{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:11:41Z","timestamp":1791652301602,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST-104-2628-E-007 -002 -MY3"],"award-info":[{"award-number":["MOST-104-2628-E-007 -002 -MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST-104-2221-E-007 -140 -MY2"],"award-info":[{"award-number":["MOST-104-2221-E-007 -140 -MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST-106-2622-E-007-003 -CC2"],"award-info":[{"award-number":["MOST-106-2622-E-007-003 -CC2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.biomaterials.2018.05.009","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T06:56:26Z","timestamp":1525762586000},"page":"17-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration"],"prefix":"10.1016","volume":"174","author":[{"given":"Wei-Hong","family":"Jian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Chih","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsiang","family":"Kuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Chin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Sheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2018.05.009_bib1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tips.2010.09.005","volume":"31","author":"Loane","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/aps.2012.107","volume":"34","author":"Dibajnia","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12265-013-9508-6","volume":"6","author":"Jin","year":"2013","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/npp.2013.237","volume":"39","author":"Tam","year":"2014","journal-title":"Neuropsychopharmacol. Off. Publ. Am. College Neuropsychopharmacol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib5","volume":"10","author":"Addington","year":"2015","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/glia.22851","volume":"63","author":"Gr\u00e9goire","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/stem.306","volume":"28","author":"Kojima","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib8","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1073\/pnas.1508545112","volume":"112","author":"Sun","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U..S..A."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib9","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","volume":"101","author":"Imitola","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U..S..A."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib10","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1073\/pnas.101034998","volume":"98","author":"Yoshimura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U..S..A."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.expneurol.2004.06.004","volume":"189","author":"Kiprianova","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.tips.2015.04.003","volume":"36","author":"Gyoneva","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2013.07.032","volume":"172","author":"Wang","year":"2013","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/glycob\/6.5.489","volume":"6","author":"Ruoslahti","year":"1996","journal-title":"Glycobiology"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib15","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1367-5931(00)00145-9","volume":"4","author":"Sasisekharan","year":"2000","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nnano.2017.109","volume":"12","author":"Lee","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/bm401736c","volume":"15","author":"Place","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib18","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1002\/adma.200903790","volume":"22","author":"Boddohi","year":"2010","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib19","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1096\/fj.12-221515","volume":"27","author":"Lim","year":"2013","journal-title":"Faseb. J."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1189\/jlb.72.2.353","volume":"72","author":"Netelenbos","year":"2002","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/stem.309","volume":"28","author":"Sirko","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib22","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1016\/j.actbio.2010.02.037","volume":"6","author":"Su","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib23","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1227\/01.NEU.0000351768.11363.48","volume":"65","author":"Grossetete","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nmat3586","volume":"12","author":"Khetan","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmat3922","volume":"13","author":"Purcell","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib26","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1021\/acs.bioconjchem.5b00397","volume":"26","author":"Karumbaiah","year":"2015","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib27","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1016\/j.actbio.2012.09.039","volume":"9","author":"Chen","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.carbpol.2014.05.039","volume":"112","author":"Oueslati","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11671-008-9239-9","volume":"4","author":"Ge","year":"2009","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib30","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1177\/1545968310361958","volume":"24","author":"Zhong","year":"2010","journal-title":"Neurorehabil. Neural. Repair."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib31","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1161\/01.STR.0000037675.97888.9D","volume":"33","author":"Lin","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib32","doi-asserted-by":"crossref","first-page":"8861","DOI":"10.1002\/adma.201601908","volume":"28","author":"Freudenberg","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/09205063.2014.975393","volume":"26","author":"Hardy","year":"2015","journal-title":"J.\u00a0Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0021-9290(69)90079-7","volume":"2","author":"Fallenstein","year":"1969","journal-title":"J.\u00a0Biomech."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.copbio.2016.04.021","volume":"40","author":"Nih","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/adhm.201400235","volume":"4","author":"Segovia","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib37","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1021\/ja210638x","volume":"134","author":"Vulic","year":"2012","journal-title":"JACS"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib38","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1002\/smll.201601017","volume":"12","author":"Fiorini","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm1787","volume":"14","author":"Su","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1471-2202-15-58","volume":"15","author":"Li","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib41","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1002\/adma.201500417","volume":"27","author":"Zhu","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.nbd.2006.10.019","volume":"25","author":"Sifringer","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib43","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1074\/jbc.M608796200","volume":"282","author":"Murphy","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib44","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.actbio.2011.12.009","volume":"8","author":"Huang","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056289","volume":"8","author":"Lotz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.expneurol.2015.03.020","volume":"275","author":"Burda","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.07.023","volume":"215","author":"Tuladhar","year":"2015","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib48","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1038\/s41598-017-02107-2","volume":"7","author":"Spencer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib49","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/STROKEAHA.114.005078","volume":"45","author":"Li","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.biomaterials.2018.05.009_bib50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-017-1667-0","volume":"133","author":"Sommer","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.biomaterials.2018.05.009_bib51","doi-asserted-by":"crossref","first-page":"H41","DOI":"10.1002\/adma.201003963","volume":"23","author":"Burdick","year":"2011","journal-title":"Adv. Mater."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218303442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218303442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:33:49Z","timestamp":1758904429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218303442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":51,"alternative-id":["S0142961218303442"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.05.009","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycosaminoglycan-based hybrid hydrogel encapsulated with polyelectrolyte complex nanoparticles for endogenous stem cell regulation in central nervous system regeneration","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}