{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:22:46Z","timestamp":1777879366919,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Korean government, MSIP, South Korea","award":["2016R1A2B4011184"],"award-info":[{"award-number":["2016R1A2B4011184"]}]},{"name":"Korean government, MSIP, South Korea","award":["2016K2A9A1A06921661"],"award-info":[{"award-number":["2016K2A9A1A06921661"]}]},{"name":"Korean government, MSIP, South Korea","award":["NRF-2017M3A9F5030940"],"award-info":[{"award-number":["NRF-2017M3A9F5030940"]}]},{"name":"Korean government, MSIP, South Korea","award":["NRF-2017M3A9E2056374"],"award-info":[{"award-number":["NRF-2017M3A9E2056374"]}]},{"name":"Ministry of Science, ICT & Future Planning, South Korea","award":["2014M3C1A3053035"],"award-info":[{"award-number":["2014M3C1A3053035"]}]},{"name":"Chonnam National University Hwasun Hospital Institute for Biomedical Science, South Korea","award":["HCRI 17901-22"],"award-info":[{"award-number":["HCRI 17901-22"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biomaterials.2018.03.051","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T11:25:16Z","timestamp":1522409116000},"page":"45-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Programmed \u2018triple-mode\u2019 anti-tumor therapy: Improving peritoneal retention, tumor penetration and activatable drug release properties for effective inhibition of peritoneal carcinomatosis"],"prefix":"10.1016","volume":"169","author":[{"given":"Kondareddy","family":"Cherukula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Kyun","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyuk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2018.03.051_bib1","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.3748\/wjg.v19.i41.6979","article-title":"Peritoneal carcinomatosis","volume":"19","author":"Coccolini","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1046\/j.1365-2168.2002.02274.x","article-title":"Peritoneal carcinomatosis from colorectal cancer","volume":"89","author":"Jayne","year":"2002","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal cisplatin and paclitaxel in ovarian cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib4","first-page":"97","article-title":"Breast gemmangioma","volume":"98","author":"Schneider","year":"1973","journal-title":"Zentralbl. Chir."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib5","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s11095-007-9298-0","article-title":"Effects of carrier on disposition and antitumor activity of intraperitoneal paclitaxel","volume":"24","author":"Tsai","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/IJWH.S7012","article-title":"Clinical trials and progress with paclitaxel in ovarian cancer","volume":"2","author":"Kumar","year":"2010","journal-title":"Int. J. Womens. Health"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/720858","article-title":"Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent","volume":"2013","author":"De Smet","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/jbm.a.30654","article-title":"Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum","volume":"77","author":"Kohane","year":"2006","journal-title":"J.\u00a0Biomed. Mater. Res. A"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0959-8049(05)80025-5","article-title":"Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture","volume":"30A","author":"Bennis","year":"1994","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrclinonc.2010.139","article-title":"Delivering nanomedicine to solid tumors","volume":"7","author":"Jain","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib11","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1021\/nl900031y","article-title":"Mediating tumor targeting efficiency of nanoparticles through design","volume":"9","author":"Perrault","year":"2009","journal-title":"Nano Lett."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib12","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A\u00a0versatile vector for gene and oligonucleotide transfer into cells in culture and in\u00a0vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.colsurfb.2017.02.030","article-title":"Multifunctional nanoparticles self-assembled from polyethylenimine-based graft polymers as efficient anticancer drug delivery","volume":"155","author":"Yan","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.biomaterials.2012.09.039","article-title":"PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor","volume":"34","author":"Shi","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib15","doi-asserted-by":"crossref","first-page":"10034","DOI":"10.1021\/acsami.7b02196","article-title":"Receptor-mediated surface charge inversion platform based on porous silicon nanoparticles for efficient cancer cell recognition and combination therapy","volume":"9","author":"Zhang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib16","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1021\/acs.biomac.6b00234","article-title":"Polymeric micelles with uniform surface properties and tunable size and charge: positive charges improve tumor accumulation","volume":"17","author":"Shen","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.biomaterials.2016.04.037","article-title":"Evaluation of drug penetration with cationic micelles and their penetration mechanism using an in\u00a0vitro tumor model","volume":"98","author":"Suzuki","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib18","doi-asserted-by":"crossref","first-page":"e24374","DOI":"10.1371\/journal.pone.0024374","article-title":"Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles","volume":"6","author":"Arvizo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib19","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.2147\/IJN.S129300","article-title":"Protein corona: a new approach for nanomedicine design","volume":"12","author":"Nguyen","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib20","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1002\/jps.21718","article-title":"A\u00a0photophysical study on the role of bile salt hydrophobicity in solubilizing amphotericin B aggregates","volume":"98","author":"Selvam","year":"2009","journal-title":"J.\u00a0Pharmaceut. Sci."