progpolymsci.2012.08.002","article-title":"Recent progress of in situ formed gels for biomedical applications","volume":"38","author":"Ko","year":"2013","journal-title":"Prog Polym Sci"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2011.11.031","article-title":"Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers","volume":"159","author":"Wolinsky","year":"2012","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib18","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1021\/cr200157d","article-title":"Hydrogels for protein delivery","volume":"112","author":"Vermonden","year":"2012","journal-title":"Chem Rev"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib19","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/polym3020779","article-title":"Thermosensitive self-assembling block copolymers as drug delivery systems","volume":"3","author":"Bonacucina","year":"2011","journal-title":"Polymers"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2008.01.057","article-title":"In situ gelling hydrogels for pharmaceutical and biomedical applications","volume":"355","author":"van Tomme","year":"2008","journal-title":"Int J Pharm"},{"issue":"27","key":"10.1016\/j.biomaterials.2015.02.109_bib21","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1016\/j.biomaterials.2014.05.064","article-title":"Release behavior and intra-articular biocompatibility of celecoxib-loaded acetyl-capped PCLA-PEG-PCLA thermogels","volume":"35","author":"Petit","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0168-3659(01)00276-0","article-title":"Biodegradable block copolymers for delivery of proteins and water-insoluble drugs","volume":"72","author":"Zentner","year":"2001","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijpharm.2005.01.017","article-title":"Injectable biodegradable temperature-responsive PLGA\u2013PEG\u2013PLGA copolymers: synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels","volume":"294","author":"Qiao","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3109\/1061186X.2010.519031","article-title":"A\u00a0thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel","volume":"19","author":"Gao","year":"2011","journal-title":"J\u00a0Drug Target"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.addr.2009.04.010","article-title":"OncoGel\u00ae (ReGel\u00ae\/paclitaxel) - clinical applications for a novel paclitaxel delivery system","volume":"61","author":"Elstad","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jbm.a.31300","article-title":"Characterization, degradation, and mechanical strength of poly(D,L-lactide-co-\u03b5-caprolactone)-poly(ethylene glycol)-poly(D,L-lactide-co-\u03b5-caprolactone)","volume":"83A","author":"Bramfeldt","year":"2007","journal-title":"J\u00a0Biomed Mater Res A"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib27","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1016\/j.biomaterials.2011.03.046","article-title":"Biodegradable and thermoreversible PCLA\u2013PEG\u2013PCLA hydrogel as a barrier for prevention of post-operative adhesion","volume":"32","author":"Zhang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib28","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1021\/bm400804w","article-title":"Effect of polymer composition on rheological and degradation properties of temperature-responsive gelling systems composed of acyl-capped PCLA-PEG-PCLA","volume":"14","author":"Petit","year":"2013","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib29","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1016\/j.actbio.2012.07.044","article-title":"Modulating the rheological and degradation properties of hydrogels composed of blends of PCLA-PEG-PCLA triblock copolymers and their fully hexanoyl-capped derivatives","volume":"8","author":"Petit","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib30","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1016\/j.biomaterials.2013.07.046","article-title":"In situ forming acyl-capped PCLA-PEG-PCLA triblock copolymer based hydrogels","volume":"34","author":"Sandker","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib31","first-page":"p19","article-title":"Guide for veterinary services and judging of equestrian events","author":"Anonymous","year":"1991","journal-title":"Am Assoc Equine Pract"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib32","doi-asserted-by":"crossref","first-page":"764621","DOI":"10.1155\/2012\/764621","article-title":"A\u00a0review of translational animal models for knee osteoarthritis","volume":"2012","author":"Gregory","year":"2012","journal-title":"Arthritis"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tvjl.2004.07.008","article-title":"Medical treatment of osteoarthritis in the horse - a review","volume":"171","author":"Goodrich","year":"2006","journal-title":"Vet J"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib34","first-page":"10","article-title":"Intraarticular hyaluronan injections in the treatment of osteoarthritis: state-of-the-art review","volume":"39","author":"Peyron","year":"1993","journal-title":"J\u00a0Rheumatol Suppl"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF03261884","article-title":"Hyaluronic acid in the treatment of knee osteoarthritis: a systematic review and meta-analysis with emphasis on the efficacy of different products","volume":"26","author":"Colen","year":"2012","journal-title":"BioDrugs"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1308\/rcsann.2013.95.8.545","article-title":"The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain","volume":"95","author":"Trigkilidas","year":"2013","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib37","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/1529-0131(200006)43:6<1192::AID-ANR2>3.0.CO;2-L","article-title":"Intra-articular