{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:46:01Z","timestamp":1780091161446,"version":"3.54.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"GLOBVAC","award":["143575l"],"award-info":[{"award-number":["143575l"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.biomaterials.2016.09.027","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:02:06Z","timestamp":1475539326000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Layer-by-layer nanocoating of live Bacille-Calmette-Gu\u00e9rin mycobacteria with poly(I:C) and chitosan enhances pro-inflammatory activation and bactericidal capacity in murine macrophages"],"prefix":"10.1016","volume":"111","author":[{"given":"Martin Tobias","family":"Speth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urska","family":"Repnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biomaterials.2016.09.027_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG - implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"issue":"31","key":"10.1016\/j.biomaterials.2016.09.027_bib2","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1016\/j.vaccine.2008.04.083","article-title":"Poor immunogenicity of BCG in helminth infected population is associated with increased in\u00a0vitro TGF-beta production","volume":"26","author":"Elias","year":"2008","journal-title":"Vaccine"},{"issue":"35","key":"10.1016\/j.biomaterials.2016.09.027_bib3","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1016\/j.vaccine.2009.05.021","article-title":"The potential impact of helminth infection on trials of novel tuberculosis vaccines","volume":"27","author":"Hatherill","year":"2009","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.clim.2007.07.007","article-title":"Supplementation with RD antigens enhances the protective efficacy of BCG in tuberculous mice","volume":"125","author":"Kalra","year":"2007","journal-title":"Clin. Immunol. (Orlando, Fla.)"},{"issue":"4","key":"10.1016\/j.biomaterials.2016.09.027_bib5","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/1521-4141(200204)32:4<994::AID-IMMU994>3.0.CO;2-6","article-title":"Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production","volume":"32","author":"Demangel","year":"2002","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib6","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.4049\/jimmunol.168.3.1294","article-title":"Dendritic cells are host cells for mycobacteria in\u00a0vivo that trigger innate and acquired immunity","volume":"168","author":"Jiao","year":"2002","journal-title":"J.\u00a0Immunol. (Baltimore, Md. 1950)"},{"issue":"8","key":"10.1016\/j.biomaterials.2016.09.027_bib7","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.4049\/jimmunol.175.8.5324","article-title":"Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S","volume":"175","author":"Sendide","year":"2005","journal-title":"J.\u00a0Immunol. Baltim.(Baltimore, Md. 1950)"},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cellimm.2008.07.002","article-title":"Mycobacterium bovis BCG decreases MHC-II expression in\u00a0vivo on murine lung macrophages and dendritic cells during aerosol infection","volume":"254","author":"Pecora","year":"2009","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.biomaterials.2016.09.027_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4049\/jimmunol.179.1.211","article-title":"A\u00a0reduced antigen load in\u00a0vivo, rather than weak inflammation, causes a substantial delay in CD8+ T cell priming against Mycobacterium bovis (bacillus Calmette-Guerin)","volume":"179","author":"Russell","year":"2007","journal-title":"J.\u00a0Immunol. (Baltimore, Md. 1950)"},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib10","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.4049\/jimmunol.172.6.3491","article-title":"Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes","volume":"172","author":"van Faassen","year":"2004","journal-title":"J.\u00a0Immunol. (Baltimore, Md. 1950)"},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.smim.2014.10.003","article-title":"Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis","volume":"26","author":"Urdahl","year":"2014","journal-title":"Semin. Immunol."},{"issue":"4","key":"10.1016\/j.biomaterials.2016.09.027_bib12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrmicro3230","article-title":"In search of a new paradigm for protective immunity to TB","volume":"12","author":"Nunes-Alves","year":"2014","journal-title":"Nat. Rev. Micro"},{"issue":"1","key":"10.1016\/j.biomaterials.2016.09.027_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cellimm.2013.11.007","article-title":"BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9","volume":"287","author":"Bakhru","year":"2014","journal-title":"Cell. Immunol."},{"issue":"10","key":"10.1016\/j.biomaterials.2016.09.027_bib14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/intimm\/dxp084","article-title":"Lactoferrin modulation of BCG-infected dendritic cell functions","volume":"21","author":"Hwang","year":"2009","journal-title":"Int. Immunol."