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.colsurfb.2009.03.029","article-title":"Solubilization of resveratrol in micellar solutions of different bile acids","volume":"72","author":"Atanackovi\u0107","year":"2009","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib22","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.2147\/IJN.S82558","article-title":"Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine","volume":"10","author":"Elnaggar","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1039\/C4MD00223G","article-title":"Synthesis, structure-activity relationship, and mechanistic investigation of lithocholic acid amphiphiles for colon cancer therapy","volume":"6","author":"Singh","year":"2015","journal-title":"MedChemComm"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib24","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.7717\/peerj.122","article-title":"Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells","volume":"1","author":"Goldberg","year":"2013","journal-title":"Peer J."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib25","doi-asserted-by":"crossref","first-page":"12218","DOI":"10.1073\/pnas.94.22.12218","article-title":"Design of compounds that increase the absorption of polar molecules","volume":"94","author":"Bowe","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib26","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.1021\/acs.chemmater.6b03896","article-title":"Structure-dependent and glutathione-responsive biodegradable dendritic mesoporous organosilica nanoparticles for safe protein delivery","volume":"28","author":"Yang","year":"2016","journal-title":"Chem. Mater."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2011.01.030","article-title":"Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery","volume":"152","author":"Cheng","year":"2011","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib28","doi-asserted-by":"crossref","unstructured":"M.L. Forrest, J.T. Koerber, D.W. Pack, A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery., Bioconjugate Chem. 14 (n.d.) 934\u2013940. doi:10.1021\/bc034014g.","DOI":"10.1021\/bc034014g"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib29","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1016\/j.biomaterials.2008.07.045","article-title":"The influence of RGD addition on the gene transfer characteristics of disulfide-containing polyethyleneimine\/DNA complexes","volume":"29","author":"Sun","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1021\/bc7003236","article-title":"Disulfide cross-linked polyethylenimines (PEI) prepared via thiolation of low molecular weight PEI as highly efficient gene vectors","volume":"19","author":"Peng","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib31","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1016\/j.biomaterials.2010.04.047","article-title":"Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier","volume":"31","author":"Son","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jcis.2008.09.080","article-title":"Synthesis and pH-dependent micellization of diblock copolymer mixtures","volume":"329","author":"Van Butsele","year":"2009","journal-title":"J.\u00a0Colloid Interface Sci."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib33","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ygyno.2011.05.032","article-title":"Intraperitoneal administration of novel doxorubicin loaded polymeric delivery systems against peritoneal carcinomatosis: experimental study in a murine model of ovarian cancer","volume":"122","author":"Colombo","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.nantod.2016.04.008","article-title":"Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines","volume":"11","author":"Wang","year":"2016","journal-title":"Nano Today"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jconrel.2010.08.026","article-title":"Peritoneal retention of liposomes: effects of lipid composition, PEG coating and liposome charge","volume":"148","author":"Dadashzadeh","year":"2010","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib36","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1016\/j.biomaterials.2011.05.050","article-title":"Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery","volume":"32","author":"Li","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/IJN.S1796","article-title":"Formation of potential titanium antigens based on protein binding to titanium dioxide nanoparticles","volume":"3","author":"Vamanu","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib38","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nmat2442","article-title":"Understanding biophysicochemical interactions at the nano\u2013bio interface","volume":"8","author":"Nel","year":"2009","journal-title":"Nat. Mater."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib39","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.2147\/IJN.S129300","article-title":"Protein corona: a new approach for nanomedicine design","volume":"12","author":"Nguyen","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib40","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1039\/C4NR05982D","article-title":"Complementary analysis of the hard and soft protein corona: sample preparation critically effects corona composition","volume":"7","author":"Winzen","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/smll.200901158","article-title":"Effect of surface properties on nanoparticle-cell interactions","volume":"6","author":"Verma","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0168-3659(94)90099-X","article-title":"P17 Diffusion rates and transport pathways of FITC-labelled model compounds through porcine buccal epithelium","volume":"29","author":"Hoogstraate","year":"1994","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib43","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1016\/j.biomaterials.2013.07.095","article-title":"Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations","volume":"34","author":"Wu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib44","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2217\/17435889.3.6.761","article-title":"Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer","volume":"3","author":"Saad","year":"2008","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib45","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/smll.201503292","article-title":"A\u00a0nanoplatform with precise control over release of cargo for enhanced cancer therapy","volume":"12","author":"Qu","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib46","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/mabi.201300175","article-title":"Redox-sensitive shell-crosslinked polypeptide-block-polysaccharide micelles for efficient intracellular anticancer drug delivery","volume":"13","author":"Zhang","year":"2013","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib47","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1590\/1414-431X20132647","article-title":"A\u00a0spheroid-based 3-D culture model for pancreatic cancer drug testing, using the acid phosphatase assay","volume":"46","author":"Wen","year":"2013","journal-title":"Braz. J. Med. Biol. Res. - Rev. Bras. Pesqui. Medicas E Biol."