{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:39:47Z","timestamp":1793144387718,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010187","name":"Universiti Sains Islam Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010187","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.biomaterials.2018.06.009","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T06:46:53Z","timestamp":1528958813000},"page":"134-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":116,"special_numbering":"C","title":["Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa"],"prefix":"10.1016","volume":"178","author":[{"given":"H.E.","family":"Colley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Santocildes-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"D'Apice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Siim","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Thornhill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.V.","family":"Hatton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2018.06.009_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bjoms.2007.07.199","article-title":"Oral mucosal disease: lichen planus","volume":"46","author":"Scully","year":"2008","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bjoms.2007.07.201","article-title":"Oral mucosal disease: recurrent aphthous stomatitis","volume":"46","author":"Scully","year":"2008","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib3","first-page":"385","article-title":"A\u00a0review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods","volume":"19","author":"Chinna Reddy","year":"2011","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5173(03)00087-5","article-title":"Bioadhesive microspheres as a controlled drug delivery system","volume":"255","author":"Vasir","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ejpb.2013.05.017","article-title":"Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration","volume":"85","author":"Sander","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jconrel.2003.12.018","article-title":"Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease","volume":"95","author":"Perioli","year":"2004","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ejpb.2010.07.014","article-title":"A\u00a0new mucoadhesive dosage form for the management of oral lichen planus: formulation study and clinical study","volume":"76","author":"Cilurzo","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib8","first-page":"213","article-title":"Preparation and pharmaceutical evaluation of glibenclamide slow release mucoadhesive buccal film","volume":"9","author":"Bahri-Najafi","year":"2014","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib9","doi-asserted-by":"crossref","first-page":"580146","DOI":"10.1155\/2015\/580146","article-title":"Carmellose mucoadhesive oral films containing vermiculite\/chlorhexidine nanocomposites as innovative biomaterials for treatment of oral infections","volume":"2015","author":"Gajdziok","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.03.006","article-title":"Oral films: current status and future perspectives: I - galenical development and quality attributes","volume":"206","author":"Borges","year":"2015","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib11","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1208\/s12249-015-0300-6","article-title":"Fabrication and in\u00a0vitro\/in\u00a0vivo performance of mucoadhesive electrospun nanofiber mats containing alpha-mangostin","volume":"16","author":"Samprasit","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijpharm.2015.10.077","article-title":"Ex-vivo and in-vitro assessment of mucoadhesive patches containing the gel-forming polysaccharide psyllium for buccal delivery of chlorhexidine base","volume":"496","author":"Cavallari","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib13","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1021\/acs.molpharmaceut.5b00532","article-title":"Creating drug solubilization compartments via phase separation in multicomponent buccal patches prepared by direct hot melt extrusion-injection molding","volume":"12","author":"Alhijjaj","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib14","doi-asserted-by":"crossref","first-page":"11557","DOI":"10.1021\/acsami.7b02337","article-title":"Fabrication of electrospun mucoadhesive membranes for therapeutic applications in oral medicine","volume":"9","author":"Santocildes-Romero","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.carbpol.2015.06.032","article-title":"Fabrication of mucoadhesive chitosan coated polyvinylpyrrolidone\/cyclodextrin\/clotrimazole sandwich patches for oral candidiasis","volume":"132","author":"Tonglairoum","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib16","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3109\/21691401.2015.1052472","article-title":"Development, optimization, and characterization of polymeric electrospun nanofiber: a new attempt in sublingual delivery of nicorandil for the management of angina pectoris","volume":"44","author":"Singh","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib17","first-page":"e1","article-title":"A\u00a0mucoadhesive electrospun nanofibrous matrix for rapid oramucosal drug delivery","author":"Dott","year":"2013","journal-title":"J.\u00a0Nanomater."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib18","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.biomaterials.2008.01.011","article-title":"Electrospinning: applications in drug delivery and tissue engineering","volume":"29","author":"Sill","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib19","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.2174\/138161212803307617","article-title":"Topical therapies for oral lichen planus management and their efficacy: a narrative review","volume":"18","author":"Bagan","year":"2012","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib20","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.4317\/jced.51401","article-title":"Treatment of recurrent aphthous stomatitis. A literature review","volume":"6","author":"Belenguer-Guallar","year":"2014","journal-title":"J.\u00a0Clin. Exp. Dent."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2133.2005.06920.x","article-title":"Ciclosporin vs. clobetasol in the topical management of atrophic and erosive oral lichen planus: a double-blind, randomized controlled trial","volume":"154","author":"Conrotto","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0030-4220(91)90300-2","article-title":"Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases","volume":"71","author":"Lozada-Nur","year":"1991","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0714.2011.01087.x","article-title":"Pharmacokinetics study about topical clobetasol on oral mucosa","volume":"41","author":"Varoni","year":"2012","journal-title":"J.\u00a0Oral Pathol. Med."