},{"issue":"4","key":"10.1016\/j.biomaterials.2016.09.027_bib15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/0394632015599832","article-title":"CHO expressed recombinant human lactoferrin as an adjuvant for BCG","volume":"28","author":"Hwang","year":"2015","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nm.1928","article-title":"Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells","volume":"15","author":"Jagannath","year":"2009","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib17","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.micinf.2008.12.003","article-title":"Adjuvanticity effect of sodium alginate on subcutaneously injected BCG in BALB\/c mice","volume":"11","author":"Dobakhti","year":"2009","journal-title":"Microbes Infect.\/Institut Pasteur"},{"issue":"10","key":"10.1016\/j.biomaterials.2016.09.027_bib18","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.addr.2013.05.013","article-title":"Particulate formulations for the delivery of poly(I: C) as vaccine adjuvant","volume":"65","author":"Hafner","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2016.09.027_bib19","article-title":"Immunomodulatory effects of dsRNA and its potential as vaccine adjuvant","volume":"2010","author":"Jin","year":"2010","journal-title":"J.\u00a0Biomed. Biotechnol."},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1586\/14760584.2015.966085","article-title":"Vaccine adjuvant uses of poly-IC and derivatives","volume":"14","author":"Martins","year":"2015","journal-title":"Expert Rev. Vacc."},{"issue":"17","key":"10.1016\/j.biomaterials.2016.09.027_bib21","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1016\/j.vaccine.2010.08.002","article-title":"TLR-based immune adjuvants","volume":"29","author":"Steinhagen","year":"2011","journal-title":"Vaccine"},{"issue":"10","key":"10.1016\/j.biomaterials.2016.09.027_bib22","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.biomaterials.2010.12.021","article-title":"Tuning the immune response of dendritic cells to surface-assembled poly(I: C) on microspheres through synergistic interactions between phagocytic and TLR3 signaling","volume":"32","author":"Hafner","year":"2011","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2016.09.027_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijpharm.2008.08.039","article-title":"Poly(I: C) coated PLGA microparticles induce dendritic cell maturation","volume":"365","author":"Wischke","year":"2009","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jconrel.2012.02.002","article-title":"Surface assembly of poly(I: C) on PEGylated microspheres to shield from adverse interactions with fibroblasts","volume":"159","author":"Hafner","year":"2012","journal-title":"J.\u00a0Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.biomaterials.2016.09.027_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcimb.2013.00013","article-title":"Vaccine delivery using nanoparticles","volume":"3","author":"Gregory","year":"2013","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"17","key":"10.1016\/j.biomaterials.2016.09.027_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/app.40714","article-title":"Development of methods for encapsulation of viruses into polymeric nano- and microparticles for aquaculture vaccines","volume":"131","author":"Ulanova","year":"2014","journal-title":"J.\u00a0Appl. Polym. Sci."},{"issue":"14","key":"10.1016\/j.biomaterials.2016.09.027_bib27","first-page":"3043","article-title":"Poly(lactide-co-glycolide)-rifampicin nanoparticles efficiently clear Mycobacterium bovis BCG infection in macrophages and remain membrane-bound in phago-lysosomes","volume":"126","author":"Kalluru","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"issue":"5","key":"10.1016\/j.biomaterials.2016.09.027_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.placenta.2008.02.004","article-title":"Comparison of macrophage phenotype between decidua basalis and decidua parietalis by flow cytometry","volume":"29","author":"Repnik","year":"2008","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in\u00a0vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J.\u00a0Clin. Investig."},{"issue":"5","key":"10.1016\/j.biomaterials.2016.09.027_bib30","doi-asserted-by":"crossref","first-page":"e19105","DOI":"10.1371\/journal.pone.0019105","article-title":"Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis","volume":"6","author":"Herbst","year":"2011","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.biomaterials.2016.09.027_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nri3405","article-title":"Molecular mechanisms of T cell co-stimulation and co-inhibition","volume":"13","author":"Chen","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib32","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1128\/IAI.68.3.1428-1434.2000","article-title":"Activated T cells induce macrophages to produce NO and control Leishmania major in the absence of tumor necrosis factor receptor p55","volume":"68","author":"Nashleanas","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biomaterials.2016.09.027_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib34","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018523","article-title":"Novel vaccination strategies against tuberculosis","volume":"4","author":"Andersen","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib35","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.4049\/jimmunol.0900858","article-title":"Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin","volume":"183","author":"Venkataswamy","year":"2009","journal-title":"J.