{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:54:49Z","timestamp":1792803289794,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273460"],"award-info":[{"award-number":["81273460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573356"],"award-info":[{"award-number":["81573356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomaterials"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.biomaterials.2018.09.017","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T06:41:49Z","timestamp":1536648109000},"page":"117-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":171,"special_numbering":"C","title":["Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells"],"prefix":"10.1016","volume":"185","author":[{"given":"Yudong","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biomaterials.2018.09.017_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.canlet.2013.01.024","article-title":"Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer","volume":"332","author":"Tang","year":"2013","journal-title":"Canc. Lett."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharmthera.2014.11.004","article-title":"Targeting breast cancer through its microenvironment: current status of preclinical and clinical research in finding relevant targets","volume":"147","author":"Nienhuis","year":"2015","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1586\/erm.10.97","article-title":"Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics","volume":"11","author":"Mukhtar","year":"2011","journal-title":"Expert Rev. Mol. Diagn"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00428-012-1362-4","article-title":"In human invasive breast ductal carcinoma, tumor stromal macrophages and tumor nest macrophages have distinct relationships with clinicopathological parameters and tumor angiogenesis","volume":"462","author":"Ch'ng","year":"2013","journal-title":"Virchows Arch."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3892\/ijo.2013.1938","article-title":"The role of tumor-associated macrophages in breast cancer regression","volume":"43","author":"Obeid","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib7","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.celrep.2016.04.084","article-title":"Reprogramming tumor-associated macrophages by antibody targeting inhibits cancer progression and metastasis","volume":"15","author":"Georgoudaki","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib8","first-page":"1","article-title":"Huaier extract suppresses breast cancer via regulating tumor associated macrophages","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep. U.K."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib9","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1158\/0008-5472.CAN-07-0912","article-title":"Tumor-associated macrophages press the angiogenic switch in breast cancer","volume":"67","author":"Lin","year":"2007","journal-title":"Canc. Res."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.canlet.2015.07.044","article-title":"Tumor microenvironment and cancer therapy resistance","volume":"380","author":"Sun","year":"2016","journal-title":"Canc. Lett."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ygyno.2006.09.031","article-title":"The prognostic value of vascular endothelial growth factors (VEGFs)-A and -B and their receptor, VEGFR-1, in tnvasive breast carcinoma","volume":"104","author":"Mylona","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib12","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/ijc.21865","article-title":"The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma","volume":"119","author":"Wu","year":"2006","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrendo.2014.114","article-title":"VEGF-targeted cancer therapeutics-paradoxical effects in endocrine organs","volume":"10","author":"Cao","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cell.2007.10.023","article-title":"\u03b1PlGF: a new kid on the antiangiogenesis block","volume":"131","author":"Rakesh","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nrc2524","article-title":"FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?","volume":"8","author":"Fischer","year":"2008","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib16","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm884","article-title":"Role of PIGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1","volume":"9","author":"Autiero","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib17","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","article-title":"Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels","volume":"131","author":"Fischer","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1130-3","article-title":"Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis","volume":"15","author":"Jayasinghe","year":"2015","journal-title":"BMC Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib20","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.ejca.2005.07.022","article-title":"Placenta growth factor is over-expressed and has prognostic value in human breast cancer","volume":"41","author":"Parr","year":"2005","journal-title":"Eur. J. Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccr.2010.11.009","article-title":"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PIGF","volume":"19","author":"Rolny","year":"2011","journal-title":"Canc. Cell"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib22","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nmat3765","article-title":"Delivery materials for siRNA therapeutics","volume":"12","author":"Kanasty","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.addr.2016.06.011","article-title":"Recent progress in development of siRNA delivery vehicles for cancer therapy","volume":"104","author":"Kim","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mattod.2015.07.005","article-title":"RNAi nanomaterials targeting immune cells as an anti-tumor therapy: the missing link in cancer treatment?","volume":"19","author":"Conde","year":"2016","journal-title":"Mater. Today"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib25","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.addr.2017.03.004","article-title":"Responsive nanocarriers as an emerging platform for cascaded delivery of nucleic acids to cancer","volume":"115","author":"Liu","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1021\/bm701084w","article-title":"pH-triggered reversible \"stealth\" polycationic micelles","volume":"9","author":"Gu","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib27","doi-asserted-by":"crossref","first-page":"23498","DOI":"10.1021\/acsami.6b07173","article-title":"pH-responsive core-shell structured nanoparticles for triple-stage targeted delivery of doxorubicin to tumors","volume":"8","author":"Han","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib28","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/nn101638u","article-title":"Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte","volume":"9","author":"Guo","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib29","doi-asserted-by":"crossref","first-page":"12203","DOI":"10.1021\/acsami.6b16556","article-title":"Impact of PEG chain length on the physical properties and bioactivity of PEGylated chitosan\/siRNA nanoparticles in vitro and in vivo","volume":"9","author":"Yang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib30","doi-asserted-by":"crossref","first-page":"70109","DOI":"10.1039\/C5RA11600G","article-title":"In situ synthesis of multidentate PEGylated chitosan modified gold nanoparticles