{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:16:50Z","timestamp":1787977010338,"version":"build-2784847793"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"publisher","award":["96-04-33-31629"],"award-info":[{"award-number":["96-04-33-31629"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Medical Research Development NIMAD","award":["957572"],"award-info":[{"award-number":["957572"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.biomaterials.2018.08.017","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T14:29:50Z","timestamp":1533911390000},"page":"191-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets"],"prefix":"10.1016","volume":"182","author":[{"given":"Zhila","family":"Izadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensiyeh","family":"Hajizadeh-Saffar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid","family":"Hadjati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Habibi-Anbouhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Ghanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Sadeghi-Abandansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kazemi","family":"Ashtiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakieh","family":"Samsonchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Raoufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh","family":"Moazenchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Izadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anava sadat Sadr Hashemi","family":"Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haideh","family":"Namdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Tahamtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Nasser","family":"Ostad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Akbari-Javar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Baharvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 1","key":"10.1016\/j.biomaterials.2018.08.017_bib1","doi-asserted-by":"crossref","first-page":"s5","DOI":"10.2337\/diacare.27.2007.S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","author":"A.D. Association","year":"2004","journal-title":"Diabetes Care"},{"issue":"7067","key":"10.1016\/j.biomaterials.2018.08.017_bib2","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1038\/nature04424","article-title":"Immunology: insulin auto-antigenicity in type 1 diabetes (Reply)","volume":"438","author":"Hafler","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.biomaterials.2018.08.017_bib3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2337\/dci18-0007","article-title":"Economic costs of diabetes in the US in 2017","volume":"41","author":"A.D. Association","year":"2018","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13153","article-title":"Islet transplantation as safe and efficacious method to restore glycemic control and to avoid severe hypoglycemia after donor organ failure in pancreas transplantation","volume":"32","author":"Gerber","year":"2018","journal-title":"Clin. Transplant."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.08.017_bib5","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrd.2016.232","article-title":"Advances in islet encapsulation technologies","volume":"16","author":"Desai","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib6","series-title":"Transplantation 50 Years Later\u2014progress, Challenges, and Promises","author":"Sayegh","year":"2004"},{"issue":"8","key":"10.1016\/j.biomaterials.2018.08.017_bib7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nbt.2960","article-title":"Overcoming immunological barriers in regenerative medicine","volume":"32","author":"Zakrzewski","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.08.017_bib8","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1177\/193229681000400525","article-title":"Enhancing clinical islet transplantation through tissue engineering strategies","volume":"4","author":"Giraldo","year":"2010","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2016.08.015","article-title":"TGF-\u03b2 affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation","volume":"45","author":"Orr","year":"2016","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.biomaterials.2018.08.017_bib10","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1089\/ten.tea.2009.0640","article-title":"Encapsulation of pancreatic islets within nano-thin functional polyethylene glycol coatings for enhanced insulin secretion","volume":"16","author":"Kizilel","year":"2010","journal-title":"Tissue Eng."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.08.017_bib11","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0142-9612(03)00605-7","article-title":"Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin","volume":"25","author":"Chae","year":"2004","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib12","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/excr.1994.1187","article-title":"Interleukin-1\u03b2-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells","volume":"213","author":"Ankarcrona","year":"1994","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.biomaterials.2018.08.017_bib13","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1210\/endo.134.3.8119136","article-title":"Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide","volume":"134","author":"Suarez-Pinzon","year":"1994","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.biomaterials.2018.08.017_bib14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jconrel.2009.11.022","article-title":"Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation","volume":"142","author":"Lin","year":"2010","journal-title":"J. Contr. Release"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/jlb.60.6.729","article-title":"Cytotoxicity of peritoneal murine macrophages against encapsulated pancreatic rat islets: in vivo and in vitro studies","volume":"60","author":"Kessler","year":"1996","journal-title":"J. Leukoc. Biol."},{"issue":"S 02","key":"10.1016\/j.biomaterials.2018.08.017_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-0029-1211412","article-title":"Evaluation of the effect of microencapsulation and immuno-modulation on islet immunogenicity in vitro","volume":"103","author":"Siebers","year":"1995","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/(SICI)1097-4636(199801)39:1<61::AID-JBM8>3.0.CO;2-G","article-title":"Control and measurement of permeability for design of microcapsule cell delivery system","volume":"39","author":"Bri\u0161\u0161ov\u00e1","year":"1998","journal-title":"J. Biomed. Mater. Res."