{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:28:15Z","timestamp":1792783695374,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"FWO Flanders"},{"name":"Flemish Liga Against Cancer"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN272201400056C"],"award-info":[{"award-number":["HHSN272201400056C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.biomaterials.2018.03.026","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T14:54:26Z","timestamp":1521384866000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7\/8 agonist"],"prefix":"10.1016","volume":"178","author":[{"given":"Lutz","family":"Nuhn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Van Hoecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Deswarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Schepens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart N.","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefaan","family":"De Koker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil A.","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Saelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno G.","family":"De Geest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2018.03.026_bib1","volume":"vol. 1","year":"2017"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/sj.bjc.6602022","article-title":"Targeting cytotoxic T lymphocytes for cancer immunotherapy","volume":"91","author":"Maher","year":"2004","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ccr.2013.02.013","article-title":"Macrophage regulation of tumor responses to anticancer therapies","volume":"23","author":"De Palma","year":"2013","journal-title":"Canc. Cell"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri2073","article-title":"Prospects for the use of NK cells in immunotherapy of human cancer","volume":"7","author":"Ljunggren","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib5","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single- stranded RNA.pdf","volume":"303","author":"Diebold","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib6","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1038\/cti.2016.22","article-title":"Toll-like receptors: the swiss army knife of immunity and vaccine development","volume":"5","author":"Dowling","year":"2016","journal-title":"Clin. Translat. Immunol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1586\/14760584.2013.811208","article-title":"The use of Toll-like receptor 7\/8 agonists as vaccine adjuvants","volume":"12","author":"Vasilakos","year":"2013","journal-title":"Expet Rev. Vaccine"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nri3845","article-title":"Type I interferons in anticancer immunity","volume":"15","author":"Zitvogel","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.4049\/jimmunol.1000060","article-title":"Generation of Th1-Polarizing dendritic cells using the TLR7\/8 agonist CL075","volume":"185","author":"Spranger","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib10","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1039\/c3cs60039d","article-title":"Targeting Toll-like receptors with small molecule agents","volume":"42","author":"Wang","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib11","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1021\/cb500079s","article-title":"Directing the immune system with chemical compounds","volume":"9","author":"Mancini","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/cmdc.201500566","article-title":"Cancer immunotherapy: selected targets and small-molecule modulators","volume":"11","author":"Weinmann","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib13","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.chembiol.2017.08.019","article-title":"Small-molecule targets in immuno-oncology","volume":"24","author":"Dhanak","year":"2017","journal-title":"Cell Chem. BioL."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/ajh.23280","article-title":"Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic malignancies","volume":"87","author":"Weigel","year":"2012","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib15","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1158\/1078-0432.CCR-07-1443","article-title":"First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer","volume":"13","author":"Dudek","year":"2007","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib16","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nbt.3371","article-title":"In\u00a0vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity","volume":"33","author":"Lynn","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib17","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.1600816113","article-title":"pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation","volume":"113","author":"Nuhn","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jconrel.2006.01.006","article-title":"In\u00a0vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles","volume":"112","author":"Reddy","year":"2006","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/nbt1332","article-title":"Exploiting lymphatic transport and complement activation in nanoparticle vaccines","volume":"25","author":"Reddy","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib20","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/anie.201508626","article-title":"Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery","volume":"55","author":"De Koker","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ppul.23570","article-title":"Respiratory syncytial virus hospitalization and mortality: systematic review and meta-analysis","volume":"52","author":"Stein","year":"2017","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib22","first-page":"105","article-title":"Challenges and opportunities for respiratory syncytial virus vaccines","volume":"372","author":"Lotz","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/v5020577","article-title":"Respiratory syncytial virus: current progress in vaccine development","volume":"5","author":"Rudraraju","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-065X.2010.00972.x","article-title":"Biological challenges and technological opportunities for RSV vaccine development","volume":"239","author":"Graham","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib25","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1021\/acs.bioconjchem.6b00370","article-title":"Thermoresponsive polymer nanoparticles Co-deliver RSV F trimers with a TLR-7\/8 adjuvant","volume":"27","author":"Francica","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib26","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.15252\/emmm.201404005","article-title":"Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein","volume":"6","author":"Schepens","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib27","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1021\/nn204116u","article-title":"Cationic nanohydrogel particles as potential siRNA carriers for cellular delivery","volume":"6","author":"Nuhn","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib28","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1021\/jm100358c","article-title":"Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues","volume":"53","author":"Shukla","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib29","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/macp.201600246","article-title":"Imaging of polymeric nanoparticles: hard challenge for soft objects","volume":"217","author":"Renz","year":"2016","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-1119(88)90219-3","article-title":"Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells","volume":"66","author":"Berger","year":"1988","journal-title":"Gene"},{"key":"10.1016\/j.biomaterials.2018.03.026_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ddtec.2005.05.006","article-title":"Subcutaneous drug delivery and the role of the lymphatics","volume":"2","author":"McLennan","year":"2005","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib32","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s11095-012-0708-6","article-title":"Fluorescence imaging of the lymph node uptake of proteins in mice after subcutaneous injection: molecular weight dependence","volume":"29","author":"Wu","year":"2012","journal-title":"Pharmaceut. Res."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib33","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1021\/acs.bioconjchem.5b00103","article-title":"Guiding principles in the design of molecular bioconjugates for vaccine applications","volume":"26","author":"Liu","year":"2015","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biomaterials.2018.03.026_bib34","series-title":"Sheet Data Sigma Adjuvant System","year":"2018"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218301935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218301935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:38:15Z","timestamp":1758904695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218301935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":34,"alternative-id":["S0142961218301935"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.03.026","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7\/8 agonist","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}