{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:00:36Z","timestamp":1771603236262,"version":"3.50.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2013CB934400"],"award-info":[{"award-number":["2013CB934400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB932400"],"award-info":[{"award-number":["2012CB932400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61361160412 and 21575096"],"award-info":[{"award-number":["61361160412 and 21575096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271429"],"award-info":[{"award-number":["31271429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province of China","doi-asserted-by":"publisher","award":["BK20130052"],"award-info":[{"award-number":["BK20130052"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province of China","doi-asserted-by":"publisher","award":["BK20130298"],"award-info":[{"award-number":["BK20130298"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Six Talent Peaks Project of Jiangsu Province","award":["2013-XCL-036"],"award-info":[{"award-number":["2013-XCL-036"]}]},{"name":"Jiangsu Provincial Innovative Research Team and Program for Changjiang Scholars and Innovative Research Team in University","award":["IRT1075"],"award-info":[{"award-number":["IRT1075"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.biomaterials.2015.08.044","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T18:01:20Z","timestamp":1440784880000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["A real-time documentation and mechanistic investigation of quantum dots-induced autophagy in live Caenorhabditis elegans"],"prefix":"10.1016","volume":"72","author":[{"given":"Yanfeng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2015.08.044_bib1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/anie.200602866","article-title":"Magnetic nanoparticles: synthesis, protection, functionalization, and application","volume":"46","author":"Lu","year":"2007","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.1060928","article-title":"Carbon nanotubes-the route toward applications","volume":"297","author":"Baughman","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib3","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1126\/science.281.5385.2016","article-title":"Quantum dot bioconjugates for ultrasensitive nonisotopic detection","volume":"281","author":"Chan","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib4","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.281.5385.2013","article-title":"Semiconductor nanocrystals as fluorescent biological labels","volume":"281","author":"Bruchez","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nmat1390","article-title":"Quantum dot bioconjugates for imaging, labelling and sensing","volume":"4","author":"Medintz","year":"2005","journal-title":"Nat. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib6","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1021\/cr200359p","article-title":"Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy","volume":"114","author":"Yao","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib7","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1021\/ar9000026","article-title":"Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications","volume":"42","author":"Gao","year":"2009","journal-title":"Accounts Chem. Res."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib8","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","article-title":"Toxic potential of materials at the nanolevel","volume":"311","author":"Nel","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib9","doi-asserted-by":"crossref","first-page":"7581","DOI":"10.1021\/cr400372p","article-title":"Exploiting intrinsic nanoparticle toxicity: the pros and cons of nanoparticle-induced autophagy in biomedical research","volume":"114","author":"Peynshaert","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib10","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Cell biology-Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2004.07.009","article-title":"Role and regulation of starvation-induced autophagy in the Drosophila fat body","volume":"7","author":"Scott","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.4161\/auto.5.8.9842","article-title":"Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal","volume":"5","author":"Zhang","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib14","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1016\/j.biomaterials.2012.05.064","article-title":"Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib15","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1016\/j.biomaterials.2012.06.060","article-title":"Graphene quantum dots as autophagy-inducing photodynamic agents","volume":"33","author":"Markovic","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib16","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/nn500376w","article-title":"Tuning cell autophagy by diversifying carbon nanotube surface chemistry","volume":"8","author":"Wu","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib17","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1002\/adfm.201203767","article-title":"Tuning magnetic property and autophagic response for self-assembled Ni-Co alloy nanocrystals","volume":"23","author":"Dong","year":"2013","journal-title":"Adv. Funct. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib18","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1016\/j.biomaterials.2011.03.006","article-title":"The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy","volume":"32","author":"Wu","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nnano.2011.153","article-title":"Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response","volume":"6","author":"Li","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib20","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1016\/j.biomaterials.2014.02.021","article-title":"Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts","volume":"35","author":"Lee","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nmat3363","article-title":"Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides","volume":"11","author":"Zhang","year":"2012","journal-title":"Nat. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib22","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biomaterials.2013.10.024","article-title":"Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods","volume":"35","author":"Wei","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4161\/auto.6.4.11612","article-title":"Induction of genuine autophagy by cationic lipids in mammalian cells","volume":"6","author":"Man","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib24","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1016\/j.biomaterials.2014.05.029","article-title":"The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib25","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1021\/nl0619711","article-title":"Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation","volume":"6","author":"Seleverstov","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib26","doi-asserted-by":"crossref","first-page":"10172","DOI":"10.1016\/j.biomaterials.2013.09.048","article-title":"The role of elevated autophagy on the synaptic plasticity impairment caused by CdSe\/ZnS quantum dots","volume":"34","author":"Chen","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/adhm.201300294","article-title":"Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells","volume":"3","author":"Li","year":"2014","journal-title":"Adv. Healthc. