{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:28:16Z","timestamp":1792783696158,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Natural Science and Engineering Council Discovery Accelerator Supplement, Canada","award":["RGPIN-314056"],"award-info":[{"award-number":["RGPIN-314056"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.biomaterials.2018.01.038","type":"journal-article","created":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T11:24:26Z","timestamp":1519039466000},"page":"54-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"C","title":["A TRACER 3D Co-Culture tumour model for head and neck cancer"],"prefix":"10.1016","volume":"164","author":[{"given":"Miki","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Rodenhizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"D'Arcangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Ailles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison P.","family":"McGuigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.biomaterials.2018.01.038_bib1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.01.038_bib2","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3390\/cancers7040902","article-title":"Cancer-associated fibroblasts: their characteristics and their roles in tumor growth","volume":"7","author":"Shiga","year":"2015","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib3","first-page":"66","article-title":"The tumor microenvironment contribution to development, growth, invasion and metastasis of head and neck squamous cell carcinomas","volume":"4","author":"Koontongkaew","year":"2013","journal-title":"J.\u00a0Canc."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.01.038_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/cas.12096","article-title":"Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients","volume":"104","author":"Herrera","year":"2013","journal-title":"Cancer Sci."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.01.038_bib5","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.yexcr.2013.05.026","article-title":"Introduction to tumor-stroma interactions","volume":"319","author":"Ostman","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2004.06.010","article-title":"Molecular characterization of the tumor microenvironment in breast cancer","volume":"6","author":"Allinen","year":"2004","journal-title":"Canc. Cell"},{"issue":"7015","key":"10.1016\/j.biomaterials.2018.01.038_bib7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature03096","article-title":"Stromal fibroblasts in cancer initiation and progression","volume":"432","author":"Bhowmick","year":"2004","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biomaterials.2018.01.038_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","article-title":"Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion","volume":"121","author":"Orimo","year":"2005","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/scbi.2000.0361","article-title":"Stromal cells can contribute oncogenic signals","volume":"11","author":"Tlsty","year":"2001","journal-title":"Semin. Canc. Biol."},{"issue":"8","key":"10.1016\/j.biomaterials.2018.01.038_bib10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/jop.12172","article-title":"A\u00a0role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma","volume":"43","author":"Zhou","year":"2014","journal-title":"J.\u00a0Oral Pathol. Med."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ijc.25060","article-title":"Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7","volume":"127","author":"Jung","year":"2010","journal-title":"Int J Cancer"},{"issue":"5","key":"10.1016\/j.biomaterials.2018.01.038_bib12","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1667\/RR13583.1","article-title":"Crosstalk with cancer-associated fibroblasts increases the growth and radiation survival of cervical cancer cells","volume":"181","author":"Chu","year":"2014","journal-title":"Radiat. Res."},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2018.01.038_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10555-011-9340-x","article-title":"Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression","volume":"31","author":"Cirri","year":"2012","journal-title":"Canc. Metastasis Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2009.10.001","article-title":"Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?","volume":"21","author":"Gonda","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.biomaterials.2018.01.038_bib15","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.bbadis.2012.10.013","article-title":"Fibroblasts as architects of cancer pathogenesis","volume":"1832","author":"Marsh","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pharmthera.2012.10.003","article-title":"Tumor stroma as targets for cancer therapy","volume":"137","author":"Zhang","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biomaterials.2018.01.038_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-bioeng-071811-150028","article-title":"Engineered culture models for studies of tumor-microenvironment interactions","volume":"15","author":"Infanger","year":"2013","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib18","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jconrel.2012.04.045","article-title":"Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy","volume":"164","author":"Mehta","year":"2012","journal-title":"J.\u00a0Contr. Release"},{"issue":"16","key":"10.1016\/j.biomaterials.2018.01.038_bib19","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1016\/j.biomaterials.2009.02.047","article-title":"Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids","volume":"30","author":"Hsiao","year":"2009","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biomaterials.2018.01.038_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092511","article-title":"Development of an innovative 3D cell culture system to study tumour\u2013stroma interactions in non-small cell lung cancer cells","volume":"9","author":"Amann","year":"2014","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.biomaterials.2018.01.038_bib21","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1073\/pnas.86.18.7043","article-title":"Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces","volume":"86","author":"Friedlander","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ajpath.2011.03.015","article-title":"Modeling colon adenocarcinomas