\u00a0Immunol. (Baltimore, Md. 1950)"},{"key":"10.1016\/j.biomaterials.2016.09.027_bib36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-61779-430-8_18","article-title":"Rapamycin-induced enhancement of vaccine efficacy in mice","volume":"821","author":"Jagannath","year":"2012","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nm.1928","article-title":"Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells","volume":"15","author":"Jagannath","year":"2009","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.biomaterials.2016.09.027_bib38","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/j.vaccine.2005.11.017","article-title":"Oral delivery of lipid-encapsulated Mycobacterium bovis BCG extends survival of the bacillus in\u00a0vivo and induces a long-term protective immune response against tuberculosis","volume":"24","author":"Aldwell","year":"2006","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib39","doi-asserted-by":"crossref","first-page":"e32959","DOI":"10.1371\/journal.pone.0032959","article-title":"Formulation of a mmaA4 gene deletion mutant of Mycobacterium bovis BCG in cationic liposomes significantly enhances protection against tuberculosis","volume":"7","author":"Derrick","year":"2012","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.biomaterials.2016.09.027_bib40","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1080\/02652040601034013","article-title":"Stabilizing effects of calcium alginate microspheres on mycobacterium bovis BCG intended for oral vaccination","volume":"23","author":"Dobakhti","year":"2006","journal-title":"J.\u00a0Microencapsul."},{"issue":"23","key":"10.1016\/j.biomaterials.2016.09.027_bib41","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1016\/j.vaccine.2007.03.039","article-title":"Oral administration of BCG encapsulated in alginate microspheres induces strong Th1 response in BALB\/c mice","volume":"25","author":"Ajdary","year":"2007","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.biomaterials.2016.09.027_bib42","doi-asserted-by":"crossref","first-page":"e0145833","DOI":"10.1371\/journal.pone.0145833","article-title":"Improving the immunogenicity of the Mycobacterium bovis BCG vaccine by non-genetic bacterial surface decoration using the avidin-biotin system","volume":"10","author":"Liao","year":"2015","journal-title":"PloS One"},{"issue":"21","key":"10.1016\/j.biomaterials.2016.09.027_bib43","doi-asserted-by":"crossref","first-page":"11838","DOI":"10.1021\/jf203378s","article-title":"Enhanced survival of probiotic Lactobacillus acidophilus by encapsulation with nanostructured polyelectrolyte layers through layer-by-layer approach","volume":"59","author":"Priya","year":"2011","journal-title":"J.\u00a0Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/mabi.200900142","article-title":"Layer-by-layer nano-encapsulation of microbes: controlled cell surface modification and investigation of substrate uptake in bacteria","volume":"10","author":"Franz","year":"2010","journal-title":"Macromol. Biosci."},{"issue":"11","key":"10.1016\/j.biomaterials.2016.09.027_bib45","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1039\/c2cs15264a","article-title":"Cyborg cells: functionalisation of living cells with polymers and nanomaterials","volume":"41","author":"Fakhrullin","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"8","key":"10.1016\/j.biomaterials.2016.09.027_bib46","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1021\/la803871z","article-title":"Living fungi cells encapsulated in polyelectrolyte shells doped with metal nanoparticles","volume":"25","author":"Fakhrullin","year":"2009","journal-title":"Langmuir ACS J. Surfaces Colloids"},{"issue":"9","key":"10.1016\/j.biomaterials.2016.09.027_bib47","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.addr.2011.05.011","article-title":"Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly","volume":"63","author":"de Villiers","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib48","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1021\/nn301776y","article-title":"\u201cFace-Lifting\u201d and \u201cMake-Up\u201d for microorganisms: layer-by-layer polyelectrolyte nanocoating","volume":"6","author":"Fakhrullin","year":"2012","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1049\/ip-nbt:20040535","article-title":"Nanoscale surface engineered living cells with extended substrate spectrum","volume":"151","author":"Mak","year":"2004","journal-title":"IEEE Proc. Nanobiotechnol."