},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib18","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.2337\/diabetes.54.6.1755","article-title":"Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation","volume":"54","author":"Johansson","year":"2005","journal-title":"Diabetes"},{"issue":"1\u20132","key":"10.1016\/j.biomaterials.2018.08.017_bib19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijpharm.2010.11.022","article-title":"Design of a composite drug delivery system to prolong functionality of cell-based scaffolds","volume":"407","author":"Murua","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"14","key":"10.1016\/j.biomaterials.2018.08.017_bib20","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/j.biomaterials.2012.02.009","article-title":"Strategies to reduce dendritic cell activation through functional biomaterial design","volume":"33","author":"Hume","year":"2012","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib21","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.biomaterials.2006.10.017","article-title":"PEGylation of microspheres for therapeutic embolization: preparation, characterization and biological performance evaluation","volume":"28","author":"Madani","year":"2007","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.biomaterials.2018.08.017_bib22","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.2337\/db16-0320","article-title":"Biopatterned CTLA4\/Fc matrices facilitate local immunomodulation, engraftment, and glucose homeostasis after pancreatic islet transplantation","volume":"65","author":"Zhang","year":"2016","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib23","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/00007890-200201151-00013","article-title":"Immunomodulation with CTLA4-Ig in islet transplantation","volume":"73","author":"Benhamou","year":"2002","journal-title":"Transplantation"},{"issue":"28","key":"10.1016\/j.biomaterials.2018.08.017_bib24","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1016\/j.biomaterials.2009.05.083","article-title":"Functional PEG\u2013peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNF\u03b1","volume":"30","author":"Lin","year":"2009","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.08.017_bib25","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1021\/bc060023o","article-title":"Synthesis of immunoisolation barriers that provide localized immunosuppression for encapsulated pancreatic islets","volume":"17","author":"Cheung","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biomaterials.2015.07.009","article-title":"Engineering an \u201cinfectious\u201d Treg biomimetic through chemoselective tethering of TGF-\u03b21 to PEG brush surfaces","volume":"67","author":"Yang","year":"2015","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.08.017_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/TP.0000000000001925","article-title":"Anti-inflammatory strategies in intrahepatic islet transplantation: a comparative study in preclinical models","volume":"102","author":"Citro","year":"2018","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.biomaterials.2018.08.017_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.autrev.2014.10.012","article-title":"Regulatory T-cells in autoimmune diseases: challenges, controversies and\u2014yet\u2014unanswered questions","volume":"14","author":"Grant","year":"2015","journal-title":"Autoimmun. Rev."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.08.017_bib29","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1172\/JCI0214947","article-title":"Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance","volume":"109","author":"Kishimoto","year":"2002","journal-title":"JCI (J. Clin. Investig.)"},{"issue":"9","key":"10.1016\/j.biomaterials.2018.08.017_bib30","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-11-3687","article-title":"T-regulatory cells: key players in tumor immune escape and angiogenesis","volume":"72","author":"Facciabene","year":"2012","journal-title":"Canc. Res."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib31","series-title":"Tr1 Cells and the Counter-regulation of Immunity: Natural Mechanisms and Therapeutic Applications, Interleukin-10 in Health and Disease","first-page":"39","author":"Roncarolo","year":"2014"},{"issue":"83","key":"10.1016\/j.biomaterials.2018.08.017_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002076","article-title":"Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells","volume":"3","author":"Sagoo","year":"2011","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.biomaterials.2018.08.017_bib33","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007021","article-title":"Treg cells, life history, and diversity","volume":"4","author":"Benoist","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.08.017_bib34","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1084\/jem.20110767","article-title":"Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance","volume":"208","author":"Kendal","year":"2011","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.biomaterials.2018.08.017_bib35","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nri2132","article-title":"Tolerogenic dendritic cells and the quest for transplant tolerance","volume":"7","author":"Morelli","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.biomaterials.2018.08.017_bib36","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.bpj.2013.11.012","article-title":"Membrane tethered delta activates notch and reveals a role for spatio-mechanical regulation of the signaling pathway","volume":"105","author":"Narui","year":"2013","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1158\/0008-5472.CAN-14-2538","article-title":"Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge","volume":"75","author":"Makkouk","year":"2015","journal-title":"Canc. Res."},{"issue":"15","key":"10.1016\/j.biomaterials.2018.08.017_bib38","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1158\/1078-0432.CCR-07-0472","article-title":"A unique subset of CD4+ CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-\u03b21 mediates suppression in the tumor microenvironment","volume":"13","author":"Strauss","year":"2007","journal-title":"Clin. Canc. Res."