in\u00a0vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction","volume":"179","author":"Dolznig","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.yexcr.2015.05.016","article-title":"Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial-mesenchymal transition in\u00a0vitro","volume":"335","author":"Kim","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"12","key":"10.1016\/j.biomaterials.2018.01.038_bib24","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/ncb1658","article-title":"Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells","volume":"9","author":"Gaggioli","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.01.038_bib25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ncb3478","article-title":"A\u00a0mechanically active heterotypic E-cadherin\/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion","volume":"19","author":"Labernadie","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.biomaterials.2018.01.038_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159013","article-title":"Co-culture of tumor spheroids and fibroblasts in a collagen matrix-incorporated microfluidic chip mimics reciprocal activation in solid tumor microenvironment","volume":"11","author":"Jeong","year":"2016","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.biomaterials.2018.01.038_bib27","doi-asserted-by":"crossref","first-page":"25593","DOI":"10.18632\/oncotarget.8232","article-title":"Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device","volume":"7","author":"Yu","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.biomaterials.2018.01.038_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076373","article-title":"Understanding the impact of 2D and 3D fibroblast cultures on in\u00a0vitro breast cancer models","volume":"8","author":"Sung","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2018.01.038_bib29","doi-asserted-by":"crossref","first-page":"34094","DOI":"10.1038\/srep34094","article-title":"Breast cancer cell invasion into a three dimensional tumor-stroma microenvironment","volume":"6","author":"Truong","year":"2016","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.biomaterials.2018.01.038_bib30","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1039\/c3lc50487e","article-title":"A\u00a0bioengineered heterotypic stroma-cancer microenvironment model to study pancreatic ductal adenocarcinoma","volume":"13","author":"Drifka","year":"2013","journal-title":"Lab a Chip"},{"issue":"13","key":"10.1016\/j.biomaterials.2018.01.038_bib31","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1039\/c000022a","article-title":"Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device","volume":"10","author":"Liu","year":"2010","journal-title":"Lab a Chip"},{"issue":"8","key":"10.1016\/j.biomaterials.2018.01.038_bib32","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1039\/C5LC01569C","article-title":"Digital microfluidics for spheroid-based invasion assays","volume":"16","author":"Bender","year":"2016","journal-title":"Lab a Chip"},{"issue":"7","key":"10.1016\/j.biomaterials.2018.01.038_bib33","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nprot.2012.051","article-title":"Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels","volume":"7","author":"Shin","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biomaterials.2018.01.038_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12885-015-1007-5","article-title":"Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure","volume":"15","author":"Bischel","year":"2015","journal-title":"BMC Canc."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.01.038_bib35","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1158\/1541-7786.MCR-12-0307","article-title":"Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue","volume":"10","author":"Karagiannis","year":"2012","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.biomaterials.2018.01.038_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ceb.2015.06.004","article-title":"Modes of cancer cell invasion and the role of the microenvironment","volume":"36","author":"Clark","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biomaterials.2018.01.038_bib37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nmat4482","article-title":"A\u00a0three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients","volume":"15","author":"Rodenhizer","year":"2016","journal-title":"Nat Materials"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.01.038_bib38","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/8\/4\/045008","article-title":"Development of TRACER: tissue roll for analysis of cellular environment and response","volume":"8","author":"Rodenhizer","year":"2016","journal-title":"Biofabrication"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.01.038_bib39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/adhm.201500709","article-title":"Fibroblasts enhance migration of human lung cancer cells in a paper-based coculture system","volume":"5","author":"Camci-Unal","year":"2016","journal-title":"Adv Healthc Mater"},{"issue":"44","key":"10.1016\/j.biomaterials.2018.01.038_bib40","doi-asserted-by":"crossref","first-page":"18457","DOI":"10.1073\/pnas.0910666106","article-title":"Paper-supported 3D cell culture for tissue-based bioassays","volume":"106","author":"Derda","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1039\/C5AN01787D","article-title":"Real-time imaging of cancer cell chemotaxis in paper-based scaffolds","volume":"141","author":"Kenney","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.biomaterials.2018.01.038_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-61779-207-6_8","article-title":"Transwell((R)) invasion assays","volume":"769","author":"Marshall","year":"2011","journal-title":"Methods Mol Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.oraloncology.2010.10.013","article-title":"Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer","volume":"47","author":"Bello","year":"2011","journal-title":"Oral Oncol."},{"issue":"6","key":"10.1016\/j.biomaterials.2018.01.038_bib44","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1600-0714.2012.01127.x","article-title":"Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance","volume":"41","author":"Fujii","year":"2012","journal-title":"J.\u00a0Oral Pathol. Med."},{"issue":"19","key":"10.1016\/j.biomaterials.2018.01.038_bib45","first-page":"5002","article-title":"Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium","volume":"59","author":"Olumi","year":"1999","journal-title":"Cancer Res."