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Dev."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib85","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2106\/JBJS.K.01422","article-title":"North Amer Orthopedic Foot Ankle S. Recombinant human platelet-derived growth factor-BB and beta-tricalcium phosphate (rhPDGF-BB\/beta-TCP): an alternative to autogenous bone graft","volume":"95A","author":"DiGiovanni","year":"2013","journal-title":"J.\u00a0Bone Joint Surg-Am"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib86","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2106\/JBJS.15.00879","article-title":"The importance of sufficient graft material in achieving foot or ankle fusion","volume":"98","author":"DiGiovanni","year":"2016","journal-title":"J.\u00a0Bone Joint Surg-Am"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib87","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.2174\/1381612811319190003","article-title":"Growth differentiation factor 5 regulation in bone regeneration","volume":"19","author":"Jin","year":"2013","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1359\/jbmr.1998.13.3.383","article-title":"Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis","volume":"13","author":"Erlacher","year":"1998","journal-title":"J.\u00a0Bone Miner. Res. Off. J. Am. Soc. Bone Min. Res."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib89","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.spinee.2007.05.012","article-title":"Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression","volume":"8","author":"Cui","year":"2008","journal-title":"Spine J."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib90","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1016\/j.biomaterials.2013.04.029","article-title":"Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2","volume":"34","author":"Kleinschmidt","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib91","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2106\/JBJS.M.01462","article-title":"Superior angiogenic potential of GDF-5 and GDF-5(V453\/V456) compared with BMP-2 in a rabbit long-bone defect model","volume":"96","author":"Kleinschmidt","year":"2014","journal-title":"J.\u00a0Bone Joint Surg. 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Res."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib94","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00264-013-2201-1","article-title":"The clinical use of bone morphogenetic proteins revisited: a novel biocompatible Carrier device OSTEOGROW for bone healing","volume":"38","author":"Vukicevic","year":"2014","journal-title":"Int. Orthop."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib95","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/08977194.2012.671310","article-title":"B2A as a positive BMP receptor modulator","volume":"30","author":"Lin","year":"2012","journal-title":"Growth Factors"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib96","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/08977194.2012.745520","article-title":"B2A, a receptor modulator, increases the growth of pluripotent and preosteoblast cells through bone morphogenetic protein receptors","volume":"30","author":"Liu","year":"2012","journal-title":"Growth Factors"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib97","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3171\/2009.1.SPINE08565","article-title":"Ceramic granules enhanced with B2A peptide for lumbar interbody spine fusion: an experimental study using an instrumented model in sheep Laboratory investigation","volume":"10","author":"Cunningham","year":"2009","journal-title":"J.\u00a0Neurosurg. 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Res."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbrc.2003.09.192","article-title":"Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels","volume":"311","author":"Nguyen","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib101","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1016\/j.biomaterials.2008.12.053","article-title":"The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces","volume":"30","author":"Hennessy","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib102","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00264-006-0087-x","article-title":"P-15 small peptide bone graft substitute in the treatment of non-unions and delayed union. A pilot clinical trial","volume":"31","author":"Gomar","year":"2007","journal-title":"Int. Orthop."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib103","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1007\/s00586-010-1546-z","article-title":"Evaluation of ABM\/P-15 versus autogenous bone in an ovine lumbar interbody fusion model","volume":"19","author":"Sherman","year":"2010","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib104","first-page":"9","article-title":"Prospective analysis of a new bone graft in lumbar interbody fusion: results of a 2- year prospective clinical and radiological study","author":"Lauweryns","year":"2015","journal-title":"Internet J. Spine Surg."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib105","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/BRS.0000000000001466","article-title":"Efficacy of i-Factor bone graft versus autograft in anterior cervical discectomy and fusion: results of the prospective, randomized, single-blinded food and drug administration investigational device exemption study","volume":"41","author":"Arnold","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib106","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1016\/j.biomaterials.2010.07.042","article-title":"Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and\/or BMPs mimetic peptides","volume":"31","author":"Zouani","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib107","series-title":"Engineering Mineralized and Load Bearing Tissues","first-page":"95","article-title":"Morphogenic peptides in regeneration of load bearing tissues","author":"Moeinzadeh","year":"2015"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib108","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.febslet.2012.02.043","article-title":"Promiscuity and specificity in BMP receptor activation","volume":"586","author":"Mueller","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib109","first-page":"18","article-title":"The roles of parathyroid hormone in bone remodeling: prospects for novel therapeutics","volume":"34","author":"Lombardi","year":"2011","journal-title":"J.\u00a0Endocrinol. Invest."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib110","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.biomaterials.2008.12.023","article-title":"Bone healing induced by local delivery of an engineered parathyroid hormone prodrug","volume":"30","author":"Arrighi","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.07.017_bib111","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1439-0442.2007.00890.x","article-title":"Use of a parathyroid hormone peptide (PTH(1-34))-enriched fibrin hydrogel for the treatment of a subchondral cystic lesion in the proximal interphalangeal joint of a warmblood filly. Journal of veterinary medicine A","volume":"54","author":"Fuerst","year":"2007","journal-title":"Physiol. Pathol. Clin. Med."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib112","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1177\/0022034510376401","article-title":"The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration","volume":"89","author":"Zhang","year":"2010","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib113","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/ten.tea.2011.0142","article-title":"NELL-1 promotes cartilage regeneration in an in\u00a0vivo rabbit model","volume":"18","author":"Siu","year":"2012","journal-title":"Tissue Eng."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib114","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1089\/ten.tea.2012.0367","article-title":"Human perivascular stem cells show enhanced osteogenesis and vasculogenesis with Nel-like molecule I protein","volume":"19","author":"Askarinam","year":"2013","journal-title":"Tissue Eng."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib115","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/stem.1884","article-title":"Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1","volume":"33","author":"Pang","year":"2015","journal-title":"Stem Cell."},{"key":"10.1016\/j.biomaterials.2018.07.017_bib116","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1038\/ncomms8362","article-title":"NELL-1 in the treatment of osteoporotic bone loss","volume":"6","author":"James","year":"2015","journal-title":"Nat. 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