{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:49:06Z","timestamp":1792784946000,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/110859\/2015"],"award-info":[{"award-number":["SFRH\/BD\/110859\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Walter och Lisi Wahls Stiftelse f\u00f6r Naturvetenskaplig Forskning and the Academy of Finland","award":["108376"],"award-info":[{"award-number":["108376"]}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["252215"],"award-info":[{"award-number":["252215"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["281300"],"award-info":[{"award-number":["281300"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Helsinki Research Funds","id":[{"id":"https:\/\/ror.org\/040af2s02","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Biocentrum Helsinki"},{"name":"European Union's Seventh Framework Programme","award":["310892"],"award-info":[{"award-number":["310892"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.biomaterials.2016.12.034","type":"journal-article","created":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T17:01:16Z","timestamp":1483549276000},"page":"97-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":394,"special_numbering":"C","title":["In\u00a0vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells"],"prefix":"10.1016","volume":"121","author":[{"given":"Patr\u00edcia","family":"Figueiredo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Lintinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Kiriazis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Hynninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Bauleth-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Rahikkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Kohout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Yli-Kauhaluoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni","family":"Hirvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Ikkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauri A.","family":"Kostiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lder A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2016.12.034_bib1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jmrt.2014.10.009","article-title":"Extraction and characterization of lignin from different biomass resources","volume":"4","author":"Watkins","year":"2015","journal-title":"J.\u00a0Mater. Res. Technol."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ijbiomac.2014.09.044","article-title":"Recent advances in green hydrogels from lignin: a review","volume":"72","author":"Thakur","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nchem.2120","article-title":"Biomass conversion: lignin up for break-down","volume":"6","author":"Bruijnincx","year":"2014","journal-title":"Nat. Chem."},{"issue":"Part A","key":"10.1016\/j.biomaterials.2016.12.034_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijbiomac.2016.08.030","article-title":"Lignin-derivatives based polymers, blends and composites: a review","volume":"93","author":"Naseem","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib5","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/cssc.201000157","article-title":"Lignin as renewable raw material","volume":"3","author":"Calvo-Flores","year":"2010","journal-title":"ChemSusChem"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.reactfunctpolym.2014.09.017","article-title":"A\u00a0review on lignin-based polymeric, micro- and nano-structured materials","volume":"85","author":"Duval","year":"2014","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib7","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1039\/C5GC02616D","article-title":"Towards lignin-based functional materials in a sustainable world","volume":"18","author":"Kai","year":"2016","journal-title":"Green Chem."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.progpolymsci.2013.11.004","article-title":"Chemical modification of lignins: towards biobased polymers","volume":"39","author":"Laurichesse","year":"2014","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib9","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/app.25098","article-title":"Lignin-based polycondensation resins for wood adhesives","volume":"103","author":"Mansouri","year":"2007","journal-title":"J.\u00a0Appl. Polym. Sci."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib10","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/pc.21087","article-title":"Physical properties of lignin-based polypropylene blends","volume":"32","author":"Chen","year":"2011","journal-title":"Polym. Compos."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib11","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1002\/cphc.201200537","article-title":"Fabrication of environmentally biodegradable lignin nanoparticles","volume":"13","author":"Frangville","year":"2012","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib12","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1039\/C4GC01242A","article-title":"CO2-responsive diethylaminoethyl-modified lignin nanoparticles and their application as surfactants for CO2\/N2-switchable Pickering emulsions","volume":"16","author":"Qian","year":"2014","journal-title":"Green Chem."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib13","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1039\/C5GC01436K","article-title":"A\u00a0simple process for lignin nanoparticle preparation","volume":"18","author":"Lievonen","year":"2016","journal-title":"Green Chem."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib14","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nnano.2015.141","article-title":"An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core","volume":"10","author":"Richter","year":"2015","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib15","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1039\/C4SM02851A","article-title":"Lignin supracolloids synthesized from (W\/O) microemulsions: use in the interfacial stabilization of Pickering systems and organic carriers for silver metal","volume":"11","author":"Nypelo","year":"2015","journal-title":"Soft Matter"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib16","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nrd3186","article-title":"Targeted cancer therapies","volume":"9","author":"Aggarwal","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.drudis.2010.08.006","article-title":"Cancer nanotechnology: application of nanotechnology in cancer therapy","volume":"15","author":"Misra","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.18433\/J30C7D","article-title":"Nanotherapeutics to overcome conventional cancer chemotherapy limitations","volume":"14","author":"Chidambaram","year":"2011","journal-title":"J.