},{"issue":"7162","key":"10.1016\/j.biomaterials.2018.01.038_bib46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature06188","article-title":"Mesenchymal stem cells within tumour stroma promote breast cancer metastasis","volume":"449","author":"Karnoub","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2018.01.038_bib47","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.2147\/OTT.S89659","article-title":"Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition","volume":"8","author":"Choe","year":"2015","journal-title":"OncoTargets Ther."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1590\/S0365-05962012000100013","article-title":"Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects","volume":"87","author":"Vieira","year":"2012","journal-title":"An. Bras. Dermatol."},{"issue":"6352","key":"10.1016\/j.biomaterials.2018.01.038_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2507","article-title":"A\u00a0pathology atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2006.08.006","article-title":"Protein diffusion in agarose hydrogel in situ measured by improved refractive index method","volume":"115","author":"Liang","year":"2006","journal-title":"J.\u00a0Contr. Release"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib51","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0006-3495(99)76911-0","article-title":"Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations","volume":"77","author":"Pluen","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.biomaterials.2018.01.038_bib52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(02)52003-6","article-title":"Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5","volume":"352","author":"Koch","year":"2002","journal-title":"Methods Enzymol."},{"issue":"9","key":"10.1016\/j.biomaterials.2018.01.038_bib53","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.oraloncology.2011.06.011","article-title":"Myofibroblasts in the stroma of oral cancer promote tumorigenesis via secretion of activin A","volume":"47","author":"Sobral","year":"2011","journal-title":"Oral Oncol."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.01.038_bib54","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/annonc\/mdq732","article-title":"Is the Ki-67 labelling index ready for clinical use?","volume":"22","author":"Jonat","year":"2011","journal-title":"Ann. Oncol."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.01.038_bib55","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0962-8924(03)00057-6","article-title":"Fibroblast biology in three-dimensional collagen matrices","volume":"13","author":"Grinnell","year":"2003","journal-title":"Trends Cell Biol."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.01.038_bib56","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/archotol.134.11.1218","article-title":"Modulation of tumor cell growth in\u00a0vivo by extracellular matrix metalloprotease inducer","volume":"134","author":"Newman","year":"2008","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.01.038_bib57","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/bjc.2011.403","article-title":"Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma","volume":"105","author":"Colley","year":"2011","journal-title":"Br. J. Canc."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib58","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jbiotec.2010.01.012","article-title":"Multicellular tumor spheroids: an underestimated tool is catching up again","volume":"148","author":"Hirschhaeuser","year":"2010","journal-title":"J.\u00a0Biotechnol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib59","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/1097-0142(197201)29:1<117::AID-CNCR2820290119>3.0.CO;2-R","article-title":"A\u00a0new human cell line (FaDu) from a hypopharyngeal carcinoma","volume":"29","author":"Rangan","year":"1972","journal-title":"Cancer"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2018.01.038_bib60","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.drup.2013.01.001","article-title":"Understanding the functions of tumor stroma in resistance to ionizing radiation: emerging targets for pharmacological modulation","volume":"16","author":"Chargari","year":"2013","journal-title":"Drug Resist. Updates"},{"issue":"8","key":"10.1016\/j.biomaterials.2018.01.038_bib61","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ncb2548","article-title":"Classifying collective cancer cell invasion","volume":"14","author":"Friedl","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.01.038_bib62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bios.2012.06.017","article-title":"Long-term three-dimensional cell culture and anticancer drug activity evaluation in a microfluidic chip","volume":"40","author":"Ziolkowska","year":"2013","journal-title":"Biosens. Bioelectron."},{"issue":"6","key":"10.1016\/j.biomaterials.2018.01.038_bib63","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrc1367","article-title":"Exploiting tumour hypoxia in cancer treatment","volume":"4","author":"Brown","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"14","key":"10.1016\/j.biomaterials.2018.01.038_bib64","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/onc.2013.121","article-title":"Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment","volume":"33","author":"Casazza","year":"2014","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.01.038_bib65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","article-title":"Hypoxia in cancer: significance and impact on clinical outcome","volume":"26","author":"Vaupel","year":"2007","journal-title":"Canc. Metastasis Rev."},{"issue":"23","key":"10.1016\/j.biomaterials.2018.01.038_bib66","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","article-title":"The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma","volume":"8","author":"Pavlides","year":"2009","journal-title":"Cell Cycle"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218300528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218300528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:31:54Z","timestamp":1758904314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218300528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":66,"alternative-id":["S0142961218300528"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.01.038","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A TRACER 3D Co-Culture tumour model for head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.01.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}