},{"issue":"10","key":"10.1016\/j.biomaterials.2016.09.027_bib50","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1021\/bm060266j","article-title":"Biorecognition through layer-by-layer polyelectrolyte assembly: in-situ hybridization on living cells","volume":"7","author":"Hillberg","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2016.09.027_bib51","series-title":"Consultation on the Characterization of BCG Vaccines Geneva","author":"WHO","year":"2004"},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib52","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3181\/00379727-79-19389","article-title":"Comparative antigenic potency of killed irradiated tubercle bacilli and living BCG vaccine, Proceedings of the Society for Experimental Biology and Medicine","volume":"79","author":"Birkhaug","year":"1952","journal-title":"Soc. Exp. Biol. Med. (New York, N.Y.)"},{"issue":"7","key":"10.1016\/j.biomaterials.2016.09.027_bib53","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1286-4579(03)00096-0","article-title":"Inducible nitric oxide synthase and control of intracellular bacterial pathogens","volume":"5","author":"Chakravortty","year":"2003","journal-title":"Microbes Infect."},{"issue":"4","key":"10.1016\/j.biomaterials.2016.09.027_bib54","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.175.4.1111","article-title":"Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages","volume":"175","author":"Chan","year":"1992","journal-title":"J.\u00a0Exp. Med."},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib55","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"Gutierrez","year":"2004","journal-title":"Cell"},{"issue":"Supplement","key":"10.1016\/j.biomaterials.2016.09.027_bib56","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/S1472-9792(13)70008-8","article-title":"Harnessing of TLR-mediated autophagy to combat mycobacteria in macrophages","volume":"93","author":"Xu","year":"2013","journal-title":"Tuberculosis"},{"issue":"1","key":"10.1016\/j.biomaterials.2016.09.027_bib57","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"O'Garra","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"31","key":"10.1016\/j.biomaterials.2016.09.027_bib58","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1016\/j.biomaterials.2014.07.014","article-title":"Chitosan as an adjuvant-like substrate for dendritic cell culture to enhance antitumor effects","volume":"35","author":"Lin","year":"2014","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib59","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2016.02.004","article-title":"The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferons","volume":"44","author":"Carroll","year":"2016","journal-title":"Immunity"},{"issue":"41","key":"10.1016\/j.biomaterials.2016.09.027_bib60","doi-asserted-by":"crossref","first-page":"35447","DOI":"10.1074\/jbc.M111.274936","article-title":"Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis","volume":"286","author":"Bueter","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"issue":"12","key":"10.1016\/j.biomaterials.2016.09.027_bib61","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.4049\/jimmunol.1301695","article-title":"Spectrum and mechanisms of inflammasome activation by chitosan","volume":"192","author":"Bueter","year":"2014","journal-title":"J.\u00a0Immunol."},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib62","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/icb.2014.21","article-title":"Activation of the NLRP3 inflammasome is not a feature of all particulate vaccine adjuvants","volume":"92","author":"Neumann","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.biomaterials.2016.09.027_bib63","doi-asserted-by":"crossref","first-page":"18423","DOI":"10.1038\/srep18423","article-title":"Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol","volume":"6","author":"Farace","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biomaterials.2016.09.027_bib64","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jbm.a.32860","article-title":"Surface modification of poly(D,L-lactic-co-glycolic acid) nanoparticles with protamine enhanced cross-presentation of encapsulated ovalbumin by bone marrow-derived dendritic cells","volume":"96","author":"Han","year":"2011","journal-title":"J.\u00a0Biomed. Mater. Res. Part A"},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2008.06.003","article-title":"Surface coating of PLGA microparticles with protamine enhances their immunological performance through facilitated phagocytosis","volume":"130","author":"Martinez Gomez","year":"2008","journal-title":"J.\u00a0Control. Release Off. J. Control. Release Soc."},{"issue":"1","key":"10.1016\/j.biomaterials.2016.09.027_bib66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijpharm.2009.06.006","article-title":"Influence of surface charge of PLGA particles of recombinant hepatitis B surface antigen in enhancing systemic and mucosal immune responses","volume":"379","author":"Thomas","year":"2009","journal-title":"Int. J. Pharm."