{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:46:00Z","timestamp":1787669160641,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2014CB931900"],"award-info":[{"award-number":["2014CB931900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NSFC, China","award":["2013CB932503"],"award-info":[{"award-number":["2013CB932503"]}]},{"name":"NSFC, China","award":["81373357"],"award-info":[{"award-number":["81373357"]}]},{"name":"NSFC, China","award":["81422048"],"award-info":[{"award-number":["81422048"]}]},{"name":"NSFC, China","award":["81673382"],"award-info":[{"award-number":["81673382"]}]},{"name":"NSFC, China","award":["81402883"],"award-info":[{"award-number":["81402883"]}]},{"name":"NSFC, China","award":["81521005"],"award-info":[{"award-number":["81521005"]}]},{"name":"Fudan-SIMM Joint Research Fund","award":["FU-SIMM20174009"],"award-info":[{"award-number":["FU-SIMM20174009"]}]},{"name":"Scientific Research and Equipment Development Project","award":["YZ201437"],"award-info":[{"award-number":["YZ201437"]}]},{"DOI":"10.13039\/501100012492","name":"Youth Innovation Promotion Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012492","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.biomaterials.2017.12.018","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T02:25:27Z","timestamp":1513909527000},"page":"56-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites"],"prefix":"10.1016","volume":"158","author":[{"given":"Fan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihai","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhuo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2017.12.018_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/path.1706","article-title":"Molecular mechanisms of drug resistance","volume":"205","author":"Longley","year":"2005","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib2","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/annonc\/mdw191","article-title":"Challenging chemoresistant metastatic colorectal cancer: therapeutic strategies from the clinic and from the laboratory","volume":"27","author":"Sartore-Bianchi","year":"2016","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/bjc.2016.111","article-title":"Targeting cell death signalling in cancer: minimising 'Collateral damage'","volume":"115","author":"Fox","year":"2016","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib4","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1021\/acs.molpharmaceut.6b00987","article-title":"Prodrug-like, PEGylated protein toxin trichosanthin for reversal of chemoresistance","volume":"14","author":"Chen","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.molcel.2007.03.019","article-title":"Phosphorylation of caspase-9 by CDK1\/cyclin B1 protects mitotic cells against apoptosis","volume":"26","author":"Allan","year":"2007","journal-title":"Mol. Cell."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-3565(24)29298-3","article-title":"Preclinical studies to predict the disposition of Apo2L\/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in\u00a0vivo efficacy, pharmacokinetics, and safety","volume":"299","author":"Kelley","year":"2001","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib7","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1039\/C6TB02990F","article-title":"Poly-gamma-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy","volume":"5","author":"Tan","year":"2017","journal-title":"J.\u00a0Mater. Chem. B"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2017.12.018_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12026-012-8284-8","article-title":"Resistance to TRAIL and how to surmount it","volume":"52","author":"Maksimovic-Ivanic","year":"2012","journal-title":"Immunol. Res."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fonc.2015.00069","article-title":"Trailing TRAIL resistance: novel targets for TRAIL sensitization in cancer cells","volume":"5","author":"Trivedi","year":"2015","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib10","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1093\/carcin\/bgt137","article-title":"Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation","volume":"34","author":"Yoon","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib11","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1159\/000430286","article-title":"Upregulation of death receptor 5 and production of reactive oxygen species mediate sensitization of PC-3 prostate cancer cells to TRAIL induced apoptosis by vitisin a","volume":"36","author":"Shin","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib12","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2217\/fon.12.139","article-title":"Polymer nanoparticulate drug delivery and combination cancer therapy","volume":"8","author":"Cao","year":"2012","journal-title":"Future Oncol."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib13","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/aps.2016.48","article-title":"Nuclear-targeting TAT-PEG-Asp8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer","volume":"37","author":"Pan","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib14","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/aps.2017.10","article-title":"Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy","volume":"38","author":"Kang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201700403","article-title":"Dual-targeting to cancer cells and M2 macrophages via biomimetic delivery of mannosylated albumin nanoparticles for drug-resistant cancer therapy","volume":"27","author":"Zhao","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib16","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1016\/j.biomaterials.2010.07.086","article-title":"Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan\/siRNA complexes via the inclusion of a negatively charged poly(\u03b3-glutamic acid)","volume":"31","author":"Liao","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib17","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1016\/j.biomaterials.2012.01.013","article-title":"Mechanistic study of transfection of chitosan\/DNA complexes coated by anionic poly(gamma-glutamic acid)","volume":"33","author":"Liao","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib18","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1002\/adma.201403547","article-title":"Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging","volume":"26","author":"Jiang","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib19","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/adma.201504288","article-title":"Fusogenic reactive oxygen species triggered charge-reversal vector for effective gene delivery","volume":"28","author":"Liu","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib20","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1002\/adma.201603095","article-title":"Esterase-activated charge-reversal polymer for fibroblast-exempt cancer gene therapy","volume":"28","author":"Qiu","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib21","article-title":"Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib22","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.21873\/anticanres.11168","article-title":"Monensin induces PC-3 prostate cancer cell apoptosis via ROS production and Ca2+ homeostasis disruption","volume":"36","author":"Kim","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1535-6108(04)00113-8","article-title":"Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway","volume":"5","author":"Wang","year":"2004","journal-title":"Canc. Cell"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib24","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1016\/j.biomaterials.2012.05.035","article-title":"TAT-modified nanosilver for combating multidrug-resistant cancer","volume":"33","author":"Liu","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2014.06.051","article-title":"Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer","volume":"192C","author":"Wang","year":"2014","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib26","doi-asserted-by":"crossref","first-page":"9788","DOI":"10.1021\/nn2033105","article-title":"Controlled intracellular release of doxorubicin in multidrug-resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles","volume":"5","author":"Gao","year":"2011","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.biomaterials.2017.12.018_bib27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s10495-017-1375-1","article-title":"Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)","volume":"22","author":"Rathore","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib28","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1002\/adfm.201300793","article-title":"Co-delivery of cell-permeable chimeric apoptosis AVPIR8 peptide\/p53 DNA for cocktail therapy","volume":"23","author":"Wang","year":"2013","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib29","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1038\/sj.onc.1210374","article-title":"Targeting death-inducing receptors in cancer therapy","volume":"26","author":"Takeda","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib30","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fonc.2014.00128","article-title":"Depolarization controls TRAIL-sensitization and tumor-selective killing of cancer cells: crosstalk with ROS","volume":"4","author":"Suzuki-Karasaki","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib31","doi-asserted-by":"crossref","first-page":"35418","DOI":"10.1074\/jbc.M110.172767","article-title":"Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL","volume":"285","author":"Sung","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biomaterials.2017.12.018_bib32","article-title":"Sandwich-type Au-PEI\/DNA\/PEI-Dexa nanocomplex for nucleus-targeted gene delivery in\u00a0vitro and in\u00a0vivo","volume":"6","author":"Chen","year":"2014","journal-title":"Acs Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2017.12.018_bib33","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jconrel.2011.10.011","article-title":"Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in\u00a0vitro and in\u00a0vivo","volume":"157","author":"Xia","year":"2012","journal-title":"J.\u00a0Contr. Release"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217308244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961217308244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:31:20Z","timestamp":1758904280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961217308244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":33,"alternative-id":["S0142961217308244"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.12.018","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2017.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}