{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:32:26Z","timestamp":1793640746203,"version":"4.5.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T00:00:00Z","timestamp":1524268800000},"content-version":"am","delay-in-days":294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF 0812348"],"award-info":[{"award-number":["NSF 0812348"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McGowan Foundation and the Commonwealth of Pennsylvania"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.biomaterials.2017.04.015","type":"journal-article","created":{"date-parts":[[2017,4,14]],"date-time":"2017-04-14T11:27:17Z","timestamp":1492169237000},"page":"132-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Sustained viral gene delivery from a micro-fibrous, elastomeric cardiac patch to the ischemic rat heart"],"prefix":"10.1016","volume":"133","author":[{"given":"Xinzhu","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumoto","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2017.04.015_bib1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2010.06.039","article-title":"Intra-myocardial biomaterial injection therapy in the treatment of heart failure: materials, outcomes and challenges","volume":"7","author":"Nelson","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib3","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.jacc.2007.02.050","article-title":"An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction","volume":"49","author":"Fujimoto","year":"2007","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib4","series-title":"Experimental and Clinical Studies with the Paracor Cardiac Restraint Device. Seminars in Thoracic and Cardiovascular Surgery","first-page":"364","author":"Magovern","year":"2006"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib5","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.jacc.2013.01.072","article-title":"Magnitude and time course of changes induced by continuous-flow left ventricular assist device unloading in chronic heart failure: insights into cardiac recovery","volume":"61","author":"Drakos","year":"2013","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s12265-016-9708-y","article-title":"Stem cell therapy for the heart: blind alley or magic bullet?","author":"Bruyneel","year":"2016","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.pcad.2016.01.006","article-title":"Mechanical circulatory support: current status and future directions","volume":"58","author":"Enciso","year":"2016","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/MOT.0b013e32835a34a6","article-title":"Biomaterials for stem cell culture and seeding for the generation and delivery of cardiac myocytes","volume":"17","author":"Castells-Sala","year":"2012","journal-title":"Curr. Opin. organ Transplant."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/cvr\/cvv205","article-title":"Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation","volume":"108","author":"Rincon","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib10","first-page":"285","article-title":"Advances in gene therapy for heart failure","volume":"19","author":"Fish","year":"2015","journal-title":"Discov. Med."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib11","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/01.CIR.98.25.2800","article-title":"Gene therapy for myocardial angiogenesis initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia","volume":"98","author":"Losordo","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib12","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00636.2010","article-title":"Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs","volume":"300","author":"Rastogi","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib13","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s11033-009-9665-5","article-title":"Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium-and high-dose groups","volume":"37","author":"Yang","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib14","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1161\/hc1102.105595","article-title":"Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris","volume":"105","author":"Grines","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib15","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/CIRCRESAHA.111.300440","article-title":"An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure","volume":"112","author":"Penn","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1517\/14712598.2011.570749","article-title":"Gene therapy for ischemic heart disease","volume":"11","author":"Hinkel","year":"2011","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1517\/14712598.2014.866085","article-title":"Cardiovascular gene therapy for myocardial infarction","volume":"14","author":"Scimia","year":"2014","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In\u00a0vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib21","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1161\/CIRCRESAHA.116.304377","article-title":"MicroRNAs and cardiac regeneration","volume":"116","author":"Hodgkinson","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib22","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/01.RES.73.6.1202","article-title":"Efficient gene transfer into myocardium by direct injection of adenovirus vectors","volume":"73","author":"Guzman","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/2277-9175.98152","article-title":"Viral and nonviral delivery systems for gene delivery","volume":"1","author":"Nayerossadat","year":"2012","journal-title":"Adv. Biomed. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib24","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0140-6736(09)61836-5","article-title":"Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial","volume":"374","author":"Maguire","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib25","unstructured":"http:\/\/www.abedia.com\/wiley\/vectors.php."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib26","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.athoracsur.2006.06.085","article-title":"In\u00a0vivo evaluation of a porous, elastic, biodegradable patch for reconstructive cardiac procedures","volume":"83","author":"Fujimoto","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cardfail.2012.05.006","article-title":"Placement of an elastic biodegradable cardiac patch on a subacute infarcted heart leads to cellularization with early developmental cardiomyocyte characteristics","volume":"18","author":"Fujimoto","year":"2012","journal-title":"J.\u00a0Card. Fail."