\u00a0Pharm. Pharm. Sci."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib20","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1021\/acs.molpharmaceut.5b00473","article-title":"Smart porous silicon nanoparticles with polymeric coatings for sequential combination therapy","volume":"12","author":"Xu","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib21","doi-asserted-by":"crossref","first-page":"23197","DOI":"10.1021\/acsami.5b07033","article-title":"Cyclodextrin-modified porous silicon nanoparticles for efficient sustained drug delivery and proliferation inhibition of breast cancer cells","volume":"7","author":"Correia","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s12274-014-0635-4","article-title":"A\u00a0prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors","volume":"8","author":"Shahbazi","year":"2015","journal-title":"Nano Res."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib23","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/adfm.201404122","article-title":"On-chip self-assembly of a smart hybrid nanocomposite for antitumoral applications","volume":"25","author":"Herranz-Blanco","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biomaterials.2015.01.008","article-title":"Multifunctional porous silicon nanoparticles for cancer theranostics","volume":"48","author":"Wang","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib25","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/adhm.201600160","article-title":"Ph-switch nanoprecipitation of polymeric nanoparticles for multimodal cancer targeting and intracellular triggered delivery of doxorubicin","volume":"5","author":"Herranz-Blanco","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ijpharm.2016.07.066","article-title":"Angiopep2-functionalized polymersomes for targeted doxorubicin delivery to glioblastoma cells","volume":"511","author":"Figueiredo","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib27","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1002\/adfm.201500594","article-title":"Inhibition of multidrug resistance of cancer cells by co-delivery of DNA nanostructures and drugs using porous silicon nanoparticles@giant liposomes","volume":"25","author":"Kong","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib28","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3109\/1061186X.2013.837469","article-title":"Nanotechnology in cancer therapy","volume":"21","author":"Aslan","year":"2013","journal-title":"J.\u00a0Drug Target"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib30","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.biomaterials.2013.10.065","article-title":"Copper-free azide\u2013alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib31","doi-asserted-by":"crossref","first-page":"7488","DOI":"10.1016\/j.biomaterials.2014.05.020","article-title":"Augmented cellular trafficking and endosomal escape of porous silicon nanoparticles via zwitterionic bilayer polymer surface engineering","volume":"35","author":"Shahbazi","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib32","first-page":"e3966","article-title":"Nanocarriers usage for drug delivery in cancer therapy","volume":"9","author":"Khodabandehloo","year":"2016","journal-title":"Iran. J. Cancer Prev."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib33","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1021\/acs.langmuir.6b01088","article-title":"Synthesis and characterization of biodegradable lignin nanoparticles with tunable surface properties","volume":"32","author":"Richter","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib34","doi-asserted-by":"crossref","first-page":"31790","DOI":"10.1039\/C6RA03865D","article-title":"Structural diversity in metal-organic nanoparticles based on iron isopropoxide treated lignin","volume":"6","author":"Lintinen","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib35","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1021\/ol2001528","article-title":"Synthesis and tautomerization of benzo[cd]azulen-3-ones","volume":"13","author":"Aumuller","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib36","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1016\/j.biomaterials.2013.06.052","article-title":"The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility","volume":"34","author":"Shahbazi","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib37","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1016\/j.actbio.2009.12.043","article-title":"In\u00a0vitro cytotoxicity of porous silicon microparticles: effect of the particle concentration, surface chemistry and size","volume":"6","author":"Santos","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2007.08.001","article-title":"Nanoparticles for drug delivery: the need for precision in reporting particle size parameters","author":"Gaumet","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib39","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1021\/acsnano.6b02819","article-title":"Mesoporous silica nanoparticle-supported lipid bilayers (protocells) for active targeting and delivery to individual leukemia cells","volume":"10","author":"Durfee","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib40","doi-asserted-by":"crossref","first-page":"12404","DOI":"10.1016\/S1452-3981(23)16554-0","article-title":"Zeta potentials and isoelectric points of biomolecules: the effects of ion types and ionic strengths","volume":"7","author":"Salg\u0131n","year":"2012","journal-title":"Int. J. Electrochem. Sci."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib42","doi-asserted-by":"crossref","first-page":"9134","DOI":"10.1016\/j.biomaterials.2013.08.034","article-title":"Tumour homing peptide-functionalized porous silicon nanovectors for cancer therapy","volume":"34","author":"Kinnari","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib43","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jconrel.2015.10.006","article-title":"Control of polymeric nanoparticle size to improve therapeutic delivery","volume":"219","author":"Hickey","year":"2015","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/138920012798356934","article-title":"PEGylation of proteins and liposomes: a powerful and flexible strategy to improve the drug delivery","volume":"13","author":"Milla","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib45","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jmmm.2014.10.137","article-title":"Water dispersible oleic acid-coated Fe3O4 nanoparticles for biomedical applications","volume":"377","author":"Shete","year":"2015","journal-title":"J.