{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:44:37Z","timestamp":1792115077913,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.biomaterials.2015.03.037","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T01:31:26Z","timestamp":1428543086000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer"],"prefix":"10.1016","volume":"55","author":[{"given":"Long Binh","family":"Vong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yoshitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2015.03.037_bib1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","article-title":"Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences","volume":"126","author":"Loftus","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00281-012-0352-6","article-title":"Inflammation and colorectal cancer: colitis-associated neoplasia","volume":"35","author":"Grivennikov","year":"2013","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrg2574","article-title":"New insights into the aetiology of colorectal cancer from genome-wide association studies","volume":"10","author":"Tenesa","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib8","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1128\/MCB.01454-06","article-title":"Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1","volume":"27","author":"Gommeaux","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1158\/1940-6207.CAPR-09-0117","article-title":"Resveratrol suppresses colitis and colon cancer associated with colitis","volume":"3","author":"Cui","year":"2010","journal-title":"Cancer Prev Res"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib10","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/carcin\/23.6.993","article-title":"Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine","volume":"23","author":"Seril","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(00)02034-1","article-title":"Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial","volume":"355","author":"Douillard","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib12","first-page":"2182","article-title":"Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)","volume":"7","author":"Mathijssen","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib13","doi-asserted-by":"crossref","first-page":"19143","DOI":"10.1073\/pnas.1319123110","article-title":"Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11)","volume":"110","author":"Chen","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib14","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrd2614","article-title":"Nanoparticle therapeutics: an emerging treatment modality for cancer","volume":"7","author":"Davis","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1126\/scitranslmed.3003651","article-title":"Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile","volume":"4","author":"Hrkach","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib16","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1056\/NEJMra0912273","article-title":"Nanomedicine","volume":"363","author":"Kim","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib17","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1158\/1535-7163.MCT-08-0476","article-title":"In\u00a0vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities","volume":"7","author":"Bisht","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib18","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1021\/nn405674m","article-title":"Nanoparticles for combination drug therapy","volume":"7","author":"Ma","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1504\/IJBNN.2013.054515","article-title":"Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps","volume":"3","author":"Bergin","year":"2013","journal-title":"Int J Biomed Nanosci Nanotechnol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.etap.2010.05.004","article-title":"Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles","volume":"30","author":"Park","year":"2010","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1053\/j.gastro.2012.06.043","article-title":"An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice","volume":"143","author":"Vong","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib22","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1016\/j.biomaterials.2013.06.032","article-title":"Suppression of NSAID-induced small intestinal inflammation by orally administered redox nanoparticles","volume":"34","author":"Sha","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib23","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib24","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s00535-013-0836-8","article-title":"Oral nanotherapeutics: effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis","volume":"49","author":"Vong","year":"2014","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib25","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1016\/j.biomaterials.2011.07.014","article-title":"The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles","volume":"32","author":"Yoshitomi","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib26","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1158\/0008-5472.CAN-05-4199","article-title":"Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models","volume":"66","author":"Kirpotin","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib27","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1038\/nprot.2006.446","article-title":"High resolution colonoscopy in live mice","volume":"1","author":"Becker","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib28","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1111\/bph.12584","article-title":"Targeted inhibition of IL-18 attenuates irinotecan-induced intestinal mucositis in mice","volume":"171","author":"Lima-Junior","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00280-003-0682-0","article-title":"Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion","volume":"52","author":"Kurita","year":"2003","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib30","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrgastro.2013.35","article-title":"The gastrointestinal mucus system in health and disease","volume":"10","author":"Johansson","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"21","key":"10.1016\/j.biomaterials.2015.03.037_bib31","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1158\/0008-5472.CAN-05-2782","article-title":"Claudin proteins in human cancer: promising new targets for diagnosis and therapy","volume":"65","author":"Morin","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jconrel.2013.08.011","article-title":"Redox nanoparticle therapeutics to cancer\u2013increase in therapeutic effect of doxorubicin, suppressing its adverse effect","volume":"172","author":"Yoshitomi","year":"2013","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib33","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/annonc\/mdf337","article-title":"Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity","volume":"13","author":"Xu","year":"2002","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.biomaterials.2015.03.037_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.canlet.2005.06.039","article-title":"The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB","volume":"229","author":"Kokura","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/7410","article-title":"Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB","volume":"5","author":"Wang","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1172\/JCI11991","article-title":"Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB","volume":"107","author":"Baldwin","year":"2001","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib37","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1053\/j.gastro.2010.01.058","article-title":"Inflammation and colon cancer","volume":"138","author":"Terzic","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1200\/JCO.2005.05.2597","article-title":"Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06","volume":"25","author":"Kopec","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib39","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1200\/JCO.2007.13.1193","article-title":"EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer","volume":"26","author":"Sobrero","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib40","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","article-title":"Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer","volume":"350","author":"Hurwitz","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib41","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1200\/JCO.2008.19.5362","article-title":"Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials","volume":"27","author":"Sargent","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrd4201","article-title":"Targeting tumour-supportive cellular machineries in anticancer drug development","volume":"13","author":"Dobbelstein","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib43","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1158\/0008-5472.CAN-12-1879","article-title":"The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation","volume":"72","author":"Mitchell","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4155\/tde.11.153","article-title":"Nitroxide radicals and nanoparticles: a partnership for nanomedicine radical delivery","volume":"3","author":"Nagasaki","year":"2012","journal-title":"Ther Deliv"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib45","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.freeradbiomed.2007.02.030","article-title":"The chemistry and biology of nitroxide compounds","volume":"42","author":"Soule","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib46","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1021\/bm801278n","article-title":"Design of core\u2013shell-type nanoparticles carrying stable radicals in the core","volume":"10","author":"Yoshitomi","year":"2009","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib47","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2217\/nnm.12.2","article-title":"Redox nanoparticle treatment protects against neurological deficit in focused ultrasound-induced intracerebral hemorrhage","volume":"7","author":"Chonpathompikunlert","year":"2012","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib48","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1227\/NEU.0b013e31820c02d9","article-title":"Newly synthesized radical-containing nanoparticles enhance neuroprotection after cerebral ischemia-reperfusion injury","volume":"68","author":"Marushima","year":"2011","journal-title":"Neurosurgery"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2008.12.023","article-title":"Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles","volume":"236","author":"Cho","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib50","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/10937404.2011.615113","article-title":"Toxicology of nanomaterials used in nanomedicine","volume":"14","author":"Zhao","year":"2011","journal-title":"J\u00a0Toxicol Environ Health B Crit Rev"},{"key":"10.1016\/j.biomaterials.2015.03.037_bib51","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","article-title":"Inflammation meets cancer, with NF-kappaB as the matchmaker","volume":"12","author":"Ben-Neriah","year":"2011","journal-title":"Nat Immunol"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961215003154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961215003154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:06:17Z","timestamp":1758902777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961215003154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":51,"alternative-id":["S0142961215003154"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2015.03.037","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2015.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}