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib28","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1016\/j.biomaterials.2013.06.020","article-title":"The effect of polymer degradation time on functional outcomes of temporary elastic patch support in ischemic cardiomyopathy","volume":"34","author":"Hashizume","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jbm.10204","article-title":"Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly (ester-urethane) ureas based on poly (caprolactone) and putrescine","volume":"61","author":"Guan","year":"2002","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib30","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/gt.2010.110","article-title":"Inhibition of the IKK\/NF-\u03baB pathway by AAV gene transfer improves muscle regeneration in older mdx mice","volume":"17","author":"Tang","year":"2010","journal-title":"Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib31","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1128\/JVI.75.24.12382-12392.2001","article-title":"Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector","volume":"75","author":"Passini","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib32","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/mt.2011.111","article-title":"Engineering biomaterial systems to enhance viral vector gene delivery","volume":"19","author":"Jang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jconrel.2009.06.007","article-title":"Sustained viral gene delivery through core-shell fibers","volume":"139","author":"Liao","year":"2009","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib34","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1016\/j.actbio.2011.06.035","article-title":"Electrospun nanofibrous scaffolds for controlled release of adeno-associated viral vectors","volume":"7","author":"Lee","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib35","first-page":"1","article-title":"Electrospun nanofibers as versatile interfaces for efficient gene delivery","volume":"8","author":"Lee","year":"2014","journal-title":"J.\u00a0Biol. Eng."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1391","article-title":"Coaxial electrospun fibers: applications in drug delivery and tissue engineering","author":"Lu","year":"2016","journal-title":"Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2009.12.009","article-title":"Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds","volume":"143","author":"Saraf","year":"2010","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib38","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1016\/j.actbio.2011.02.031","article-title":"Core\u2013sheath structured fibers with pDNA polyplex loadings for the optimal release profile and transfection efficiency as potential tissue engineering scaffolds","volume":"7","author":"Yang","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib39","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.actbio.2012.03.044","article-title":"Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels","volume":"8","author":"He","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5385137","article-title":"Fabrication of core-shell PEI\/pBMP2-PLGA electrospun scaffold for gene delivery to periodontal ligament stem cells","volume":"2016","author":"Xie","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib41","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/bit.20393","article-title":"Gene delivery through cell culture substrate adsorbed DNA complexes","volume":"90","author":"Bengali","year":"2005","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib42","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/ten.teb.2012.0437","article-title":"Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size","volume":"19","author":"Loh","year":"2013","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib43","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1016\/j.biomaterials.2011.01.025","article-title":"Mechanical properties and in\u00a0vivo behavior of a biodegradable synthetic polymer microfiber\u2013extracellular matrix hydrogel biohybrid scaffold","volume":"32","author":"Hong","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.07.039","article-title":"Bi-layered polyurethane\u2013Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model","volume":"107","author":"D'Amore","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib45","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1089\/hum.2008.123","article-title":"Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat","volume":"19","author":"Bish","year":"2008","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib46","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1161\/01.RES.0000237661.18885.f6","article-title":"Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in\u00a0vivo","volume":"99","author":"Pacak","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib47","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/mt.2008.76","article-title":"Analysis of AAV serotypes 1\u20139 mediated gene expression and tropism in mice after systemic injection","volume":"16","author":"Zincarelli","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cardfail.2009.01.013","article-title":"Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1\/2 clinical trial","volume":"15","author":"Jaski","year":"2009","journal-title":"J.\u00a0Cardiac Fail."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib49","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCULATIONAHA.111.022889","article-title":"Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID) a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure","volume":"124","author":"Jessup","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/CIRCRESAHA.113.302421","article-title":"Long-term effects of AAV1\/SERCA2a gene transfer in patients with severe heart failure analysis of recurrent cardiovascular events and mortality","volume":"114","author":"Zsebo","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib51","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(16)00082-9","article-title":"Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial","volume":"387","author":"Greenberg","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/mt.2011.268","article-title":"Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1. SERCA2a enhances gene transfer in porcine hearts","volume":"20","author":"Karakikes","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib53","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/FJC.0b013e3182116e39","article-title":"Fibroblasts and myofibroblasts: what are we talking about?","volume":"57","author":"Baum","year":"2011","journal-title":"J.