},{"issue":"16","key":"10.1016\/j.biomaterials.2016.09.027_bib67","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1002\/anie.201200048","article-title":"Surface-Engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function","volume":"51","author":"De Geest","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"issue":"10","key":"10.1016\/j.biomaterials.2016.09.027_bib68","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1023\/A:1012269226066","article-title":"Cationic microparticles are an effective delivery system for immune stimulatory CpG DNA","volume":"18","author":"Singh","year":"2001","journal-title":"Pharm. Res."},{"issue":"44","key":"10.1016\/j.biomaterials.2016.09.027_bib69","doi-asserted-by":"crossref","first-page":"16952","DOI":"10.1073\/pnas.0809218105","article-title":"Membrane proteomics of phagosomes suggests a connection to autophagy","volume":"105","author":"Shui","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib70","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1600-0854.2009.00899.x","article-title":"How location governs toll-like receptor signaling","volume":"10","author":"Chaturvedi","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.biomaterials.2016.09.027_bib71","doi-asserted-by":"crossref","first-page":"405310","DOI":"10.1155\/2011\/405310","article-title":"Innate immune recognition of Mycobacterium tuberculosis","volume":"2011","author":"Kleinnijenhuis","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.biomaterials.2016.09.027_bib72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fcimb.2012.00145","article-title":"Mycobacterial signaling through toll-like receptors","volume":"2","author":"Basu","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib73","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/imm.12306","article-title":"Mycobacterium indicus pranii and Mycobacterium bovis BCG lead to differential macrophage activation in Toll-like receptor-dependent manner","volume":"143","author":"Kumar","year":"2014","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib74","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1189\/jlb.0103026","article-title":"TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG","volume":"74","author":"Heldwein","year":"2003","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.biomaterials.2016.09.027_bib75","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","article-title":"TLR3: interferon induction by double-stranded RNA including poly(I: C)","volume":"60","author":"Matsumoto","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.biomaterials.2016.09.027_bib76","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/08830185.2014.921164","article-title":"TLR cross-talk confers specificity to innate immunity","volume":"33","author":"Tan","year":"2014","journal-title":"Int. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.biomaterials.2016.09.027_bib77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nri2038","article-title":"Cooperation of Toll-like receptor signals in innate immune defence","volume":"7","author":"Trinchieri","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.biomaterials.2016.09.027_bib78","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.4049\/jimmunol.178.2.1164","article-title":"MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists","volume":"178","author":"Bagchi","year":"2007","journal-title":"J.\u00a0Immunol. (Baltimore, Md. 1950)"},{"issue":"4","key":"10.1016\/j.biomaterials.2016.09.027_bib79","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bbrc.2007.01.090","article-title":"Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation","volume":"354","author":"Ouyang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.biomaterials.2016.09.027_bib80","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/icb.2013.13","article-title":"The synergy in cytokine production through MyD88-TRIF pathways is co-ordinated with ERK phosphorylation in macrophages","volume":"91","author":"Suet Ting Tan","year":"2013","journal-title":"Immunol. cell Biol."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961216305348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961216305348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:20:26Z","timestamp":1758903626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961216305348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":80,"alternative-id":["S0142961216305348"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2016.09.027","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Layer-by-layer nanocoating of live Bacille-Calmette-Gu\u00e9rin mycobacteria with poly(I:C) and chitosan enhances pro-inflammatory activation and bactericidal capacity in murine macrophages","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2016.09.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}