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib48","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/jgm.947","article-title":"Optimising non-viral gene delivery in a tumour spheroid model","volume":"8","author":"Mellor","year":"2006","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/10717544.2010.512024","article-title":"Effects of bile salts on the lovastatin pharmacokinetics following oral administration to rats","volume":"18","author":"Kim","year":"2011","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib50","doi-asserted-by":"crossref","unstructured":"B.K. Nanjwade, D.J. Patel, R.A. Udhani, F. V Manvi, Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs., Sci. Pharm. 79 (n.d.) 705\u2013727. doi:10.3797\/scipharm.1105-09.","DOI":"10.3797\/scipharm.1105-09"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/0471142956.cy1227s60","article-title":"Near-infrared molecular probes for in\u00a0vivo imaging","author":"Zhang","year":"2012","journal-title":"Curr. Protoc. Cytometry"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib52","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1016\/j.biomaterials.2011.01.021","article-title":"The effect of surface charge on in\u00a0vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles","volume":"32","author":"Xiao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib53","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib54","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s11095-007-9298-0","article-title":"Effects of carrier on disposition and antitumor activity of intraperitoneal paclitaxel","volume":"24","author":"Tsai","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2967\/jnumed.112.106609","article-title":"Neutron-activatable holmium-containing mesoporous silica nanoparticles as a potential radionuclide therapeutic agent for ovarian cancer","volume":"54","author":"Di Pasqua","year":"2013","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib56","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.nano.2016.04.013","article-title":"Improving paclitaxel pharmacokinetics by using tumor-specific mesoporous silica nanoparticles with intraperitoneal delivery","volume":"12","author":"Fu","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib57","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1349-7006.2010.01747.x","article-title":"Spatial distribution of intraperitoneally administrated paclitaxel nanoparticles solubilized with poly (2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) in peritoneal metastatic nodules","volume":"102","author":"Kamei","year":"2011","journal-title":"Canc. Sci."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib58","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1039\/c2nr30278k","article-title":"Efficient inhibition of colorectal peritoneal carcinomatosis by drug loaded micelles in thermosensitive hydrogel composites","volume":"4","author":"Gong","year":"2012","journal-title":"Nanoscale"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejpb.2016.05.010","article-title":"Thermosensitive hydrogel system assembled by PTX-loaded copolymer nanoparticles for sustained intraperitoneal chemotherapy of peritoneal carcinomatosis","volume":"104","author":"Xu","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s13346-013-0190-7","article-title":"Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model","volume":"4","author":"Yang","year":"2014","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib61","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/j.actbio.2014.03.012","article-title":"Colloidal stability of nano-sized particles in the peritoneal fluid: towards optimizing drug delivery systems for intraperitoneal therapy","volume":"10","author":"Dakwar","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib62","first-page":"119","article-title":"Development of a mouse model for assessing fatigue during chemotherapy","volume":"61","author":"Ray","year":"2011","journal-title":"Comp. Med."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib63","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1039\/c3py00478c","article-title":"Tunable thermo-, pH- and light-responsive copolymer micelles","volume":"4","author":"Yuan","year":"2013","journal-title":"Polym. Chem."},{"key":"10.1016\/j.biomaterials.2018.03.051_bib64","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1016\/j.biomaterials.2013.05.071","article-title":"IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy","volume":"34","author":"Yue","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.03.051_bib65","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.biomaterials.2013.11.038","article-title":"Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations","volume":"35","author":"Charoen","year":"2014","journal-title":"Biomaterials"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218302308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218302308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:33:06Z","timestamp":1758904386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218302308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":65,"alternative-id":["S0142961218302308"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.03.051","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Programmed \u2018triple-mode\u2019 anti-tumor therapy: Improving peritoneal retention, tumor penetration and activatable drug release properties for effective inhibition of peritoneal carcinomatosis","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.03.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}