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib39","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1016\/S1470-2045(11)70155-3","article-title":"Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?","volume":"13","author":"Jacobs","year":"2012","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13287-015-0021-5","article-title":"Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells","volume":"6","author":"Cahill","year":"2015","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.08.017_bib41","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1182\/blood-2002-12-3826","article-title":"Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells","volume":"102","author":"Yvon","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib42","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.gene.2015.10.065","article-title":"Jagged1 (JAG1): structure, expression, and disease associations","volume":"576","author":"Grochowski","year":"2016","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.biomaterials.2018.08.017_bib43","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.4049\/jimmunol.179.9.5990","article-title":"JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis","volume":"179","author":"Elyaman","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib44","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fonc.2014.00254","article-title":"The notch ligand JAGGED1 as a target for anti-tumor therapy","volume":"4","author":"Li","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib45","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1038\/srep09322","article-title":"Inducible VEGF expression by human embryonic stem cell-derived mesenchymal stromal cells reduces the minimal islet mass required to reverse diabetes","volume":"5","author":"Hajizadeh-Saffar","year":"2015","journal-title":"Sci. Rep."},{"issue":"36","key":"10.1016\/j.biomaterials.2018.08.017_bib46","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1016\/j.biomaterials.2009.09.010","article-title":"Induction of notch signaling by immobilization of jagged-1 on self-assembled monolayers","volume":"30","author":"Gon\u00e7alves","year":"2009","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib47","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nri3227","article-title":"Regulatory immune cells in transplantation","volume":"12","author":"Wood","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib48","series-title":"Microencapsulation of Pancreatic Islets for Use in a Bioartificial Pancreas, Organ Regeneration","first-page":"261","author":"Opara","year":"2013"},{"issue":"7","key":"10.1016\/j.biomaterials.2018.08.017_bib49","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.2337\/db17-0065","article-title":"Islet encapsulation: physiological possibilities and limitations","volume":"66","author":"Korsgren","year":"2017","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ccell.2017.11.002","article-title":"Therapeutic antibody targeting tumor-and osteoblastic niche-derived Jagged1 sensitizes bone metastasis to chemotherapy","volume":"32","author":"Zheng","year":"2017","journal-title":"Canc. Cell"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.08.017_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.137","article-title":"Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer","volume":"5","author":"Dai","year":"2014","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.biomaterials.2018.08.017_bib52","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3727\/000000007783472336","article-title":"Multifunctional pancreatic islet encapsulation barriers achieved via multilayer PEG hydrogels","volume":"16","author":"Weber","year":"2007","journal-title":"Cell Transplant."},{"issue":"12","key":"10.1016\/j.biomaterials.2018.08.017_bib53","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/pj.2011.93","article-title":"Construction of a densely poly(ethylene glycol)-chain-tethered surface and its performance","volume":"43","author":"Nagasaki","year":"2011","journal-title":"Polym. J."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib54","series-title":"Combined PEG Immobilization on Polystyrene Microspheres: Ability of Protein Resistance","first-page":"1214","author":"Xiao","year":"2012"},{"issue":"17","key":"10.1016\/j.biomaterials.2018.08.017_bib55","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1016\/j.biomaterials.2003.10.062","article-title":"Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets","volume":"25","author":"Jang","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.biomaterials.2018.08.017_bib56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.actbio.2016.11.060","article-title":"The impact of cell surface PEGylation and short-course immunotherapy on islet graft survival in an allogeneic murine model","volume":"49","author":"Giraldo","year":"2017","journal-title":"Acta. Biomater."},{"issue":"7","key":"10.1016\/j.biomaterials.2018.08.017_bib57","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/adhm.201300573","article-title":"Long\u2010term survival of allograft murine islets coated via covalently stabilized polymers","volume":"3","author":"Rengifo","year":"2014","journal-title":"Adv. Healthc. Mater."},{"issue":"18","key":"10.1016\/j.biomaterials.2018.08.017_bib58","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1039\/c2cs35088b","article-title":"Layer-by-layer assembly of microcapsules and their biomedical applications","volume":"41","author":"Tong","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"5","key":"10.1016\/j.biomaterials.2018.08.017_bib59","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.biomaterials.2007.10.015","article-title":"Complement activation on surfaces modified with ethylene glycol units","volume":"29","author":"Arima","year":"2008","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.08.017_bib60","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1021\/ac980959t","article-title":"A strategy for the generation of surfaces presenting ligands for studies of binding based on an active ester as a common reactive intermediate: a surface plasmon resonance study","volume":"71","author":"Lahiri","year":"1999","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1039\/B612355D","article-title":"Synthesis of protein\u2013polymer conjugates","volume":"5","author":"Heredia","year":"2006","journal-title":"Org. Biomol. Chem."