{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:19:38Z","timestamp":1773166778993,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2012M3A9C7050224"],"award-info":[{"award-number":["2012M3A9C7050224"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Council of Science & Technology (NST)"},{"name":"Korean government","award":["CRC-15-02-KRIBB"],"award-info":[{"award-number":["CRC-15-02-KRIBB"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.biomaterials.2016.08.042","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T03:27:51Z","timestamp":1472786871000},"page":"61-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Pro-fibrotic effects of PFKFB4-mediated glycolytic reprogramming in fibrous dysplasia"],"prefix":"10.1016","volume":"107","author":[{"given":"Mi-Ok","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Hwa","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Young","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Dae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyejin","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Suk","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6224-6685","authenticated-orcid":false,"given":"Yee Sook","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2016.08.042_bib1","first-page":"1848","article-title":"Fibrous dysplasia. Pathophysiology, evaluation, and treatment","volume":"87","author":"DiCaprio","year":"2005","journal-title":"J.\u00a0Bone Jt. Surg. Am."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1053\/berh.1999.0071","article-title":"Fibrous dysplasia of bone","volume":"14","author":"Chapurlat","year":"2000","journal-title":"Baillieres Best. Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib3","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM199112123252403","article-title":"Activating mutations of the stimulatory G protein in the McCune-Albright syndrome","volume":"325","author":"Weinstein","year":"1991","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1677\/JME-10-0097","article-title":"Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells","volume":"45","author":"Riminucci","year":"2010","journal-title":"J.\u00a0Mol. Endocrinol."},{"issue":"Suppl 2","key":"10.1016\/j.biomaterials.2016.08.042_bib5","doi-asserted-by":"crossref","first-page":"P125","DOI":"10.1359\/jbmr.06s224","article-title":"Fibrous dysplasia as a stem cell disease","volume":"21","author":"Riminucci","year":"2006","journal-title":"J.\u00a0Bone Min. Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/path.4033","article-title":"The CREB-Smad6-Runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone","volume":"228","author":"Fan","year":"2012","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib7","doi-asserted-by":"crossref","first-page":"20101","DOI":"10.1073\/pnas.1114656108","article-title":"Wnt\/beta-catenin signaling is differentially regulated by Galpha proteins and contributes to fibrous dysplasia","volume":"108","author":"Regard","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib8","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1359\/jbmr.1999.14.7.1104","article-title":"Glucocorticoids decrease interleukin-6 levels and induce mineralization of cultured osteogenic cells from children with fibrous dysplasia","volume":"14","author":"Stanton","year":"1999","journal-title":"J.\u00a0Bone Min. Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib9","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1359\/jbmr.091036","article-title":"Transfer, analysis, and reversion of the fibrous dysplasia cellular phenotype in human skeletal progenitors","volume":"25","author":"Piersanti","year":"2010","journal-title":"J.\u00a0Bone Min. Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib10","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1172\/JCI2361","article-title":"Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells","volume":"101","author":"Bianco","year":"1998","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/491347a","article-title":"Metabolism and disease","volume":"491","author":"Finkelstein","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2016.08.042_bib12","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cell.2012.02.032","article-title":"Cellular metabolism and disease: what do metabolic outliers teach us?","volume":"148","author":"DeBerardinis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2016.08.042_bib13","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1148\/radiology.219.3.r01ma08774","article-title":"FDG PET of primary benign and malignant bone tumors: standardized uptake value in 52 lesions","volume":"219","author":"Aoki","year":"2001","journal-title":"Radiology"},{"issue":"Suppl 1","key":"10.1016\/j.biomaterials.2016.08.042_bib14","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1007\/s00256-006-0152-y","article-title":"PET-positive fibrous dysplasia\u2013a potentially misleading incidental finding in a patient with intimal sarcoma of the pulmonary artery","volume":"36","author":"Strobel","year":"2007","journal-title":"Skelet. Radiol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00402-012-1588-2","article-title":"Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET\/CT","volume":"132","author":"Hoshi","year":"2012","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/path.4551","article-title":"A\u00a0novel human model of the neurodegenerative disease GM1 gangliosidosis using induced pluripotent stem cells demonstrates inflammasome activation","volume":"237","author":"Son","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib17","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1038\/emm.2016.27","article-title":"Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease","volume":"48","author":"Son","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib18","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1038\/nprot.2011.394","article-title":"Generation and differentiation of microtissues from multipotent precursor cells for use in tissue engineering","volume":"6","author":"Langenbach","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2144\/03342mt01","article-title":"TM4: a free, open-source system for microarray data management and analysis","volume":"34","author":"Saeed","year":"2003","journal-title":"Biotechniques"},{"key":"10.1016\/j.biomaterials.2016.08.042_bib20","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib21","first-page":"750","article-title":"An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome","volume":"79","author":"Shenker","year":"1994","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"issue":"Suppl 2","key":"10.1016\/j.biomaterials.2016.08.042_bib22","doi-asserted-by":"crossref","first-page":"P120","DOI":"10.1359\/jbmr.06s223","article-title":"G(s)alpha mutations in fibrous dysplasia and McCune-Albright syndrome","volume":"21","author":"Weinstein","year":"2006","journal-title":"J.