with good stability and biocompatibility","volume":"5","author":"Liu","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2013.07.026","article-title":"The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage","volume":"172","author":"Abu Lila","year":"2013","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/acsnano.5b06779","article-title":"Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia","volume":"10","author":"Song","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib35","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1039\/C4NR03962A","article-title":"Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophages","volume":"7","author":"Ortega","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib36","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nbt.2614","article-title":"Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling","volume":"31","author":"Sahay","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1124\/pr.58.1.8","article-title":"Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery","volume":"58","author":"Khalil","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib38","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1089\/hum.2005.16.1422","article-title":"Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A","volume":"16","author":"Roy","year":"2005","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1990-6","article-title":"Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma","volume":"16","author":"Vandewynckel","year":"2016","journal-title":"BMC Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib40","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1111\/jcmm.13158","article-title":"Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease","volume":"21","author":"Li","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2016.07.007","article-title":"Targeting the angio-proteostasis network: combining the forces against cancer","volume":"167","author":"Devisscher","year":"2016","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2007.12.012","article-title":"VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis","volume":"200","author":"Fujii","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/nrc3627","article-title":"VEGF targets the tumour cell","volume":"13","author":"Goel","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib44","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature12626","article-title":"Influence of tumour micro-environment heterogeneity on therapeutic response","volume":"501","author":"Junttila","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib45","first-page":"6656","article-title":"The role of tumor-associated macrophages in breast carcinoma invasion and metastasis","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-016-2612-7","article-title":"Angiogenic cytokines and their influence on circulating tumour cells in sera of patients with the primary diagnosis of breast cancer before treatment","volume":"16","author":"Vilsmaier","year":"2016","journal-title":"BMC Canc."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s004280100458","article-title":"Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma","volume":"440","author":"Valkovic","year":"2002","journal-title":"Virchows Arch."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pharmthera.2016.06.001","article-title":"Antagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents","volume":"164","author":"Falcon","year":"2016","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib49","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ctrv.2016.12.009","article-title":"Anti-angiogenic treatment in breast cancer: facts, successes, failures and future perspectives","volume":"53","author":"Aalders","year":"2009","journal-title":"Canc. Treat Rev."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib50","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1158\/1535-7163.MCT-06-0461","article-title":"Role of placenta growth factor in malignancy and evidence that an antagonistic PlGF\/Flt-1 peptide inhibits the growth and metastasis of human breast cancer xenografts","volume":"6","author":"Taylor","year":"2007","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib51","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1002\/adfm.201501283","article-title":"Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-Peptide nanoparticles to tumor-associated macrophages and cancer cells","volume":"25","author":"Conde","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.smim.2017.09.004","article-title":"Targeting tumor associated macrophages: the new challenge for nanomedicine","volume":"34","author":"Andon","year":"2017","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.pharmthera.2016.04.009","article-title":"Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer","volume":"164","author":"Wigerup","year":"2016","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib54","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1016\/j.semcancer.2015.01.001","article-title":"Broad targeting of angiogenesis for cancer prevention and therapy","volume":"35","author":"Wang","year":"2015","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib55","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.smim.2017.09.002","article-title":"Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells","volume":"34","author":"Shen","year":"2017","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib56","first-page":"1","article-title":"Re-polarizing myeloid-derived suppressor cells (MDSCs) with cationic polymers for cancer immunotherapy","volume":"6","author":"He","year":"2016","journal-title":"Sci. Rep. U.K."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib57","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1073\/pnas.1525349113","article-title":"Dual inhibition of ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages","volume":"113","author":"Peterson","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib58","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.canlet.2016.04.036","article-title":"Dual blockade of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) exhibits potent anti-angiogenic effects","volume":"337","author":"Li","year":"2016","journal-title":"Canc. Lett."},{"key":"10.1016\/j.biomaterials.2018.09.017_bib59","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1021\/acsnano.7b05465","article-title":"Molecular-targeted immunotherapeutic strategy for melanoma via dual-targeting nanoparticles delivering small interfering RNA to tumor-associated macrophages","volume":"11","author":"Qian","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.biomaterials.2018.09.017_bib60","doi-asserted-by":"crossref","first-page":"11719","DOI":"10.1039\/C8NR02796J","article-title":"How can nanotechnology help the fight against breast cancer?","volume":"10","author":"Avitabile","year":"2018","journal-title":"Nanoscale"}],"container-title":["Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218306483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0142961218306483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T19:35:31Z","timestamp":1736537731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0142961218306483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":60,"alternative-id":["S0142961218306483"],"URL":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.09.017","relation":{},"ISSN":["0142-9612"],"issn-type":[{"value":"0142-9612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biomaterials.2018.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}