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib28","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1016\/j.biomaterials.2010.04.014","article-title":"Autophagy and oxidative stress associated with gold nanoparticles","volume":"31","author":"Li","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.biomaterials.2011.10.080","article-title":"Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles","volume":"33","author":"Khan","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib30","doi-asserted-by":"crossref","first-page":"8629","DOI":"10.1021\/nn202155y","article-title":"Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment","volume":"5","author":"Ma","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.freeradbiomed.2013.07.013","article-title":"Deconvoluting the role of reactive oxygen species and autophagy in human diseases","volume":"65","author":"Wen","year":"2013","journal-title":"Free Radic. Bio Med."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib32","doi-asserted-by":"crossref","first-page":"9863","DOI":"10.1021\/nn303444b","article-title":"Docking of ubiquitin to gold nanoparticles","volume":"6","author":"Brancolini","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4161\/auto.3916","article-title":"Nanoparticles as a novel class of autophagy activators","volume":"3","author":"Zabirnyk","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jhazmat.2014.01.028","article-title":"Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species","volume":"270","author":"Yu","year":"2014","journal-title":"J.\u00a0Hazard Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib35","doi-asserted-by":"crossref","first-page":"165102","DOI":"10.1088\/0957-4484\/24\/16\/165102","article-title":"Induction of cyto-protective autophagy by paramontroseite VO2 nanocrystals","volume":"24","author":"Zhou","year":"2013","journal-title":"Nanotechnology"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib36","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/ja107583h","article-title":"Physical-chemical aspects of protein corona: relevance to in\u00a0vitro and in\u00a0vivo biological impacts of nanoparticles","volume":"133","author":"Monopoli","year":"2011","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib37","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/adhm.201300591","article-title":"Graphene oxide triggers toll-like receptors\/autophagy responses in\u00a0vitro and inhibits tumor growth in\u00a0vivo","volume":"3","author":"Chen","year":"2014","journal-title":"Adv. Healthc. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-8977-10-40","article-title":"Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration","volume":"10","author":"Lee","year":"2013","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jmcb\/mjp002","article-title":"PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway","volume":"1","author":"Li","year":"2009","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib40","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1021\/es803477u","article-title":"Ecotoxicity of silver nanoparticles on the soil nematode Caenorhabditis elegans using functional ecotoxicogenomics","volume":"43","author":"Roh","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib41","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1021\/es404444n","article-title":"Silver nanoparticle behavior, uptake, and toxicity in Caenorhabditis elegans: effects of natural organic matter","volume":"48","author":"Yang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib42","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1016\/j.biomaterials.2010.03.077","article-title":"The effect of TAT conjugated platinum nanoparticles on lifespan in a nematode Caenorhabditis elegans model","volume":"31","author":"Kim","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib43","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1021\/nl1021909","article-title":"In\u00a0vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans","volume":"10","author":"Mohan","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib44","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/nl204388p","article-title":"Graphite nanoplatelets and Caenorhabditis elegans: insights from an in\u00a0vivo model","volume":"12","author":"Zanni","year":"2012","journal-title":"Nano Lett."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib45","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1002\/adma.201202678","article-title":"Unraveling stress-induced toxicity properties of grapheme oxide and the underlying mechanism","volume":"24","author":"Zhang","year":"2012","journal-title":"Adv. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib46","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1016\/j.biomaterials.2013.03.093","article-title":"Molecular characterization of toxicity mechanism of single-walled carbon nanotubes","volume":"34","author":"Chen","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biomaterials.2014.11.048","article-title":"Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans","volume":"42","author":"Cong","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib48","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1021\/nl201391e","article-title":"Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism","volume":"11","author":"Qu","year":"2011","journal-title":"Nano Lett."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib49","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1021\/es3036785","article-title":"Toxicity of quantum dots and cadmium salt to Caenorhabditis elegans after multigenerational exposure","volume":"47","author":"Contreras","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib50","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jhazmat.2014.09.063","article-title":"Translocation and neurotoxicity of CdTe quantum dots in RMEs motor neurons in nematode Caenorhabditis elegans","volume":"283","author":"Zhao","year":"2015","journal-title":"J.\u00a0Hazard Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib51","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1021\/nl0519175","article-title":"In\u00a0vivo and scanning electron microscopy imaging of upconverting nanophosphors in Caenorhabditis elegans","volume":"6","author":"Lim","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib52","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1016\/j.biomaterials.2011.08.038","article-title":"Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals","volume":"32","author":"Zhou","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib53","doi-asserted-by":"crossref","first-page":"e6622","DOI":"10.1371\/journal.pone.0006622","article-title":"In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence","volume":"4","author":"Pluskota","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib54","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1021\/nn403443r","article-title":"Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans","volume":"7","author":"Scharf","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib55","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cell.2010.04.034","article-title":"C.