\u00a0Bone Min. Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib23","doi-asserted-by":"crossref","first-page":"40967","DOI":"10.1074\/jbc.M307380200","article-title":"Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis","volume":"278","author":"van der Slot","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/jmcb\/mju039","article-title":"Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation","volume":"6","author":"Cheng","year":"2014","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib25","first-page":"215","article-title":"Cytokines and human fibrosis","volume":"1","author":"LeRoy","year":"1990","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib26","doi-asserted-by":"crossref","first-page":"F631","DOI":"10.1152\/ajprenal.00379.2006","article-title":"In\u00a0vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents","volume":"293","author":"Xu","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib27","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib28","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1101\/gr.139105.112","article-title":"Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors","volume":"22","author":"Wang","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2049-3002-1-8","article-title":"Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase\/fructose 2,6-bisphosphatases in cancer metabolism","volume":"1","author":"Ros","year":"2013","journal-title":"Cancer Metab."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jtbi.2006.09.010","article-title":"Metabolic changes during carcinogenesis: potential impact on invasiveness","volume":"244","author":"Smallbone","year":"2007","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib31","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/ki.1997.188","article-title":"Latent transforming growth factor-beta: structural features and mechanisms of activation","volume":"51","author":"Munger","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib32","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1164\/rccm.201201-0084OC","article-title":"Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-beta","volume":"186","author":"Kottmann","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib33","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00441-013-1601-2","article-title":"Duchenne muscular dystrophy fibroblast nodules: a cell-based assay for screening anti-fibrotic agents","volume":"352","author":"Zanotti","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.lfs.2015.12.015","article-title":"Anti-fibrotic effect of pirfenidone in muscle derived-fibroblasts from Duchenne muscular dystrophy patients","volume":"145","author":"Zanotti","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.026","article-title":"Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in\u00a0vitro","volume":"78","author":"Leite","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.08.042_bib36","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1164\/rccm.201504-0780OC","article-title":"Glycolytic reprogramming mediates myofibroblast differentiation and promotes lung fibrosis","volume":"192","author":"Xie","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib37","doi-asserted-by":"crossref","first-page":"4626073","DOI":"10.1155\/2016\/4626073","article-title":"3D spheroid culture enhances the expression of antifibrotic factors in human adipose-derived MSCs and improves their therapeutic effects on hepatic fibrosis","volume":"2016","author":"Zhang","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib38","doi-asserted-by":"crossref","first-page":"E695","DOI":"10.1152\/ajpendo.00381.2011","article-title":"Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK\/ERK\/CREB pathway","volume":"303","author":"Gomez","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35093131","article-title":"CREB regulates hepatic gluconeogenesis through the coactivator PGC-1","volume":"413","author":"Herzig","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2016.08.042_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib41","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrm2455","article-title":"Cancer as an overhealing wound: an old hypothesis revisited","volume":"9","author":"Schafer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib42","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib43","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/bonekey.2015.58","article-title":"Acidic microenvironment and bone pain in cancer-colonized bone","volume":"4","author":"Yoneda","year":"2015","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.biomaterials.2016.08.042_bib44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S8756-3282(03)00064-4","article-title":"Osteoclastogenesis in fibrous dysplasia of bone: in situ and in\u00a0vitro analysis of IL-6 expression","volume":"33","author":"Riminucci","year":"2003","journal-title":"Bone"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961216304434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961216304434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:19:27Z","timestamp":1758903567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961216304434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":44,"alternative-id":["S0142961216304434"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2016.08.042","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pro-fibrotic effects of PFKFB4-mediated glycolytic reprogramming in fibrous dysplasia","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2016.08.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}