{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:44:47Z","timestamp":1781149487450,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["105-2119-M-007-008"],"award-info":[{"award-number":["105-2119-M-007-008"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biomaterials.2017.08.023","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T10:00:49Z","timestamp":1502964049000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds"],"prefix":"10.1016","volume":"145","author":[{"given":"Wei-Chih","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jyuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Lin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chien","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing-Wen","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2017.08.023_bib1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2014.11.001","article-title":"Early controlled release of peroxisome proliferator-activated receptor \u03b2\/\u03b4 agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment","volume":"197","author":"Wang","year":"2015","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib2","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.2337\/dbi16-0042","article-title":"Hydrogen sulfide therapy in diabetes-accelerated atherosclerosis: a whiff of success","volume":"65","author":"Durante","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib3","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib4","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib6","doi-asserted-by":"crossref","first-page":"e36974","DOI":"10.1371\/journal.pone.0036974","article-title":"Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial","volume":"7","author":"Lima","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/wound.2013.0473","article-title":"Epithelialization in wound healing: a comprehensive review","volume":"3","author":"Pastar","year":"2014","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2353\/ajpath.2009.081080","article-title":"MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing","volume":"175","author":"Hattori","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cca.2014.10.037","article-title":"Hydrogen sulfide in signaling pathways","volume":"439","author":"Olas","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib11","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1002\/anie.201305201","article-title":"Emerging applications of phase-change materials (PCMs): teaching an old dog new tricks","volume":"53","author":"Hyun","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib12","first-page":"1","article-title":"The return of a forgotten polymer\u2014polycaprolactone in the 21st century","author":"Woodruff","year":"2010","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib13","first-page":"1103","article-title":"Hyperglycaemic conditions decrease cultured keratinocyte mobility: implications for impaired wound healing in patients with diabetes","volume":"159","author":"Lan","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib14","first-page":"1","article-title":"H2S, a novel gasotransmitter, involves in gastric accommodation","author":"Xiao","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jconrel.2010.07.123","article-title":"A\u00a0simple method to achieve high doxorubicin loading in biodegradable polymersomes","volume":"147","author":"Sanson","year":"2010","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib16","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1161\/01.CIR.0000147825.97879.E7","article-title":"Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1\/2 and phosphatidylinositol 3-kinase pathways","volume":"110","author":"Calabro","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/gt.2011.14","article-title":"MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors","volume":"18","author":"Bhoopathi","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nprot.2010.6","article-title":"In\u00a0vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract","volume":"5","author":"Arnaoutova","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib19","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/eji.201041178","article-title":"CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5\/X4) HIV-1 infection","volume":"41","author":"Gouwy","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib20","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.2337\/db13-0483","article-title":"Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes","volume":"63","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/adhm.201300537","article-title":"Reduction in wound bioburden using a silver-loaded dissolvable microfilm construct","volume":"3","author":"Herron","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib22","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1056\/NEJM200108093450603","article-title":"Dysfunction of endothelial protein C activation in severe meningococcal sepsis","volume":"345","author":"Faust","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib24","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.3390\/ma6104758","article-title":"Form-stable phase change materials based on eutectic mixture of tetradecanol and fatty acids for building energy storage: preparation and performance analysis","volume":"6","author":"Huang","year":"2013","journal-title":"Materials"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib25","first-page":"274","article-title":"Correlation between wound temperature obtained with an infrared camera and clinical wound bed score in venous leg ulcers","volume":"27","author":"Dini","year":"2015","journal-title":"Wounds"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib26","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.biomaterials.2004.06.011","article-title":"Physically crosslinked alginate\/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs","volume":"26","author":"Lin","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/ars.2011.4401","article-title":"A\u00a0practical look at the chemistry and biology of hydrogen sulfide","volume":"17","author":"Olson","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.biomaterials.2017.08.023_bib28","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.freeradbiomed.2011.01.025","article-title":"Measurement of plasma hydrogen sulfide in\u00a0vivo and in\u00a0vitro","volume":"50","author":"Shen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib29","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1152\/ajpregu.00025.2008","article-title":"Reappraisal of H2S\/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling","volume":"294","author":"Whitfield","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.biomaterials.2017.08.023_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound healing - aiming for perfect skin regeneration","volume":"276","author":"Martin","year":"1997","journal-title":"Science"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217305331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217305331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:28:47Z","timestamp":1758904127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961217305331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":30,"alternative-id":["S0142961217305331"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.08.023","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}