\u00a0elegans screen identifies autophagy genes specific to multicellular organisms","volume":"141","author":"Tian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib56","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/embr.201338310","article-title":"Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development","volume":"15","author":"Guo","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/cr.2013.154","article-title":"You are what you eat: multifaceted functions of autophagy during C.\u00a0elegans development","volume":"24","author":"Yang","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib58","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/ncomms3267","article-title":"The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans","volume":"4","author":"Lapierre","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib59","doi-asserted-by":"crossref","first-page":"12480","DOI":"10.1073\/pnas.1405032111","article-title":"Autophagy protects C.\u00a0elegans against necrosis during Pseudomonas aeruginosa infection","volume":"111","author":"Zou","year":"2014","journal-title":"P\u00a0Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib60","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1021\/cm061863f","article-title":"Microwave-assisted synthesis of water-dispersed CdTe nanocrystals with high luminescent efficiency and narrow size distribution","volume":"19","author":"He","year":"2007","journal-title":"Chem. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib61","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1002\/adma.200701166","article-title":"Microwave synthesis of water-dispersed CdTe\/CdS\/ZnS core-shell-shell quantum dots with excellent photostability and biocompatibility","volume":"20","author":"He","year":"2008","journal-title":"Adv. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib62","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"Kamath","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib63","doi-asserted-by":"crossref","first-page":"6345","DOI":"10.1021\/cm702278u","article-title":"Magnetic nanoparticles grafted with cyclodextrin for drug delivery","volume":"19","author":"Banerjee","year":"2007","journal-title":"Chem. Mater"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib64","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/anie.200802230","article-title":"Ultrastable, highly fluorescent, and water-dispersed silicon-based nanospheres as cellular probes","volume":"48","author":"He","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib65","doi-asserted-by":"crossref","first-page":"622","DOI":"10.4161\/auto.6.5.12252","article-title":"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C.\u00a0elegans","volume":"6","author":"Alberti","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib66","first-page":"9","article-title":"Guidelines for monitoring autophagy in Caenorhabditis elegans","volume":"11","author":"Zhang","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib67","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1016\/j.biomaterials.2010.02.074","article-title":"The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties","volume":"31","author":"Su","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib68","doi-asserted-by":"crossref","first-page":"e19052","DOI":"10.1371\/journal.pone.0019052","article-title":"Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK\/mTOR network","volume":"6","author":"Xu","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib69","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.taap.2011.06.024","article-title":"Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells","volume":"255","author":"Son","year":"2011","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/kfn266","article-title":"Cadmium toxicity toward autophagy through ROS-activated GSK-3\u03b2 in mesangial cells","volume":"108","author":"Wang","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib71","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1007\/s00018-008-8383-9","article-title":"Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway","volume":"65","author":"Wang","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib72","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jmcb\/mjp002","article-title":"PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway","volume":"1","author":"Li","year":"2009","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib73","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1091\/mbc.e07-12-1292","article-title":"Atg8 controls phagophore expansion during autophagosome formation","volume":"19","author":"Xie","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib74","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/la060093j","article-title":"Long-term exposure to CdTe quantum dots causes functional impairments in live cells","volume":"23","author":"Cho","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib75","doi-asserted-by":"crossref","first-page":"e1001235","DOI":"10.1371\/journal.pgen.1001235","article-title":"Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1\/CHAT-1","volume":"6","author":"Chen","year":"2010","journal-title":"Plos Genet."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib76","first-page":"1","article-title":"C.\u00a0elegans as a model for membrane traffic","author":"Sato","year":"2014","journal-title":"Wormb. Online Rev. C.\u00a0elegans Biol."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib77","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C-elegans","volume":"301","author":"Melendez","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib78","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1002\/anie.201008206","article-title":"Chirality of glutathione surface coating affects the cytotoxicity of quantum dots","volume":"50","author":"Li","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2015.08.044_bib79","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1039\/c2lc40502d","article-title":"Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues","volume":"12","author":"Wu","year":"2012","journal-title":"Lab. Chip"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib80","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/17435390.2011.572195","article-title":"Mechanisms of cellular adaptation to quantum dots- the role of glutathione and transcription factor EB","volume":"6","author":"Neibert","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.biomaterials.2015.08.044_bib81","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/adhm.201300294","article-title":"Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells","volume":"3","author":"Li","year":"2014","journal-title":"Adv. Healthc. Mater"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961215007188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961215007188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:11:07Z","timestamp":1758903067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961215007188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":81,"alternative-id":["S0142961215007188"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2015.08.044","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A real-time documentation and mechanistic investigation of quantum dots-induced autophagy in live Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2015.08.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}