{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:23:59Z","timestamp":1793298239479,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.biomaterials.2017.05.019","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T17:30:50Z","timestamp":1494523850000},"page":"11-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Selective targeting and therapy of metastatic and multidrug resistant tumors using a long circulating podophyllotoxin nanoparticle"],"prefix":"10.1016","volume":"137","author":[{"given":"Aniruddha","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Szeitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Klassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyh-Dar","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"64","key":"10.1016\/j.biomaterials.2017.05.019_bib1","first-page":"9","article-title":"Cancer statistics","volume":"2014","author":"Siegel","year":"2014","journal-title":"CA a cancer J. Clin."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrc706","article-title":"Multidrug resistance in cancer: role of ATP-dependent transporters","volume":"2","author":"Gottesman","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1081\/DMR-120001389","article-title":"Drugs as P-glycoprotein substrates, inhibitors, and inducers","volume":"34","author":"Kim","year":"2002","journal-title":"Drug metab. Rev."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.drudis.2011.11.003","article-title":"Computational models for predicting substrates or inhibitors of P-glycoprotein","volume":"17","author":"Chen","year":"2012","journal-title":"Drug Discov. today"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib5","first-page":"1827","article-title":"Treating the treatment: toxicity of cancer chemotherapy","volume":"36","author":"Plenderleith","year":"1990","journal-title":"Can. Fam. physician Med. Fam. Can."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-74039-3_1","article-title":"Overview of resistance to systemic therapy in patients with breast cancer","volume":"608","author":"Gonzalez-Angulo","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.biomaterials.2015.02.041","article-title":"A\u00a0highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors","volume":"52","author":"Roy","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0300-9084(98)80004-7","article-title":"Discovery of podophyllotoxins","volume":"80","author":"Imbert","year":"1998","journal-title":"Biochimie"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/sj.bjc.6605489","article-title":"Class III beta-tubulin expression and in\u00a0vitro resistance to microtubule targeting agents","volume":"102","author":"Stengel","year":"2010","journal-title":"Br. J. cancer"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib11","first-page":"6387","article-title":"A\u00a0new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-60761-609-2_3","article-title":"Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting","volume":"624","author":"Greish","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-022X(95)00032-M","article-title":"Determination of surfactant critical micelle concentration by a novel fluorescence depolarization technique","volume":"31","author":"Zhang","year":"1996","journal-title":"J.\u00a0Biochem. Biophys. methods"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jconrel.2015.03.023","article-title":"Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle","volume":"206","author":"Ernsting","year":"2015","journal-title":"J.\u00a0Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bdd.2510150102","article-title":"Dose-dependent pharmacokinetics: experimental observations and theoretical considerations","volume":"15","author":"Lin","year":"1994","journal-title":"Biopharm. drug Dispos."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/physrev.00055.2006","article-title":"Properties of the glomerular barrier and mechanisms of proteinuria","volume":"88","author":"Haraldsson","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1053\/j.ackd.2013.07.006","article-title":"Applications of nanoparticles in the detection and treatment of kidney diseases","volume":"20","author":"Brede","year":"2013","journal-title":"Adv. chronic kidney Dis."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib19","doi-asserted-by":"crossref","first-page":"12369","DOI":"10.1073\/pnas.0913667107","article-title":"Paradoxical glomerular filtration of carbon nanotubes","volume":"107","author":"Ruggiero","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib20","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1016\/j.biomaterials.2003.10.097","article-title":"The targeting of anionized polyvinylpyrrolidone to the renal system","volume":"25","author":"Kodaira","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jconrel.2003.11.017","article-title":"Poly(vinylpyrrolidone-co-dimethyl maleic acid) as a novel renal targeting carrier","volume":"95","author":"Yamamoto","year":"2004","journal-title":"J.\u00a0Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jconrel.2013.09.013","article-title":"Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles","volume":"172","author":"Ernsting","year":"2013","journal-title":"J.\u00a0Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib23","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.2174\/09298673113209990004","article-title":"Deep penetration of nanoparticulate drug delivery systems into tumors: challenges and solutions","volume":"20","author":"Li","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/1471-2407-9-356","article-title":"The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors","volume":"9","author":"Patel","year":"2009","journal-title":"BMC cancer"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10555-008-9173-4","article-title":"Mechanics, malignancy, and metastasis: the force journey of a tumor cell","volume":"28","author":"Kumar","year":"2009","journal-title":"Cancer metastasis Rev."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib30","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1021\/acsnano.5b00067","article-title":"Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration","volume":"9","author":"Rychahou","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2007.11.002","article-title":"Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles","volume":"126","author":"Li","year":"2008","journal-title":"J.\u00a0Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib32","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1021\/nn205070h","article-title":"Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs","volume":"6","author":"Kievit","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib33","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1021\/nn303833p","article-title":"Imaging metastasis using an integrin-targeting chain-shaped nanoparticle","volume":"6","author":"Peiris","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib34","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1021\/acsnano.5b01552","article-title":"Spatiotemporal targeting of a dual-ligand nanoparticle to cancer metastasis","volume":"9","author":"Doolittle","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2017.05.019_bib35","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Gerlinger","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib36","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1200\/JCO.2003.08.013","article-title":"Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial (E1193)","volume":"21","author":"Sledge","year":"2003","journal-title":"J.\u00a0Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ygyno.2013.05.029","article-title":"Current standards of care for chemotherapy of optimally cytoreduced advanced epithelial ovarian cancer","volume":"131","author":"Markman","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1586\/17512433.2014.909723","article-title":"Vintafolide (EC145) for the treatment of folate-receptor-alpha positive platinum-resistant ovarian cancer","volume":"7","author":"Ambrosio","year":"2014","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib39","first-page":"2069","article-title":"Advanced epithelial ovarian cancer: from standard chemotherapy to promising molecular pathway targets\u2013where are we now?","volume":"34","author":"Syrios","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib40","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/096032719201100607","article-title":"Podophyllotoxin intoxication: toxic effect of Bajiaolian in herbal therapeutics","volume":"11","author":"Kao","year":"1992","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biomaterials.2017.05.019_bib41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1212\/WNL.32.3.308","article-title":"Neurologic manifestations of podophyllin toxicity","volume":"32","author":"Filley","year":"1982","journal-title":"Neurology"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217303319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217303319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:26:07Z","timestamp":1758903967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961217303319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":37,"alternative-id":["S0142961217303319"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.05.019","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective targeting and therapy of metastatic and multidrug resistant tumors using a long circulating podophyllotoxin nanoparticle","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}