\u00a0Magn. Magn. Mater."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib46","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.2147\/IJN.S30320","article-title":"Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers","volume":"7","author":"Wahajuddin","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib47","doi-asserted-by":"crossref","first-page":"43284","DOI":"10.1039\/C6RA04659B","article-title":"Paclitaxel modified Fe3O4 loaded albumin nanoparticles as drug delivery vehicles by self-assembly","volume":"6","author":"Tang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/0883911509360735","article-title":"Bleomycin loaded magnetic chitosan nanoparticles as multifunctional nanocarriers","volume":"25","author":"Kavaz","year":"2010","journal-title":"J.\u00a0Bioact. Compat. Polym."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpharm.2015.10.058","article-title":"Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in\u00a0vitro and in\u00a0vivo cancer nanotheranostics","volume":"496","author":"Kandasamy","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib50","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/smll.200901158","article-title":"Effect of surface properties on nanoparticle\u2013cell interactions","volume":"6","author":"Verma","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1155\/2013\/942916","article-title":"Mechanisms of nanoparticle-induced oxidative stress and toxicity","volume":"2013","author":"Manke","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jfda.2014.01.007","article-title":"Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides","volume":"22","author":"Wu","year":"2014","journal-title":"J.\u00a0Food Drug Anal."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib53","doi-asserted-by":"crossref","first-page":"116","DOI":"10.7150\/thno.5411","article-title":"Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy","volume":"3","author":"Huang","year":"2013","journal-title":"Theranostics"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib54","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bioelechem.2003.09.023","article-title":"Influence of PAMAM dendrimers on human red blood cells","volume":"63","author":"Domanski","year":"2004","journal-title":"Bioelectrochemistry Amst. Neth."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib55","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1021\/nn103077k","article-title":"Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects","volume":"5","author":"Zhao","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib56","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/jps.20627","article-title":"In\u00a0vitro hemolysis: guidance for the pharmaceutical scientist","volume":"95","author":"Amin","year":"2006","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib57","first-page":"51","article-title":"Endocytosis and exocytosis of nanoparticles in mammalian cells","volume":"9","author":"Oh","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.urolonc.2007.03.015","article-title":"Nanoparticles for drug delivery in cancer treatment","volume":"26","author":"Haley","year":"2008","journal-title":"Urol. Oncol. Semin. Orig."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib59","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.biomaterials.2009.09.101","article-title":"The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents","volume":"31","author":"Sahay","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib60","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3390\/nano5031163","article-title":"Nanotoxicity: an interplay of oxidative stress, inflammation and cell death","volume":"5","author":"Khanna","year":"2015","journal-title":"Nanomaterials"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib61","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jfda.2014.01.005","article-title":"Mechanisms of nanotoxicity: generation of reactive oxygen species","volume":"22","author":"Fu","year":"2014","journal-title":"J.\u00a0Food Drug Anal."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib62","doi-asserted-by":"crossref","first-page":"e55409","DOI":"10.1371\/journal.pone.0055409","article-title":"Tricyclic benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells","volume":"8","author":"Kiriazis","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib63","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.ejca.2008.06.044","article-title":"Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal","volume":"44","author":"Shah","year":"2008","journal-title":"Eur. J. Cancer (Oxford, Engl. 1990)"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib64","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3324\/haematol.2009.017079","article-title":"PIM serine\/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers","volume":"95","author":"Brault","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.biomaterials.2016.12.034_bib65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/btm2.10003","article-title":"Nanoparticles in the clinic","volume":"1","author":"Anselmo","year":"2016","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.biomaterials.2016.12.034_bib66","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-1-61779-956-3_21","article-title":"Lignin-degrading enzyme activities","volume":"908","author":"Chen","year":"2012","journal-title":"Methods Mol. Biol."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961216307542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961216307542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:23:26Z","timestamp":1758903806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961216307542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":66,"alternative-id":["S0142961216307542"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2016.12.034","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2016.12.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}