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib24","first-page":"4757","article-title":"Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine","volume":"62","author":"McGregor","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib25","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/bjc.2011.403","article-title":"Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma","volume":"105","author":"Colley","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib26","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1089\/ten.tec.2016.0310","article-title":"Development and characterization of in\u00a0vitro human oral mucosal equivalents derived from immortalized oral keratinocytes","volume":"22","author":"Jennings","year":"2016","journal-title":"Tissue Eng. C Meth."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib27","series-title":"In\u00a0Vitro Skin Irritation: Reconstructed Human Epidermis Test Method","author":"OECD. Test No 439","year":"2015"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib28","article-title":"Magnetite and silica-coated magnetite nanoparticles are highly biocompatible on endothelial cells in\u00a0vitro","volume":"3","author":"Enrico","year":"2017","journal-title":"Biomed. Phys. Eng. Express"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib29","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.addr.2005.07.001","article-title":"The basics and underlying mechanisms of mucoadhesion","volume":"57","author":"Smart","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jconrel.2004.06.005","article-title":"Development of mucoadhesive patches for buccal administration of ibuprofen","volume":"99","author":"Perioli","year":"2004","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/156720109787048195","article-title":"Fluconazole mucoadhesive buccal films: in\u00a0vitro\/in\u00a0vivo performance","volume":"6","author":"Yehia","year":"2009","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/10717544.2014.920058","article-title":"Buccal films of prednisolone with enhanced bioavailability","volume":"23","author":"Kumria","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jconrel.2009.11.013","article-title":"Lecithin\/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin","volume":"142","author":"Senyigit","year":"2010","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejpb.2011.05.002","article-title":"Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate","volume":"79","author":"Fontana","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib35","first-page":"233","article-title":"Clobetasol propionate solid lipid nanoparticles cream for effective treatment of eczema: formulation and clinical implications","volume":"43","author":"Kalariya","year":"2005","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib36","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/20\/5\/055104","article-title":"Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers","volume":"20","author":"Yu","year":"2009","journal-title":"Nanotechnology"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijpharm.2012.07.075","article-title":"Electrospun zein\/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole","volume":"438","author":"Karthikeyan","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib38","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1002\/jps.24587","article-title":"Fabrication, physico-chemical, and pharmaceutical characterization of budesonide-loaded electrospun fibers for drug targeting to the colon","volume":"104","author":"Bruni","year":"2015","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib39","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1021\/bm300520u","article-title":"Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response","volume":"13","author":"Vacanti","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2018.06.009_bib40","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s11095-016-1894-4","article-title":"Hybrid electrospun polycaprolactone mats consisting of nanofibers and microbeads for extended release of dexamethasone","volume":"33","author":"Hsu","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijpharm.2013.08.085","article-title":"Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen","volume":"457","author":"Vrbata","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib42","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/0022034511435702","article-title":"Tissue-engineered oral mucosa","volume":"91","author":"Moharamzadeh","year":"2012","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejps.2015.09.019","article-title":"Histological features of oral epithelium in seven animal species: as a reference for selecting animal models","volume":"81","author":"Sa","year":"2016","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000074057","article-title":"Factors affecting the formation of a skin reservoir for topically applied solutes","volume":"17","author":"Roberts","year":"2004","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib45","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1590\/S1984-82502012000400025","article-title":"In\u00a0vitro skin penetration of clobetasol from lipid nanoparticles: drug extraction and quantitation in different skin layers","volume":"48","author":"Silva","year":"2012","journal-title":"Br. J. Pharm. Sci."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib46","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1007\/s00204-014-1382-8","article-title":"Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, Guinea pig, man, and in human skin models","volume":"88","author":"Oesch","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib47","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/exd.13483","article-title":"Expression and enzyme activity of Cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue engineered skin equivalents","volume":"27","author":"Smith","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib48","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1177\/014107688708000709","article-title":"Adrenal suppression following low-dose topical clobetasol propionate","volume":"80","author":"Ohman","year":"1987","journal-title":"J.\u00a0R. Soc. Med."},{"key":"10.1016\/j.biomaterials.2018.06.009_bib49","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0190-9622(86)70164-3","article-title":"Topical clobetasol-17-propionate: review of its clinical efficacy and safety","volume":"15","author":"Olsen","year":"1986","journal-title":"J.\u00a0Am. Acad. Dermatol."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218304289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218304289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:36:00Z","timestamp":1758904560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218304289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":49,"alternative-id":["S0142961218304289"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.06.009","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-clinical evaluation of novel mucoadhesive bilayer patches for local delivery of clobetasol-17-propionate to the oral mucosa","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}