injection of hyaluronan as treatment for knee osteoarthritis: what is the evidence?","volume":"43","author":"Brandt","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib38","article-title":"Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis","volume":"15","author":"Reichenbach","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib39","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/mabi.200600127","article-title":"Reverse thermal gelation of aliphatically modified biodegradable triblock copolymers","volume":"6","author":"Jo","year":"2006","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib40","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1053\/jvet.2001.28430","article-title":"Synovial fluid cytokines and eicosanoids as markers of joint disease in horses","volume":"30","author":"Bertone","year":"2001","journal-title":"Vet Surg"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2746\/042516409X436286","article-title":"In\u00a0vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis","volume":"41","author":"de Grauw","year":"2009","journal-title":"Equine Vet J"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib42","doi-asserted-by":"crossref","DOI":"10.1186\/ar2640","article-title":"Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study","volume":"11","author":"de Grauw","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib44","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1099-081X(199909)20:6<293::AID-BDD188>3.0.CO;2-X","article-title":"Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human","volume":"20","author":"Paulson","year":"1999","journal-title":"Biopharm Drug Dispos"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib45","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.2042-3306.2010.00077.x","article-title":"Intra-articular opioid analgesia is effective in reducing pain and inflammation in an equine LPS induced synovitis model","volume":"42","author":"van Loon","year":"2010","journal-title":"Equine Vet J"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib46","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1021\/bp060121o","article-title":"Proteomic analysis for the assessment of different lots of fetal bovine serum as a raw material for cell culture. Part IV. Application of proteomics to the manufacture of biological drugs","volume":"22","author":"Zheng","year":"2006","journal-title":"Biotechnol Prog"},{"issue":"19\u201320","key":"10.1016\/j.biomaterials.2015.02.109_bib47","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ten.tea.2011.0657","article-title":"Hypoxia impedes hypertrophic chondrogenesis of human multipotent stromal cells","volume":"18","author":"Gawlitta","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib48","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1002\/jps.22630","article-title":"In\u00a0vitro and in\u00a0vivo characteristics of celecoxib in situ formed suspensions for intra-articular administration","volume":"100","author":"Larsen","year":"2011","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2474-14-18","article-title":"Cartilage collagen damage in hip osteoarthritis similar to that seen in knee osteoarthritis; a case-control study of relationship between collagen, glycosaminoglycan and cartilage swelling","volume":"14","author":"Hosseininia","year":"2013","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"10.1016\/j.biomaterials.2015.02.109_bib50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijpharm.2011.03.051","article-title":"Higuchi equation: derivation, applications, use and misuse","volume":"418","author":"Siepmann","year":"2011","journal-title":"Int J Pharm"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar2515","article-title":"Vascular involvement in rheumatic diseases: 'vascular rheumatology'","volume":"10","author":"Szekanecz","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00003086-197503000-00003","article-title":"Synovial fluid analysis","volume":"107","author":"Yehia","year":"1975","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.biomaterials.2015.02.109_bib53","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jpba.2008.12.006","article-title":"Determination of two COX-2 inhibitors in serum and synovial fluid of patients with inflammatory arthritis by ultra performance liquid chromatography\u2013inductively coupled plasma mass spectroscopy and quadrupole time-of-flight mass spectrometry","volume":"49","author":"Gika","year":"2009","journal-title":"J\u00a0Pharm Biomed Anal"},{"issue":"9894","key":"10.1016\/j.biomaterials.2015.02.109_bib54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(13)60900-9","article-title":"Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials","volume":"382","author":"Bhala","year":"2013","journal-title":"Lancet"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961215002471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961215002471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:09:13Z","timestamp":1758902953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961215002471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":54,"alternative-id":["S0142961215002471"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2015.02.109","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained intra-articular release of celecoxib from in situ forming gels made of acetyl-capped PCLA-PEG-PCLA triblock copolymers in horses","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2015.02.109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}