\u00a0Cardiovasc Pharmacol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib54","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/CIRCRESAHA.113.300269","article-title":"Heart failure gene therapy the path to clinical practice","volume":"113","author":"Pleger","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib55","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jgm.1576","article-title":"A\u00a0single direct injection into the left ventricular wall of an adeno-associated virus 9 (AAV9) vector expressing extracellular superoxide dismutase from the cardiac troponin-T promoter protects mice against myocardial infarction","volume":"13","author":"Prasad","year":"2011","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib56","doi-asserted-by":"crossref","first-page":"11498","DOI":"10.1073\/pnas.90.24.11498","article-title":"Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in\u00a0vitro and in\u00a0vivo","volume":"90","author":"Kass-Eisler","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/hum.2005.16.235","article-title":"Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors","volume":"16","author":"Chen","year":"2005","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib58","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/mthe.2001.0424","article-title":"Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells","volume":"4","author":"Nicklin","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ymthe.2003.11.006","article-title":"Development of efficient viral vectors selective for vascular smooth muscle cells","volume":"9","author":"Work","year":"2004","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib60","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/01.CIR.0000109697.68832.5D","article-title":"Targeted gene delivery to vascular tissue in\u00a0vivo by tropism-modified adeno-associated virus vectors","volume":"109","author":"White","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib61","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1128\/JVI.75.13.6199-6203.2001","article-title":"Hybrid vectors based on adeno-associated virus serotypes 2 and 5 for muscle-directed gene transfer","volume":"75","author":"Hildinger","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib62","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physiolgenomics.2000.2.3.117","article-title":"Adeno-associated virus vector transduction of vascular smooth muscle cells in\u00a0vivo","volume":"2","author":"Richter","year":"2000","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib63","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/gt.2013.13","article-title":"Efficient transduction of vascular smooth muscle cells with a translational AAV2. 5 vector: a new perspective for in-stent restenosis gene therapy","volume":"20","author":"Lompr\u00e9","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib64","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cardiores.2004.08.020","article-title":"Structural and functional characterisation of cardiac fibroblasts","volume":"65","author":"Camelliti","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib65","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/01.CIR.0000085658.98621.49","article-title":"Ventricular remodeling after infarction and the extracellular collagen matrix when is enough enough?","volume":"108","author":"Jugdutt","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib66","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.brainresbull.2009.07.005","article-title":"Transduction efficiency of AAV 2\/6, 2\/8 and 2\/9 vectors for delivering genes in human corneal fibroblasts","volume":"81","author":"Sharma","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib67","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1089\/hum.2010.005","article-title":"High-efficiency transduction of fibroblasts and mesenchymal stem cells by tyrosine-mutant AAV2 vectors for their potential use in cellular therapy","volume":"21","author":"Li","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib68","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.stem.2016.05.005","article-title":"In\u00a0vivo hepatic reprogramming of myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosis","volume":"18","author":"Rezvani","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib69","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/gt.2016.20","article-title":"Systemic injection of AAV9 carrying a periostin promoter targets gene expression to a myofibroblast-like lineage in mouse hearts after reperfused myocardial infarction","volume":"23","author":"Piras","year":"2016","journal-title":"Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib70","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1089\/ten.tea.2010.0586","article-title":"Release of bioactive adeno-associated virus from fibrin scaffolds: effects of fibrin glue concentrations","volume":"17","author":"Lee","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib71","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.actbio.2015.02.013","article-title":"Effective and durable genetic modification of human mesenchymal stem cells via controlled release of rAAV vectors from self-assembling peptide hydrogels with a maintained differentiation potency","volume":"18","author":"Rey-Rico","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib72","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/jbm.a.32619","article-title":"Lentivirus delivery by adsorption to tissue engineering scaffolds","volume":"93","author":"Shin","year":"2010","journal-title":"J.\u00a0Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib73","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/jbm.a.34449","article-title":"Sustained, localized transgene expression mediated from lentivirus-loaded biodegradable polyester elastomers","volume":"101","author":"Jen","year":"2013","journal-title":"J.\u00a0Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib74","doi-asserted-by":"crossref","first-page":"8050","DOI":"10.1021\/nn5020787","article-title":"Injectable graphene oxide\/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair","volume":"8","author":"Paul","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib75","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/01.CIR.0000153338.47507.83","article-title":"Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer","volume":"111","author":"Kikuchi","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.04.015_bib76","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/gt.2008.104","article-title":"Construction and analysis of compact muscle-specific promoters for AAV vectors","volume":"15","author":"Wang","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib77","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nbt1073","article-title":"Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart","volume":"23","author":"Wang","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib78","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/gt.2010.105","article-title":"Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in\u00a0vivo gene delivery follows a Poisson distribution","volume":"18","author":"Prasad","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.04.015_bib79","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ncpcardio0319","article-title":"Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart","volume":"2","author":"Iacobellis","year":"2005","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217302430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217302430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:25:51Z","timestamp":1758903951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961217302430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":79,"alternative-id":["S0142961217302430"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.04.015","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained viral gene delivery from a micro-fibrous, elastomeric cardiac patch to the ischemic rat heart","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}