},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib62","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.devcel.2012.04.005","article-title":"Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin","volume":"22","author":"Meloty-Kapella","year":"2012","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.biomaterials.2018.08.017_bib63","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.devcel.2012.04.007","article-title":"Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis","volume":"22","author":"Shergill","year":"2012","journal-title":"Dev. Cell"},{"issue":"7","key":"10.1016\/j.biomaterials.2018.08.017_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022837","article-title":"Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.biomaterials.2018.08.017_bib65","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1242\/jcs.113.23.4313","article-title":"Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling","volume":"113","author":"Varnum-Finney","year":"2000","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.08.017_bib66","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.200609014","article-title":"DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur","volume":"176","author":"Nichols","year":"2007","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.biomaterials.2018.08.017_bib67","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.str.2011.01.016","article-title":"Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation","volume":"19","author":"Tiyanont","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.biomaterials.2018.08.017_bib68","series-title":"Notch Ligand Endocytosis: Mechanistic Basis of Signaling Activity, Seminars in Cell & Developmental Biology","first-page":"429","author":"Musse","year":"2012"},{"issue":"4","key":"10.1016\/j.biomaterials.2018.08.017_bib69","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jcb.25744","article-title":"Identification of domains for efficient notch signaling activity in immobilized notch ligand proteins","volume":"118","author":"Liu","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.08.017_bib70","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jbm.a.34332","article-title":"Surface\u2010bound orientated Jagged\u20101 enhances osteogenic differentiation of human periodontal ligament\u2010derived mesenchymal stem cells","volume":"101","author":"Osathanon","year":"2013","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.archoralbio.2018.01.007","article-title":"Characterization of a bioactive Jagged1-coated polycaprolactone-based membrane for guided tissue regeneration","volume":"88","author":"Nowwarote","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archoralbio.2016.01.010","article-title":"Effect of Jagged-1 and Dll-1 on osteogenic differentiation by stem cells from human exfoliated deciduous teeth","volume":"65","author":"Sukarawan","year":"2016","journal-title":"Arch. Oral Biol."},{"issue":"36","key":"10.1016\/j.biomaterials.2018.08.017_bib73","doi-asserted-by":"crossref","first-page":"13737","DOI":"10.1039\/c1jm10984g","article-title":"Biological modifications of materials surfaces with proteins for regenerative medicine","volume":"21","author":"Joddar","year":"2011","journal-title":"J. Mater. Chem."},{"issue":"11","key":"10.1016\/j.biomaterials.2018.08.017_bib74","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1002\/jps.21350","article-title":"PEGylation as a tool for the biomedical engineering of surface modified microparticles","volume":"97","author":"Wattendorf","year":"2008","journal-title":"J. Pharmaceut. Sci."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib75","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2014.06.046","article-title":"PEG\u2014a versatile conjugating ligand for drugs and drug delivery systems","volume":"192","author":"Kolate","year":"2014","journal-title":"J. Contr. Release"},{"issue":"28","key":"10.1016\/j.biomaterials.2018.08.017_bib76","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1016\/j.biomaterials.2011.05.078","article-title":"Immune responses to implants\u2013a review of the implications for the design of immunomodulatory biomaterials","volume":"32","author":"Franz","year":"2011","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.biomaterials.2018.08.017_bib77","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/bit.24559","article-title":"Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts","volume":"109","author":"Bryers","year":"2012","journal-title":"Biotechnol. Bioeng."},{"issue":"35","key":"10.1016\/j.biomaterials.2018.08.017_bib78","doi-asserted-by":"crossref","first-page":"9494","DOI":"10.1016\/j.biomaterials.2011.08.061","article-title":"Induction of immunotolerance via mPEG grafting to allogeneic leukocytes","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.biomaterials.2018.08.017_bib79","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/eji.200526294","article-title":"Notch ligands Delta\u2010like1, Delta\u2010like4 and Jagged1 differentially regulate activation of peripheral T helper cells","volume":"35","author":"Rutz","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib80","series-title":"Notch Signalling in the Regulation of Peripheral T-cell Function, Seminars in Cell & Developmental Biology","first-page":"127","author":"Mckenzie","year":"2003"},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib81","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.0105-2896.2006.00420.x","article-title":"Interleukin\u201010\u2010secreting type 1 regulatory T cells in rodents and humans","volume":"212","author":"Grazia Roncarolo","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biomaterials.2018.08.017_bib82","unstructured":"M.A. Boks, Modulation of Immune Tolerance: the Role of Tolerogenic Dendritic Cells and TNF\u03b1, 97894618215392012."},{"issue":"2","key":"10.1016\/j.biomaterials.2018.08.017_bib83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/intimm\/12.2.177","article-title":"Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells","volume":"12","author":"Hoyne","year":"2000","journal-title":"Int. Immunol."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib84","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1600-065X.2003.00079.x","article-title":"Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction","volume":"196","author":"Morelli","year":"2003","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib85","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.0105-2896.2006.00407.x","article-title":"The roles for cytokines in the generation and maintenance of regulatory T cells","volume":"212","author":"Wan","year":"2006","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.biomaterials.2018.08.017_bib86","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.0105-2896.2006.00414.x","article-title":"Regulatory T cells in the periphery","volume":"212","author":"Lohr","year":"2006","journal-title":"Immunol. Rev."}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218305714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218305714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:37:41Z","timestamp":1758904661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218305714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":86,"alternative-id":["S0142961218305714"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.08.017","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}